| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Arka Bagchi, Analabha Roy, Anindya Halder, Arunima Biswa. A multifaceted examination of the action of PDE4 inhibitor rolipram on MMP2/9 reveals therapeutic implications. Scientific reports. vol 15. issue 1. 2025-03-31. PMID:40164643. |
a pde4 (phosphodiesterase 4) inhibitor, rolipram, was previously found to down-regulate (in a manner dependent on camp (cyclic adenosine monophosphate)-pka (protein kinase a)) mmp2 (matrix metalloproteinase 2) and mmp9 protein expression levels, important markers of epithelial-to-mesenchymal transition in human breast cancer cell lines. |
2025-03-31 |
2025-04-03 |
human |
| Min Wu, Dong Liu, Xiaoman Xiong, Qiang Su, Yi Xiang, Lang Shen, Zhenxiang An, Xiaofang Yan. Analysis of the molecular mechanisms of ulcerative colitis and atherosclerosis by microarray data. Scientific reports. vol 15. issue 1. 2025-03-29. PMID:40155679. |
finally, a total of 16 hub genes were identified by cytohubba and mcode plugins in cytoscape, including chemokine (c-c motif) ligand 4(ccl4), toll-like receptor 2 (tlr2), integrin beta 2(itgb2), chemokine (c-c motif) receptor 1(ccr1), toll-like receptor 8 (tlr8), fc fragment of igg receptor iia (fcgr2a), neutrophil cytosolic factor 2(ncf2), leukocyte immunoglobulin-like receptor b2(lilrb2), fgr proto-oncogene, src family tyrosine kinase(fgr), intercellular adhesion molecule 1 (icam1), caspase 1(casp1), matrix metallopeptidase 9(mmp9), cluster of differentiation 163(cd163), complement component 5a receptor 1 (c5ar1), neutrophil cytosolic factor 4 (ncf4), selectin p (selp). |
2025-03-29 |
2025-04-01 |
Not clear |
| Weiming Luo, Yunhai Li, Gang Li, Mei Yan. RING box protein-1 promotes the metastasis of cervical cancer through regulating matrix metalloproteinases via PI3K/AKT signaling pathway. Journal of molecular histology. vol 56. issue 2. 2025-03-28. PMID:40153066. |
mechanistically, the regulatory effect of rbx1 on cell metastasis was associated with changes in matrix metalloproteinases (mmp3 and mmp9) and altered activity of pi3k/akt signaling. |
2025-03-28 |
2025-03-31 |
Not clear |
| Yafen Wang, Xiaoshuang Wu, Zhixin Liu, Xinlei Li, Yaozhen Chen, Ning An, Xingbin H. [Unveiling the molecular features and diagnosis and treatment prospects of immunothrombosis via integrated bioinformatics analysis]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 41. issue 3. 2025-03-27. PMID:40145454. |
through ppi network analysis, several hub genes were identified, with matrix metalloproteinase 9 (mmp9) and s100 calcium-binding protein a12 (s100a12) emerging as the best shared diagnostic cg for sle (auc: 0.936 and 0.832) and vte (auc: 0.719 and 0.759). |
2025-03-27 |
2025-03-30 |
Not clear |
| Wanqi Wu, Jun Wang, Guanglu Wang, Feibiao Wang, Yue Yang, Zhijun Liu, Qimei Song, Si Chen, Huizhen Che. Monotropein inhibits MMP9-mediated cardiac oxidative stress, inflammation, matrix degradation and apoptosis in a mouse and cell line models of septic cardiac injury. Molecular biology reports. vol 52. issue 1. 2025-03-20. PMID:40111530. |
sepsis can cause severe cardiac damage, and matrix metalloproteinase 9 (mmp9) is involved in the inflammatory response and tissue injury processes. |
2025-03-20 |
2025-03-23 |
mouse |
| Qingyu Zhao, Yong Li, Qian Sun, Ronggui Wang, Haoran Lu, Xinyi Zhang, Lun Gao, Qiang Cai, Baohui Liu, Gang Den. Self-assembled genistein nanoparticles suppress the epithelial-mesenchymal transition in glioblastoma by targeting MMP9. Materials today. Bio. vol 31. 2025-03-19. PMID:40104644. |
mechanistic analysis indicated that ge nps inhibited the degradation of the extracellular matrix by targeting the catalytic domain of mmp9, thereby effectively suppressing the emt of gbm. |
2025-03-19 |
2025-03-21 |
mouse |
| Karunya Jenin Ravindranath, Hemalatha Srinivasa. Regulating the expression of matrix metalloproteinases to inhibit ovarian carcinoma using isoquinoline alkaloid from Allium ascalonicum. Scientific reports. vol 15. issue 1. 2025-03-18. PMID:40097575. |
