| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P P Pandolf. PML, PLZF and NPM genes in the molecular pathogenesis of acute promyelocytic leukemia. Haematologica. vol 81. issue 5. 1997-01-23. PMID:8952164. |
rar alpha translocates in 99% of cases to a gene located on chromosome 15 that we initially named myl and is now known as pml. |
1997-01-23 |
2023-08-12 |
Not clear |
| V Brunel, M Lafage-Pochitaloff, M Alcalay, P G Pelicci, F Bir. Variant and masked translocations in acute promyelocytic leukemia. Leukemia & lymphoma. vol 22. issue 3-4. 1997-01-16. PMID:8819070. |
acute promyelocytic leukemia (apl) is characterized by a unique hemorrhagic syndrome, disseminated intravascular coagulation, and the association with the specific (15;17 chi q22-23:q12-21) translocation, which disrupts the retinoic acid receptor alpha (rara) and the promyelocytic leukemia (pml) genes. |
1997-01-16 |
2023-08-12 |
Not clear |
| T Ito. [Analysis of JC pseudotype virus generated by expression of VP231-SR alpha in COS7 cells]. [Hokkaido igaku zasshi] The Hokkaido journal of medical science. vol 71. issue 5. 1997-01-06. PMID:8934208. |
jc virus (jcv), the etiological agent of progressive multifocal leukoencephalopathy (pml), which is particularly difficult to grow in culture, has been artificially generated as a pseudotype virus (jcpv) by transfecting and expressing the genes coding the viral coat proteins (vp1, vp2, vp3) in cos7 cells under control of the sr alpha promoter. |
1997-01-06 |
2023-08-12 |
Not clear |
| K Nason-Burchenal, D Gandini, M Botto, J Allopenna, J R Seale, N C Cross, J M Goldman, E Dmitrovsky, P P Pandolf. Interferon augments PML and PML/RAR alpha expression in normal myeloid and acute promyelocytic cells and cooperates with all-trans retinoic acid to induce maturation of a retinoid-resistant promyelocytic cell line. Blood. vol 88. issue 10. 1996-12-17. PMID:8916959. |
interferon augments pml and pml/rar alpha expression in normal myeloid and acute promyelocytic cells and cooperates with all-trans retinoic acid to induce maturation of a retinoid-resistant promyelocytic cell line. |
1996-12-17 |
2023-08-12 |
human |
| K Nason-Burchenal, D Gandini, M Botto, J Allopenna, J R Seale, N C Cross, J M Goldman, E Dmitrovsky, P P Pandolf. Interferon augments PML and PML/RAR alpha expression in normal myeloid and acute promyelocytic cells and cooperates with all-trans retinoic acid to induce maturation of a retinoid-resistant promyelocytic cell line. Blood. vol 88. issue 10. 1996-12-17. PMID:8916959. |
the pml gene is fused to the retinoic acid receptor alpha gene (rar alpha) in the acute promyelocytic leukemia (apl) 15; 17 translocation. |
1996-12-17 |
2023-08-12 |
human |
| K Nason-Burchenal, D Gandini, M Botto, J Allopenna, J R Seale, N C Cross, J M Goldman, E Dmitrovsky, P P Pandolf. Interferon augments PML and PML/RAR alpha expression in normal myeloid and acute promyelocytic cells and cooperates with all-trans retinoic acid to induce maturation of a retinoid-resistant promyelocytic cell line. Blood. vol 88. issue 10. 1996-12-17. PMID:8916959. |
we report here that pml is expressed at low levels or not expressed in normal circulating human monocytes, lymphocytes, and polymorphonucleate cells, but is markedly induced by interferon; that pml and pml/rar alpha expression is augmented by interferon in the nb4 apl cell line, which carries the t(15; 17), and in apl blasts from patients; that interferon inhibits growth and survival of nb4 apl cells in cooperation with ra; that interferons alone have minimal maturation effect on nb4 cells; and, finally, that interferon gamma, but not alpha or beta, induces maturation and growth suppression of nb4 cells with de novo retinoid resistance, and partially restores ra response. |
