| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alison M Wallace, Andrew J Sandfor. Genetic polymorphisms of matrix metalloproteinases: functional importance in the development of chronic obstructive pulmonary disease? American journal of pharmacogenomics : genomics-related research in drug development and clinical practice. vol 2. issue 3. 2003-03-03. PMID:12383023. |
here we review evidence that genetic polymorphisms in matrix metalloproteinase genes mmp1, mmp9 and mmp12 may be important in the development of copd. |
2003-03-03 |
2023-08-12 |
Not clear |
| Patricia A Elkins, Yen Sen Ho, Ward W Smith, Cheryl A Janson, Karla J D'Alessio, Michael S McQueney, Maxwell D Cummings, Anne M Romani. Structure of the C-terminally truncated human ProMMP9, a gelatin-binding matrix metalloproteinase. Acta crystallographica. Section D, Biological crystallography. vol 58. issue Pt 7. 2003-02-11. PMID:12077439. |
the x-ray crystal structure of the proform of human matrix metalloproteinase mmp9 has been solved to 2.5 a resolution. |
2003-02-11 |
2023-08-12 |
human |
| Mijung Kwon, Sooryun Seo, Hoyoung Chun, Jun-Mo Chung, In Kwon Chung, Kyu Chung Hu. Dual effect of nerve growth factor on cell death of PC12 cells Induced by serum deprivation. Molecules and cells. vol 13. issue 2. 2003-01-29. PMID:12018837. |
the acceleration of cell death in the ngf-treated cells was anoikis, caused by the loss of the anchorage of the cell via the action of increased activities of matrix metalloproteinases (mmp2, mmp9). |
2003-01-29 |
2023-08-12 |
Not clear |
| Carol A Hitchon, Carol L Danning, Gabor G Illei, Hani S El-Gabalawy, Dimitrios T Boumpa. Gelatinase expression and activity in the synovium and skin of patients with erosive psoriatic arthritis. The Journal of rheumatology. vol 29. issue 1. 2002-07-02. PMID:11824946. |
matrix metalloproteinases (mmp), especially the gelatinases (mmp2, mmp9), have been implicated in several features of inflammatory arthritis including angiogenesis and bone erosions. |
2002-07-02 |
2023-08-12 |
Not clear |
| Bruno Legallicier, Germain Trugnan, Gillian Murphy, Brigitte Lelongt, Pierre Ronc. Expression of the type IV collagenase system during mouse kidney development and tubule segmentation. Journal of the American Society of Nephrology : JASN. vol 12. issue 11. 2002-02-15. PMID:11675412. |
type iv collagenases matrix metalloproteinase-2 (mmp2) and mmp9 and their related proteins, mt1-mmp, tissue inhibitor of metalloproteinases 1 (timp1), timp2, and timp3, are expressed during kidney morphogenesis and nephrogenesis, but the renal ontogeny of these proteins is only partially known, and their persistence in the adult remains controversial. |
2002-02-15 |
2023-08-12 |
mouse |
| Bruno Legallicier, Germain Trugnan, Gillian Murphy, Brigitte Lelongt, Pierre Ronc. Expression of the type IV collagenase system during mouse kidney development and tubule segmentation. Journal of the American Society of Nephrology : JASN. vol 12. issue 11. 2002-02-15. PMID:11675412. |
all components persisted in specific segments of the adult renal tubule, where mmp9, mmp2, and mt1-mmp showed an apical expression, suggesting that substrates for these enzymes should be in the tubule lumen or in the apical cell domain and not in the extracellular matrix. |
2002-02-15 |
2023-08-12 |
mouse |
| A S Rigg, N R Lemoin. Adenoviral delivery of TIMP1 or TIMP2 can modify the invasive behavior of pancreatic cancer and can have a significant antitumor effect in vivo. Cancer gene therapy. vol 8. issue 11. 2002-02-14. PMID:11773977. |
