| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P P Pandolfi, M Alcalay, M Fagioli, D Zangrilli, A Mencarelli, D Diverio, A Biondi, F Lo Coco, A Rambaldi, F Grignan. Genomic variability and alternative splicing generate multiple PML/RAR alpha transcripts that encode aberrant PML proteins and PML/RAR alpha isoforms in acute promyelocytic leukaemia. The EMBO journal. vol 11. issue 4. 1992-05-15. PMID:1314166. |
molecular studies on a large series of apls revealed great heterogeneity of the pml/rar alpha transcripts due to: (i) variable breaking of chromosome 15 within three pml breakpoint cluster regions (bcr1, bcr2 and bcr3), (ii) alternative splicings of the pml portion and (iii) alternative usage of two rar alpha polyadenylation sites. |
1992-05-15 |
2023-08-11 |
Not clear |
| P P Pandolfi, M Alcalay, M Fagioli, D Zangrilli, A Mencarelli, D Diverio, A Biondi, F Lo Coco, A Rambaldi, F Grignan. Genomic variability and alternative splicing generate multiple PML/RAR alpha transcripts that encode aberrant PML proteins and PML/RAR alpha isoforms in acute promyelocytic leukaemia. The EMBO journal. vol 11. issue 4. 1992-05-15. PMID:1314166. |
nucleotide sequence analysis predicted two types of proteins: multiple pml/rar alpha and aberrant pml. |
1992-05-15 |
2023-08-11 |
Not clear |
| P P Pandolfi, M Alcalay, M Fagioli, D Zangrilli, A Mencarelli, D Diverio, A Biondi, F Lo Coco, A Rambaldi, F Grignan. Genomic variability and alternative splicing generate multiple PML/RAR alpha transcripts that encode aberrant PML proteins and PML/RAR alpha isoforms in acute promyelocytic leukaemia. The EMBO journal. vol 11. issue 4. 1992-05-15. PMID:1314166. |
the fusion proteins contained variable portions of the pml n terminus joined to the b-f rar alpha domains; the only pml region retained was the putative dna binding domain. |
1992-05-15 |
2023-08-11 |
Not clear |
| P P Pandolfi, M Alcalay, M Fagioli, D Zangrilli, A Mencarelli, D Diverio, A Biondi, F Lo Coco, A Rambaldi, F Grignan. Genomic variability and alternative splicing generate multiple PML/RAR alpha transcripts that encode aberrant PML proteins and PML/RAR alpha isoforms in acute promyelocytic leukaemia. The EMBO journal. vol 11. issue 4. 1992-05-15. PMID:1314166. |
the aberrant pml proteins lacked the c terminus, which had been replaced by from two to ten amino acid residues from the rar alpha sequence. |
1992-05-15 |
2023-08-11 |
Not clear |
| P P Pandolfi, M Alcalay, M Fagioli, D Zangrilli, A Mencarelli, D Diverio, A Biondi, F Lo Coco, A Rambaldi, F Grignan. Genomic variability and alternative splicing generate multiple PML/RAR alpha transcripts that encode aberrant PML proteins and PML/RAR alpha isoforms in acute promyelocytic leukaemia. The EMBO journal. vol 11. issue 4. 1992-05-15. PMID:1314166. |
multiple pml/rar alpha isoforms and aberrant pml proteins were found to coexist in all apls. |
1992-05-15 |
2023-08-11 |
Not clear |
| W H Miller, A Kakizuka, S R Frankel, R P Warrell, A DeBlasio, K Levine, R M Evans, E Dmitrovsk. Reverse transcription polymerase chain reaction for the rearranged retinoic acid receptor alpha clarifies diagnosis and detects minimal residual disease in acute promyelocytic leukemia. Proceedings of the National Academy of Sciences of the United States of America. vol 89. issue 7. 1992-05-06. PMID:1372989. |
the characteristic t(15;17) of acute promyelocytic leukemia (apl) fuses the retinoic acid receptor alpha (rar-alpha) gene on chromosome 17 to a gene on chromosome 15 called pml, a putative transcription factor. |
1992-05-06 |
2023-08-11 |
Not clear |
