| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| William J Sandborn, Bal R Bhandari, Charles Randall, Ziad H Younes, Tomasz Romanczyk, Yan Xin, Emily Wendt, Hao Chai, Matt McKevitt, Sally Zhao, John S Sundy, Satish Keshav, Silvio Danes. Andecaliximab [Anti-matrix Metalloproteinase-9] Induction Therapy for Ulcerative Colitis: A Randomised, Double-Blind, Placebo-Controlled, Phase 2/3 Study in Patients With Moderate to Severe Disease. Journal of Crohn's & colitis. vol 12. issue 9. 2020-04-06. PMID:29767728. |
matrix metalloproteinase-9 [mmp9] is implicated in the pathogenesis of ulcerative colitis [uc] via disruption of intestinal barrier integrity and function. |
2020-04-06 |
2023-08-13 |
Not clear |
| Stefan Schreiber, Corey A Siegel, Keith A Friedenberg, Ziad H Younes, Ursula Seidler, Bal R Bhandari, Ke Wang, Emily Wendt, Matt McKevitt, Sally Zhao, John S Sundy, Scott D Lee, Edward V Loftu. A Phase 2, Randomized, Placebo-Controlled Study Evaluating Matrix Metalloproteinase-9 Inhibitor, Andecaliximab, in Patients With Moderately to Severely Active Crohn's Disease. Journal of Crohn's & colitis. vol 12. issue 9. 2020-04-06. PMID:29846530. |
matrix metalloproteinase-9 [mmp9] is implicated in the pathogenesis of crohn's disease and may serve as a potential biomarker. |
2020-04-06 |
2023-08-13 |
Not clear |
| Masaki Nakano, Mika Ikegame, Junko Igarashi-Migitaka, Yusuke Maruyama, Nobuo Suzuki, Atsuhiko Hattor. Suppressive effect of melatonin on osteoclast function via osteocyte calcitonin. The Journal of endocrinology. vol 242. issue 2. 2020-04-06. PMID:31042672. |
in ovo injection of melatonin (5, 50 and 500 µg) dose-dependently decreased the mrna expression levels of cathepsin k and matrix metalloproteinase 9 (mmp9) in chick calvariae without affecting the expression levels of receptor activator of nf-κb ligand or osteoprotegerin. |
2020-04-06 |
2023-08-13 |
chicken |
| Ben Shackleton, Charis Ringland, Laila Abdullah, Michael Mullan, Fiona Crawford, Corbin Bachmeie. Influence of Matrix Metallopeptidase 9 on Beta-Amyloid Elimination Across the Blood-Brain Barrier. Molecular neurobiology. vol 56. issue 12. 2020-04-02. PMID:31209784. |
to interrogate this further, the current studies investigated an enzyme implicated in lipoprotein receptor shedding, matrix metalloproteinase 9 (mmp9). |
2020-04-02 |
2023-08-13 |
mouse |
| Simona Slezakova, Petra Borilova Linhartova, Jirina Bartova, Jitka Petanova, Pavel Kuklinek, Antonin Fassmann, Ladislav Dusek, Lydie Izakovicova Holl. Gene variability in matrix metalloproteinases in patients with recurrent aphthous stomatitis. Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology. vol 49. issue 3. 2020-04-02. PMID:31968135. |
the aim of this study was to investigate polymorphisms located in seven genes coding different types of matrix metalloproteinases (mmps)-collagenases (mmp1, mmp8, and mmp13), gelatinases (mmp2 and mmp9), stromelysin (mmp3), and membrane-type metalloproteinase (mmp16) in patients with ras and healthy controls. |
2020-04-02 |
2023-08-13 |
Not clear |
| Jinku Yan, Xi Chen, Chengbo Pu, Yilang Zhao, Xiaozhen Liu, Tao Liu, Guoqing Pan, Jun Lin, Ming Pei, Huilin Yang, Fan H. Synovium stem cell-derived matrix enhances anti-inflammatory properties of rabbit articular chondrocytes via the SIRT1 pathway. Materials science & engineering. C, Materials for biological applications. vol 106. 2020-04-01. PMID:31753397. |
in addition, the gene expression of il-1β- or tnf-α-induced matrix degrading enzymes (mmp3, mmp9, mmp13, and adamts5) was significantly lower in decm-expanded chondrocytes than tcps-expanded cells. |
2020-04-01 |
2023-08-13 |
rabbit |
| Kai Chen, Yu Yuan, Ziyi Wang, Dezhi Song, Jinmin Zhao, Zhen Cao, Junhao Chen, Qiang Guo, Li Chen, Jennifer Tickner, Jiake X. Helvolic acid attenuates osteoclast formation and function via suppressing RANKL-induced NFATc1 activation. Journal of cellular physiology. vol 234. issue 5. 2020-03-30. PMID:30341897. |
