| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| David L Gossage, Blanka Cieslarová, Sophe Ap, Hao Zheng, Yan Xin, Preeti Lal, Guang Chen, Victoria Smith, John S Sund. Phase 1b Study of the Safety, Pharmacokinetics, and Disease-related Outcomes of the Matrix Metalloproteinase-9 Inhibitor Andecaliximab in Patients With Rheumatoid Arthritis. Clinical therapeutics. vol 40. issue 1. 2018-07-10. PMID:29287749. |
andecaliximab (gs-5745) is a highly selective monoclonal antibody against matrix metalloproteinase-9 (mmp9), a proteolytic enzyme implicated in the pathogenesis of rheumatoid arthritis (ra). |
2018-07-10 |
2023-08-13 |
Not clear |
| Zoi Piperigkou, Marco Franchi, Martin Götte, Nikos K Karamano. Estrogen receptor beta as epigenetic mediator of miR-10b and miR-145 in mammary cancer. Matrix biology : journal of the International Society for Matrix Biology. vol 64. 2018-07-09. PMID:28797712. |
our data revealed that mir-10b is strongly implicated in the regulation of functional properties, emt program and erk1/2 signaling in sherβ mda-mb-231 cells, thus affecting the extracellular matrix (ecm) composition, including syndecan-1, proteolytic behavior, especially mmp2, mmp7 and mmp9 expression and subsequently the aggressiveness of these cells. |
2018-07-09 |
2023-08-13 |
Not clear |
| Sigal Kfir, Raghavendra Basavaraja, Noa Wigoda, Shifra Ben-Dor, Irit Orr, Rina Meida. Genomic profiling of bovine corpus luteum maturation. PloS one. vol 13. issue 3. 2018-07-09. PMID:29590145. |
genes related to the angiogenic process such as nos3, which maintains dilated vessels and mmp9, matrix degrading enzyme, were higher on day 4. |
2018-07-09 |
2023-08-13 |
cattle |
| Liang Li, Mahesh Sapkota, Ming Gao, Hyukjae Choi, Yunjo So. Macrolactin F inhibits RANKL-mediated osteoclastogenesis by suppressing Akt, MAPK and NFATc1 pathways and promotes osteoblastogenesis through a BMP-2/smad/Akt/Runx2 signaling pathway. European journal of pharmacology. vol 815. 2018-07-05. PMID:28919027. |
in addition, mf suppressed the expression of osteoclast-related genes, including c-myc, rank, tartrate-resistant acid phosphatase (trap), nuclear factor of activated t cells c1 (nfatc1), cathepsin k and matrix metalloproteinase 9 (mmp9). |
2018-07-05 |
2023-08-13 |
Not clear |
| R Sharony, Z Borochowitz, L Cohen, A Shtorch-Asor, R Rosenfeld, S Modai, E Reinstei. Prenatal course of metaphyseal anadysplasia associated with homozygous mutation in MMP9 identified by exome sequencing. Clinical genetics. vol 92. issue 6. 2018-07-03. PMID:28342220. |
although several families with mandp have been reported, homozygous mutations in the matrix metalloproteinase type 9 (mmp9) gene have been described in only one consanguineous family, and thus the pre and postnatal phenotypic spectrum is still obscure. |
2018-07-03 |
2023-08-13 |
Not clear |
| Jing Cheng, Jifu Zheng, Ninghong Guo, Fuming Z. I‑BET151 inhibits osteoclastogenesis via the RANKL signaling pathway in RAW264.7 macrophages. Molecular medicine reports. vol 16. issue 6. 2018-06-26. PMID:28983590. |
mrna expression levels of osteoclast specific genes tracp, matrix metalloproteinase‑9 (mmp9), cathepsin k (ctsk) and proto‑oncogene tyrosine‑protein kinase src (c‑src) were measured using the reverse transcription‑quantitative polymerase chain reaction (rt‑qpcr). |
2018-06-26 |
2023-08-13 |
Not clear |
| Ming Xu, Cong Wang, Minglin Zhu, Xianguo Wang, Li Zhang, Jinping Zha. 2,3,5,4‑tetrahydroxy diphenylethylene‑2‑O‑glucoside inhibits the adhesion and invasion of A549 human lung cancer cells. Molecular medicine reports. vol 16. issue 6. 2018-06-26. PMID:28990072. |
reverse transcription‑quantitative polymerase chain reaction analysis was performed to examine the mrna expression levels of snail, e‑cadherin, vimentin, matrix metalloproteinase (mmp) 2 and mmp9 following thsg treatment for 12 h. |
2018-06-26 |
2023-08-13 |
human |