1996-12-17 |
2023-08-12 |
human |
| J V Raelson, C Nervi, A Rosenauer, L Benedetti, Y Monczak, M Pearson, P G Pelicci, W H Mille. The PML/RAR alpha oncoprotein is a direct molecular target of retinoic acid in acute promyelocytic leukemia cells. Blood. vol 88. issue 8. 1996-12-02. PMID:8874178. |
because the ratio of expression of pml/rar alpha to wild-type rar alpha and pml may be important in maintaining the dominant negative block of myelocytic differentiation, these data suggest a molecular mechanism for restoration by tra normal myeloid differentiation in apl cells. |
1996-12-02 |
2023-08-12 |
human |
| M N Boddy, K Howe, L D Etkin, E Solomon, P S Freemon. PIC 1, a novel ubiquitin-like protein which interacts with the PML component of a multiprotein complex that is disrupted in acute promyelocytic leukaemia. Oncogene. vol 13. issue 5. 1996-11-05. PMID:8806687. |
acute promyelocytic leukaemia (apl) arises following a reciprocal translocation t(15;17) that fuses pml with retinoic acid receptor alpha (rara). |
1996-11-05 |
2023-08-12 |
mouse |
| E Early, M A Moore, A Kakizuka, K Nason-Burchenal, P Martin, R M Evans, E Dmitrovsk. Transgenic expression of PML/RARalpha impairs myelopoiesis. Proceedings of the National Academy of Sciences of the United States of America. vol 93. issue 15. 1996-10-29. PMID:8755574. |
the translocation found in acute promyelocytic leukemia rearranges the promyelocytic leukemia gene (pml) on chromosome 15 with the retinoic acid receptor alpha (raralpha) on chromosome 17. |
1996-10-29 |
2023-08-12 |
mouse |
| G Q Chen, J Zhu, X G Shi, J H Ni, H J Zhong, G Y Si, X L Jin, W Tang, X S Li, S M Xong, Z X Shen, G L Sun, J Ma, P Zhang, T D Zhang, C Gazin, T Naoe, S J Chen, Z Y Wang, Z Che. In vitro studies on cellular and molecular mechanisms of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia: As2O3 induces NB4 cell apoptosis with downregulation of Bcl-2 expression and modulation of PML-RAR alpha/PML proteins. Blood. vol 88. issue 3. 1996-09-12. PMID:8704214. |
the micropunctates characteristic of pml-rar alpha in nb4 cells dissappear after treatment with as2o3, whereas a diffuse pml staining occurs in the perinuclear cytoplasmic region. |
1996-09-12 |
2023-08-12 |
Not clear |
| G Q Chen, J Zhu, X G Shi, J H Ni, H J Zhong, G Y Si, X L Jin, W Tang, X S Li, S M Xong, Z X Shen, G L Sun, J Ma, P Zhang, T D Zhang, C Gazin, T Naoe, S J Chen, Z Y Wang, Z Che. In vitro studies on cellular and molecular mechanisms of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia: As2O3 induces NB4 cell apoptosis with downregulation of Bcl-2 expression and modulation of PML-RAR alpha/PML proteins. Blood. vol 88. issue 3. 1996-09-12. PMID:8704214. |
moreover, this apoptosis induction occurs independently of the retinoid pathway and may be mediated, at least partly, through the modulation of bcl-2, as well as pml-rar alpha and/ or pml proteins. |
1996-09-12 |
2023-08-12 |
Not clear |
| J R Kane, D R Head, L Balazs, M G Hulshof, T A Motroni, S C Raimondi, A J Carroll, F G Behm, R A Krance, S A Shurtleff, J R Downin. Molecular analysis of the PML/RAR alpha chimeric gene in pediatric acute promyelocytic leukemia. Leukemia. vol 10. issue 8. 1996-09-09. PMID:8709634. |
consistent with previously published data, case analysis demonstrated fusion products resulting from three breakpoint cluster regions (bcr) in pml, and a single breakpoint region in intron 2 of rar alpha. |
1996-09-09 |
2023-08-12 |
Not clear |
