| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S Dong, J H Tong, W Huang, S J Chen, Z Chen, Z Y Wang, J P Geng, Z W Q. Molecular study on the chromosome 15 breakpoints in the translocation t(15; 17) in acute promyelocytic leukemia (APL). Science in China. Series B, Chemistry, life sciences & earth sciences. vol 36. issue 9. 1994-02-08. PMID:8274203. |
it has been shown that the retinoic acid receptor alpha (rara) gene, normally located on chromosome 17, was fused with a new transcription unit pml, normally localized on chromosome 15. |
1994-02-08 |
2023-08-12 |
Not clear |
| V Doucas, J P Brockes, M Yaniv, H de Thé, A Dejea. The PML-retinoic acid receptor alpha translocation converts the receptor from an inhibitor to a retinoic acid-dependent activator of transcription factor AP-1. Proceedings of the National Academy of Sciences of the United States of America. vol 90. issue 20. 1993-11-19. PMID:8415704. |
we report here that the fusion of pml, a nuclear protein defined by the t(15;17) chromosomal translocation in acute promyelocytic leukemia, with retinoic acid receptor alpha (rar alpha) changes the rar alpha from a retinoic acid (ra)-dependent inhibitor to a ra-dependent activator of ap-1 transcriptional activity. |
1993-11-19 |
2023-08-12 |
Not clear |
| V Doucas, J P Brockes, M Yaniv, H de Thé, A Dejea. The PML-retinoic acid receptor alpha translocation converts the receptor from an inhibitor to a retinoic acid-dependent activator of transcription factor AP-1. Proceedings of the National Academy of Sciences of the United States of America. vol 90. issue 20. 1993-11-19. PMID:8415704. |
deletion of the dimerization, transactivation, or dna-binding domains of c-jun and removal of the pml dimerization domain in the pml-rar alpha hybrid abrogates their transcriptional cooperatively. |
1993-11-19 |
2023-08-12 |
Not clear |
| b' M T Daniel, M Koken, O Romagn\\xc3\\xa9, S Barbey, A Bazarbachi, M Stadler, M C Guillemin, L Degos, C Chomienne, H de Th\\xc3\\xa. PML protein expression in hematopoietic and acute promyelocytic leukemia cells. Blood. vol 82. issue 6. 1993-10-25. PMID:8400236.' |
acute promyelocytic leukemia (apl) is thought to be caused by the t(15,17) translocation that fuses the pml gene to that of the retinoic acid receptor alpha (rar alpha) and generates a pml/rar alpha fusion protein. |
1993-10-25 |
2023-08-12 |
Not clear |
| b' M T Daniel, M Koken, O Romagn\\xc3\\xa9, S Barbey, A Bazarbachi, M Stadler, M C Guillemin, L Degos, C Chomienne, H de Th\\xc3\\xa. PML protein expression in hematopoietic and acute promyelocytic leukemia cells. Blood. vol 82. issue 6. 1993-10-25. PMID:8400236.' |
in this report, we have examined the expression of pml and pml/rar alpha in normal and apl cells. |
1993-10-25 |
2023-08-12 |
Not clear |
| b' M T Daniel, M Koken, O Romagn\\xc3\\xa9, S Barbey, A Bazarbachi, M Stadler, M C Guillemin, L Degos, C Chomienne, H de Th\\xc3\\xa. PML protein expression in hematopoietic and acute promyelocytic leukemia cells. Blood. vol 82. issue 6. 1993-10-25. PMID:8400236.' |
by immunofluorescence or immunocytochemistry, we show that pml has a speckled nuclear pattern of expression that contrasts with that of pml/rar alpha (mostly a micropunctuated nuclear pattern or a cytoplasmic localization). |
1993-10-25 |
2023-08-12 |
Not clear |
| b' M T Daniel, M Koken, O Romagn\\xc3\\xa9, S Barbey, A Bazarbachi, M Stadler, M C Guillemin, L Degos, C Chomienne, H de Th\\xc3\\xa. PML protein expression in hematopoietic and acute promyelocytic leukemia cells. Blood. vol 82. issue 6. 1993-10-25. PMID:8400236.' |
the apl-derived cell line nb4 that expresses both the pml and pml/rar alpha genes also shows the fine micropunctuated nuclear pattern, suggesting a dominant effect of the fusion protein over the localization of wild-type pml. |
1993-10-25 |
2023-08-12 |
Not clear |
| b' M T Daniel, M Koken, O Romagn\\xc3\\xa9, S Barbey, A Bazarbachi, M Stadler, M C Guillemin, L Degos, C Chomienne, H de Th\\xc3\\xa. PML protein expression in hematopoietic and acute promyelocytic leukemia cells. Blood. vol 82. issue 6. 1993-10-25. PMID:8400236.' |
ra treatment of nb4 cells or clones expressing pml/rar alpha gradually leads to a pml pattern before apparent morphologic maturation. |
1993-10-25 |
2023-08-12 |
Not clear |
| b' M T Daniel, M Koken, O Romagn\\xc3\\xa9, S Barbey, A Bazarbachi, M Stadler, M C Guillemin, L Degos, C Chomienne, H de Th\\xc3\\xa. PML protein expression in hematopoietic and acute promyelocytic leukemia cells. Blood. vol 82. issue 6. 1993-10-25. PMID:8400236.' |
these results establish that fusion of pml to rar alpha results in an altered localization of pml that is reverted upon ra treatment. |
1993-10-25 |
2023-08-12 |
Not clear |