research studies have reported that three predominant matrix metalloproteinases (mmps), namely, mmp14, mmp2 and mmp9 can induce the migration of ovarian cancer cells, epithelial-mesenchymal transition, breakdown of extracellular matrix, upregulation of expression of transcription factors etc. |
2025-03-18 |
2025-03-20 |
Not clear |
| He Zhu, Bei Wen, Jijun Xu, Li Xu, Yuguang Huan. Wnt5a in keratinocytes contributes to complex regional pain syndrome through the activation of NR2B and MMP9 in rats. Regional anesthesia and pain medicine. 2025-03-13. PMID:40081928. |
our study examined whether wnt5a in skin keratinocytes contributes to crps-related pain hypersensitivity by activating downstream n-methyl-d-aspartate receptor subunit 2b (nr2b) and matrix metalloproteinase-9 (mmp9) signaling in rats. |
2025-03-13 |
2025-03-16 |
rat |
| Wei Lin, Yongping Chen, Mingqin Lu, Cheng Peng, Xiang Chen, Xiaoqin Liu, Yunyun Wan. Identification and validation of neutrophil-related biomarkers in acute-on-chronic liver failure. Frontiers in immunology. vol 16. 2025-03-12. PMID:40070835. |
among these, matrix metallopeptidase-9 (mmp9) and s100 calcium binding protein a12 (s100a12) were upregulated, whereas c-c chemokine ligand 5 (ccl5) was downregulated in circulating immune cells from patients with aclf compared to those from healthy controls. |
2025-03-12 |
2025-03-14 |
Not clear |
| Marwa Sharaky, Shereen M El Kiki, Heba Effat, Heba H Mansou. Effect of palliative radiotherapy and cyclin-dependent kinase 4/6 inhibitor on breast cancer cell lines. Naunyn-Schmiedeberg's archives of pharmacology. 2025-03-04. PMID:40035822. |
the intrinsic treatment objectives for mbc are presented in this study, along with the pi3k/akt/mtor pathway; cdk4, cdk6, and the nf-κβ/tgf-β pathway; bax/bcl2, p53; caspase-3, caspase-6, caspase-7, caspase-8, and caspase-9; cytokeratin 18 (ck18); cycloxygenase-2 (cox2); il-6; il1β; matrix metalloproteinases (mmp2 and mmp9); and oxidative stress markers. |
2025-03-04 |
2025-03-06 |
human |
| Tapasi Roy, Rachana Banerjee, Abhishek Chatterjee, Snehasikta Swarnaka. Dopamine Toxicity Induces ROS-Dependent Death of Murine Neuroblastoma Cells: Impact on the Interactions of Cofilin With UCHL1 and MMP9. Neurochemical research. vol 50. issue 2. 2025-03-04. PMID:40035962. |
the activity and expression of matrix metalloproteinases9 (mmp9), involved in neuro-inflammation, was enhanced upon da-exposure. |
2025-03-04 |
2025-03-06 |
Not clear |
| Natalia Yunusova, Eldar Tulendinov, Dmitry Svarovsky, Anastasia Ryabova, Irina Kondakova, Anastasia Ponomaryova, Sergey Vtorushin, Stanislav Tabakaev, Dmitry Korshunov, Tatiana Shtam, Svetlana Tamkovich, Evgeny Choynzono. Levels of Proangiogenic Molecules and Terminal Complement Complex C5b-9 in the Crown of Circulating sEVs in Patients with Recurrent Glioblastomas: Relationship with Tumor Molecular Characteristics. Current issues in molecular biology. vol 47. issue 2. 2025-02-25. PMID:39996852. |
this study aimed to compare the levels of matrix metalloproteinases (mmp2 and mmp9), terminal complement complex (c5b-9), and vegf-a in circulating sevs in glioblastoma patients (gbmps) with and without tumor recurrence. |
2025-02-25 |
2025-02-27 |
Not clear |
| b' Alba Irisarri, Ana Corral, N\\xc3\\xbaria Perez-Salvador, Aina Bellver-Sanchis, Marta Ribalta-Vilella, Roger Bentanachs, Marta Alegret, Juan Carlos Laguna, Emma Barroso, Xavier Palomer, Daniel Ortu\\xc3\\xb1o-Sahag\\xc3\\xban, Manuel V\\xc3\\xa1zquez-Carrera, Merc\\xc3\\xa8 Pall\\xc3\\xa0s, Laura Herrero, Christian Gri\\xc3\\xb1\\xc3\\xa1n-Ferr\\xc3\\xa. FTO inhibition mitigates high-fat diet-induced metabolic disturbances and cognitive decline in SAMP8 mice. Molecular medicine (Cambridge, Mass.). vol 31. issue 1. 2025-02-22. PMID:39984825.' |
fto inhibition reduced the activity of matrix metalloproteases (mmp2, mmp9) and altered igf1 signaling (igf1, pten). |
2025-02-22 |
2025-02-24 |
mouse |
| Prasanti Sharma, Joydeep Bhattacharyya, Neelima Sharm. Phloretin and Enalapril co-administration ameliorates hyperglycemia mediated exacerbation of myocardial injury in rats. European journal of pharmacology. 2025-02-20. PMID:39978711. |
