| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dongfeng Zhao, Xiaofeng Li, Yongjian Zhao, Ping Qiao, Dezhi Tang, Yan Chen, Chunchun Xue, Chenguang Li, Shufen Liu, Jing Wang, Sheng Lu, Qi Shi, Yan Zhang, Yufeng Dong, Yongjun Wang, Bing Shu, Xu Fen. Oleanolic acid exerts bone protective effects in ovariectomized mice by inhibiting osteoclastogenesis. Journal of pharmacological sciences. vol 137. issue 1. 2018-09-05. PMID:29703642. |
moreover, oa significantly suppresses the expression of rankl-activated osteoclast genes encoding matrix metalloproteinase 9 (mmp9), cathepsin k(ctsk), tartrate-resistant acid phosphatase (trap) and carbonic anhydrase ii (car2). |
2018-09-05 |
2023-08-13 |
mouse |
| Debmalya Bhunia, Krishnangsu Pradhan, Gaurav Das, Subhajit Ghosh, Prasenjit Mondal, Surajit Ghos. Matrix metalloproteinase targeted peptide vesicles for delivering anticancer drugs. Chemical communications (Cambridge, England). vol 54. issue 67. 2018-09-04. PMID:30070277. |
a matrix metalloproteinase (mmp) targeted tetrapeptide vesicle has been designed and developed, which strongly binds at a mmp9 enzymatic site. |
2018-09-04 |
2023-08-13 |
Not clear |
| Janet P C Wong, Ran Wei, Peng Lyu, Olivia L H Tong, Shu Dong Zhang, Qing Wen, Hiu Fung Yuen, Mohamed El-Tanani, Hang Fai Kwo. Clinical and International journal of biological sciences. vol 13. issue 11. 2018-08-27. PMID:29209142. |
we further identified matrix metallopeptidase 9 (mmp9) and s100 calcium-binding protein a8 (s100a8) were both downstream factors for opn in bladder cancer specimens and bladder cancer cell lines. |
2018-08-27 |
2023-08-13 |
Not clear |
| Li Ling, Libo Chen, Changning Zhang, Shuyan Gui, Haiyan Zhao, Zhengzhang L. High glucose induces podocyte epithelial‑to‑mesenchymal transition by demethylation‑mediated enhancement of MMP9 expression. Molecular medicine reports. vol 17. issue 4. 2018-08-27. PMID:29436620. |
abnormal expression of matrix metalloproteinase 9 (mmp9) is correlated with podocyte epithelial-to---mesenchymal transition (emt) in diabetic nephropathy (dn). |
2018-08-27 |
2023-08-13 |
human |
| Xinxing Lu, Lu Xue, Wenbin Sun, Jilu Ye, Zhiyun Zhu, Haifeng Me. Identification of key pathogenic genes of sepsis based on the Gene Expression Omnibus database. Molecular medicine reports. vol 17. issue 2. 2018-08-20. PMID:29257295. |
furthermore, rt‑qpcr results demonstrated that irak3, adrenomedullin (adm), arachidonate 5‑lipoxygenase (alox5), matrix metallopeptidase 9 (mmp9) and s100a8 were significantly upregulated, while ectonucleoside triphosphate diphosphohydrolase 1 (entpd1) was upregulated but not significantly, in blood samples from patients with sepsis compared with healthy individuals, which was consistent with bioinformatics analysis results. |
2018-08-20 |
2023-08-13 |
Not clear |
| Liedao Yu, Shuo Wang, Xiangjin Lin, Yang Lu, Pengcheng G. MicroRNA-124a inhibits cell proliferation and migration in liver cancer by regulating interleukin-11. Molecular medicine reports. vol 17. issue 3. 2018-08-15. PMID:29286137. |
finally, it was identified that mimics of mir‑124a increased the expression of tissue inhibitor of matrix metalloproteinase‑2 (timp‑2) and caspase‑3 and decreased the expression levels of matrix metalloproteinase 2 (mmp2), mmp9, b‑cell lymphoma 2, signal transducer and activator of transcription 3 (stat3), and phosphorylated‑stat3. |
2018-08-15 |
2023-08-13 |
Not clear |
| Linwen Zeng, Shaofeng Yuan, Jianliang Shen, Ming Wu, Liangming Pan, Xiangdong Kon. Suppression of human breast cancer cells by tectorigenin through downregulation of matrix metalloproteinases and MAPK signaling in vitro. Molecular medicine reports. vol 17. issue 3. 2018-08-15. PMID:29359782. |
tec treatment decreased the expression of matrix metalloproteinase (mmp)‑2, mmp9, bcl‑2, phosphorylated‑akt and components of the mitogen‑activated protein kinase (mapk) signaling pathway, and increased the expression of bcl‑2‑associated x, cleaved poly [adp‑ribose] polymerase and cleaved caspase‑3. |
