| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jinfang Luo, Yi Zhu, Yang Yu, Yujie Chen, Kang He, Jianxin Li. Sinomenine treats rheumatoid arthritis by inhibiting MMP9 and inflammatory cytokines expression: bioinformatics analysis and experimental validation. Scientific reports. vol 14. issue 1. 2024-06-04. PMID:38834626. |
the matrix metalloproteinase 9 (mmp9) was identified as the hub m1 macrophages-related biomarker in ra using bioinformatic analysis and molecular docking. |
2024-06-04 |
2024-06-07 |
Not clear |
| T L Reeder, D S Zarlenga, A L Zeigler, R M Dye. Transcriptional responses consistent with perturbation in dermo-epidermal homeostasis in septic sole ulceration. Journal of dairy science. 2024-06-02. PMID:38825108. |
these changes were accompanied by upregulation of pro-inflammatory transcripts interleukin 1 α (il1a), interleukin1 β (il1b), interleukin 1 receptor 1 (il1r1), inducible nitric oxide synthase (nos2), the inflammasome components nod like receptor protein 3 (nlrp3), pyrin and caspase recruitment domain (pycard), and caspase-1 interleukin converting enzyme (caspase), the matrix metalloproteinases (mmp2 and mmp9), and anti-inflammatory genes interleukin 1 receptor antagonist (il1rn) and interleukin1 receptor 2 (il1r2). |
2024-06-02 |
2024-06-05 |
cattle |
| Meng Zhang, Fenghua Zhao, Yuxuan Zhu, Linda A Brouwer, Hasse Van der Veen, Janette K Burgess, Martin C Harmse. Physical Properties and Biochemical Composition of Extracellular Matrix-Derived Hydrogels Dictate Vascularization Potential in an Organ-Dependent Fashion. ACS applied materials & interfaces. 2024-05-31. PMID:38819955. |
furthermore, cellular ecm remodeling responses varied with skin ecm hydrogels promoting matrix metalloproteinase 1 (mmp1) secretion, while hybrid ecm hydrogels exhibited increased mmp9, fibronectin, and collagen iv deposition. |
2024-05-31 |
2024-06-02 |
Not clear |
| Xiao-Juan Jiang, Ya-Dong Wang, Juan Sun, Ke-Long Ma, Da-Qiang Wu, Jing Shao, Tian-Ming Wang, Chang-Zhong Wan. [Mechanism of n-butanol extract of Pulsatilla Decoction in treating ulcerative colitis by activating BMP signaling pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 49. issue 7. 2024-05-30. PMID:38812188. |
alcian blue/periodic acid-schiff(ab/pas) staining was used to detect the number and mucus secretion status of goblet cells; immunohistochemistry was performed to measure the expression of ki67, cleaved caspase-3, mucin 2(muc2), and matrix metalloproteinase-9(mmp9) in colon tissues; and immunofluorescence was used to analyze the expression of tight junction proteins in colon tissues, and enzyme linked immunosorbent assay(elisa) was employed to quantify the levels of tumor necrosis factor-α(tnf-α), interleukin(il)-1β, and il-6. |
2024-05-30 |
2024-06-17 |
mouse |
| Dan Ma, Yongting Lu, Hong Ye, Chunyan Li, Jie Zhang, Tian Hao Bao, Jianhong Ha. miR-4685-3p Alleviates Human Brain Microvascular Endothelial Cells Injury by Regulating MMP9. Annals of clinical and laboratory science. vol 54. issue 2. 2024-05-27. PMID:38802152. |
the primary objective of this study is to investigate the potential role of mir-4685-3p and underlying mechanisms by which mir-4685-3p modulates matrix metalloproteinase-9 (mmp9) in cerebral microvascular endothelial cell injury. |
2024-05-27 |
2024-06-01 |
human |
| Yun Hu, Xu-Dong Hu, Zi-Qing He, Yang Liu, Yong-Kang Gui, Si-Hui Zhu, Xin Da, Yi-Nuo Liu, Li-Xia Liu, Qi-Ying Shen, Guang-Hong X. Anesthesia/surgery activate MMP9 leading to blood-brain barrier disruption, triggering neuroinflammation and POD-like behavior in aged mice. International immunopharmacology. vol 135. 2024-05-26. PMID:38796964. |
anesthesia and surgery activate matrix metalloproteinase 9 (mmp9), leading to blood-brain barrier (bbb) disruption and postoperative delirium (pod)-like behavior, especially in the elderly. |
2024-05-26 |
2024-05-31 |
mouse |
| Qiong Zhou, Geng Chen. Ampelopsin facilitates diabetic wound healing and keratinocyte cell progression by inhibiting the NLRP3 inflammasome pathway in macrophages. General physiology and biophysics. vol 43. issue 3. 2024-05-22. PMID:38774919. |