| Joseph V Moxon, Eugene Ng, Sharon M Lazzaroni, Margaret Boult, Ramesh Velu, Robert A Fitridge, Jonathan Golledg. Circulating biomarkers are not associated with endoleaks after endovascular repair of abdominal aortic aneurysms. Journal of vascular surgery. vol 67. issue 3. 2018-06-25. PMID:28843790. |
this study examined the potential for circulating matrix metalloproteinase 9 (mmp9), osteoprotegerin (opg), d-dimer, homocysteine (hcy), and c-reactive protein (crp) to act as diagnostic markers for endoleak in aaa patients undergoing elective evar. |
2018-06-25 |
2023-08-13 |
Not clear |
| Tae-Min Park, Donggu Kang, Ilho Jang, Won-Soo Yun, Jin-Hyung Shim, Young Hun Jeong, Jong-Young Kwak, Sik Yoon, Songwan Ji. Fabrication of In Vitro Cancer Microtissue Array on Fibroblast-Layered Nanofibrous Membrane by Inkjet Printing. International journal of molecular sciences. vol 18. issue 11. 2018-06-25. PMID:29112150. |
expression of both matrix metalloproteinase 2 (mmp2) and matrix metalloproteinase 9 (mmp9) was higher in cancer microtissues than in fibroblast-free microtissues. |
2018-06-25 |
2023-08-13 |
human |
| Ratana Lim, Gillian Barker, Martha Lappa. SMAD7 regulates proinflammatory and prolabor mediators in amnion and myometrium. Biology of reproduction. vol 97. issue 2. 2018-06-20. PMID:29044425. |
infection (bacterial and or viral) and inflammation, by stimulating proinflammatory cytokines, adhesion molecules, and matrix metalloproteinase 9 (mmp9), play a central role in the rupture of membranes and myometrial contractions. |
2018-06-20 |
2023-08-13 |
human |
| Amanda Kasneci, Jun Seong Lee, Tae Jin Yun, Jijun Shang, Shaun Lampen, Tamar Gomolin, Cheolho C Cheong, Lorraine E Chalifou. From the Cover: Lifelong Exposure of C57bl/6n Male Mice to Bisphenol A or Bisphenol S Reduces Recovery From a Myocardial Infarction. Toxicological sciences : an official journal of the Society of Toxicology. vol 159. issue 1. 2018-06-19. PMID:28903498. |
in vitro bpa and bps addition increased matrix metalloproteinase-9 (mmp) protein and secreted activity in raw264.7 macrophage cells suggesting that invivo increases in mmp2 and mmp9 in exposed infarcts were myeloid-derived. |
2018-06-19 |
2023-08-13 |
mouse |
| Pengfei Feng, Xiaona Li, Weiyi Chen, Rui He, Xiaojun Wan. [Effects of Tumor Necrosis Factor Alpha on the Expression of Matrix Metalloproteinases and Tissue Inhibitors of Matrix Metalloproteinases in Keratoconus Fibroblasts]. Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi. vol 33. issue 6. 2018-06-18. PMID:29714979. |
the aim of this article is to study the effect of tumor necrosis factor alpha(tnf-α)on the expression of matrix metalloproteinases(mmps)and tissue inhibitors of matrix metalloproteinases(timps)in keratoconus fibroblasts in vitro.normal cornea and keratoconus fibroblasts were extracted using enzyme digestion method and were cultured in the medium containing tnf-α(0,10 and 100ng/ml).the expression of mmps proteins in the supernatant of corneal fibroblasts and the expression of timps in the normal cornea and keratoconus fibroblasts were detected by western blot and real-time quantitative polymerase chain reaction respectively.the active form of mmp1 could be detected in the supernatant of keratoconus fibroblasts and upregulated by tnf-α.tnf-αcould increase the protein expression of mmp2,mmp3,mmp9 in the supernatant of keratoconus fibroblasts and decrease the gene expression of timp1,timp2 in keratoconus fibroblasts.the increased mmps and the decreased timps can increase the degradation of the extracellular matrix.tnf-αmay play an important role in the occurrence and development of keratoconus by regulating the expression of mmps/timps. |
2018-06-18 |
2023-08-13 |
Not clear |
| Chengye Che, Jie Liu, Lei Ma, Huirong Xu, Na Bai, Qian Zhan. LOX-1 is involved in IL-1β production and extracellular matrix breakdown in dental peri-implantitis. International immunopharmacology. vol 52. 2018-06-12. PMID:28898769. |