2018-08-15 |
2023-08-13 |
human |
| Qiang Wang, Yongjian Zhao, Nannan Sha, Yan Zhang, Chenguang Li, Hao Zhang, Dezhi Tang, Sheng Lu, Qi Shi, Yongjun Wang, Bing Shu, Dongfeng Zha. The systemic bone protective effects of Gushukang granules in ovariectomized mice by inhibiting osteoclastogenesis and stimulating osteoblastogenesis. Journal of pharmacological sciences. vol 136. issue 3. 2018-08-13. PMID:29501580. |
gsk also inhibited bone resorbed genetic expression of matrix metalloproteinase 9 (mmp9), cathepsin k (ctsk), trap and carbonic anhydrase ii (car2). |
2018-08-13 |
2023-08-13 |
mouse |
| Dongsheng Sun, Yang Liu, Huihui Wang, Fei Deng, Ying Zhang, Shan Zhao, Xiaojun Ma, Huijian Wu, Guangwei Su. Novel decellularized liver matrix-alginate hybrid gel beads for the 3D culture of hepatocellular carcinoma cells. International journal of biological macromolecules. vol 109. 2018-08-08. PMID:29157906. |
the protein expression of urokinase plasminogen activator system and activity of matrix metalloproteinases (mmps) of hcclm3 cells, including mmp2 and mmp9, were more significantly promoted in dlm-alg beads compared with that in conventional alg beads without dlm powder. |
2018-08-08 |
2023-08-13 |
Not clear |
| Yuan Yuan, Hai-Qiong Ye, Qian-Chuan Re. Upregulation of the BDNF/TrKB pathway promotes epithelial-mesenchymal transition, as well as the migration and invasion of cervical cancer. International journal of oncology. vol 52. issue 2. 2018-08-06. PMID:29345295. |
importantly, we demonstrated that the silencing of trkb suppressed the activation of emt via the downregulation of n-cadherin, vimentin, matrix metalloproteinase (mmp)2 and mmp9, and the upregulation of e-cadherin and tissue inhibitor of metalloproteinases (timp)2, which resulted in suppressed cell proliferation, migration and invasion. |
2018-08-06 |
2023-08-13 |
Not clear |
| Muhammad Yasir Asghar, Kati Kemppainen, Taru Lassila, Kid Törnquis. Sphingosine 1-phosphate attenuates MMP2 and MMP9 in human anaplastic thyroid cancer C643 cells: Importance of S1P2. PloS one. vol 13. issue 5. 2018-08-03. PMID:29734379. |
in the present study, we show that stimulating c643 cells with s1p decreases the expression, secretion and activity of matrix metalloproteinase-2 (mmp2), and to a lesser extent mmp9. |
2018-08-03 |
2023-08-13 |
human |
| V V Klimontov, V A Shevchenko, M D Bulumbaeva, F V Prokof 'ev, I V Konenko. [Polymorphisms in Genes of Cytokines and Matrix Metalloproteinases Associated With Ischemic Heart Disease in Patients With Type 2 Diabetes]. Kardiologiia. vol 57. issue 8. 2018-08-01. PMID:29041886. |
to examine associations between ischemic heart disease (ihd) and polymorphisms in cytokine genes (il-1b, il-4, il-6, il-10, tnfa, vegf) and matrix metalloproteinase genes (mmp2, mmp3, mmp9) in patients with type 2 diabetes. |
2018-08-01 |
2023-08-13 |
Not clear |
| Rachel A Schmidt, Craig N Morrell, Frederick S Ling, Preya Simlote, Genaro Fernandez, David Q Rich, David Adler, Joe Gervase, Scott J Camero. The platelet phenotype in patients with ST-segment elevation myocardial infarction is different from non-ST-segment elevation myocardial infarction. Translational research : the journal of laboratory and clinical medicine. vol 195. 2018-07-31. PMID:29274308. |
matrix metalloproteinase 9 (mmp9) protein content and enzymatic activity were several-fold greater in platelets with mi than in control. |
2018-07-31 |
2023-08-13 |
human |
| Can Zhang, Lin Wang, Jiaying Chen, Jie Liang, Yaming Xu, Zhe Li, Fuxue Chen, Dongshu D. Knockdown of Diaph1 expression inhibits migration and decreases the expression of MMP2 and MMP9 in human glioma cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 96. 2018-07-26. PMID:29035824. |