| C Gambacorti-Passerini, L Mologni, C Bertazzoli, P le Coutre, E Marchesi, F Grignani, P E Nielse. In vitro transcription and translation inhibition by anti-promyelocytic leukemia (PML)/retinoic acid receptor alpha and anti-PML peptide nucleic acid. Blood. vol 88. issue 4. 1996-09-05. PMID:8695861. |
in vitro transcription and translation inhibition by anti-promyelocytic leukemia (pml)/retinoic acid receptor alpha and anti-pml peptide nucleic acid. |
1996-09-05 |
2023-08-12 |
Not clear |
| A L Dent, J Yewdell, F Puvion-Dutilleul, M H Koken, H de The, L M Staud. LYSP100-associated nuclear domains (LANDs): description of a new class of subnuclear structures and their relationship to PML nuclear bodies. Blood. vol 88. issue 4. 1996-09-05. PMID:8695863. |
the pml gene is fused to the retinoic acid receptor alpha (rar alpha) gene in t(15;17) acute promyelocytic leukemia (apl), creating a pml-rar alpha fusion oncoprotein. |
1996-09-05 |
2023-08-12 |
Not clear |
| J P Park, R B Fairweathe. Complex t(1;15;17) in acute promyelocytic leukemia with duplication of RAR alpha and PML sequences. Cancer genetics and cytogenetics. vol 89. issue 1. 1996-08-29. PMID:8689611. |
complex t(1;15;17) in acute promyelocytic leukemia with duplication of rar alpha and pml sequences. |
1996-08-29 |
2023-08-12 |
Not clear |
| J P Park, R B Fairweathe. Complex t(1;15;17) in acute promyelocytic leukemia with duplication of RAR alpha and PML sequences. Cancer genetics and cytogenetics. vol 89. issue 1. 1996-08-29. PMID:8689611. |
fluorescence in situ hybridization (fish) with t(15;17), rar alpha, and 17qter probes and with chromosome 1, 15, and 17 paints demonstrated that the der(17) consisted of a complex rearrangement with duplication of both rar alpha and pml, insertion of chromosome 1 sequences, and double insertion of chromosome 15 sequences. |
1996-08-29 |
2023-08-12 |
Not clear |
| J P Park, R B Fairweathe. Complex t(1;15;17) in acute promyelocytic leukemia with duplication of RAR alpha and PML sequences. Cancer genetics and cytogenetics. vol 89. issue 1. 1996-08-29. PMID:8689611. |
the fusion of rar alpha and pml consistent with apl appears to have occurred at the distal juxtaposition of these sequences in the derivative chromosome. |
1996-08-29 |
2023-08-12 |
Not clear |
| M Altabef, M Garcia, C Lavau, S C Bae, A Dejean, J Samaru. A retrovirus carrying the promyelocyte-retinoic acid receptor PML-RARalpha fusion gene transforms haematopoietic progenitors in vitro and induces acute leukaemias. The EMBO journal. vol 15. issue 11. 1996-07-30. PMID:8654368. |
the promyelocyte (pml)-retinoic acid receptor alpha (raralpha) fusion gene results from a t(15;17) chromosome translocation in acute promyelocytic leukaemia. |
1996-07-30 |
2023-08-12 |
human |
| K L Borden, J M Lally, S R Martin, N J O'Reilly, E Solomon, P S Freemon. In vivo and in vitro characterization of the B1 and B2 zinc-binding domains from the acute promyelocytic leukemia protooncoprotein PML. Proceedings of the National Academy of Sciences of the United States of America. vol 93. issue 4. 1996-07-17. PMID:8643677. |
acute promyelocytic leukemia (apl) has been ascribed to a chromosomal translocation event which results in a fusion protein comprising the pml protein and retinoic acid receptor alpha. |
1996-07-17 |
2023-08-12 |
Not clear |
| b' M K Chelbi-Alix, L Pelicano, F Quignon, M H Koken, L Venturini, M Stadler, J Pavlovic, L Degos, H de Th\\xc3\\xa. Induction of the PML protein by interferons in normal and APL cells. Leukemia. vol 9. issue 12. 1996-05-29. PMID:8609713.' |
pml has been identified through its fusion to the rar alpha gene in acute promyelocytic leukemia (apl). |
1996-05-29 |
2023-08-12 |
human |