| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J H Jansen, A Mahfoudi, S Rambaud, C Lavau, W Wahli, A Dejea. Multimeric complexes of the PML-retinoic acid receptor alpha fusion protein in acute promyelocytic leukemia cells and interference with retinoid and peroxisome-proliferator signaling pathways. Proceedings of the National Academy of Sciences of the United States of America. vol 92. issue 16. 1995-09-11. PMID:7638205. |
the t(15;17) chromosomal translocation, specific for acute promyelocytic leukemia (apl), fuses the pml gene to the retinoic acid receptor alpha (rar alpha) gene, resulting in expression of a pml-rar alpha hybrid protein. |
1995-09-11 |
2023-08-12 |
drosophila_melanogaster |
| D Diverio, R Riccioni, F Mandelli, F Lo Coc. The PML/RAR alpha fusion gene in the diagnosis and monitoring of acute promyelocytic leukemia. Haematologica. vol 80. issue 2. 1995-09-05. PMID:7628753. |
the acute promyelocytic leukemia (apl)-specific t(15;17) chromosome abnormality is characterized at the molecular level by rearrangement of the pml and rar alpha genes, resulting in fusion pml/rar alpha mrna and a chimeric protein. |
1995-09-05 |
2023-08-12 |
Not clear |
| J A Dyck, R P Warrell, R M Evans, W H Mille. Rapid diagnosis of acute promyelocytic leukemia by immunohistochemical localization of PML/RAR-alpha protein. Blood. vol 86. issue 3. 1995-08-29. PMID:7620182. |
acute promyelocytic leukemia (apl) is characterized by a consistent chromosomal aberration that fuses the retinoic acid receptor alpha (rar alpha) gene with the novel gene pml, resulting in the expression of a pml/rar-alpha fusion protein. |
1995-08-29 |
2023-08-12 |
Not clear |
| A Goy, T Passalaris, Y H Xiao, W H Miller, D S Siegel, A D Zelenet. The PML gene is linked to a megabase-scale insertion/deletion restriction fragment length polymorphism. Genomics. vol 26. issue 2. 1995-08-08. PMID:7601459. |
the pml gene located on chromosome band 15q22 is involved with the rar alpha locus (17q21) in a balanced reciprocal translocation uniquely observed in acute promyelocytic leukemia. |
1995-08-08 |
2023-08-12 |
Not clear |
| K S Chang, Y H Fan, M Andreeff, J Liu, Z M M. The PML gene encodes a phosphoprotein associated with the nuclear matrix. Blood. vol 85. issue 12. 1995-07-20. PMID:7780148. |
the pml and retinoic acid receptor-alpha (rar alpha) transcription factor genes are involved at translocation breakpoint. |
1995-07-20 |
2023-08-12 |
Not clear |
| K S Chang, Y H Fan, M Andreeff, J Liu, Z M M. The PML gene encodes a phosphoprotein associated with the nuclear matrix. Blood. vol 85. issue 12. 1995-07-20. PMID:7780148. |
this antibody was able to detect a 90-kd pml protein and a 110-kd pml-rar alpha fusion protein by western blotting and a nuclear speckled pattern in all cell lines by immunofluorescent staining. |
1995-07-20 |
2023-08-12 |
Not clear |
| M J Ahn, K Nason-Burchenal, M M Moasser, E Dmitrovsk. Growth suppression of acute promyelocytic leukemia cells having increased expression of the non-rearranged alleles: RAR alpha or PML. Oncogene. vol 10. issue 12. 1995-07-18. PMID:7784078. |
growth suppression of acute promyelocytic leukemia cells having increased expression of the non-rearranged alleles: rar alpha or pml. |
1995-07-18 |
2023-08-12 |
Not clear |
| M J Ahn, K Nason-Burchenal, M M Moasser, E Dmitrovsk. Growth suppression of acute promyelocytic leukemia cells having increased expression of the non-rearranged alleles: RAR alpha or PML. Oncogene. vol 10. issue 12. 1995-07-18. PMID:7784078. |
the balanced t(15;17) rearrangement found in acute promyelocytic leukemia (apl) cells fuses pml on chromosome 15 to the retinoic acid receptor alpha (rar alpha) on chromosome 17. |
1995-07-18 |
2023-08-12 |
Not clear |
| M J Ahn, K Nason-Burchenal, M M Moasser, E Dmitrovsk. Growth suppression of acute promyelocytic leukemia cells having increased expression of the non-rearranged alleles: RAR alpha or PML. Oncogene. vol 10. issue 12. 1995-07-18. PMID:7784078. |
pml/rar alpha is expressed in apl cells with the non-rearranged alleles, pml and rar alpha. |
1995-07-18 |
2023-08-12 |
Not clear |
| M J Ahn, K Nason-Burchenal, M M Moasser, E Dmitrovsk. Growth suppression of acute promyelocytic leukemia cells having increased expression of the non-rearranged alleles: RAR alpha or PML. Oncogene. vol 10. issue 12. 1995-07-18. PMID:7784078. |
the roles of pml and rar alpha in the ra response of apl have not yet been fully explored. |
