| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jeris Cox, Minnie Malik, Joy Britten, Terrence Lewis, William H Catherin. Ulipristal Acetate and Extracellular Matrix Production in Human Leiomyomas In Vivo: A Laboratory Analysis of a Randomized Placebo Controlled Trial. Reproductive sciences (Thousand Oaks, Calif.). vol 25. issue 2. 2018-11-14. PMID:28929861. |
increased mmp2 and decreased mmp9 in treated patient leiomyomas indicate both degradation of the matrix and inhibition of the pathway involved in matrix production. |
2018-11-14 |
2023-08-13 |
human |
| Lawei Yang, Ziying Lin, Yahong Wang, Chunyan Li, Wenya Xu, Qinglan Li, Weimin Yao, Zeqing Song, Gang Li. Nickle(II) ions exacerbate bleomycin-induced pulmonary inflammation and fibrosis by activating the ROS/Akt signaling pathway. Environmental science and pollution research international. vol 25. issue 5. 2018-11-13. PMID:29185215. |
ni ions also increased extracellular matrix protein levels, including those of type i collagen and mmp9 in mouse lung tissues and cell lines. |
2018-11-13 |
2023-08-13 |
mouse |
| Xuanzhi Wang, Xinda Li, Xingliang Dai, Xinzhi Zhang, Jing Zhang, Tao Xu, Qing La. Coaxial extrusion bioprinted shell-core hydrogel microfibers mimic glioma microenvironment and enhance the drug resistance of cancer cells. Colloids and surfaces. B, Biointerfaces. vol 171. 2018-11-12. PMID:30048904. |
furthermore, compared with shell/core-u118 (u) hydrogel microfibers, the expressions of matrix metalloproteinase-2 (mmp2), mmp9, vascular endothelial growth factor receptor-2 (vegfr2) and o6-methylguanine-dna methyltransferase (mgmt) which are related to tumor invasion and drug resistance were significantly enhanced in g/u hydrogel microfibers. |
2018-11-12 |
2023-08-13 |
Not clear |
| Marcin Poreba, Aleksandra Szalek, Wioletta Rut, Paulina Kasperkiewicz, Izabela Rutkowska-Wlodarczyk, Scott J Snipas, Yoshifumi Itoh, Dusan Turk, Boris Turk, Christopher M Overall, Leszek Kaczmarek, Guy S Salvesen, Marcin Dra. Highly sensitive and adaptable fluorescence-quenched pair discloses the substrate specificity profiles in diverse protease families. Scientific reports. vol 7. 2018-11-09. PMID:28230157. |
using caspase-3, caspase-7, caspase-8, neutrophil elastase, legumain, and two matrix metalloproteinases (mmp2 and mmp9), we demonstrated that substrates containing acc/lys(dnp) exhibit 7 to 10 times higher sensitivity than conventional 7-methoxy-coumarin-4-yl acetic acid (mca)/lys(dnp) substrates; thus, substantially lower amounts of substrate and enzyme can be used for each assay. |
2018-11-09 |
2023-08-13 |
human |
| Changli Wang, Xihui Bai, Shiyu Liu, Jing Wang, Zhuo Su, Wenjuan Zhang, Diaodiao Bu, Yonggang Yan, Xiao Son. RNA-seq based transcriptome analysis of the protective effect of compound longmaining decoction on acute myocardial infarction. Journal of pharmaceutical and biomedical analysis. vol 158. 2018-11-08. PMID:29933226. |
in addition, qpcr technology was used to verify the expression of chemokine (c-c motif) ligand 6 (ccl6), chemokine (c-c motif) receptor 5 (ccr5), integrin alpha m (itgam), neutrophil cytosolic factor 1 (ncf1), and matrix metallopeptidase 9 (mmp9). |
2018-11-08 |
2023-08-13 |
Not clear |
| Yu-Wei Ge, Zhi-Qing Liu, Zhen-Yu Sun, De-Gang Yu, Kai Feng, Zhen-An Zhu, Yuan-Qing Ma. Titanium particle‑mediated osteoclastogenesis may be attenuated via bidirectional ephrin‑B2/eph‑B4 signaling in vitro. International journal of molecular medicine. vol 42. issue 4. 2018-11-08. PMID:30015911. |
the data demonstrated that ti significantly promoted the differentiation of bmms into mature osteoclasts in the presence of rankl and significantly promoted expression of the ephrin‑b2, nuclear factor of activated t‑cells 1 (nfatc1), trap, fos proto‑oncogene, ap‑1 transcription factor subunit (c‑fos), and matrix metalloproteinase 9 (mmp9) genes. |
2018-11-08 |
2023-08-13 |
mouse |
| Xiaoting Wang, Bin Wang, Jieqiong Xie, Diyu Hou, Hui Zhang, Huifang Huan. Melatonin inhibits epithelial‑to‑mesenchymal transition in gastric cancer cells via attenuation of IL‑1β/NF‑κB/MMP2/MMP9 signaling. International journal of molecular medicine. vol 42. issue 4. 2018-11-08. PMID:30066836. |
