| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Peng Zhang, George Cyriac, Theresa Kopajtic, Yongfang Zhao, Jonathan A Javitch, Jonathan L Katz, Amy Hauck Newma. Structure-activity relationships for a novel series of citalopram (1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile) analogues at monoamine transporters. Journal of medicinal chemistry. vol 53. issue 16. 2010-09-16. PMID:20672825. |
to further explore structure-activity relationships at the serotonin transporter (sert), a series of (+/-)-4- and 5-substituted citalopram analogues were designed, synthesized, and evaluated for binding at the sert, dopamine transporter (dat) and norepinephrine transporter (net) in native rodent tissue. |
2010-09-16 |
2023-08-12 |
Not clear |
| J Best, M Reed, H F Nijhou. Models of dopaminergic and serotonergic signaling. Pharmacopsychiatry. vol 43 Suppl 1. 2010-08-25. PMID:20480448. |
three results from recent in silico experiments with the dopaminergic and serotonergic synapse models are described: (1) influence of substrate inhibition on the stability of dopamine and serotonin synthesis; (2) a predicted connection between serotonin reuptake transporter (sert) density on terminals and tonic firing rates; (3) an explanation of data from autoreceptor knock-out experiments. |
2010-08-25 |
2023-08-12 |
Not clear |
| Gang Zhao, Jie Wang, Guo-Wei Qin, Li-He Gu. Cynomorium songaricum extracts functionally modulate transporters of gamma-aminobutyric acid and monoamine. Neurochemical research. vol 35. issue 4. 2010-08-02. PMID:20084455. |
here, we assessed these potential actions using chinese hamster ovary cells expressing gamma-aminobutyric acid (gaba) transporter (gat-1), dopamine transporter (dat), norepinephrine transporter (net), or serotonin transporter (sert) (i.e. |
2010-08-02 |
2023-08-12 |
Not clear |
| Dianca R Graham, Anita Sidh. Mice expressing the A53T mutant form of human alpha-synuclein exhibit hyperactivity and reduced anxiety-like behavior. Journal of neuroscience research. vol 88. issue 8. 2010-07-12. PMID:20077428. |
in this study, we examined the effect of the ha53t mutation during development by analyzing the protein expression of norepinephrine (net), serotonin (sert), and dopamine (dat) transporters in addition to assessing locomotor and anxiety-like behavior. |
2010-07-12 |
2023-08-12 |
mouse |
| Donatella Marazziti, Giorgio Consoli, Irene Masala, Mario Catena Dell'Osso, Stefano Baron. Latest advancements on serotonin and dopamine transporters in lymphocytes. Mini reviews in medicinal chemistry. vol 10. issue 1. 2010-07-12. PMID:20105129. |
different data show that circulating lymphocytes possess functional serotonin and dopamine transporters (sert and dat, respectively). |
2010-07-12 |
2023-08-12 |
Not clear |
| Carolina Chavez, Marianne Hollaus, Elizabeth Scarr, Geoff Pavey, Andrea Gogos, Maarten van den Buus. The effect of estrogen on dopamine and serotonin receptor and transporter levels in the brain: an autoradiography study. Brain research. vol 1321. 2010-06-09. PMID:20079719. |
the aim of the present study was to elucidate the effect of estrogen on dopaminergic and serotonergic regulation of prepulse inhibition (ppi) by measuring its effects on the density of dopamine transporters (dat), dopamine d(1) and d(2) receptors, serotonin transporters (sert), serotonin-1a (5-ht(1a)) and 5-ht(2a) receptors using radioligand binding autoradiography. |
2010-06-09 |
2023-08-12 |
rat |
| Carolina Chavez, Marianne Hollaus, Elizabeth Scarr, Geoff Pavey, Andrea Gogos, Maarten van den Buus. The effect of estrogen on dopamine and serotonin receptor and transporter levels in the brain: an autoradiography study. Brain research. vol 1321. 2010-06-09. PMID:20079719. |