moreover, data obtained from qrt-pcr and western-blot analysis showed that the mrna and protein expression of matrix metalloproteinase2 and 9 (mmp2 and mmp9) was significantly suppressed in these diaph1 knockdown cell lines, as well as gelatin zymography analysis revealed that the activity of mmp2 and mmp9 in conditioned medium was markedly decreased. |
2018-07-26 |
2023-08-13 |
human |
| Xiaoman Li, Xiaodan Zha, Yongan Wang, Rong Jia, Burong Hu, Baoquan Zha. Toxic effects and foundation of proton radiation on the early-life stage of zebrafish development. Chemosphere. vol 200. 2018-07-24. PMID:29494911. |
the expressions of matrix metallopeptidase 9 (mmp9) and timp metallopeptidase inhibitor 2b (timp2b) genes, and enzymatic activity of mmp9 were significantly upregulated in irradiated group. |
2018-07-24 |
2023-08-13 |
zebrafish |
| Juneo F Silva, Natália M Ocarino, Rogéria Serakide. Spatiotemporal expression profile of proteases and immunological, angiogenic, hormonal and apoptotic mediators in rat placenta before and during intrauterine trophoblast migration. Reproduction, fertility, and development. vol 29. issue 9. 2018-07-23. PMID:27737730. |
in addition, the expression of the vegf, flk1, placental growth factor (pigf), soluble fms-like tyrosine kinase 1 (sflt1), placental lactogen 1 (pl1), proliferin-related protein (rplf), placental leptin (lep), toll-like receptor 2 (tlr2), toll-like receptor 4 (tlr4), infg, mif, tumour necrosis factor-α (tnf), interleukin-10 (il10), nos2, caspase 3 (casp3), bax, bcl2, matrix metalloproteinase 2 (mmp2) and matrix metalloproteinase 9 (mmp9) genes was determined by real-time reverse transcription-polymerase chain reaction. |
2018-07-23 |
2023-08-13 |
rat |
| Shahrzad Rahimi, Arezou Sayad, Elham Moslemi, Soudeh Ghafouri-Fard, Mohammad Taher. Blood assessment of the expression levels of matrix metalloproteinase 9 (MMP9) and its natural inhibitor, TIMP1 genes in Iranian schizophrenic patients. Metabolic brain disease. vol 32. issue 5. 2018-07-23. PMID:28578515. |
blood assessment of the expression levels of matrix metalloproteinase 9 (mmp9) and its natural inhibitor, timp1 genes in iranian schizophrenic patients. |
2018-07-23 |
2023-08-13 |
human |
| Shahrzad Rahimi, Arezou Sayad, Elham Moslemi, Soudeh Ghafouri-Fard, Mohammad Taher. Blood assessment of the expression levels of matrix metalloproteinase 9 (MMP9) and its natural inhibitor, TIMP1 genes in Iranian schizophrenic patients. Metabolic brain disease. vol 32. issue 5. 2018-07-23. PMID:28578515. |
the aim of the present study was to evaluate the expression levels of two genes that are involved in the ltp regulation in the developing and adult brain, matrix metallopeptidase9 (mmp9) and timp metallopeptidase inhibitor 1 (timp1) genes in a blood assessment of schizophrenic patients in comparison to healthy controls by means of quantitative real time pcr. |
2018-07-23 |
2023-08-13 |
human |
| Dingqing Feng, Tingting Zhao, Keqin Yan, Haiyan Liang, Jing Liang, Ying Zhou, Weidong Zhao, Bin Lin. Gonadotropins promote human ovarian cancer cell migration and invasion via a cyclooxygenase 2-dependent pathway. Oncology reports. vol 38. issue 2. 2018-07-23. PMID:28677781. |
further results showed that enhancement of epithelial-mesenchymal transition (emt) and upregulation of matrix metalloproteinase (mmp)2 and mmp9 contributed to the stimulatory effect of gonadotropins on cell migration and invasion; these effects were sufficiently blocked by a selective cox2 inhibitor. |
2018-07-23 |
2023-08-13 |
human |
| Jung Min Shin, Se Jin Oh, Seunglee Kwon, V G Deepagan, Minchang Lee, Seok Ho Song, Hyo-Jung Lee, Suyeon Kim, Kwon-Ho Song, Tae Woo Kim, Jae Hyung Par. A PEGylated hyaluronic acid conjugate for targeted cancer immunotherapy. Journal of controlled release : official journal of the Controlled Release Society. vol 267. 2018-07-23. PMID:28844759. |
in this study, we prepared matrix metalloproteinase 9 (mmp9)-responsive polymeric conjugates consisting of pegylated hyaluronic acid (ha) as the targeting moiety and ovalbumin (ova) as the model foreign antigen. |
2018-07-23 |
2023-08-13 |
mouse |