sequential treatment of ga cells with melatonin after il‑1β challenge markedly reversed the il‑1β‑induced morphological changes, reduced cell invasion and migration, increased β‑catenin and e‑cadherin expression, and downregulated fibronectin, vimentin, snail, matrix metalloproteinase (mmp)2 and mmp9 expression. |
2018-11-08 |
2023-08-13 |
human |
| Branka Djordjevic, Tatjana Cvetkovic, Tatjana Jevtovic Stoimenov, Milena Despotovic, Slavoljub Zivanovic, Jelena Basic, Andrej Veljkovic, Aleksandra Velickov, Gordana Kocic, Dusica Pavlovic, Dusan Sokolovi. Oral supplementation with melatonin reduces oxidative damage and concentrations of inducible nitric oxide synthase, VEGF and matrix metalloproteinase 9 in the retina of rats with streptozotocin/nicotinamide induced pre-diabetes. European journal of pharmacology. vol 833. 2018-11-05. PMID:29890158. |
hyperglycemia mediated oxidative stress and pro-angiogenic molecules such as vascular endothelial growth factor (vegf) and matrix metalloproteinase 9 (mmp9) are considered important for diabetic retinopathy onset and progression. |
2018-11-05 |
2023-08-13 |
rat |
| Yan Huang, Gang Li, Kai Wang, Zhongyi Mu, Qingpeng Xie, Hongchen Qu, Hang Lv, Bin H. Collagen Type VI Alpha 3 Chain Promotes Epithelial-Mesenchymal Transition in Bladder Cancer Cells via Transforming Growth Factor β (TGF-β)/Smad Pathway. Medical science monitor : international medical journal of experimental and clinical research. vol 24. 2018-11-05. PMID:30066698. |
in addition, col6a3 silencing obviously suppressed the levels of matrix metalloproteinase-2 (mmp2), matrix metalloproteinase-9 (mmp9), and vimentin. |
2018-11-05 |
2023-08-13 |
Not clear |
| Guohua Yuan, Lei Chen, Junsheng Feng, Guobin Yang, Qingwen Ni, Xiaoping Xu, Chunyan Wan, Merry Lindsey, Kevin J Donly, Mary MacDougall, Zhi Chen, Shuo Che. Dentin Sialoprotein is a Novel Substrate of Matrix Metalloproteinase 9 in vitro and in vivo. Scientific reports. vol 7. 2018-10-30. PMID:28195206. |
matrix metalloproteinase 9 (mmp9) is expressed in teeth from early embryonic to adult stage. |
2018-10-30 |
2023-08-13 |
mouse |
| Bai-He Li, Lei Yua. [Inhibitory effects of capsaicin on migration and invasion of breast cancer MDA-MB-231 cells and its mechanism]. Sheng li xue bao : [Acta physiologica Sinica]. vol 69. issue 2. 2018-10-30. PMID:28435977. |
the protein levels of c-src, p-c-src (tyr416), fak, p-fak (tyr576), paxillin, p-paxillin (tyr118), matrix metalloproteinase 2 (mmp2) and mmp9 in the mda-mb-231 cells were detected by western blotting. |
2018-10-30 |
2023-08-13 |
Not clear |
| Zhi-Bin Zhou, Bo Yang, Xiaohao Li, Hao Liu, Gang Le. Lysophosphatidic Acid Promotes Expression and Activation of Matrix Metalloproteinase 9 (MMP9) in THP-1 Cells via Toll-Like Receptor 4/Nuclear Factor-κB (TLR4/NF-κB) Signaling Pathway. Medical science monitor : international medical journal of experimental and clinical research. vol 24. 2018-10-30. PMID:30005060. |
lysophosphatidic acid promotes expression and activation of matrix metalloproteinase 9 (mmp9) in thp-1 cells via toll-like receptor 4/nuclear factor-κb (tlr4/nf-κb) signaling pathway. |
2018-10-30 |
2023-08-13 |
human |
| You Li, Linfa Chen, Shaoyu Yao, Jianya Chen, Weidong Hu, Mengxu Wang, Shaofeng Chen, Xinglan Chen, Shengnan Li, Xuefeng Gu, Guoda Ma, Bin Zhao, Wangtao Zhong, Keshen L. Association of Polymorphisms of the Matrix Metalloproteinase 9 Gene with Ischaemic Stroke in a Southern Chinese Population. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 49. issue 6. 2018-10-23. PMID:30257242. |
matrix metalloproteinase 9 (mmp9), a potent endopeptidase degrading extracellular matrix, plays a pivotal role in the pathogenesis of ischaemic stroke (is). |
2018-10-23 |
2023-08-13 |
Not clear |
| Li Li, Jia Liu, Shuang Qin, Ruiman L. The association of polymorphisms in promoter region of MMP2 and MMP9 with recurrent spontaneous abortion risk in Chinese population. Medicine. vol 97. issue 40. 2018-10-23. PMID:30290617. |