there were no differences between the groups with respect to the densities of dopamine d(1) receptors, sert, 5-ht(1a) receptors or 5-ht(2a) receptors. |
2010-06-09 |
2023-08-12 |
rat |
| Sonja Sucic, Stefan Dallinger, Barbara Zdrazil, René Weissensteiner, Trine N Jørgensen, Marion Holy, Oliver Kudlacek, Stefan Seidel, Joo Hwan Cha, Ulrik Gether, Amy H Newman, Gerhard F Ecker, Michael Freissmuth, Harald H Sitt. The N terminus of monoamine transporters is a lever required for the action of amphetamines. The Journal of biological chemistry. vol 285. issue 14. 2010-05-14. PMID:20118234. |
most importantly, sert(t81a) (and the homologous mutations in noradrenaline and dopamine) failed to support amphetamine-induced efflux, and this was not remedied by aspartate at this position. |
2010-05-14 |
2023-08-12 |
Not clear |
| Jermaine D Jones, F Scott Hall, George R Uhl, Anthony L Rile. Dopamine, norepinephrine and serotonin transporter gene deletions differentially alter cocaine-induced taste aversion. Pharmacology, biochemistry, and behavior. vol 94. issue 4. 2010-04-29. PMID:19969013. |
monoamine transporter knockout mice have been useful in the study of many different aspects of cocaine effects relevant to human drug use and addiction, yet an assessment of the effects of deletion of the genes for the dopamine, norepinephrine and serotonin transporters (dat, net, and sert, respectively) on cocaine's aversive properties has yet to be performed (uhl et al., 2002). |
2010-04-29 |
2023-08-12 |
mouse |
| Jermaine D Jones, F Scott Hall, George R Uhl, Anthony L Rile. Dopamine, norepinephrine and serotonin transporter gene deletions differentially alter cocaine-induced taste aversion. Pharmacology, biochemistry, and behavior. vol 94. issue 4. 2010-04-29. PMID:19969013. |
when compared to their respective wt controls, dopamine transporter deletion slightly attenuated cocaine-induced aversion while deletion of sert or net resulted in a more significant delay in the onset and strength of cocaine-induced taste aversions. |
2010-04-29 |
2023-08-12 |
mouse |
| Marhaba Hojahmat, David B Horton, Seth D Norrholm, Dennis K Miller, Vladimir P Grinevich, Agripina Gabriela Deaciuc, Linda P Dwoskin, Peter A Crook. Lobeline esters as novel ligands for neuronal nicotinic acetylcholine receptors and neurotransmitter transporters. Bioorganic & medicinal chemistry. vol 18. issue 2. 2010-04-27. PMID:20036131. |
a series of carboxylic acid and sulfonic acid ester analogs 2-20 of lobeline were synthesized and evaluated for interaction with alpha4beta2 * and alpha7 * neuronal nicotinic acetylcholine receptors (nachrs), the dopamine transporter (dat), serotonin transporter (sert) and vmat2. |
2010-04-27 |
2023-08-12 |
rat |
| Jocelien D A Olivier, Alexander R Cools, Peter M T Deen, Berend Olivier, Bart A Ellenbroe. Blockade of dopamine, but not noradrenaline, transporters produces hyperthermia in rats that lack serotonin transporters. European journal of pharmacology. vol 629. issue 1-3. 2010-03-30. PMID:20004658. |
the dopamine transporter blocker gbr12909 increased the core body temperature in sert(-/-) rats, and had no effect on the sert(+/+) rats. |
2010-03-30 |
2023-08-12 |
rat |
| Jocelien D A Olivier, Alexander R Cools, Peter M T Deen, Berend Olivier, Bart A Ellenbroe. Blockade of dopamine, but not noradrenaline, transporters produces hyperthermia in rats that lack serotonin transporters. European journal of pharmacology. vol 629. issue 1-3. 2010-03-30. PMID:20004658. |
finally, the noradrenalin transporter together with dopamine transporter blocker bupropion was more effective in decreasing the stress of an injection in sert(-/-) rats than in sert(+/+) rats. |
