| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Alcalay, L Tomassoni, E Colombo, S Stoldt, F Grignani, M Fagioli, L Szekely, K Helin, P G Pelicc. The promyelocytic leukemia gene product (PML) forms stable complexes with the retinoblastoma protein. Molecular and cellular biology. vol 18. issue 2. 1998-02-24. PMID:9448006. |
both pml and pml-rar alpha form complexes with the nonphosphorylated form of prb in vivo, and they interact with the pocket region of prb. |
1998-02-24 |
2023-08-12 |
Not clear |
| M Alcalay, L Tomassoni, E Colombo, S Stoldt, F Grignani, M Fagioli, L Szekely, K Helin, P G Pelicc. The promyelocytic leukemia gene product (PML) forms stable complexes with the retinoblastoma protein. Molecular and cellular biology. vol 18. issue 2. 1998-02-24. PMID:9448006. |
the regions of pml and pml-rar alpha involved in prb binding differ; in fact, the b boxes and the c-terminal region of pml, the latter of which is not present in pml-rar alpha, are essential for the formation of stable complexes with prb. |
1998-02-24 |
2023-08-12 |
Not clear |
| M Alcalay, L Tomassoni, E Colombo, S Stoldt, F Grignani, M Fagioli, L Szekely, K Helin, P G Pelicc. The promyelocytic leukemia gene product (PML) forms stable complexes with the retinoblastoma protein. Molecular and cellular biology. vol 18. issue 2. 1998-02-24. PMID:9448006. |
functionally, pml abolishes activation of glucocorticoid receptor-regulated transcription by prb, whereas pml-rar alpha further increases it. |
1998-02-24 |
2023-08-12 |
Not clear |
| M Alcalay, L Tomassoni, E Colombo, S Stoldt, F Grignani, M Fagioli, L Szekely, K Helin, P G Pelicc. The promyelocytic leukemia gene product (PML) forms stable complexes with the retinoblastoma protein. Molecular and cellular biology. vol 18. issue 2. 1998-02-24. PMID:9448006. |
our results suggest that pml may be part of transcription-regulatory complexes and that the oncogenic potential of the pml-rar alpha protein may derive from the alteration of pml-regulated transcription. |
1998-02-24 |
2023-08-12 |
Not clear |
| L Z He, F Guidez, C Tribioli, D Peruzzi, M Ruthardt, A Zelent, P P Pandolf. Distinct interactions of PML-RARalpha and PLZF-RARalpha with co-repressors determine differential responses to RA in APL. Nature genetics. vol 18. issue 2. 1998-02-24. PMID:9462740. |
acute promyelocytic leukaemia (apl), associated with chromosomal translocations involving the retinoic acid receptor alpha gene (rara) and the pml gene, is sensitive to retinoic acid (ra) treatment, while apl patients harbouring translocations between rara and the plzf gene do not respond to ra. |
1998-02-24 |
2023-08-12 |
mouse |
| L Dego. Differentiation therapy in acute promyelocytic leukemia: European experience. Journal of cellular physiology. vol 173. issue 2. 1997-12-11. PMID:9365538. |
apl was further characterized by a specific sensitivity to all-trans retinoic acid's differentiation effect and the production of a fusion gene altering the gene of rar alpha and a gene called pml. |
1997-12-11 |
2023-08-12 |
Not clear |
| S Kalantry, L Delva, M Gaboli, D Gandini, M Giorgio, N Hawe, L Z He, D Peruzzi, R Rivi, C Tribioli, Z G Wang, H Zhang, P P Pandolf. Gene rearrangements in the molecular pathogenesis of acute promyelocytic leukemia. Journal of cellular physiology. vol 173. issue 2. 1997-12-11. PMID:9365539. |
rar alpha translocates in 99% of cases to a gene located on chromosome 15 that we initially named myl and subsequently has been called pml. |
1997-12-11 |
2023-08-12 |
mouse |
| K Nason-Burchenal, W Maerz, J Albanell, J Allopenna, P Martin, M A Moore, E Dmitrovsk. Common defects of different retinoic acid resistant promyelocytic leukemia cells are persistent telomerase activity and nuclear body disorganization. Differentiation; research in biological diversity. vol 61. issue 5. 1997-12-09. PMID:9342843. |
the acute promyelocytic leukemia (apl) t(15;17) rearrangement fuses the promyelocytic leukemia (pml) gene to the retinoic acid receptor-alpha (rar alpha). |
1997-12-09 |
2023-08-12 |
Not clear |
| K Nason-Burchenal, W Maerz, J Albanell, J Allopenna, P Martin, M A Moore, E Dmitrovsk. Common defects of different retinoic acid resistant promyelocytic leukemia cells are persistent telomerase activity and nuclear body disorganization. Differentiation; research in biological diversity. vol 61. issue 5. 1997-12-09. PMID:9342843. |
when cultured in atra, these resistant cells still express pml, rar alpha, and pml/rar alpha proteins. |
1997-12-09 |
2023-08-12 |
Not clear |
| B Falini, L Flenghi, M Fagioli, F Lo Coco, I Cordone, D Diverio, L Pasqualucci, A Biondi, D Riganelli, A Orleth, A Liso, M F Martelli, P G Pelicci, S Piler. Immunocytochemical diagnosis of acute promyelocytic leukemia (M3) with the monoclonal antibody PG-M3 (anti-PML). Blood. vol 90. issue 10. 1997-12-08. PMID:9354674. |
acute promyelocytic leukemia (apl) is characterized by a reciprocal 15; 17 chromosomal translocation, which fuses the promyelocytic leukemia (pml) and retinoic acid receptor alpha (raralpha) genes, leading to the expression of the pml/raralpha fusion oncoprotein. |
