| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nachwa Jarkas, Ronald J Voll, Larry Williams, John R Votaw, Mike Owens, Mark M Goodma. Synthesis and in vivo evaluation of halogenated N,N-dimethyl-2-(2'-amino-4'-hydroxymethylphenylthio)benzylamine derivatives as PET serotonin transporter ligands. Journal of medicinal chemistry. vol 51. issue 2. 2008-04-17. PMID:18085744. |
the in vitro binding studies in cells transfected with human sert, norepinephrine transporter (net), and dopamine transporter (dat) showed that 35, 36, and 37 exhibited high sert affinity with k is (sert) = 1.26, 0.29, and 0.31 nm (vs [(3)h]citalopram), respectively. |
2008-04-17 |
2023-08-12 |
human |
| L Keith Henry, Jens Meiler, Randy D Blakel. Bound to be different: neurotransmitter transporters meet their bacterial cousins. Molecular interventions. vol 7. issue 6. 2008-04-17. PMID:18199851. |
the neurotransmitter transporters belonging to the solute carrier 6 (slc6) family, including the gamma-aminobutyric acid (gat), norepinephrine (net), serotonin (sert) and dopamine (dat) transporters are extremely important drug targets of great clinical relevance. |
2008-04-17 |
2023-08-12 |
human |
| Yosuke Yamauchi, Takaya Izumi, Kazuhiro Unemura, Yoshie Uenishi, Takayuki Nakagawa, Shuji Kanek. Acceleration of serotonin transporter transport-associated current by 3,4-methylenedioxymethamphetamine (MDMA) under acidic conditions. Neuroscience letters. vol 428. issue 2-3. 2008-03-26. PMID:17949903. |
perfusion with sert substrates at ph 7.4 dose-dependently evoked a transport-associated inward current response with the following rank order of potency: 5-ht>mdma>dopamine>>norepinephrine. |
2008-03-26 |
2023-08-12 |
xenopus_laevis |
| Seth D Norrholm, David B Horton, Linda P Dwoski. The promiscuity of the dopamine transporter: implications for the kinetic analysis of [3H]serotonin uptake in rat hippocampal and striatal synaptosomes. Neuropharmacology. vol 53. issue 8. 2008-03-21. PMID:18022203. |
for example, serotonin is transported by the dopamine transporter (dat) under conditions in which serotonin transporter (sert) activity is eliminated (e.g., pharmacological inhibition). |
2008-03-21 |
2023-08-12 |
rat |
| Ann J Barbier, Leah Aluisio, Brian Lord, Ying Qu, Sandy J Wilson, Jamin D Boggs, Pascal Bonaventure, Kirsten Miller, Ian Fraser, Lisa Dvorak, Cindy Pudiak, Christine Dugovic, Jonathan Shelton, Curt Mazur, Michael A Letavic, Nicholas I Carruthers, Timothy W Lovenber. Pharmacological characterization of JNJ-28583867, a histamine H(3) receptor antagonist and serotonin reuptake inhibitor. European journal of pharmacology. vol 576. issue 1-3. 2008-03-06. PMID:17765221. |
jnj-28583867 (2-methyl-4-(4-methylsulfanyl-phenyl)-7-(3-morpholin-4-yl-propoxy)-1,2,3,4-tetrahydro-isoquinoline) is a selective and potent histamine h(3) receptor antagonist (k(i)=10.6 nm) and inhibitor of the serotonin transporter (sert) (k(i)=3.7 nm), with 30-fold selectivity for sert over the dopamine and norepinephrine transporters. |
2008-03-06 |
2023-08-12 |
mouse |
| Stephen J Kish, Junchao Tong, Oleh Hornykiewicz, Ali Rajput, Li-Jan Chang, Mark Guttman, Yoshiaki Furukaw. Preferential loss of serotonin markers in caudate versus putamen in Parkinson's disease. Brain : a journal of neurology. vol 131. issue Pt 1. 2008-03-06. PMID:17956909. |
we measured levels of sert immunoreactivity, and for comparison, protein levels of tryptophan hydroxylase (tph; the marker synthetic enzyme) using a western blot procedure, as well as concentrations of serotonin, its metabolite 5-hydroxyindoleacetic acid (5-hiaa), and dopamine by hplc in post-mortem striatum of patients with pd and normal controls. |
2008-03-06 |
2023-08-12 |
Not clear |