2010-03-30 |
2023-08-12 |
rat |
| David L Gray, Wenjian Xu, Brian M Campbell, Amy B Dounay, Nancy Barta, Susan Boroski, Lynne Denny, Lori Evans, Nancy Stratman, Al Prober. Discovery and pharmacological characterization of aryl piperazine and piperidine ethers as dual acting norepinephrine reuptake inhibitors and 5-HT1A partial agonists. Bioorganic & medicinal chemistry letters. vol 19. issue 23. 2010-01-19. PMID:19854053. |
in addition, optimization of these molecules provided compounds which exhibit selectivity for nri over the dopamine (dat) and serotonin (sert) reuptake transporters. |
2010-01-19 |
2023-08-12 |
Not clear |
| Aina W Ravna, Ingebrigt Sylte, Svein G Dah. Structure and localisation of drug binding sites on neurotransmitter transporters. Journal of molecular modeling. vol 15. issue 10. 2009-12-31. PMID:19238460. |
the dopamine (dat), serotontin (sert) and noradrenalin (net) transporters are molecular targets for different classes of psychotropic drugs. |
2009-12-31 |
2023-08-12 |
Not clear |
| Simone Macrì, Oleg Granstrem, Maria Shumilina, Fernando João Antunes Gomes dos Santos, Alessandra Berry, Luciano Saso, Giovanni Laviol. Resilience and vulnerability are dose-dependently related to neonatal stressors in mice. Hormones and behavior. vol 56. issue 4. 2009-12-22. PMID:19632235. |
offspring attentional set-shifting abilities, central neurotrophic regulation and levels of natural auto-antibodies (na-abs) directed to serotonin (sert) and dopamine (dat) transporters were assessed in adulthood. |
2009-12-22 |
2023-08-12 |
mouse |
| Alex Ward, Vyvyca J Walker, Zhaoyang Feng, X Z Shawn X. Cocaine modulates locomotion behavior in C. elegans. PloS one. vol 4. issue 6. 2009-11-17. PMID:19536276. |
cocaine, a potent addictive substance, is an inhibitor of monoamine transporters, including dat (dopamine transporter), sert (serotonin transporter) and net (norepinephrine transporter). |
2009-11-17 |
2023-08-12 |
caenorhabditis_elegans |
| F S Hall, X-F Li, J Randall-Thompson, I Sora, D L Murphy, K-P Lesch, M Caron, G R Uh. Cocaine-conditioned locomotion in dopamine transporter, norepinephrine transporter and 5-HT transporter knockout mice. Neuroscience. vol 162. issue 4. 2009-11-10. PMID:19482066. |
the behavioral effects of cocaine are affected by gene knockout (ko) of the dopamine transporter (dat), the serotonin transporter (sert) and the norepinephrine transporter (net). |
2009-11-10 |
2023-08-12 |
mouse |
| Zheng Zhou, Juan Zhen, Nathan K Karpowich, Christopher J Law, Maarten E A Reith, Da-Neng Wan. Antidepressant specificity of serotonin transporter suggested by three LeuT-SSRI structures. Nature structural & molecular biology. vol 16. issue 6. 2009-10-27. PMID:19430461. |
conversely, when the only nonconserved hbp residue in both norepinephrine and dopamine transporters is mutated into that found in sert, their affinities for all the three ssris increase uniformly. |
2009-10-27 |
2023-08-12 |
Not clear |
| Xingrong Liu, Olga Vilenski, Joyce Kwan, Subbu Apparsundaram, Robert Weiker. Unbound brain concentration determines receptor occupancy: a correlation of drug concentration and brain serotonin and dopamine reuptake transporter occupancy for eighteen compounds in rats. Drug metabolism and disposition: the biological fate of chemicals. vol 37. issue 7. 2009-09-28. PMID:19389861. |
the objective of this study was to test this hypothesis by examining the relationship between in vitro binding affinity (k(i)) and in vivo activity quantified as the drug concentration occupying 50% of the transporters (oc(50)) for 18 serotonin (sert) and dopamine transporter (dat) inhibitors. |
2009-09-28 |
2023-08-12 |
rat |