this study aimed to reveal the genetic association between polymorphisms in promoter region of matrix metalloproteinase 2 (mmp2) and matrix metalloproteinase 9 (mmp9) and the risk of recurrent spontaneous abortion (rsa) in chinese population.a total of 129 rsa patients and 116 relative controls were selected and the genotyping of polymorphism was conducted by polymerase chain reaction with sequencing. |
2018-10-23 |
2023-08-13 |
Not clear |
| Genai Zhang, Wenping Zhang, Yu Hou, Yingchun Chen, Jipeng Song, Lixiang Din. Detection of miR‑29a in plasma of patients with lumbar spinal stenosis and the clinical significance. Molecular medicine reports. vol 18. issue 1. 2018-10-19. PMID:29749498. |
plasma expression levels of matrix metalloproteinase 9 (mmp9) and a disintegrin and metalloproteinase with thrombospondin motifs 5 (adamts5) were detected elisa. |
2018-10-19 |
2023-08-13 |
Not clear |
| Yuwen Wang, Shujun Zhang, Jia Liu, Biaobiao Fang, Jie Yao, Binglin Chen. Matrine inhibits the invasive and migratory properties of human hepatocellular carcinoma by regulating epithelial‑mesenchymal transition. Molecular medicine reports. vol 18. issue 1. 2018-10-19. PMID:29845189. |
additionally, matrine increased epithelial‑cadherin expression and decreased the expression levels of vimentin, matrix metalloproteinase (mmp)2, mmp9, zinc finger protein snai1 and zinc finger protein snai2. |
2018-10-19 |
2023-08-13 |
human |
| Jiang Su, Changqing Gao, Rong Wang, Cangsong Xiao, Ming Yan. Genes associated with inflammation and the cell cycle may serve as biomarkers for the diagnosis and prognosis of acute myocardial infarction in a Chinese population. Molecular medicine reports. vol 18. issue 2. 2018-10-19. PMID:29845217. |
the upregulated degs were predicted to participate in inflammatory pathways, including the toll‑like receptor (tlr) signaling pathway, including ras‑related c3 botulinum toxin substrate 1 (rac1), tlr4, c‑c motif chemokine receptor (ccr)1; cytokine‑cytokine receptor interaction, including signal transducer and activator of transcription (stat)3; chemokine signaling pathway, including ccr10; pathways associated with cancer, including colony stimulating factor 3 receptor (csf3r); and leukocyte transendothelial migration, including matrix metallopeptidase 9 (mmp9). |
2018-10-19 |
2023-08-13 |
Not clear |
| Julian K Christians, Kendra I Lennie, Maria F Huicochea Munoz, Nimrat Binnin. PAPP-A2 deficiency does not exacerbate the phenotype of a mouse model of intrauterine growth restriction. Reproductive biology and endocrinology : RB&E. vol 16. issue 1. 2018-10-16. PMID:29895300. |
we predicted that, if the upregulation of papp-a2 in pregnancy complications reflects a compensatory response, then deletion of pappa2 in mice would exacerbate the effects of a gene deletion previously reported to impair placental development: deficiency of matrix metalloproteinase-9 (mmp9). |
2018-10-16 |
2023-08-13 |
mouse |
| Xiang Chen, Chaowen Shi, Cong Wang, Weilin Liu, Yanhong Chu, Zou Xiang, Kebin Hu, Ping Dong, Xiaodong Ha. The role of miR-497-5p in myofibroblast differentiation of LR-MSCs and pulmonary fibrogenesis. Scientific reports. vol 7. 2018-10-15. PMID:28098218. |
in addition, as determined by luciferase assays and western blot analysis, reversion-inducing cysteine-rich protein with kazal motifs (reck) was identified to be one of the target genes of mir-497-5p, and reck could suppress the expression of matrix metalloproteinase-2 (mmp2) and mmp9, which could activate latent transforming growth factor-β1 (tgf-β1). |
2018-10-15 |
2023-08-13 |
Not clear |
| Shuping Yang, Yange Zhang, Yi Luo, Bocheng Xu, Yuqin Yao, Yuanle Deng, Fangfang Yang, Tinghong Ye, Gang Wang, Zhiqiang Cheng, Yu Zheng, Yongmei Xi. Hinokiflavone induces apoptosis in melanoma cells through the ROS-mitochondrial apoptotic pathway and impairs cell migration and invasion. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 103. 2018-10-15. PMID:29635122. |
furthermore, hinokiflavone effectively impaired a375 cells migration and invasion, and down-regulated the expression of matrix metalloproteinase (mmp) mmp2 and mmp9. |
2018-10-15 |
2023-08-13 |
human |