pancreatic carcinomas overexpress several matrix metalloproteinases (mmps), in particular mmp2 and mmp9. |
2002-02-14 |
2023-08-12 |
mouse |
| S Lepidi, R D Kenagy, E W Raines, E S Chiu, A Chait, R Ross, A W Clowe. MMP9 production by human monocyte-derived macrophages is decreased on polymerized type I collagen. Journal of vascular surgery. vol 34. issue 6. 2002-01-18. PMID:11743569. |
the production of matrix metalloproteinases (mmps), such as mmp9, by macrophages may be a critical factor in the rupture of unstable atherosclerotic plaques and aortic aneurysms. |
2002-01-18 |
2023-08-12 |
human |
| S Lepidi, R D Kenagy, E W Raines, E S Chiu, A Chait, R Ross, A W Clowe. MMP9 production by human monocyte-derived macrophages is decreased on polymerized type I collagen. Journal of vascular surgery. vol 34. issue 6. 2002-01-18. PMID:11743569. |
therefore, we studied the role of matrix and soluble cytokines in the regulation of monocyte/macrophage expression of mmp9. |
2002-01-18 |
2023-08-12 |
human |
| J F Maddo. Mapping the matrix metalloproteinase 9 (MMP9) gene and the BL1071 microsatellite to ovine chromosome 13 (OAR13). Animal genetics. vol 32. issue 5. 2002-01-17. PMID:11683731. |
mapping the matrix metalloproteinase 9 (mmp9) gene and the bl1071 microsatellite to ovine chromosome 13 (oar13). |
2002-01-17 |
2023-08-12 |
Not clear |
| M H Rabinowitz, R C Andrews, J D Becherer, D M Bickett, D G Bubacz, J G Conway, D J Cowan, M Gaul, K Glennon, M H Lambert, M A Leesnitzer, D L McDougald, M L Moss, D L Musso, M C Rizzoli. Design of selective and soluble inhibitors of tumor necrosis factor-alpha converting enzyme (TACE). Journal of medicinal chemistry. vol 44. issue 24. 2001-12-12. PMID:11708926. |
inhibitors containing these arginine mimetics were found to have increased solubility in simulated gastric fluid (sgf) relative to 1, allowing for the incorporation of lipophilic p1' side chains which had the effect of retaining potent tace inhibition, but reducing potency against matrix metalloproteases (mmps) thus increasing overall selectivity against mmp1, mmp3, and mmp9. |
2001-12-12 |
2023-08-12 |
rat |
| J C Rodriguez-Manzaneque, T F Lane, M A Ortega, R O Hynes, J Lawler, M L Iruela-Arisp. Thrombospondin-1 suppresses spontaneous tumor growth and inhibits activation of matrix metalloproteinase-9 and mobilization of vascular endothelial growth factor. Proceedings of the National Academy of Sciences of the United States of America. vol 98. issue 22. 2001-12-04. PMID:11606713. |
interestingly, absence of tsp1 resulted in increased association of vascular endothelial growth factor (vegf) with its receptor vegfr2 and higher levels of active matrix metalloproteinase-9 (mmp9), a molecule previously shown to facilitate both angiogenesis and tumor invasion. |
2001-12-04 |
2023-08-12 |
mouse |
| J E Puzas, J M Landeau, R Tallents, J Albright, E M Schwarz, R Landesber. Degradative pathways in tissues of the temporomandibular joint. Use of in vitro and in vivo models to characterize matrix metalloproteinase and cytokine activity. Cells, tissues, organs. vol 169. issue 3. 2001-10-11. PMID:11455120. |
we describe the presence of a matrix metalloproteinase, mmp9 (92-kd gelatinase), in tmj disc and articular cells that likely function in the degradative process. |
2001-10-11 |
2023-08-12 |
mouse |