this inhibition was followed by the dramatically decreased expression of nfatc1-targeted genes including ctr (encoding calcitonin receptor), acp5 (encoding tartrate-resistant acid phosphatase [tracp]), ctsk (encoding cathepsin k), atp6v0d2 (encoding the vacuolar h+ atpase v0 subunit d2 [v-atpase-d2]) and mmp9 (encoding matrix metallopeptidase 9) which are osteoclastic-specific genes required for osteoclast formation and function. |
2020-03-30 |
2023-08-13 |
Not clear |
| Chen Hu, Zhi-Ling Don. MicroRNA-212 promotes the recovery function and vascular regeneration of endothelial progenitor cells in mice with ischemic stroke through inactivation of the notch signaling pathway via downregulating MMP9 expression. Journal of cellular physiology. vol 234. issue 5. 2020-03-30. PMID:30552827. |
this study intends to investigate the effects of microrna-212 (mir-212) on the recovery function and vascular regeneration of endothelial progenitor cells (epcs) by inactivation of the notch signaling pathway by binding to matrix metallopeptidase 9 (mmp9) in mice with ischemic stroke. |
2020-03-30 |
2023-08-13 |
mouse |
| Katherine Kennedy, Rachael Thomas, Jessica Durrant, Tao Jiang, Alison Motsinger-Reif, Matthew Bree. Genome-wide DNA copy number analysis and targeted transcriptional analysis of canine histiocytic malignancies identifies diagnostic signatures and highlights disruption of spindle assembly complex. Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology. vol 27. issue 3. 2020-03-30. PMID:31011867. |
a key signature detected was up-regulation of matrix metalloproteinase 9 (mmp9), supported by an immunohistochemistry-based assessment of mmp9 protein levels. |
2020-03-30 |
2023-08-13 |
human |
| Keiko Aota, Shinji Ono, Tomoko Yamanoi, Koichi Kani, Yukihiro Momota, Masayuki Azum. MMP-9 Inhibition Suppresses Interferon-γ-Induced CXCL10 Production in Human Salivary Gland Ductal Cells. Inflammation. vol 42. issue 6. 2020-03-30. PMID:31440939. |
gene expression profiling of lip salivary gland (lsg) has shown that c-x-c motif chemokine 10 (cxcl10) and matrix metalloproteinase 9 (mmp9) expression is upregulated in primary sjögren's syndrome (pss) patients. |
2020-03-30 |
2023-08-13 |
human |
| Quanrongzi Wang, Xisheng Liu, Jie Zhang, Ling Lu, Min Feng, Jie Wan. Dynamic features of liver fibrogenesis and fibrosis resolution in the absence of matrix metalloproteinase‑9. Molecular medicine reports. vol 20. issue 6. 2020-03-30. PMID:31638220. |
the two‑edged effect of matrix metalloproteinase‑9 (mmp9) makes it difficult to understand its role in liver fibrogenesis and fibrosis resolution. |
2020-03-30 |
2023-08-13 |
mouse |
| Xicheng Yue, Zhengquan Han, Ligong Zhang, Jing Li, Xiaomeng Gon. Aberrant expression of ALDH1, MMP9, Integrin αvβ3, and KiSS-1 in invasive ductal carcinoma and their clinical significance. International journal of clinical and experimental pathology. vol 11. issue 7. 2020-03-25. PMID:31949729. |
aldehyde dehydrogenase 1 (aldh1, a biomarker of cancer stem cells), matrix metalloproteinase 9 (mmp9, known as a matrilysin), integrin αvβ3 (known as a biomarker of cell-matrix adhesion) and kiss-1 (suppressor gene of tumor metastasis) are all related to cancer invasion and metastasis in many cancers. |
2020-03-25 |
2023-08-13 |
Not clear |
| Manjulata Singh, Xiao-Jun Tian, Vera S Donnenberg, Alan M Watson, JingYu Zhang, Laura P Stabile, Simon C Watkins, Jianhua Xing, Shilpa San. Targeting the Temporal Dynamics of Hypoxia-Induced Tumor-Secreted Factors Halts Tumor Migration. Cancer research. vol 79. issue 11. 2020-03-23. PMID:30952634. |
the microtumor models from various patient-derived tumor cells and patient-derived xenograft cells revealed upregulation of tumor-secreted factors, including matrix metalloproteinase-9 (mmp9), fibronectin (fn), and soluble e-cadherin, consistent with clinically reported elevated levels of fn and mmp9 in patient breast tumors compared with healthy mammary glands. |
2020-03-23 |
2023-08-13 |
Not clear |
| Zhongyuan Yin, Lin Yang, Feng Wu, Jinshuo Fan, Juanjuan Xu, Yang Jin, Guanghai Yan. Reactive Oxygen Species-Mediated Cezanne Inactivation by Oxidation of its Catalytic Cysteine Residue in Hepatocellular Carcinoma. Oncology research. vol 27. issue 9. 2020-03-20. PMID:31072419. |