| Stephen J Kish, Junchao Tong, Oleh Hornykiewicz, Ali Rajput, Li-Jan Chang, Mark Guttman, Yoshiaki Furukaw. Preferential loss of serotonin markers in caudate versus putamen in Parkinson's disease. Brain : a journal of neurology. vol 131. issue Pt 1. 2008-03-06. PMID:17956909. |
unlike the preferential loss of dopamine in putamen, the caudate was affected more than putamen by loss of all serotonin markers: serotonin (-66% versus -51%), 5-hiaa (-42% versus -31%), sert (-56% versus -30%) and tph (-59% versus -32%). |
2008-03-06 |
2023-08-12 |
Not clear |
| Fanxing Zeng, Nachwa Jarkas, Jeffrey S Stehouwer, Ronald J Voll, Michael J Owens, Clinton D Kilts, Charles B Nemeroff, Mark M Goodma. Synthesis, in vitro characterization, and radiolabeling of reboxetine analogs as potential PET radioligands for imaging the norepinephrine transporter. Bioorganic & medicinal chemistry. vol 16. issue 2. 2008-02-20. PMID:17983754. |
six new (s,s)-enantiomers of reboxetine derivatives were synthesized and their binding affinities were determined via competition binding assays in cells expressing the human norepinephrine transporter (net), serotonin transporter (sert) or dopamine transporter (dat). |
2008-02-20 |
2023-08-12 |
human |
| Anna M S Kindlundh-Högberg, Helgi B Schiöth, Per Svenningsso. Repeated intermittent MDMA binges reduce DAT density in mice and SERT density in rats in reward regions of the adolescent brain. Neurotoxicology. vol 28. issue 6. 2008-02-07. PMID:17692920. |
behavioral responses in the open-field and autoradiographic ligand-binding to dopamine (dat) and serotonin (sert) transporters in reward regions of the brain were measured. |
2008-02-07 |
2023-08-12 |
mouse |
| Yohtaro Numachi, Arihisa Ohara, Motoyasu Yamashita, Setsu Fukushima, Hideaki Kobayashi, Harumi Hata, Hidekazu Watanabe, F Scott Hall, Klaus-Peter Lesch, Dennis L Murphy, George R Uhl, Ichiro Sor. Methamphetamine-induced hyperthermia and lethal toxicity: role of the dopamine and serotonin transporters. European journal of pharmacology. vol 572. issue 2-3. 2008-01-14. PMID:17673199. |
we examined the hyperthermic and lethal toxic effects of methamphetamine in dopamine transporter (dat) and/or serotonin transporter (sert) knockout (ko) mice. |
2008-01-14 |
2023-08-12 |
mouse |
| Thomas S Hnasko, Bethany N Sotak, Richard D Palmite. Cocaine-conditioned place preference by dopamine-deficient mice is mediated by serotonin. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 46. 2007-12-19. PMID:18003826. |
these findings are consistent with the hypothesis that, in the absence of dopamine, cocaine-mediated sert blockade activates dopamine neurons, which then release some other neurotransmitter that contributes to cocaine reward in dd mice. |
2007-12-19 |
2023-08-12 |
mouse |
| Johnny Vercouillie, Winnie Deuther-Conrad, Matthias Scheunemann, Patrick Emond, Steffen Fischer, Uta Funke, Jörg Steinbach, Denis Guilloteau, Peter Brus. New fluoro-diphenylchalcogen derivatives to explore the serotonin transporter by PET. Bioorganic & medicinal chemistry letters. vol 17. issue 17. 2007-11-20. PMID:17658253. |
the compounds were synthesized and assayed toward the serotonin (sert), dopamine (dat), and norepinephrine (net) transporters. |
2007-11-20 |
2023-08-12 |
Not clear |
| Christophe Plisson, Jeffrey S Stehouwer, Ronald J Voll, Leonard Howell, John R Votaw, Michael J Owens, Mark M Goodma. Synthesis and in vivo evaluation of fluorine-18 and iodine-123 labeled 2beta-carbo(2-fluoroethoxy)-3beta-(4'-((Z)-2-iodoethenyl)phenyl)nortropane as a candidate serotonin transporter imaging agent. Journal of medicinal chemistry. vol 50. issue 19. 2007-10-23. PMID:17705359. |
the binding affinity of 1 to human monoamine transporters showed a high affinity for the sert (ki = 0.08 nm) with respect to the dopamine transporter (dat) (ki = 13 nm) and the norepinephrine transporter (net) (ki = 28 nm). |
2007-10-23 |
