| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| b' M K Chelbi-Alix, L Pelicano, F Quignon, M H Koken, L Venturini, M Stadler, J Pavlovic, L Degos, H de Th\\xc3\\xa. Induction of the PML protein by interferons in normal and APL cells. Leukemia. vol 9. issue 12. 1996-05-29. PMID:8609713.' |
in apl cells, ifns induced both pml and pml/rar alpha expression, resulting in an increased sequestration of pml and rxrs in the microspeckles induced by the fusion protein. |
1996-05-29 |
2023-08-12 |
human |
| H Takatsuki, T Umemura, J Nishimura, H Nawat. Which progenitor is the target cell in the development of acute promyelocytic leukemia? Leukemia & lymphoma. vol 17. issue 3-4. 1996-03-19. PMID:8580793. |
acute promyelocytic leukemia (apl) is characterized by the t(15;17) which involves the pml gene and the retinoic acid receptor alpha (rar alpha) gene, and the subsequent pml/rar alpha fusion gene is a key event in the leukemogenesis of apl. |
1996-03-19 |
2023-08-12 |
Not clear |
| A D Goddard, J Q Yuan, L Fairbairn, M Dexter, J Borrow, C Kozak, E Solomo. Cloning of the murine homolog of the leukemia-associated PML gene. Mammalian genome : official journal of the International Mammalian Genome Society. vol 6. issue 10. 1996-03-05. PMID:8563172. |
pml, a ring-finger protein, participates in the disruption of normal myeloid differentiation when fused to the retinoic acid receptor alpha (rar alpha) by the translocation between chromosomes (chrs) 15 and 17 in acute promyelocytic leukemia (apl). |
1996-03-05 |
2023-08-12 |
mouse |
| P Ballerini, F Besançon, Y E Cayr. [Effect of translocation t(15;17) on the gene expression regulation of myeloblastin during all trans retinoic acid induced myeloid differentiation in human leukemic cells]. Comptes rendus des seances de la Societe de biologie et de ses filiales. vol 189. issue 4. 1996-03-01. PMID:8564566. |
the t(15;17) translocation, specifically associated with the human acute promyelocytic leukemia (apl), fuses the retinoic acid receptor alpha (rar alpha) to a novel gene pml generating the hybrid protein pml-rar. |
1996-03-01 |
2023-08-12 |
human |
| M Stadler, M K Chelbi-Alix, M H Koken, L Venturini, C Lee, A Saïb, F Quignon, L Pelicano, M C Guillemin, C Schindle. Transcriptional induction of the PML growth suppressor gene by interferons is mediated through an ISRE and a GAS element. Oncogene. vol 11. issue 12. 1996-02-09. PMID:8545113. |
moreover, in the t(15;17) translocation of acute promyelocytic leukaemia (apl), pml fusion to the retinoic acid receptor alpha (rar alpha) is the likely molecular basis of leukaemogenesis. |
1996-02-09 |
2023-08-12 |
human |
| M Cornic, C Chomienn. Induction of retinoid resistance by all-trans retinoic acid in acute promyelocytic leukemia after remission. Leukemia & lymphoma. vol 18. issue 3-4. 1996-02-07. PMID:8535190. |
apl is characterized cytogenetically by a t(15;17) translocation which involves both the pml gene on chromosome 15 and the rar alpha gene on chromosome 17 and gives rise to the pml/rar alpha fusion protein. |
1996-02-07 |
2023-08-12 |
Not clear |
| H G Drexler, H Quentmeier, R A MacLeod, C C Uphoff, Z B H. Leukemia cell lines: in vitro models for the study of acute promyelocytic leukemia. Leukemia research. vol 19. issue 10. 1996-01-17. PMID:7500643. |
secondly, the 15;17 chromosomal translocation specific for apl leads at the molecular genetic level to a chimeric gene fusing the pml and rar alpha genes and appears to be an instrumental, if not actually the causative event, in the neoplastic process. |
1996-01-17 |
2023-08-12 |
Not clear |
| C Kelly, R Van Driel, G W Wilkinso. Disruption of PML-associated nuclear bodies during human cytomegalovirus infection. The Journal of general virology. vol 76 ( Pt 11). 1995-12-19. PMID:7595400. |
a defect in pml expression is observed in acute promyelocytic leukaemia as a consequence of a chromosomal translocation involving the genes encoding pml and the alpha retinoic acid receptor (rar alpha). |
1995-12-19 |
2023-08-12 |
human |
| A B Glassma. Cytogenetics, gene fusions, and cancer. Annals of clinical and laboratory science. vol 25. issue 5. 1995-12-13. PMID:7486813. |
this alters the promyelocytic leukemia (pml) and the retinoic acid receptor alpha (rara) gene sites. |
1995-12-13 |
2023-08-12 |
Not clear |
| T Carvalho, J S Seeler, K Ohman, P Jordan, U Pettersson, G Akusjärvi, M Carmo-Fonseca, A Dejea. Targeting of adenovirus E1A and E4-ORF3 proteins to nuclear matrix-associated PML bodies. The Journal of cell biology. vol 131. issue 1. 1995-10-31. PMID:7559785. |
the pml protein was first identified as part of a fusion product with the retinoic acid receptor alpha (rar alpha), resulting from the t(15;17) chromosomal translocation associated with acute promyelocytic leukemia (apl). |
