| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J L Slack, R E Gallaghe. The molecular biology of acute promyelocytic leukemia. Cancer treatment and research. vol 99. 1999-03-12. PMID:9891864. |
in addition, the demonstration that both the dbd (from rar alpha) and dimerization interface (from pml) are required for full in vitro functional activity, coupled with the finding that pml itself is a strong transcriptional suppressor, suggests that pml-rar alpha may directly repress transcription of ra target genes. |
1999-03-12 |
2023-08-12 |
mouse |
| T Okuma, R Honda, G Ichikawa, N Tsumagari, H Yasud. In vitro SUMO-1 modification requires two enzymatic steps, E1 and E2. Biochemical and biophysical research communications. vol 254. issue 3. 1999-03-01. PMID:9920803. |
the sumo-1 has been identified as a protein that is highly similar to ubiquitin and shown to conjugate to rangap1, pml, sp200 and i kappa b alpha. |
1999-03-01 |
2023-08-12 |
human |
| G Martinelli, E Ottaviani, G Visani, N Testoni, V Montefusco, S Tur. Long-term disease-free acute promyelocytic leukemia patients really can be cured at molecular level. Haematologica. vol 83. issue 9. 1999-02-22. PMID:9825588. |
at the molecular level, it fuses genes encoding pml on chromosome 15 and the nuclear retinoic acid receptor-alpha (rar alpha) on chromosome 17. |
1999-02-22 |
2023-08-12 |
Not clear |
| G Martinelli, E Ottaviani, G Visani, N Testoni, V Montefusco, S Tur. Long-term disease-free acute promyelocytic leukemia patients really can be cured at molecular level. Haematologica. vol 83. issue 9. 1999-02-22. PMID:9825588. |
using pml and rara sequence specific primers, reverse transcription-polymerase chain reaction (rt-pcr) assays have been developed for detection of pml/rar alpha transcript in leukemic cells obtained from patients; these rt-pcr assays are more sensitive than conventional cytogenetic analysis. |
1999-02-22 |
2023-08-12 |
Not clear |
| S Fu, U Consoli, E G Hanania, Z Zu, D F Claxton, M Andreeff, A B Deisserot. PML/RARalpha, a fusion protein in acute promyelocytic leukemia, prevents growth factor withdrawal-induced apoptosis in TF-1 cells. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 1. issue 6. 1999-02-08. PMID:9816019. |
a unique mrna produced by the t(15;17) (q22-24;q11-21) translocation in the leukemic cells of acute promyelocytic leukemia patients encodes a chimeric protein, pml/raralpha, which is formed by the fusion of the retinoic acid receptor alpha (raralpha) and the promyelocytic locus gene (pml). |
1999-02-08 |
2023-08-12 |
Not clear |
| b' F Quignon, F De Bels, M Koken, J Feunteun, J C Ameisen, H de Th\\xc3\\xa. PML induces a novel caspase-independent death process. Nature genetics. vol 20. issue 3. 1998-11-16. PMID:9806544.' |
the death effector bax and the cdk inhibitor p27kip1 are novel nb-associated proteins recruited by pml to these nuclear domains, whereas the acute promyelocytic leukaemia (apl) pml/rar alpha oncoprotein delocalizes them. |
1998-11-16 |
2023-08-12 |
Not clear |
| Z G Wang, D Ruggero, S Ronchetti, S Zhong, M Gaboli, R Rivi, P P Pandolf. PML is essential for multiple apoptotic pathways. Nature genetics. vol 20. issue 3. 1998-11-16. PMID:9806545. |
we also found that pml is essential for induction of programmed cell death by fas, tumour necrosis factor alpha (tnf), ceramide and type i and ii interferons (ifns). |
1998-11-16 |
2023-08-12 |
mouse |
| Z G Wang, D Ruggero, S Ronchetti, S Zhong, M Gaboli, R Rivi, P P Pandolf. PML is essential for multiple apoptotic pathways. Nature genetics. vol 20. issue 3. 1998-11-16. PMID:9806545. |
the pml-rar alpha fusion protein of apl renders haemopoietic progenitor cells resistant to fas-, tnf- and ifn-induced apoptosis with a lack of caspase 3 activation, thus acting as a pml dominant-negative product. |
1998-11-16 |
2023-08-12 |
mouse |
| M Gaboli, D Gandini, L Delva, Z G Wang, P P Pandolf. Acute promyelocytic leukemia as a model for cross-talk between interferon and retinoic acid pathways: from molecular biology to clinical applications. Leukemia & lymphoma. vol 30. issue 1-2. 1998-10-09. PMID:9669672. |
apl is associated in 99% of cases with a 15;17 translocation that fuses the pml and retinoic acid receptor alpha (raralpha) genes. |
1998-10-09 |
2023-08-12 |
Not clear |
| P Jeanteu. [Acute promyelocytic leukemia, histone deacetylase, and response to retinoids]. Bulletin du cancer. vol 85. issue 4. 1998-10-08. PMID:9752292. |
acute promyelocytic leukemia (apl) originate from chromosomal translocations generating two types of fusion proteins both involving the retinoic acid receptor alpha (rar alpha) and either the gene pml (t(15;17)) or plzf (t(11;17)). |
1998-10-08 |
2023-08-12 |
Not clear |