| F Grignani, M Fagioli, P F Ferrucci, M Alcalay, P G Pelicc. The molecular genetics of acute promyelocytic leukemia. Blood reviews. vol 7. issue 2. 1993-10-12. PMID:8396481. |
they are localized on a previously unknown gene, pml, on chromosome 15 and in the gene that encodes the alpha retinoic acid receptor (rar alpha) on 17. |
1993-10-12 |
2023-08-12 |
Not clear |
| F Grignani, M Fagioli, P F Ferrucci, M Alcalay, P G Pelicc. The molecular genetics of acute promyelocytic leukemia. Blood reviews. vol 7. issue 2. 1993-10-12. PMID:8396481. |
the pml/rar alpha gene codes for two abnormal proteins: the pml/rar alpha fusion protein and an abnormal pml protein, the rar alpha/pml gene encodes the rar alpha/pml fusion protein. |
1993-10-12 |
2023-08-12 |
Not clear |
| F Grignani, M Fagioli, P F Ferrucci, M Alcalay, P G Pelicc. The molecular genetics of acute promyelocytic leukemia. Blood reviews. vol 7. issue 2. 1993-10-12. PMID:8396481. |
however, there is accumulating evidence that it acts by interfering with normal endogenous pathways of both rar alpha and pml. |
1993-10-12 |
2023-08-12 |
Not clear |
| J Borrow, E Solomo. Molecular analysis of the t(15;17) translocation in acute promyelocytic leukaemia. Bailliere's clinical haematology. vol 5. issue 4. 1993-09-24. PMID:1339190. |
the recent cloning of the breakpoints by three groups has demonstrated that the retinoic acid receptor alpha gene (rara) on chromosome 17 is fused to a previously undescribed transcription factor gene, pml, on chromosome 15. |
1993-09-24 |
2023-08-11 |
Not clear |
| J P Gen. [Molecular study on the distinct isoforms of PML-RAR alpha fusion gene transcripts in acute promyelocytic leukemia]. Zhonghua yi xue za zhi. vol 73. issue 4. 1993-09-24. PMID:8395310. |
the results showed that the rar alpha derived sequences were the same in fusion genes while the pml sequences differed as a result of the locations of pml gene breakpoints. |
1993-09-24 |
2023-08-12 |
Not clear |
| F Grignani, P F Ferrucci, U Testa, G Talamo, M Fagioli, M Alcalay, A Mencarelli, F Grignani, C Peschle, I Nicolett. The acute promyelocytic leukemia-specific PML-RAR alpha fusion protein inhibits differentiation and promotes survival of myeloid precursor cells. Cell. vol 74. issue 3. 1993-09-15. PMID:8394219. |
acute promyelocytic leukemia is characterized by a 15;17 chromosome translocation with breakpoints within the retinoic acid alpha receptor (rar alpha) gene on 17 and the pml gene, which encodes a putative transcription factor, on 15. |
1993-09-15 |
2023-08-12 |
Not clear |
| A Perez, P Kastner, S Sethi, Y Lutz, C Reibel, P Chambo. PMLRAR homodimers: distinct DNA binding properties and heteromeric interactions with RXR. The EMBO journal. vol 12. issue 8. 1993-09-08. PMID:8393784. |
fusion proteins (named pmlrar) between pml and the retinoic acid receptor alpha (rar alpha) are generated as a result of the t(15;17) chromosomal translocation found in acute promyelocytic leukemia (apl). |
1993-09-08 |
2023-08-12 |
Not clear |
| K Kubo, T Naoe, H Kiyoi, H Fukutani, Y Kato, T Oguri, S Yamamori, Y Akatsuka, Y Kodera, R Ohn. Clonal analysis of multiple point mutations in the N-ras gene in patients with acute myeloid leukemia. Japanese journal of cancer research : Gann. vol 84. issue 4. 1993-07-16. PMID:8514604. |
each of the remaining three patients, one of whom had t(15;17) with a monoclonal rearrangement of the retinoic acid receptor alpha and pml genes, carried two missense mutations in a relatively small population of leukemia cells. |
1993-07-16 |
2023-08-12 |
Not clear |
| T Roba. [Progress in biology and the treatment of acute promyelocytic leukemia]. Acta haematologica Polonica. vol 24. issue 1. 1993-06-07. PMID:8488732. |
in particular, the breakpoint on chromosome 17 has been localized within the retinoic acid receptor alpha locus while the breakpoint on chromosome 15 has been localized within a new gene named pml. |
1993-06-07 |
2023-08-12 |
Not clear |
| M Amano, A Togawa, S Tsurugano, Y Soda, A Yuo, F Takaku, S Ogawa, H Hirai, K Yamad. Rearrangement of retinoic acid receptor alpha and PML in promyelocytic blast crisis of Ph1 chromosome positive chronic myelocytic leukemia with normal copies of chromosome 15. Blood. vol 81. issue 9. 1993-06-01. PMID:8386953. |
rearrangement of retinoic acid receptor alpha and pml in promyelocytic blast crisis of ph1 chromosome positive chronic myelocytic leukemia with normal copies of chromosome 15. |
1993-06-01 |
2023-08-12 |
Not clear |
| H Fukasawa, K Shud. [Retinoid signalling pathways]. Gan to kagaku ryoho. Cancer & chemotherapy. vol 20. issue 5. 1993-05-11. PMID:8470912. |
in many apl patients, translocation between rar alpha gene and an oncogenic gene, pml, can be detected, although the roles of their fusion products (rar alpha-pml and pml-rar alpha) in apl induction have not been understood. |
1993-05-11 |
2023-08-12 |
human |