to explore whether lectin-type oxidized ldl receptor 1 (lox-1), interleukin 1 beta (il-1β), matrix metalloproteinase 2 (mmp2) and matrix metalloproteinase 9 (mmp9) are involved in the nosogenesis of human dental peri-implantitis and determine the role of lox-1 in il-1β, mmp2 and mmp9 production in response to porphyromonas gingivalis. |
2018-06-12 |
2023-08-13 |
human |
| Yonggang Xu, Jie Wang, Yanbin Xu, Hong Xiao, Jianhua Li, Zhi Wan. Screening critical genes associated with malignant glioma using bioinformatics analysis. Molecular medicine reports. vol 16. issue 5. 2018-06-04. PMID:28901452. |
functional enrichment analyses showed that matrix metalloproteinase 9 (mmp9) and chitinase 3‑like 1 (chi3l1) were enriched in the extracellular matrix and extracellular matrix structural constituent, respectively. |
2018-06-04 |
2023-08-13 |
Not clear |
| Feng Tang, Shengjun Tang, Xiaolong Guo, Chao Yang, Ke Ji. CT45A1 siRNA silencing suppresses the proliferation, metastasis and invasion of lung cancer cells by downregulating the ERK/CREB signaling pathway. Molecular medicine reports. vol 16. issue 5. 2018-06-04. PMID:28901509. |
in addition, the levels of b‑cell lymphoma‑2 (bcl‑2), bcl‑2 associated x (bax), survivin, matrix metalloproteinase 2 (mmp2), mmp9, extracellular signal‑regulated kinase 1/2 (erk1/2), phosphorylated erk1/2 (p‑erk1/2), cyclic amp response element binding protein (creb) and p‑creb were assessed by western blotting. |
2018-06-04 |
2023-08-13 |
Not clear |
| Connor M Pettem, Jennifer M Briens, David M Janz, Lynn P Webe. Cardiometabolic response of juvenile rainbow trout exposed to dietary selenomethionine. Aquatic toxicology (Amsterdam, Netherlands). vol 198. 2018-06-04. PMID:29550715. |
exposure to se-met significantly decreased mrna abundance of citrate synthase (cs) in liver and serpin peptidase inhibitor, clad h1 (serpinh) in heart, and increased mrna abundance of sarcoplasmic reticulum calcium atpase (serca) and key cardiac remodelling enzyme matrix metalloproteinase 9 (mmp9) in heart. |
2018-06-04 |
2023-08-13 |
Not clear |
| Wang Liao, Hongbing Fan, Jianping W. Egg White-Derived Antihypertensive Peptide IRW (Ile-Arg-Trp) Inhibits Angiotensin II-Stimulated Migration of Vascular Smooth Muscle Cells via Angiotensin Type I Receptor. Journal of agricultural and food chemistry. vol 66. issue 20. 2018-06-01. PMID:29714061. |
it was found that irw could downregulate matrix metallopeptidase 9 (mmp9) expression and inhibit migration of ang ii-stimulated a7r5 cells, which was associated with inactivation of p38/mapk signaling. |
2018-06-01 |
2023-08-13 |
rat |
| Han Wang, Jianhua Zhong, Chenglong Wu, Yang Liu, Jinghua Zhang, Xiaowen Zou, Yan Chen, Jinfeng Su, Gang Yang, Yuantang Zhong, Aifa Tan. Stromal antigen 2 functions as a tumor suppressor in bladder cancer cells. Oncology reports. vol 38. issue 2. 2018-05-30. PMID:28627627. |
furthermore, stag2 overexpression upregulated e-cadherin, caspase-3, and caspase-7 and downregulated vimentin, matrix metalloproteinase (mmp)2, and mmp9. |
2018-05-30 |
2023-08-13 |
Not clear |
| Qiong Cheng, Jinfeng Wu, Yaohua Zhang, Xiao Liu, Nan Xu, Fuguo Zuo, Jinhua X. SOX4 promotes melanoma cell migration and invasion though the activation of the NF-κB signaling pathway. International journal of molecular medicine. vol 40. issue 2. 2018-05-30. PMID:28627651. |
in the melanoma cells in which sox4 was downregulated, the expression levels of nf-κb/p65, matrix metalloproteinase (mmp)2 and mmp9 were suppressed at both the mrna and protein levels. |
2018-05-30 |
2023-08-13 |
Not clear |
| Tangmeng Guo, Lili Huang, Cunfei Liu, Shengshuai Shan, Qing Li, Li Ke, Bei Chen. The clinical value of inflammatory biomarkers in coronary artery disease: PTX3 as a new inflammatory marker. Experimental gerontology. vol 97. 2018-05-30. PMID:28778748. |
previous experiments have demonstrated that several inflammatory biomarkers, including pentraxin 3 (ptx3), matrix metalloprotein 9 (mmp9), interleukin-6 (il-6), and the neutrophil to lymphocyte ratio (nlr), are differentially elevated in coronary artery disease (cad). |
2018-05-30 |
2023-08-13 |
Not clear |