amp notably facilitated platelet endothelial cell adhesion molecule-31 (cd31), collagen type i alpha 1 chain (col1a1), and alpha-smooth muscle actin (α-sma), and inhibited matrix metallopeptidase 9 (mmp9) and cyclooxygenase 2 (cox2) expression in diabetic wounds. |
2024-05-22 |
2024-05-27 |
mouse |
| Sheereen Gull, Fareeda Tasneem, Ishtiaq Ahmed, Muhammad Aamir Aslam, Asima Tayyeb, Luqman Abid, Muhammad Imran Arshad, Naveed Shahza. Ethanolic extract of Euphorbia royleana Boiss. reduces metastasis of breast cancer cells and inhibits tumor progression in vivo. Medical oncology (Northwood, London, England). vol 41. issue 6. 2024-05-14. PMID:38743193. |
the expression of mesenchymal (e-cadherin and n-cadherin), matrix metalloproteinases (mmp2, mmp9), and stemness markers (oct3) were down-regulated by era. |
2024-05-14 |
2024-05-27 |
mouse |
| Jingxuan Zhang, Ying Han, Ruhan Jia, Qinfang Zhu, Xiaozhou Wang, Meiheng Liu, Wei Zhan. Exploring the role of myeloperoxidase in the atherosclerotic process in hypoxic mice based on the MAPK signaling pathway. Biochemical pharmacology. vol 225. 2024-05-12. PMID:38729447. |
in addition, hypoxia further exacerbates plaque instability by activating the mapk signaling pathway to upregulate vascular endothelial growth factor (vegf) and matrix metalloproteinase-9 (mmp9), which in turn promotes angiogenesis within the plaque. |
2024-05-12 |
2024-05-27 |
mouse |
| Kaiping Deng, Xiaodan Li, Zhipeng Liu, Yalong Su, Xuan Sun, Wurilege Wei, Yixuan Fan, Yanli Zhang, Feng Wan. IGF2BP2 regulates the proliferation and migration of endometrial stromal cells through the PI3K/AKT/mTOR signaling pathway in Hu sheep. Journal of animal science. 2024-05-10. PMID:38727196. |
additionally, the knockdown of igf2bp2 significantly increased the expression of matrix metalloprotein 9 (mmp9), vascular endothelial growth factor (vegf), and prolactin (prl) in escs. |
2024-05-10 |
2024-05-27 |
Not clear |
| Weizhong Qi, Li Jin, Shiqian Huang, Alafate Aikebaier, Song Xue, QianYi Wang, Qiyue Chen, Yao Lu, Changhai Din. Modulating Synovial Macrophage Pyroptosis and Mitophagy Interactions to Mitigate Osteoarthritis Progression using Functionalized Nanoparticles. Acta biomaterialia. 2024-05-10. PMID:38729544. |
in this study, we noted that synovial macrophages can activate pyroptosis in a gasdermin d-dependent manner and produce reactive oxygen species (ros), aberrantly activating the mammalian target of rapamycin complex 1 (mtorc1) pathway and matrix metalloproteinase-9 (mmp9) expression in synovial tissue samples collected from both patients with oa and collagen-induced osteoarthritis (cioa) mouse model. |
2024-05-10 |
2024-05-27 |
mouse |
| Grace H Curtis, Robyn E Reeve, Erica J Cresp. Leptin signaling promotes blood vessel formation in the Xenopus tail during the embryo-larval transition. Developmental biology. 2024-05-05. PMID:38705558. |
reduced leptin signaling lowered mrna expression of cenpk, gpx1, and mmp9, markers for cell proliferation, antioxidation, and extracellular matrix remodeling/cell migration, respectively, in the developing tail, providing insight into three possible mechanisms underlying leptin's promotion of angiogenesis. |
2024-05-05 |
2024-05-08 |
xenopus_laevis |
| Jie Zhou, Chau Q Le, Yun Zhang, James A Well. A general approach for selection of epitope-directed binders to proteins. Proceedings of the National Academy of Sciences of the United States of America. vol 121. issue 19. 2024-04-29. PMID:38683990. |
we generated antibodies that recognize the junction between the pro- and catalytic domains for three different matrix metalloproteases (mmps), mmp1, mmp3, and mmp9, that selectively block activation of each of these enzymes and impair cell migration. |
2024-04-29 |
2024-05-03 |
Not clear |
| Huixian Huang, Jia Huang, Wensi Lu, Yanjun Huang, Ran Luo, Luqman Bathalian, Ming Chen, Xuemin Wan. A Four-Week High-Fat Diet Induces Anxiolytic-like Behaviors through Mature BDNF in the mPFC of Mice. Brain sciences. vol 14. issue 4. 2024-04-27. PMID:38672038. |
