| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shijian Luo, Huiqing Li, Zhihuai Mo, Junjie Lei, Lingjuan Zhu, Yanxia Huang, Ruying Fu, Chunyi Li, Yihuan Huang, Kejia Liu, Wenli Chen, Lei Zhan. Connectivity map identifies luteolin as a treatment option of ischemic stroke by inhibiting MMP9 and activation of the PI3K/Akt signaling pathway. Experimental & molecular medicine. vol 51. issue 3. 2020-05-29. PMID:30911000. |
this study aimed to explore potential new drugs in the treatment of ischemic stroke by connectivity map (cmap) and to determine the role of luteolin on ischemic stroke according to its effects on matrix metalloproteinase-9 (mmp9) and pi3k/akt signaling pathway. |
2020-05-29 |
2023-08-13 |
human |
| Qiong Zhang, Xuhong Chang, Haibing Wang, Yunlan Liu, Xiaoxia Wang, Minmin Wu, Haibing Zhan, Sheng Li, Yingbiao Su. TGF-β1 mediated Smad signaling pathway and EMT in hepatic fibrosis induced by Nano NiO in vivo and in vitro. Environmental toxicology. vol 35. issue 4. 2020-05-26. PMID:31737983. |
furthermore, nano nio increased the protein expression of tgf-β1, p-smad2, p-smad3, alpha-smooth muscle actin (α-sma), matrix metalloproteinase9 (mmp9), and tissue inhibitors of metalloproteinase1 (timp1), while decreased the protein content of e-cadherin and smad7 in rat liver and hepg2 cells. |
2020-05-26 |
2023-08-13 |
rat |
| Yu Xiao, Kai Li, Ziyi Wang, Fangsheng Fu, Siyuan Shao, Fangming Song, Jinmin Zhao, Weiwei Chen, Qian Liu, Jiake X. Pectolinarigenin prevents bone loss in ovariectomized mice and inhibits RANKL-induced osteoclastogenesis via blocking activation of MAPK and NFATc1 signaling. Journal of cellular physiology. vol 234. issue 8. 2020-05-18. PMID:30633330. |
in terms of mechanism, pec inhibited the expression of the osteoclastogenesis-related gene, including cathepsin k (ctsk), matrix metalloproteinase 9 (mmp9), and tracp (acp5). |
2020-05-18 |
2023-08-13 |
mouse |
| Otto Väyrynen, Pirjo Åström, Pia Nyberg, Ilkka Alahuhta, Emma Pirilä, Suvi-Tuuli Vilen, Mari Aikio, Ritva Heljasvaara, Maija Risteli, Meeri Sutinen, Tuula Sal. Matrix metalloproteinase 9 inhibits the motility of highly aggressive HSC-3 oral squamous cell carcinoma cells. Experimental cell research. vol 376. issue 1. 2020-05-18. PMID:30710501. |
pro-tumorigenic activities of matrix metalloproteinase (mmp) 9 have been linked to many cancers, but recently the tumour-suppressing role of mmp9 has also been elucidated. |
2020-05-18 |
2023-08-13 |
human |
| Lais Silva Nascimento, Larissa Martins Tedesco, Natiele Silva Araujo, Fernanda Bruschi Marinho Priviero, Mario Angelo Claudino, Denise Gonçalves Priolli, Thalita Roch. Molecular evidence of tissue remodeling in an animal model of heart failure. Histology and histopathology. vol 34. issue 12. 2020-05-18. PMID:31099017. |
metalloproteinases and their inhibitors, such as mmp9 and timp-1, assist in maintaining the extracellular matrix, leading to tissue remodeling observed after hf. |
2020-05-18 |
2023-08-13 |
rat |
| Cristina Oana Mărginean, Claudiu Mărginean, Claudia Bănescu, Lorena Elena Meliţ, Florin Tripon, Mihaela Ianc. The relationship between MMP9 and ADRA2A gene polymorphisms and mothers-newborns' nutritional status: an exploratory path model (STROBE compliant article). Pediatric research. vol 85. issue 6. 2020-05-11. PMID:30791043. |
the aim of this study was to evaluate the direct effects of matrix metalloproteinase (mmp9 rs17577, mmp9 rs17576) and alfa 2 adrenergic receptor (adra2a rs553668) gene polymorphisms investigated in mothers and their newborns on maternal weight gain (mwg) during pregnancy and the newborn's birth weight (bw), taking into account the presence of other related factors. |
2020-05-11 |
2023-08-13 |
Not clear |
| Ying Liang, Chuan Yang, Yongqing Lin, Yasir Parviz, Kan Sun, Wei Wang, Meng Ren, Li Ya. Matrix metalloproteinase 9 induces keratinocyte apoptosis through FasL/Fas pathway in diabetic wound. Apoptosis : an international journal on programmed cell death. vol 24. issue 7-8. 2020-05-08. PMID:30949883. |