moreover, we found that h₂o₂ could activate nf-κb-dependent inflammatory effect through increased induction of matrix metalloproteinase 2 (mmp2), mmp9, and intercellular adhesion molecule 1 (icam1) expression levels. |
2020-03-20 |
2023-08-13 |
Not clear |
| Ming Zhang, Baochang Shi, Kai Zhan. miR-186 Suppresses the Progression of Cholangiocarcinoma Cells Through Inhibition of Twist1. Oncology research. vol 27. issue 9. 2020-03-20. PMID:31072421. |
further, mir-186 inhibited the expressions of twist1, n-cadherin, vimentin, and matrix metallopeptidase 9 (mmp9) proteins, whereas it increased the expression of e-cadherin in cclp1 and sg-231 cells. |
2020-03-20 |
2023-08-13 |
human |
| Lingling Si, Jianing Fu, Weiwei Liu, Toshihiko Hayashi, Yuheng Nie, Kazunori Mizuno, Shunji Hattori, Hitomi Fujisaki, Satoshi Onodera, Takashi Ikejim. Silibinin inhibits migration and invasion of breast cancer MDA-MB-231 cells through induction of mitochondrial fusion. Molecular and cellular biochemistry. vol 463. issue 1-2. 2020-03-18. PMID:31612353. |
besides, silibinin inhibition of cell migration is associated with reduction in the protein expression of matrix metalloproteinases 2 and 9 (mmp2 and mmp9) and paxillin. |
2020-03-18 |
2023-08-13 |
human |
| J Randall McAuley, Kelly M Bailey, Prasanna Ekambaram, Linda R Klei, Heejae Kang, Dong Hu, Tanner J Freeman, Vincent J Concel, Nathaniel E Hubel, Jia-Ying Lloyd Lee, Hanna B Klei, Jing Cheng, Preethiya Sekar, Rachel E Bridwell, Lidija Covic, Peter C Lucas, Linda M McAllister-Luca. MALT1 is a critical mediator of PAR1-driven NF-κB activation and metastasis in multiple tumor types. Oncogene. vol 38. issue 49. 2020-03-11. PMID:31420608. |
we identify several metastasis-associated genes that are upregulated in a malt1-dependent manner after par1 stimulation in cancer cells, including those encoding the matrix remodeling protein, mmp9, and the cytokines, il-1β and il-8. |
2020-03-11 |
2023-08-13 |
Not clear |
| Mária Škereňová, Tatiana Matakova, Erika Halasova, Lucia Riskova, Michaela Skorvanova, Dušan Mistuna, Mirko Halasa, Dušan Dobrot. Common gene haplotypes of gelatinases and their tissue inhibitors in abdominal aortic aneurysm. General physiology and biophysics. vol 39. issue 1. 2020-03-09. PMID:32039823. |
gelatinases (mmp2 and mmp9) and their respective tissue inhibitors (timp1 and timp2) play a crucial role during extracellular matrix (ecm) turnover in aortic tissue. |
2020-03-09 |
2023-08-13 |
human |
| Zhongzheng Sun, Hao Xue, Yan Wei, Chaochao Wang, Rui Yu, Chengwei Wang, Shaobo Wang, Jianye Xu, Mingyu Qian, Qinghu Meng, Gang L. Mucin O-glycosylating enzyme GALNT2 facilitates the malignant character of glioma by activating the EGFR/PI3K/Akt/mTOR axis. Clinical science (London, England : 1979). vol 133. issue 10. 2020-03-03. PMID:31076460. |
western blot analysis and lectin pull-down assays indicated that galnt2 knockdown decreased the level of phosphorylated epidermal growth factor receptor (egfr) and the expression of the tn antigen on egfr and affected the expression levels of p21, cyclin-dependent kinase 4 (cdk4), cyclind1, matrix metalloproteinase 2 (mmp2) and matrix metalloproteinase 9 (mmp9) through the egfr/pi3k/akt/mtor pathway. |
2020-03-03 |
2023-08-13 |
human |
| Baohui Xu, Yasunori Iida, Keith J Glover, Yingbin Ge, Yan Wang, Haojun Xuan, Xiaolei Hu, Hiroki Tanaka, Wei Wang, Naoki Fujimura, Masaaki Miyata, Takahiro Shoji, Jia Guo, Xiaoya Zheng, Mary Gerritsen, Calvin Kuo, Sara A Michie, Ronald L Dalma. Inhibition of VEGF (Vascular Endothelial Growth Factor)-A or its Receptor Activity Suppresses Experimental Aneurysm Progression in the Aortic Elastase Infusion Model. Arteriosclerosis, thrombosis, and vascular biology. vol 39. issue 8. 2020-02-27. PMID:31294623. |
sunitinib therapy substantially mitigated both aaa formation and further progression of established aaas, attenuated aneurysmal aortic mmp2 (matrix metalloproteinase) and mmp9 protein expression, inhibited inflammatory monocyte and neutrophil chemotaxis to vegf-a, and reduced mmp2, mmp9, and vegf-a mrna expression in macrophages and smooth muscle cells in vitro. |
2020-02-27 |
2023-08-13 |
mouse |