| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Y P Li, J Andersen, A Zelent, S Rao, E Paietta, M S Tallman, P H Wiernik, R E Gallaghe. RAR alpha1/RAR alpha2-PML mRNA expression in acute promyelocytic leukemia cells: a molecular and laboratory-clinical correlative study. Blood. vol 90. issue 1. 1997-07-22. PMID:9207466. |
there was no association between rar alpha1-pml or rar alpha2-pml mrna expression and the type of pml-rar alpha mrna formed by either 5' or 3' breaksites in the pml gene. |
1997-07-22 |
2023-08-12 |
Not clear |
| W Shao, L Benedetti, W W Lamph, C Nervi, W H Mille. A retinoid-resistant acute promyelocytic leukemia subclone expresses a dominant negative PML-RAR alpha mutation. Blood. vol 89. issue 12. 1997-07-10. PMID:9192750. |
the unique t(15;17) of acute promyelocytic leukemia (apl) fuses the pml gene with the retinoic acid receptor alpha (rar alpha) gene. |
1997-07-10 |
2023-08-12 |
human |
| M Takeuchi, T Yano, E Omoto, K Takahashi, M Kibata, K Shudo, R Ueda, R Ohno, M Harad. Re-induction of complete remission with a new synthetic retinoid, Am-80, for relapse of acute promyelocytic leukaemia previously treated with all-trans retinoic acid. British journal of haematology. vol 97. issue 1. 1997-06-19. PMID:9136955. |
on the day of cr, pml gene rearrangement and the t(15;17) translocation disappeared, though pml-rar alpha chimaeric messenger rna was still detected by reverse transcriptase polymerase chain reaction. |
1997-06-19 |
2023-08-12 |
Not clear |
| D Grimwade, E Solomo. Characterisation of the PML/RAR alpha rearrangement associated with t(15;17) acute promyelocytic leukaemia. Current topics in microbiology and immunology. vol 220. 1997-06-12. PMID:9103677. |
in apl the nuclear bodies become disrupted, presumably as a consequence of the presence of pml-rar alpha and aberrant pml proteins that might render the structure unstable. |
1997-06-12 |
2023-08-12 |
Not clear |
| Z M Mu, X F Le, A B Glassman, K S Chan. The biologic function of PML and its role in acute promyelocytic leukemia. Leukemia & lymphoma. vol 23. issue 3-4. 1997-05-28. PMID:9031108. |
the fusion protein pml-rar alpha encoded from the breakpoint can form a heterodimer and acts as a dominant negative inhibitor against the normal function of pml. |
1997-05-28 |
2023-08-12 |
human |
| b' J Zhu, M H Koken, F Quignon, M K Chelbi-Alix, L Degos, Z Y Wang, Z Chen, H de Th\\xc3\\xa. Arsenic-induced PML targeting onto nuclear bodies: implications for the treatment of acute promyelocytic leukemia. Proceedings of the National Academy of Sciences of the United States of America. vol 94. issue 8. 1997-05-22. PMID:9108090.' |
acute promyelocytic leukemia (apl) is associated with the t(15;17) translocation, which generates a pml/rar alpha fusion protein between pml, a growth suppressor localized on nuclear matrix-associated bodies, and rar alpha, a nuclear receptor for retinoic acid (ra). |
1997-05-22 |
2023-08-12 |
Not clear |
| b' J Zhu, M H Koken, F Quignon, M K Chelbi-Alix, L Degos, Z Y Wang, Z Chen, H de Th\\xc3\\xa. Arsenic-induced PML targeting onto nuclear bodies: implications for the treatment of acute promyelocytic leukemia. Proceedings of the National Academy of Sciences of the United States of America. vol 94. issue 8. 1997-05-22. PMID:9108090.' |
in addition, in apl cells, pml/rar alpha displaces pml and other nuclear body (nb) antigens onto nuclear microspeckles, likely resulting in the loss of pml and/or nb functions. |
1997-05-22 |
2023-08-12 |
Not clear |
| b' J Zhu, M H Koken, F Quignon, M K Chelbi-Alix, L Degos, Z Y Wang, Z Chen, H de Th\\xc3\\xa. Arsenic-induced PML targeting onto nuclear bodies: implications for the treatment of acute promyelocytic leukemia. Proceedings of the National Academy of Sciences of the United States of America. vol 94. issue 8. 1997-05-22. PMID:9108090.' |
in apl cells, arsenic targets pml and pml/rar alpha onto nb and induces their degradation. |
1997-05-22 |
2023-08-12 |
Not clear |
| b' J Zhu, M H Koken, F Quignon, M K Chelbi-Alix, L Degos, Z Y Wang, Z Chen, H de Th\\xc3\\xa. Arsenic-induced PML targeting onto nuclear bodies: implications for the treatment of acute promyelocytic leukemia. Proceedings of the National Academy of Sciences of the United States of America. vol 94. issue 8. 1997-05-22. PMID:9108090.' |
thus, ra and arsenic target rar alpha and pml, respectively, but both induce the degradation of the pml/rar alpha fusion protein, which should contribute to their therapeutic effects. |
1997-05-22 |
2023-08-12 |
Not clear |
| M Altabef, M Garcia, G Varior-Krishnan, J Samaru. A truncated RAR alpha co-operates with the v-erbB oncogene to transform early haematopoietic progenitors in vitro and in vivo. Oncogene. vol 14. issue 12. 1997-05-21. PMID:9136991. |
neither truncated pml nor truncated rar alpha alone could induce transformation which suggest that the two domains should cooperate for the oncogenicity of the fusion product. |