molecular docking confirmed strong affinities of phloretin and enalapril for key targets like insulin (ins), matrix metallopeptidase 9 (mmp9), prostaglandin endoperoxide synthase 2 (ptgs2) and insulin like growth factor 1 (igf1). |
2025-02-20 |
2025-02-23 |
rat |
| Yifeng Zhang, Dongjie Wang, Xiaomei Wu, Ting Zhao, Ming He, Yunyu He, Chunmei Men. Targeting the lncRNA GAS5/TLR4/NLRP3 signaling cascade inhibits endometrial stromal cell pyroptosis and prevents the progression of intrauterine adhesions. Journal of reproductive immunology. vol 168. 2025-02-14. PMID:39951898. |
subsequently, results from the functional verification assay, including hematoxylin-eosin staining, enzyme-linked immunosorbent assay, and western blot, showed that knockdown of gas5 improved endometrial injury and uterine adhesions, decreased the levels of timp1, α-sma, vimentin, and col1a1, but elevated mmp9 level to reduce excessive accumulation of extracellular matrix (ecm), and inhibited the expression of nlrp3, cleaved caspase-1, gsdmd, and nuclear p65 to ameliorate pyroptosis in iua model mice. |
2025-02-14 |
2025-02-18 |
mouse |
| Yun-Hang Gao, Han Li, Jian-Liang Li, Ling Song, Teng-Fei Chen, Hong-Ping Hou, Bo Peng, Peng Li, Guang-Ping Zhan. [Study on mechanism of Yourenji Capsules in improving osteoporosis based on network pharmacology and proteomics]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 50. issue 2. 2025-02-10. PMID:39929632. |
the analysis of the yrj components absorbed into blood revealed 23 bioactive components of yrj, and network pharmacology results indicated that key targets involved include tumor necrosis factor(tnf), tumor protein p53(tp53), protein kinase(akt1), and matrix metalloproteinase 9(mmp9). |
2025-02-10 |
2025-02-13 |
rat |
| Tatyana Lynn, Megan E Kelleher, Hanah M Georges, Elle M McCauley, Ryan W Logan, Kimberly A Yonkers, Vikki M Abraham. Buprenorphine induces human fetal membrane sterile inflammation. Journal of reproductive immunology. vol 168. 2025-02-06. PMID:39914058. |
other factors that were elevated in fms exposed to buprenorphine included the mediators of membrane weakening, prostaglandin e2 (pge2), and matrix metalloproteinases, mmp1 and mmp9. |
2025-02-06 |
2025-02-09 |
human |
| Jianwen Li, Hongqi Meng, Wenlai Guo, Lubin Zhou, Siyu Wu, Guanghui Gao, Quanzhe Liu, Di You, Wenrui Q. In-Situ Electrospinning Dressings Loaded with Kaempferol for Reducing MMP9 to Promote Diabetic Ulcer Healing. International journal of nanomedicine. vol 20. 2025-02-03. PMID:39895983. |
the high porosity of biomaterials induces more m2 macrophages, while the natural compound kaempferol inhibits the expression of matrix metalloproteinase 9 (mmp9) and thus inhibits the associated inflammatory and immunological responses. |
2025-02-03 |
2025-02-05 |
Not clear |
| Shahin Tajeri, Perle Latré de Laté, Johanneke D Hemmink, Christina Vrettou, Gordon Langsley, W Ivan Morriso. Theileria annulata infects B-cells in sheep, which display lower dissemination potential compared to T. lestoquardi-infected ovine B-cells. Ticks and tick-borne diseases. vol 16. issue 2. 2025-01-31. PMID:39889370. |
theileria lestoquardi-transformed ovine b-cells preferentially expressed matrix metalloproteinase 2 (mmp2), whereas t. annulata-infected ovine b-cells strongly expressed mmp9. |
2025-01-31 |
2025-02-04 |
cattle |
| Shiyi Li, Katherine V Nordick, Iván Murrieta-Álvarez, Randall P Kirby, Rishav Bhattacharya, Ismael Garcia, Camila Hochman-Mendez, Todd K Rosengart, Kenneth K Liao, Nandan K Monda. Prolonged Cardiopulmonary Bypass Time-Induced Endothelial Dysfunction via Glypican-1 Shedding, Inflammation, and Matrix Metalloproteinase 9 in Patients Undergoing Cardiac Surgery. Biomedicines. vol 13. issue 1. 2025-01-25. PMID:39857617. |
this study examines how glypican-1 shedding, matrix metallopeptidase 9 (mmp9), and the pro-inflammatory cytokine il-1β may contribute to endothelial dysfunction in patients undergoing on-pump surgery with an extended cpb. |
2025-01-25 |
2025-01-28 |
Not clear |