| F Kratz, J Drevs, G Bing, C Stockmar, K Scheuermann, P Lazar, C Unge. Development and in vitro efficacy of novel MMP2 and MMP9 specific doxorubicin albumin conjugates. Bioorganic & medicinal chemistry letters. vol 11. issue 15. 2001-10-04. PMID:11454467. |
two doxorubicin albumin conjugates (a-dp1 and a-dp2), which differ in their substrate specificity for the matrix metalloproteinases mmp2 and mmp9, were prepared by binding maleimide doxorubicin peptide derivatives to the cysteine-34 position of human serum albumin. |
2001-10-04 |
2023-08-12 |
human |
| P J Pöllänen, P J Karhunen, J Mikkelsson, P Laippala, M Perola, A Penttilä, K M Mattila, T Koivula, T Lehtimäk. Coronary artery complicated lesion area is related to functional polymorphism of matrix metalloproteinase 9 gene: an autopsy study. Arteriosclerosis, thrombosis, and vascular biology. vol 21. issue 9. 2001-10-04. PMID:11557670. |
matrix metalloproteinase 9 (mmp9) is expressed in human atherosclerotic plaques, and the protein is localized in human coronary atherosclerotic lesions. |
2001-10-04 |
2023-08-12 |
human |
| Y Soini, J Satta, M Määttä, H Autio-Harmaine. Expression of MMP2, MMP9, MT1-MMP, TIMP1, and TIMP2 mRNA in valvular lesions of the heart. The Journal of pathology. vol 194. issue 2. 2001-06-21. PMID:11400152. |
this study was undertaken to investigate the mrna synthesis of mmp2, mmp9, membrane-type 1 (mt1)-mmp, and matrix metalloproteinase inhibitors timp1 and timp2 by in situ hybridization in a set of heart mitral and aortic valves operatively removed due to degenerative or inflammatory valvular diseases. |
2001-06-21 |
2023-08-12 |
Not clear |
| Y Soini, J Satta, M Määttä, H Autio-Harmaine. Expression of MMP2, MMP9, MT1-MMP, TIMP1, and TIMP2 mRNA in valvular lesions of the heart. The Journal of pathology. vol 194. issue 2. 2001-06-21. PMID:11400152. |
the results show that matrix metalloproteinases mmp2 and mmp9, and matrix metalloproteinase inhibitors timp1 and timp2 mrnas are synthesized in diseased valves and suggest that they may contribute to matrix remodelling in valvular disease. |
2001-06-21 |
2023-08-12 |
Not clear |
| John Martin, Lisa Eynstone, Malcolm Davies, Robert Steadma. Induction of metalloproteinases by glomerular mesangial cells stimulated by proteins of the extracellular matrix. Journal of the American Society of Nephrology : JASN. vol 12. issue 1. 2001-05-24. PMID:11134254. |
the present study, therefore, investigated the effect of different matrix components on the adherence of hmc and on their secretion and activation of the gelatinases mmp2 and mmp9. |
2001-05-24 |
2023-08-12 |
human |
| John Martin, Lisa Eynstone, Malcolm Davies, Robert Steadma. Induction of metalloproteinases by glomerular mesangial cells stimulated by proteins of the extracellular matrix. Journal of the American Society of Nephrology : JASN. vol 12. issue 1. 2001-05-24. PMID:11134254. |
the results demonstrate that specific matrix components increased the secretion of mmp2 and mmp9 from hmc. |
2001-05-24 |
2023-08-12 |
human |
| R L Robker, D L Russell, S Yoshioka, S C Sharma, J P Lydon, B W O'Malley, L L Espey, J S Richard. Ovulation: a multi-gene, multi-step process. Steroids. vol 65. issue 10-11. 2001-03-29. PMID:11108860. |
the matrix metalloproteinases (mmps: mmp2, mmp9, and mmp13) appear to be expressed in ovaries of prko mice in a manner similar to that in their wild-type littermates. |
2001-03-29 |
2023-08-12 |
mouse |