1997-05-21 |
2023-08-12 |
human |
| S K Gogineni, H O Shah, M Chester, J H Lin, M Garrison, A Alidina, E Bayani, R S Verm. Variant complex translocations involving chromosomes 1, 9, 9, 15 and 17 in acute promyelocytic leukemia without RAR alpha/PML gene fusion rearrangement. Leukemia. vol 11. issue 4. 1997-04-29. PMID:9096691. |
acute promyelocytic leukemia (apl;m3) is specifically characterized by a predominance of malignant promyelocytes having atypical reciprocal translocation involving chromosome 15 and 17 [t(15;17)(q22;q11)] resulting in the fusion of retinoic acid receptor alpha (rar alpha) on chromosome 17 and the putative transcription factor gene pml, ie the translocation generates two fusion transcripts, pml/rar alpha and rar alpha/pml. |
1997-04-29 |
2023-08-12 |
Not clear |
| D Brown, S Kogan, E Lagasse, I Weissman, M Alcalay, P G Pelicci, S Atwater, J M Bisho. A PMLRARalpha transgene initiates murine acute promyelocytic leukemia. Proceedings of the National Academy of Sciences of the United States of America. vol 94. issue 6. 1997-04-24. PMID:9122233. |
the malignant cells of acute promyelocytic leukemia (apl) contain a reciprocal chromosomal translocation that fuses the promyelocytic leukemia gene (pml) with the retinoic acid receptor alpha gene (rar alpha). |
1997-04-24 |
2023-08-12 |
mouse |
| D Sitterlin, P Tiollais, C Trans. The RAR alpha-PLZF chimera associated with Acute Promyelocytic Leukemia has retained a sequence-specific DNA-binding domain. Oncogene. vol 14. issue 9. 1997-04-11. PMID:9070655. |
in most cases, acute promyelocytic leukemia (apl) is associated with t(15;17) translocation which juxtaposes sequences from pml and retinoic acid receptor alpha (rar alpha) genes. |
1997-04-11 |
2023-08-12 |
Not clear |
| D Sitterlin, P Tiollais, C Trans. The RAR alpha-PLZF chimera associated with Acute Promyelocytic Leukemia has retained a sequence-specific DNA-binding domain. Oncogene. vol 14. issue 9. 1997-04-11. PMID:9070655. |
the generated pml-rar alpha fusion interferes with wild type rar alpha-mediated transcription and disrupts subnuclear compartments, known as pml bodies. |
1997-04-11 |
2023-08-12 |
Not clear |
| M A Grande, I van der Kraan, B van Steensel, W Schul, H de Thé, H T van der Voort, L de Jong, R van Drie. PML-containing nuclear bodies: their spatial distribution in relation to other nuclear components. Journal of cellular biochemistry. vol 63. issue 3. 1997-03-07. PMID:8913879. |
in the apl cell line nb4, the pml gene is fused with the rar alpha gene due to a chromosomal rearrangement. |
1997-03-07 |
2023-08-12 |
human |
| J L Grisolano, R L Wesselschmidt, P G Pelicci, T J Le. Altered myeloid development and acute leukemia in transgenic mice expressing PML-RAR alpha under control of cathepsin G regulatory sequences. Blood. vol 89. issue 2. 1997-02-24. PMID:9002938. |
a balanced t(15;17) (q22;q21) reciprocal chromosomal translocation is found in approximately 90% of apml patients; this translocation fuses the pml gene on chromosome 15 to the retinoic acid receptor alpha (rar alpha) gene on chromosome 17, creating two novel fusion genes, pml-rar alpha and rar alpha-pml. |
1997-02-24 |
2023-08-12 |
mouse |
| Y Kawachi, A Watanabe, T Nishihara, T Uchida, K Ikeda, J Takahara, K Setsu, M Mor. [CD2 and CD8 expression in acute promyelocytic leukemia]. [Rinsho ketsueki] The Japanese journal of clinical hematology. vol 37. issue 12. 1997-02-04. PMID:8997125. |
pml-rar alpha with intron 3 breakpoint of the pml locus, and rearrangements of the t-cell receptor beta and gamma genes were detected. |
1997-02-04 |
2023-08-12 |
Not clear |
| Y Hatae, H Nakadate, S Iizuka, T Takeda, T Shikano, M Imaizum. [Childhood acute promyelocytic leukemia treated with all-trans retinoic acid]. [Rinsho ketsueki] The Japanese journal of clinical hematology. vol 37. issue 12. 1997-02-04. PMID:8997131. |
there are two major isoforms of pml/rar alpha transcripts, so called short and long type transcripts, according to the breakpoints in the pml genes. |
1997-02-04 |
2023-08-12 |
Not clear |
| E Di Bona, A Montaldi, N Guercini, V Rossi, A Luciano, A Biondi, F Rodeghier. A (15;17) translocation not associated with acute promyelocytic leukaemia. British journal of haematology. vol 95. issue 4. 1997-01-30. PMID:8982049. |
fluorescence in situ hybridization (fish) using cosmidic probes specific for rar alpha and pml, regions did not show a fusion signal as in apl. |
1997-01-30 |
2023-08-12 |
Not clear |
| E Di Bona, A Montaldi, N Guercini, V Rossi, A Luciano, A Biondi, F Rodeghier. A (15;17) translocation not associated with acute promyelocytic leukaemia. British journal of haematology. vol 95. issue 4. 1997-01-30. PMID:8982049. |
detailed molecular analyses did not reveal any involvement of rar alpha and pml genes. |
1997-01-30 |
2023-08-12 |
Not clear |