matrix metalloproteinase 9 (mmp9), which is elevated in non-healed diabetic wound, is necessary for healing process but its abnormality resulted in a delayed healing. |
2020-05-08 |
2023-08-13 |
Not clear |
| Ying Liang, Chuan Yang, Yongqing Lin, Yasir Parviz, Kan Sun, Wei Wang, Meng Ren, Li Ya. Matrix metalloproteinase 9 induces keratinocyte apoptosis through FasL/Fas pathway in diabetic wound. Apoptosis : an international journal on programmed cell death. vol 24. issue 7-8. 2020-05-08. PMID:30949883. |
the classical function of mmp9 is the degradation of extracellular matrix (ecm). |
2020-05-08 |
2023-08-13 |
Not clear |
| Lopa M Das, Amy M Binko, Zachary P Traylor, Han Peng, Kurt Q L. Vitamin D improves sunburns by increasing autophagy in M2 macrophages. Autophagy. vol 15. issue 5. 2020-05-07. PMID:30661440. |
abbreviations: arg1: arginase 1; atg7 cko: autophagy related 7 conditional knockout; hpf: high powered field; klf4: kruppel like factor 4; map1lc3b/lc3: microtubule-associated protein 1 light chain 3 beta; macs: macrophage; 3-ma: 3-methyladenine; mmp9: matrix metallopeptidase 9; nos2: nitric oxide synthase 2, inducible; pparg: peroxisome proliferator activated receptor gamma; sqstm1/p62: sequestosome 1; tnf: tumor necrosis factor; uv: ultraviolet; vd: vitamin d, 25-hydroxy vitamin d |
2020-05-07 |
2023-08-13 |
mouse |
| Terrence K Allen, Matthew N Nazzal, Liping Feng, Irina A Buhimschi, Amy P Murth. Progestins Inhibit Tumor Necrosis Factor α-Induced Matrix Metalloproteinase 9 Activity via the Glucocorticoid Receptor in Primary Amnion Epithelial Cells. Reproductive sciences (Thousand Oaks, Calif.). vol 26. issue 9. 2020-05-06. PMID:30453830. |
medroxyprogesterone acetate (mpa) has previously been shown to significantly inhibit tumor necrosis factor α (tnfα)-induced matrix metalloproteinase 9 (mmp9) messenger rna (mrna) expression and activity in primary amnion epithelial cells, a process that may lead to preterm premature rupture of membranes. |
2020-05-06 |
2023-08-13 |
Not clear |
| Neha Upmanyu, Ahmed Bulldan, Klaus Failing, Georgios Scheiner-Bobi. DHEAS prevents pro-metastatic and proliferative effects of 17ß-estradiol on MCF-7 breast cancer cells. Biochimica et biophysica acta. Molecular cell research. vol 1867. issue 2. 2020-04-20. PMID:31760088. |
exposure of mcf-7 cells to 17ß-estradiol stimulated cell proliferation and the expression of pro-metastatic and pro-invasive elements such as claudin-1, matrix metalloproteinase 9 (mmp9), and the cc chemokine ligand 2 (ccl2). |
2020-04-20 |
2023-08-13 |
human |
| Rahim Heidari Barchi Nezhad, Fateme Asadi, Seyyed Meysam Abtahi Froushani, Gholamhossein Hassanshahi, Ayat Kaeidi, Soudeh Khanamani Falahati-Pour, Zahra Hashemi, Mohammad Reza Mirzae. The effects of transplanted mesenchymal stem cells treated with 17-b estradiol on experimental autoimmune encephalomyelitis. Molecular biology reports. vol 46. issue 6. 2020-04-15. PMID:31555971. |
the mrna expression of cytokines, including il-17, ifn-γ, tnf-α, il-10, il-4, and tgf-β together with mmp8 and mmp9 as the family members of matrix metalloproteinases (mmps) in the brain and spinal cord tissues were examined using real-time pcr. |
2020-04-15 |
2023-08-13 |
rat |
| Rahim Heidari Barchi Nezhad, Fateme Asadi, Seyyed Meysam Abtahi Froushani, Gholamhossein Hassanshahi, Ayat Kaeidi, Soudeh Khanamani Falahati-Pour, Zahra Hashemi, Mohammad Reza Mirzae. The effects of transplanted mesenchymal stem cells treated with 17-b estradiol on experimental autoimmune encephalomyelitis. Molecular biology reports. vol 46. issue 6. 2020-04-15. PMID:31555971. |
it was also found that the mrna levels of the examined matrix metalloproteinases (mmp8 and mmp9) were downregulated significantly. |
2020-04-15 |
2023-08-13 |
rat |
| Yujin Jin, Diem Thi Ngoc Huynh, Keon Wook Kang, Chang-Seon Myung, Kyung-Sun He. Inhibition of p90RSK activation sensitizes triple-negative breast cancer cells to cisplatin by inhibiting proliferation, migration and EMT. BMB reports. vol 52. issue 12. 2020-04-15. PMID:31818359. |