2023-08-12 |
human |
| Paul K Gong, Bruce E Blough, Lawrence E Brieaddy, Xiaodong Huang, Michael J Kuhar, Hernán A Navarro, F Ivy Carrol. Synthesis, monoamine transporter binding, properties, and functional monoamine uptake activity of 3beta-[4-methylphenyl and 4-chlorophenyl]-2 beta-[5-(substituted phenyl)thiazol-2-yl]tropanes. Journal of medicinal chemistry. vol 50. issue 15. 2007-10-15. PMID:17602602. |
in general, the compounds showed higher dopamine transporter (dat) affinity relative to the serotonin and norepinephrine transporters (sert and net, respectively) and greater [3h]dopamine uptake inhibition potency relative to [3h]serotonin and [3h]norepinephrine uptake inhibition. |
2007-10-15 |
2023-08-12 |
rat |
| Vishakantha Murthy, Huw M L Davies, Simon J Hedley, Steven R Childer. Irreversible binding of a novel phenylisothiocyanate tropane analog to monoamine transporters in rat brain. Biochemical pharmacology. vol 74. issue 2. 2007-08-16. PMID:17540345. |
irreversible tropane analogs have been useful in identifying binding sites of cocaine on biogenic amine transporters, including transporters for dopamine (dat), serotonin (sert) and norepinephrine (net). |
2007-08-16 |
2023-08-12 |
rat |
| Shunichi Oya, Seok-Rye Choi, Mei-Ping Kung, Hank F Kun. 5-Chloro-2-(2'-((dimethylamino)methyl)-4'-iodophenylthio)benzenamine: a new serotonin transporter ligand. Nuclear medicine and biology. vol 34. issue 2. 2007-07-20. PMID:17307121. |
the new ligands displayed extremely high binding affinities to sert (k(i)=0.22+/-0.09 and 0.11+/-0.04 nm, respectively), with very low binding affinities to dopamine and norepinephrine transporters (k(i)>1000 nm). |
2007-07-20 |
2023-08-12 |
rat |
| A Dahlin, L Xia, W Kong, R Hevner, J Wan. Expression and immunolocalization of the plasma membrane monoamine transporter in the brain. Neuroscience. vol 146. issue 3. 2007-07-03. PMID:17408864. |
mpmat is co-expressed in many brain regions with the high affinity 5-ht transporter (sert) and the dopamine transporter (dat), but is also found in certain sites that receive monoamine innervation but lack significant expression of sert or dat. |
2007-07-03 |
2023-08-12 |
mouse |
| J Kirchheiner, K Nickchen, J Sasse, M Bauer, I Roots, J Brockmölle. A 40-basepair VNTR polymorphism in the dopamine transporter (DAT1) gene and the rapid response to antidepressant treatment. The pharmacogenomics journal. vol 7. issue 1. 2007-06-20. PMID:16702979. |
the genes encoding the serotonin (sert) and dopamine (dat1) transporters are among the possible candidate genes modulating an individual's antidepressant response. |
2007-06-20 |
2023-08-12 |
Not clear |
| Michael Decker, Jochen Lehman. Agonistic and antagonistic bivalent ligands for serotonin and dopamine receptors including their transporters. Current topics in medicinal chemistry. vol 7. issue 4. 2007-06-07. PMID:17305576. |
selectivity profiles and affinities depend strongly on the length of the alkylene-spacer: for some dimeric inhibitors the norepinephrine transporter (net) and the dopamine transporter (dat) affinities changed gradually, but for the serotonin transporter (sert) a pentamethylene spacer showed the highest potency. |
2007-06-07 |
2023-08-12 |
Not clear |
| C Sogawa, N Sogawa, J Tagawa, A Fujino, K Ohyama, M Asanuma, M Funada, S Kitayam. 5-Methoxy-N,N-diisopropyltryptamine (Foxy), a selective and high affinity inhibitor of serotonin transporter. Toxicology letters. vol 170. issue 1. 2007-06-01. PMID:17382495. |
in the present study, we investigated the actions of 5-meo-dipt against monoamine neurotransmitter transporters, including the transporters for dopamine (dat), norepinephrine (net), and serotonin (sert), using cos-7 cells heterologously expressing these transporters and rat brain synaptosomes. |
2007-06-01 |
2023-08-12 |
rat |