furthermore, mrna levels of the n6-methyladenosine (m6a) demethylase, fat mass and obesity-associated protein (fto), and the hydrolase matrix metalloproteinase-9 (mmp9), also increased in the mpfc. |
2024-04-27 |
2024-04-29 |
mouse |
| Bingli Liu, Liping Su, Sze Jie Loo, Yu Gao, Ester Khin, Xiaocen Kong, Rinkoo Dalan, Xiaofei Su, Kok-Onn Lee, Jianhua Ma, Lei Y. Matrix metallopeptidase 9 contributes to the beginning of plaque and is a potential biomarker for the early identification of atherosclerosis in asymptomatic patients with diabetes. Frontiers in endocrinology. vol 15. 2024-04-25. PMID:38660518. |
to determine the roles of matrix metallopeptidase-9 (mmp9) on human coronary artery smooth muscle cells (hcasmcs) |
2024-04-25 |
2024-04-28 |
human |
| Marta Halasa, Ahmed Uosef, Henry V Ubelaker, Arijita Subuddhi, Krupa R Mysore, Jacek Z Kubiak, Rafik M Ghobrial, Jarek Wosik, Malgorzata Klo. Gadolinium retention effect on macrophages - a potential cause of MRI contrast agent Dotarem toxicity. Cell and tissue research. 2024-04-16. PMID:38625373. |
gadolinium retention for 7 days decreased macrophage adhesion and motility and dysregulated the expression of adhesion and fibrotic pathway-related proteins such as notch1 and its ligand jagged1, adhesion/migration-related proteins pak1 and shp1, immune response-related transcription factors smad3 and tcf19, and chemokines cxcl10 and cxcl13, and dysregulated the mrna expression of fibrosis-related genes involved in extracellular matrix (ecm) synthesis, such as col6a1, fibronectin, mmp9, and mmp12. |
2024-04-16 |
2024-04-18 |
Not clear |
| Yulong Zhang, Chenxi Gao, Juncong Luo, Arsalan Khan, Mounir M Salem-Bekhit, Mohamed M Salem, Zeng Qi, Bo Jian. Deciphering the role of wound healing genes in skin cutaneous melanoma: Insights into expression, methylation, mutations, and therapeutic implications. International wound journal. vol 21. issue 4. 2024-04-09. PMID:38591163. |
in this comprehensive study, we investigated the intricate roles of two important wound healing genes in skcm, including matrix metalloproteinase-2 (mmp2) and matrix metalloproteinase-9 (mmp9). |
2024-04-09 |
2024-04-11 |
Not clear |
| Huirong Li, Liang Ding, Jian Ding, Fudan Huan. The Influence of CD40/CD40L, MMP2/MMP9 on Uterine Artery Blood Flow and Their Expression in Recurrent Miscarriage. Alternative therapies in health and medicine. 2024-04-06. PMID:38581334. |
this study aims to investigate the expression levels of soluble cd40l (scd40l), matrix metalloproteinase 2 (mmp2), and matrix metalloproteinase 9 (mmp9) in the serum of patients experiencing recurrent abortion and their impact on uterine artery blood flow. |
2024-04-06 |
2024-04-10 |
Not clear |
| Kunlun Li, Dandan Li, Barbod Hafez, Mounir M Salem Bekhit, Yousef A Bin Jardan, Fars Kaed Alanazi, Ehab I Taha, Sayed H Auda, Faiqah Ramzan, Muhammad Jami. Identifying and validating MMP family members (MMP2, MMP9, MMP12, and MMP16) as therapeutic targets and biomarkers in kidney renal clear cell carcinoma (KIRC). Oncology research. vol 32. issue 4. 2024-04-01. PMID:38560573. |
by performing string and cytohubba analyses of the 24 mmp gene family members, mmp2 (matrix metallopeptidase 2), mmp9 (matrix metallopeptidase 9), mmp12 (matrix metallopeptidase 12), and mmp16 (matrix metallopeptidase 16) genes were denoted as hub genes having highest degree scores. |
2024-04-01 |
2024-04-04 |
Not clear |
| Wen Guo, Mangmang Xu, Xindi Song, Yajun Cheng, Yilun Deng, Ming Li. Association of Serum Macrophage Migration Inhibitory Factor with 3-Month Poor Outcome and Malignant Cerebral Edema in Patients with Large Hemispheric Infarction. Neurocritical care. 2024-04-01. PMID:38561586. |
we aimed to investigate the associations of macrophage migration inhibitory factor (mif), toll-like receptors 2 and 4 (tlr2/4), and matrix metalloproteinase 9 (mmp9) with 3-month poor outcome, death, and malignant cerebral edema (mce) in patients with large hemispheric infarction (lhi). |
2024-04-01 |
2024-04-04 |
Not clear |