1995-10-31 |
2023-08-12 |
Not clear |
| T Carvalho, J S Seeler, K Ohman, P Jordan, U Pettersson, G Akusjärvi, M Carmo-Fonseca, A Dejea. Targeting of adenovirus E1A and E4-ORF3 proteins to nuclear matrix-associated PML bodies. The Journal of cell biology. vol 131. issue 1. 1995-10-31. PMID:7559785. |
it has been previously demonstrated that pml, which is tightly bound to the nuclear matrix, concentrates in discrete subnuclear compartments that are disorganized in apl cells due to the expression of the pml-rar alpha hybrid. |
1995-10-31 |
2023-08-12 |
Not clear |
| C Lavau, J Jansen, A Dejea. The t(15;17) translocation in acute promyelocytic leukemia. Pathologie-biologie. vol 43. issue 3. 1995-10-19. PMID:7675545. |
we and others have shown that the t(15;17) translocation specifically associated with apl fuses an as yet unidentified gene, named pml, to the retinoic acid receptor alpha locus. |
1995-10-19 |
2023-08-12 |
Not clear |
| C Lavau, J Jansen, A Dejea. The t(15;17) translocation in acute promyelocytic leukemia. Pathologie-biologie. vol 43. issue 3. 1995-10-19. PMID:7675545. |
a dimerization domain within pml is able to mediate the formation of pml-rar alpha homodimers that can bind to target sequences with distinct dna binding properties if compared with rar alpha. |
1995-10-19 |
2023-08-12 |
Not clear |
| T Naoe, H Yoshida, K Kitamura, M Chino, K Osumi, R Ohn. Delayed or insufficient restoration of PML and PML-RAR alpha subcellular localization after exposure in vitro to retinoic acids in all-trans retinoic acid-resistant APL cells. Leukemia. vol 9. issue 9. 1995-10-05. PMID:7658735. |
delayed or insufficient restoration of pml and pml-rar alpha subcellular localization after exposure in vitro to retinoic acids in all-trans retinoic acid-resistant apl cells. |
1995-10-05 |
2023-08-12 |
Not clear |
| S Xiong, Z Chen, W Huan. [A study on the relationship between morphology and gene heterogeneity in acute promyelocytic leukemia]. Zhonghua nei ke za zhi. vol 34. issue 3. 1995-09-22. PMID:7648936. |
forty-five cases showed chromosomal translocation t(15; 17) and pml/rar alpha fusion gene (pml + rar alpha + apl). |
1995-09-22 |
2023-08-12 |
Not clear |
| S Xiong, Z Chen, W Huan. [A study on the relationship between morphology and gene heterogeneity in acute promyelocytic leukemia]. Zhonghua nei ke za zhi. vol 34. issue 3. 1995-09-22. PMID:7648936. |
among the 45 pml + rar alpha + apl patients 8 died early and 37 had complete remission with atra. |
1995-09-22 |
2023-08-12 |
Not clear |
| S Xiong, Z Chen, W Huan. [A study on the relationship between morphology and gene heterogeneity in acute promyelocytic leukemia]. Zhonghua nei ke za zhi. vol 34. issue 3. 1995-09-22. PMID:7648936. |
in the remainging 5 patients, three had typical apl morphologic features in cytology, but one of them displayed t (11; 17) with plzf+rara alpha +, the second showed rar alpha + pml - (pml - rar alpha + apl) and the third pml - rar alpha -(pml - rar alpha - apl). |
1995-09-22 |
2023-08-12 |
Not clear |
| W Scherulen, J Harbott, J W Janssen, J Kühl, C R Bartra. Acute promyelocytic leukaemia with hypogranular bone marrow blasts in a 16-year-old girl: diagnostic value of different genetic methods. European journal of pediatrics. vol 154. issue 5. 1995-09-21. PMID:7641768. |
reverse transcribed polymerase chain reaction assay confirmed the initial diagnosis of pml by amplification of the pml-specific pml/rar alpha fusion transcript. |
1995-09-21 |
2023-08-12 |
Not clear |
| R E Gallagher, Y P Li, S Rao, E Paietta, J Andersen, P Etkind, J M Bennett, M S Tallman, P H Wierni. Characterization of acute promyelocytic leukemia cases with PML-RAR alpha break/fusion sites in PML exon 6: identification of a subgroup with decreased in vitro responsiveness to all-trans retinoic acid. Blood. vol 86. issue 4. 1995-09-14. PMID:7632962. |
characterization of acute promyelocytic leukemia cases with pml-rar alpha break/fusion sites in pml exon 6: identification of a subgroup with decreased in vitro responsiveness to all-trans retinoic acid. |
1995-09-14 |
2023-08-12 |
Not clear |
| R E Gallagher, Y P Li, S Rao, E Paietta, J Andersen, P Etkind, J M Bennett, M S Tallman, P H Wierni. Characterization of acute promyelocytic leukemia cases with PML-RAR alpha break/fusion sites in PML exon 6: identification of a subgroup with decreased in vitro responsiveness to all-trans retinoic acid. Blood. vol 86. issue 4. 1995-09-14. PMID:7632962. |
of 113 acute promyelocytic leukemia cases documented to have diagnostic pml-rar alpha hybrid mrna, 10 cases (8.8%) had fusion sites in pml gene exon 6 (v-forms) rather than in the two common hybrid mrna configurations resulting from breaksites in either pml gene intron 6 (l-forms) or intron 3 (s-forms). |
1995-09-14 |
2023-08-12 |
Not clear |