cis-ddp increased p90rsk activation, whereas the inactivation of p90rsk using a small interfering rna (sirna) or dominant-negative kinase mutant plasmid overexpression significantly reduced cis-ddp-induced cell proliferation and migration via the inhibition of matrix metallopeptidase (mmp)2 and mmp9 in mda-mb-231 cells. |
2020-04-15 |
2023-08-13 |
human |
| Su-Ying Wen, Shi-Yann Cheng, Shang-Chuan Ng, Ritu Aneja, Chih-Jung Chen, Chih-Yang Huang, Wei-Wen Ku. Roles of p38α and p38β mitogen‑activated protein kinase isoforms in human malignant melanoma A375 cells. International journal of molecular medicine. vol 44. issue 6. 2020-04-13. PMID:31661126. |
silencing p38α downregulated the expression of epithelial‑mesenchymal transition markers, such as matrix metallopeptidase (mmp) 2, mmp9, twist family bhlh transcription factor 1, snail family transcriptional repressor 1 and vimentin, while mesenchymal‑epithelial transition markers, such as e‑cadherin, were upregulated. |
2020-04-13 |
2023-08-13 |
human |
| Abdelkrim Khadir, Dhanya Madhu, Sina Kavalakatt, Preethi Cherian, Monira Alarouj, Abdullah Bennakhi, Jehad Abubaker, Ali Tiss, Naser Elku. PR3 levels are impaired in plasma and PBMCs from Arabs with cardiovascular diseases. PloS one. vol 15. issue 1. 2020-04-13. PMID:31935243. |
plasma levels of selected proteins from the proteomics profiling: proteinase-3 (pr3), annexin-a3 (anx3), defensin (defa1), and matrix metalloproteinase-9 (mmp9), were measured in the entire cohort using human enzyme-linked immunosorbent assay kits and were subsequently correlated with various clinical parameters. |
2020-04-13 |
2023-08-13 |
human |
| William J Sandborn, Bal R Bhandari, Charles Randall, Ziad H Younes, Tomasz Romanczyk, Yan Xin, Emily Wendt, Hao Chai, Matt McKevitt, Sally Zhao, John S Sundy, Satish Keshav, Silvio Danes. Andecaliximab [Anti-matrix Metalloproteinase-9] Induction Therapy for Ulcerative Colitis: A Randomised, Double-Blind, Placebo-Controlled, Phase 2/3 Study in Patients With Moderate to Severe Disease. Journal of Crohn's & colitis. vol 12. issue 9. 2020-04-06. PMID:29767728. |
matrix metalloproteinase-9 [mmp9] is implicated in the pathogenesis of ulcerative colitis [uc] via disruption of intestinal barrier integrity and function. |
2020-04-06 |
2023-08-13 |
Not clear |
| Stefan Schreiber, Corey A Siegel, Keith A Friedenberg, Ziad H Younes, Ursula Seidler, Bal R Bhandari, Ke Wang, Emily Wendt, Matt McKevitt, Sally Zhao, John S Sundy, Scott D Lee, Edward V Loftu. A Phase 2, Randomized, Placebo-Controlled Study Evaluating Matrix Metalloproteinase-9 Inhibitor, Andecaliximab, in Patients With Moderately to Severely Active Crohn's Disease. Journal of Crohn's & colitis. vol 12. issue 9. 2020-04-06. PMID:29846530. |
matrix metalloproteinase-9 [mmp9] is implicated in the pathogenesis of crohn's disease and may serve as a potential biomarker. |
2020-04-06 |
2023-08-13 |
Not clear |
| Masaki Nakano, Mika Ikegame, Junko Igarashi-Migitaka, Yusuke Maruyama, Nobuo Suzuki, Atsuhiko Hattor. Suppressive effect of melatonin on osteoclast function via osteocyte calcitonin. The Journal of endocrinology. vol 242. issue 2. 2020-04-06. PMID:31042672. |
in ovo injection of melatonin (5, 50 and 500 µg) dose-dependently decreased the mrna expression levels of cathepsin k and matrix metalloproteinase 9 (mmp9) in chick calvariae without affecting the expression levels of receptor activator of nf-κb ligand or osteoprotegerin. |
2020-04-06 |
2023-08-13 |
chicken |
| Ben Shackleton, Charis Ringland, Laila Abdullah, Michael Mullan, Fiona Crawford, Corbin Bachmeie. Influence of Matrix Metallopeptidase 9 on Beta-Amyloid Elimination Across the Blood-Brain Barrier. Molecular neurobiology. vol 56. issue 12. 2020-04-02. PMID:31209784. |
to interrogate this further, the current studies investigated an enzyme implicated in lipoprotein receptor shedding, matrix metalloproteinase 9 (mmp9). |
2020-04-02 |
2023-08-13 |
mouse |