1995-07-18 |
2023-08-12 |
Not clear |
| M J Ahn, K Nason-Burchenal, M M Moasser, E Dmitrovsk. Growth suppression of acute promyelocytic leukemia cells having increased expression of the non-rearranged alleles: RAR alpha or PML. Oncogene. vol 10. issue 12. 1995-07-18. PMID:7784078. |
this study examines these roles by individually transfecting rar alpha and pml into nb4 apl cells. |
1995-07-18 |
2023-08-12 |
Not clear |
| M J Ahn, K Nason-Burchenal, M M Moasser, E Dmitrovsk. Growth suppression of acute promyelocytic leukemia cells having increased expression of the non-rearranged alleles: RAR alpha or PML. Oncogene. vol 10. issue 12. 1995-07-18. PMID:7784078. |
full length cdnas for rar alpha and pml were individually cloned into a cmv-driven expression vector containing the neomycin resistance gene. |
1995-07-18 |
2023-08-12 |
Not clear |
| M J Ahn, K Nason-Burchenal, M M Moasser, E Dmitrovsk. Growth suppression of acute promyelocytic leukemia cells having increased expression of the non-rearranged alleles: RAR alpha or PML. Oncogene. vol 10. issue 12. 1995-07-18. PMID:7784078. |
surprisingly, none of the obtained stable transfectants expressed exogenous rar alpha or pml mrnas even when reverse transcription polymerase chain reaction (rt-pcr) detection assays were used. |
1995-07-18 |
2023-08-12 |
Not clear |
| M J Ahn, K Nason-Burchenal, M M Moasser, E Dmitrovsk. Growth suppression of acute promyelocytic leukemia cells having increased expression of the non-rearranged alleles: RAR alpha or PML. Oncogene. vol 10. issue 12. 1995-07-18. PMID:7784078. |
an explanation explored for this lack of gene expression was that increased levels of rar alpha or pml might suppress apl cell growth. |
1995-07-18 |
2023-08-12 |
Not clear |
| M J Ahn, K Nason-Burchenal, M M Moasser, E Dmitrovsk. Growth suppression of acute promyelocytic leukemia cells having increased expression of the non-rearranged alleles: RAR alpha or PML. Oncogene. vol 10. issue 12. 1995-07-18. PMID:7784078. |
to examine this possibility, transfection experiments were repeated using an episomal vector-based expression system containing an sv40 driven rar alpha or pml cdna and the hygromycin b resistance gene. |
1995-07-18 |
2023-08-12 |
Not clear |
| M J Ahn, K Nason-Burchenal, M M Moasser, E Dmitrovsk. Growth suppression of acute promyelocytic leukemia cells having increased expression of the non-rearranged alleles: RAR alpha or PML. Oncogene. vol 10. issue 12. 1995-07-18. PMID:7784078. |
these findings indicate: (1) a growth disadvantage for nb4 cells having increased expression of rar alpha or pml and (2) increased rar alpha expression augmented ra-mediated maturation of nb4 cells. |
1995-07-18 |
2023-08-12 |
Not clear |
| M J Ahn, K Nason-Burchenal, M M Moasser, E Dmitrovsk. Growth suppression of acute promyelocytic leukemia cells having increased expression of the non-rearranged alleles: RAR alpha or PML. Oncogene. vol 10. issue 12. 1995-07-18. PMID:7784078. |
this implicates a role for rar alpha or pml in regulating the growth or differentiation of apl cells. |
1995-07-18 |
2023-08-12 |
Not clear |
| J H Liu, Z M Mu, K S Chan. PML suppresses oncogenic transformation of NIH/3T3 cells by activated neu. The Journal of experimental medicine. vol 181. issue 6. 1995-06-23. PMID:7759992. |
the chromosomal translocation t(15;17)(q22;q12) is a consistent feature of acute promyelocytic leukemia (apl) that results in the disruption of genes for the zinc finger transcription factor pml and the retinoic acid receptor alpha (rar alpha). |
1995-06-23 |
2023-08-12 |
mouse |
| K L Borden, M N Boddy, J Lally, N J O'Reilly, S Martin, K Howe, E Solomon, P S Freemon. The solution structure of the RING finger domain from the acute promyelocytic leukaemia proto-oncoprotein PML. The EMBO journal. vol 14. issue 7. 1995-05-30. PMID:7729428. |
acute promyelocytic leukaemia (apl) has been ascribed to a chromosomal translocation event which results in a fusion protein comprising the pml protein and the retinoic acid receptor alpha. |
1995-05-30 |
2023-08-12 |
Not clear |
| S J Chen, Z Y Wang, Z Che. Acute promyelocytic leukemia: from clinic to molecular biology. Stem cells (Dayton, Ohio). vol 13. issue 1. 1995-05-25. PMID:7719245. |
apl is also associated with a specific chromosomal translocation t(15;17) which fuses the retinoic acid receptor alpha (rar alpha) gene with a chromosome 15q locus, pml. |
1995-05-25 |
2023-08-12 |
human |