1997-12-08 |
2023-08-12 |
human |
| F Mandell. New strategies for the treatment of acute promyelocytic leukaemia. Journal of internal medicine. Supplement. vol 740. 1997-11-19. PMID:9350178. |
acute promyelocytic leukaemia (apl) is a distinct entity of acute myeloid leukaemia characterized by blast cell morphology, severe coagulopathy and t(15;17) translocation that fuses the pml gene on chromosome 15 to the retinoic acid receptor alpha (rar alpha) gene on chromosome 17. |
1997-11-19 |
2023-08-12 |
Not clear |
| M N Boddy, E Duprez, K L Borden, P S Freemon. Surface residue mutations of the PML RING finger domain alter the formation of nuclear matrix-associated PML bodies. Journal of cell science. vol 110 ( Pt 18). 1997-11-12. PMID:9378769. |
the human protein pml, was first identified as part of a fusion protein with retinoic acid receptor alpha as found in the chromosomal translocation which gives rise to acute promyelocytic leukaemia. |
1997-11-12 |
2023-08-12 |
mouse |
| M H Koken, A Reid, F Quignon, M K Chelbi-Alix, J M Davies, J H Kabarowski, J Zhu, S Dong, S Chen, Z Chen, C C Tan, J Licht, S Waxman, H de Thé, A Zelen. Leukemia-associated retinoic acid receptor alpha fusion partners, PML and PLZF, heterodimerize and colocalize to nuclear bodies. Proceedings of the National Academy of Sciences of the United States of America. vol 94. issue 19. 1997-10-21. PMID:9294197. |
leukemia-associated retinoic acid receptor alpha fusion partners, pml and plzf, heterodimerize and colocalize to nuclear bodies. |
1997-10-21 |
2023-08-12 |
Not clear |
| H Acar, M Dündar, J Stewar. Identification of classic and complex t(15;17) and/or RAR alpha/PML gene fusion in APL by cytogenetic and dual color-FISH techniques. Proceedings of the National Science Council, Republic of China. Part B, Life sciences. vol 21. issue 2. 1997-09-29. PMID:9276968. |
acute promyelocytic leukemia (apl) is a malignant condition characterized by t(15;17)(q22;q12), which fuses the pml gene on chromosome 15 to the retinoic acid receptor alpha (rar alpha) gene on chromosome 17. |
1997-09-29 |
2023-08-12 |
Not clear |
| R E Gallagher, C L Willman, J L Slack, J W Andersen, Y P Li, D Viswanatha, C D Bloomfield, F R Appelbaum, C A Schiffer, M S Tallman, P H Wierni. Association of PML-RAR alpha fusion mRNA type with pretreatment hematologic characteristics but not treatment outcome in acute promyelocytic leukemia: an intergroup molecular study. Blood. vol 90. issue 4. 1997-09-24. PMID:9269786. |
in each case of acute promyelocytic leukemia (apl) one of three pml-rar alpha mrna types is produced, depending on the break/fusion site in the pml gene that is linked to a common rar alpha gene segment: a short (s)-form type, pml exon 3 rar alpha exon 3; a long (l)-form type, pml exon 6 rar alpha exon 3; or a variable (v)-form type, variably deleted pml exon 6 rar alpha exon 3. |
1997-09-24 |
2023-08-12 |
Not clear |
| E Berma. Recent advances in the treatment of acute leukemia. Current opinion in hematology. vol 4. issue 4. 1997-09-23. PMID:9260053. |
the genes pml and aml1, and eto were examined in normal hematopoietic progenitors and their fusions proteins, pml/rar alpha and aml1/eto, measured in patients in clinical remission, and important data were presented concerning these proteins and measurement of minimal residual disease. |
1997-09-23 |
2023-08-12 |
Not clear |
| M Ruthardt, U Testa, C Nervi, P F Ferrucci, F Grignani, E Puccetti, F Grignani, C Peschle, P G Pelicc. Opposite effects of the acute promyelocytic leukemia PML-retinoic acid receptor alpha (RAR alpha) and PLZF-RAR alpha fusion proteins on retinoic acid signalling. Molecular and cellular biology. vol 17. issue 8. 1997-08-25. PMID:9234742. |
fusion proteins involving the retinoic acid receptor alpha (rar alpha) and the pml or plzf nuclear protein are the genetic markers of acute promyelocytic leukemias (apls). |
1997-08-25 |
2023-08-12 |
Not clear |
| S Tashiro, Z Wang, N Kotomura, O Niwa, K Ueda, N Kamad. Nuclear proteins binding to the recombination hotspot region of the retinoic acid receptor alpha gene. Leukemia. vol 11 Suppl 3. 1997-08-07. PMID:9209366. |
acute promyelocytic leukemia (apl) has been characterized by 15;17 chromosomal translocation, which involves the retinoic acid receptor alpha (rara) gene on chromosome 17 and the pml gene on chromosome 15. |
1997-08-07 |
2023-08-12 |
mouse |
| I G Schulman, R M Evan. Retinoid receptors in development and disease. Leukemia. vol 11 Suppl 3. 1997-08-07. PMID:9209395. |
in human acute promyelocytic leukemia (apl), rar alpha becomes an activated oncogene as a consequence of its fusion to the pml locus. |
1997-08-07 |
2023-08-12 |
human |
| S Dong, J Tong, S Che. [A preliminary study of the relation between topoisomerase I and translocation (15;17)]. Zhonghua zhong liu za zhi [Chinese journal of oncology]. vol 18. issue 2. 1997-08-04. PMID:9206036. |
it was identified that the rar alpha gene on chromosome 17 and pml gene on chromosome 15 were involved in this translocation. |
1997-08-04 |
2023-08-12 |
Not clear |