| L Dego. All-trans-retinoic acid treatment and retinoic acid receptor alpha gene rearrangement in acute promyelocytic leukemia: a model for differentiation therapy. International journal of cell cloning. vol 10. issue 2. 1992-04-16. PMID:1312109. |
in apl the retinoic acid receptor alpha gene is rearranged and fused with a novel gene called pml. |
1992-04-16 |
2023-08-11 |
Not clear |
| P Kastner, A Perez, Y Lutz, C Rochette-Egly, M P Gaub, B Durand, M Lanotte, R Berger, P Chambo. Structure, localization and transcriptional properties of two classes of retinoic acid receptor alpha fusion proteins in acute promyelocytic leukemia (APL): structural similarities with a new family of oncoproteins. The EMBO journal. vol 11. issue 2. 1992-03-31. PMID:1311253. |
acute promyelocytic leukemia (apl) is due to a chromosomal t(15;17) translocation which involves a novel human gene, myl, (also named pml) and the retinoic acid (ra) receptor alpha (rar-alpha) gene. |
1992-03-31 |
2023-08-11 |
human |
| A D Goddard, J Borrow, P S Freemont, E Solomo. Characterization of a zinc finger gene disrupted by the t(15;17) in acute promyelocytic leukemia. Science (New York, N.Y.). vol 254. issue 5036. 1992-01-08. PMID:1720570. |
the translocation t(15;17) associated with acute promyelocytic leukemia results in the fusion of the retinoic acid receptor alpha (rara) gene to the pml gene. |
1992-01-08 |
2023-08-11 |
Not clear |
| A Kakizuka, W H Miller, K Umesono, R P Warrell, S R Frankel, V V Murty, E Dmitrovsky, R M Evan. Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RAR alpha with a novel putative transcription factor, PML. Cell. vol 66. issue 4. 1991-09-27. PMID:1652368. |
chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses rar alpha with a novel putative transcription factor, pml. |
1991-09-27 |
2023-08-11 |
human |
| A Kakizuka, W H Miller, K Umesono, R P Warrell, S R Frankel, V V Murty, E Dmitrovsky, R M Evan. Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RAR alpha with a novel putative transcription factor, PML. Cell. vol 66. issue 4. 1991-09-27. PMID:1652368. |
a unique mrna produced in leukemic cells from a t(15;17) acute promyelocytic leukemia (apl) patient encodes a fusion protein between the retinoic acid receptor alpha (rar alpha) and a myeloid gene product called pml. |
1991-09-27 |
2023-08-11 |
human |
| H de Thé, C Lavau, A Marchio, C Chomienne, L Degos, A Dejea. The PML-RAR alpha fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered RAR. Cell. vol 66. issue 4. 1991-09-27. PMID:1652369. |
we have previously shown that the t(15;17) translocation specifically associated with acute promyelocytic leukemia (apl) fuses the retinoic acid receptor alpha (rar alpha) locus to an as yet unknown gene, initially called myl and now renamed pml. |
1991-09-27 |
2023-08-11 |
Not clear |
| H de Thé, C Lavau, A Marchio, C Chomienne, L Degos, A Dejea. The PML-RAR alpha fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered RAR. Cell. vol 66. issue 4. 1991-09-27. PMID:1652369. |
the pml-rar alpha mrna encodes a predicted 106 kd chimeric protein containing most of the pml sequences fused to a large part of rar alpha, including its dna- and hormone-binding domains. |
1991-09-27 |
2023-08-11 |
Not clear |
| M L Chen, Y H Lee, S J L. High-level production of hepatitis B viral X protein in Escherichia coli using gene II promoter of bacteriophage M13. Gene. vol 62. issue 2. 1988-06-23. PMID:2966757. |
cells harboring plasmids (pml alpha x.59 and pmlx.12d) derived from the above construct overproduced the 19-kda fused protein in escherichia coli at a level of 10%-20% of total cellular protein. |
1988-06-23 |
2023-08-11 |
Not clear |