| M Ruthardt, A Orleth, L Tomassoni, E Puccetti, D Riganelli, M Alcalay, R Mannucci, I Nicoletti, F Grignani, M Fagioli, P G Pelicc. The acute promyelocytic leukaemia specific PML and PLZF proteins localize to adjacent and functionally distinct nuclear bodies. Oncogene. vol 16. issue 15. 1998-05-28. PMID:9591778. |
acute promyelocytic leukaemia is characterized by translocations that involve the retinoic acid receptor alpha (rar alpha) locus on chromosome 17 and the pml locus on 15 or the plzf locus on 11. |
1998-05-28 |
2023-08-12 |
Not clear |
| M Ruthardt, A Orleth, L Tomassoni, E Puccetti, D Riganelli, M Alcalay, R Mannucci, I Nicoletti, F Grignani, M Fagioli, P G Pelicc. The acute promyelocytic leukaemia specific PML and PLZF proteins localize to adjacent and functionally distinct nuclear bodies. Oncogene. vol 16. issue 15. 1998-05-28. PMID:9591778. |
there is increasing experimental evidence that the apl-specific fusion proteins have similar biologic activities on differentiation and survival and that both components of the fusion proteins (pml or plzf and rar alpha) are indispensable for these biological activities. |
1998-05-28 |
2023-08-12 |
Not clear |
| M Ruthardt, A Orleth, L Tomassoni, E Puccetti, D Riganelli, M Alcalay, R Mannucci, I Nicoletti, F Grignani, M Fagioli, P G Pelicc. The acute promyelocytic leukaemia specific PML and PLZF proteins localize to adjacent and functionally distinct nuclear bodies. Oncogene. vol 16. issue 15. 1998-05-28. PMID:9591778. |
we report here immunofluorescence studies on the cellular localization of plzf and plzf/rar alpha and compare it with the localization of pml and pml/rar alpha. |
1998-05-28 |
2023-08-12 |
Not clear |
| Z Chen, Z Y Wang, S J Che. Acute promyelocytic leukemia: cellular and molecular basis of differentiation and apoptosis. Pharmacology & therapeutics. vol 76. issue 1-3. 1998-05-21. PMID:9535176. |
acute promyelocytic leukemia (apl) accounts for about 10% of all acute myeloid leukemias and is characterized by the chromosomal translocation t(15;17), which fuses the retinoic acid receptor (rar) alpha gene to the promyelocytic leukemia (pml) gene. |
1998-05-21 |
2023-08-12 |
human |
| Z Chen, Z Y Wang, S J Che. Acute promyelocytic leukemia: cellular and molecular basis of differentiation and apoptosis. Pharmacology & therapeutics. vol 76. issue 1-3. 1998-05-21. PMID:9535176. |
the pml-rar alpha fusion gene plays an important role in leukemogenesis through antagonizing retinoic acid signalling and the regulatory pathways mediated by pml. |
1998-05-21 |
2023-08-12 |
human |
| Z G Wang, L Delva, M Gaboli, R Rivi, M Giorgio, C Cordon-Cardo, F Grosveld, P P Pandolf. Role of PML in cell growth and the retinoic acid pathway. Science (New York, N.Y.). vol 279. issue 5356. 1998-03-18. PMID:9488655. |
the pml gene is fused to the retinoic acid receptor alpha (raralpha) gene in chromosomal translocations associated with acute promyelocytic leukemia (apl). |
1998-03-18 |
2023-08-12 |
Not clear |
| T Kamitani, H P Nguyen, K Kito, T Fukuda-Kamitani, E T Ye. Covalent modification of PML by the sentrin family of ubiquitin-like proteins. The Journal of biological chemistry. vol 273. issue 6. 1998-03-05. PMID:9452416. |
pml, a ring finger protein with tumor suppressor activity, has been implicated in the pathogenesis of acute promyelocytic leukemia that arises following a reciprocal chromosomal translocation that fuses the pml gene with the retinoic acid receptor alpha (raralpha) gene. |
1998-03-05 |
2023-08-12 |
Not clear |
| M Alcalay, L Tomassoni, E Colombo, S Stoldt, F Grignani, M Fagioli, L Szekely, K Helin, P G Pelicc. The promyelocytic leukemia gene product (PML) forms stable complexes with the retinoblastoma protein. Molecular and cellular biology. vol 18. issue 2. 1998-02-24. PMID:9448006. |
pml is a nuclear protein with growth-suppressive properties originally identified in the context of the pml-retinoic acid receptor alpha (rar alpha) fusion protein of acute promyelocytic leukemia. |
1998-02-24 |
2023-08-12 |
Not clear |
| M Alcalay, L Tomassoni, E Colombo, S Stoldt, F Grignani, M Fagioli, L Szekely, K Helin, P G Pelicc. The promyelocytic leukemia gene product (PML) forms stable complexes with the retinoblastoma protein. Molecular and cellular biology. vol 18. issue 2. 1998-02-24. PMID:9448006. |
pml localizes within distinct nuclear structures, called nuclear bodies, which are disrupted by the expression of pml-rar alpha. |
1998-02-24 |
2023-08-12 |
Not clear |
| M Alcalay, L Tomassoni, E Colombo, S Stoldt, F Grignani, M Fagioli, L Szekely, K Helin, P G Pelicc. The promyelocytic leukemia gene product (PML) forms stable complexes with the retinoblastoma protein. Molecular and cellular biology. vol 18. issue 2. 1998-02-24. PMID:9448006. |
we report that pml colocalizes with the nonphosphorylated fraction of the retinoblastoma protein (prb) within nuclear bodies and that prb is delocalized by pml-rar alpha expression. |
1998-02-24 |
2023-08-12 |
Not clear |