| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jing Zhang, Yunna Yang, Yipeng Dong, Cang Li. Microrchidia family CW‑type zinc finger 2 promotes the proliferation, invasion, migration and epithelial‑mesenchymal transition of glioma by regulating PTEN/PI3K/AKT signaling via binding to N‑myc downstream regulated gene 1 promoter. International journal of molecular medicine. vol 49. issue 2. 2021-12-16. PMID:34913078. |
the expression of proliferation (proliferating cell nuclear antigen, cyclin‑dependent kinase 2 and cyclin e1), migration [matrix metalloproteinase (mmp)2 and mmp9], emt (e‑cadherin, n‑cadherin and vimentin) and pten/pi3k/akt signaling proteins in tumor tissues was examined with immunohistochemistry assay or western blotting. |
2021-12-16 |
2023-08-13 |
mouse |
| Rui Dong, Renxuan Huang, Xiaohua Shi, Zhongxin Xu, Jing Man. Exploration of the Mechanism of Luteolin Against Ischemic Stroke Based on Network Pharmacology, Molecular Docking and Experimental Verification. Bioengineered. 2021-12-13. PMID:34898370. |
from 95 candidate luteolin target genes, our analysis identified six core target genes through protein-protein interaction (ppi) network analysis including matrix metalloproteinase 9 (mmp9), mitogen-activated protein kinase 3 (mapk3), prostaglandin h synthase 2 (ptgs2), jun, interleukins-1β(il1b), tumor necrosis factor (tnf). |
2021-12-13 |
2023-08-13 |
Not clear |
| Celeste Dunn, Nasya Sturdivant, Sara Venier, Syed Ali, Jeffery Wolchok, Kartik Balachandra. Blood-Brain Barrier Breakdown and Astrocyte Reactivity Evident in the Absence of Behavioral Changes after Repeated Traumatic Brain Injury. Neurotrauma reports. vol 2. issue 1. 2021-12-13. PMID:34901939. |
to examine edema and inflammation, protein levels of glial fibrillary acidic protein (gfap), s100 calcium-binding protein b, interleukin-6, and matrix metallopeptidase 9 (mmp9) were analyzed. |
2021-12-13 |
2023-08-13 |
mouse |
| Manish A Shah, David Cunningham, Jean-Philippe Metges, Eric Van Cutsem, Zev Wainberg, Emon Elboudwarej, Kai-Wen Lin, Scott Turner, Marianna Zavodovskaya, David Inzunza, Jinfeng Liu, Scott D Patterson, Jingzhu Zhou, Jing He, Dung Thai, Pankaj Bhargava, Carrie Baker Brachmann, Daniel V T Cantenacc. Randomized, open-label, phase 2 study of andecaliximab plus nivolumab versus nivolumab alone in advanced gastric cancer identifies biomarkers associated with survival. Journal for immunotherapy of cancer. vol 9. issue 12. 2021-12-11. PMID:34893523. |
matrix metalloproteinase-9 (mmp9) selectively cleaves extracellular matrix proteins contributing to tumor growth and an immunosuppressive microenvironment. |
2021-12-11 |
2023-08-13 |
Not clear |
| Niamh A Leonard, Eileen Reidy, Kerry Thompson, Emma McDermott, Eleonora Peerani, Elena Tomas Bort, Frances R Balkwill, Daniela Loessner, Aideen E Rya. Stromal Cells Promote Matrix Deposition, Remodelling and an Immunosuppressive Tumour Microenvironment in a 3D Model of Colon Cancer. Cancers. vol 13. issue 23. 2021-12-10. PMID:34885111. |
the addition of stromal cells increased transcription of matrix remodelling proteins fn1 and mmp9, induced release of tumour-promoting immune molecules mif, serpin e1, cxcl1, il-8 and cxcl12 and altered cancer cell expression of immunotherapeutic targets egfr, cd47 and pd-l1. |
2021-12-10 |
2023-08-13 |
Not clear |
| Bin Zhang, Zhi-Yi Liu, Rui Wu, Cheng-Ming Zhang, Kuan Cao, Wen-Gang Shan, Zhen Liu, Ming Ji, Zi-Lu Tian, Gautam Sethi, Heng-Liang Shi, Ren-Hao Wan. Transcriptional regulator CTR9 promotes hepatocellular carcinoma progression and metastasis via increasing PEG10 transcriptional activity. Acta pharmacologica Sinica. 2021-12-08. PMID:34876700. |
in addition, in vitro results revealed that ctr9 silencing dramatically increased cell cycle regulators, p21 and p27, but markedly decreased matrix metalloproteinases, mmp2 and mmp9, with these outcomes reversed upon ctr9 overexpression. |
2021-12-08 |
2023-08-13 |
mouse |
| Linda Große-Segerath, Eckhard Lammer. Role of vasodilation in liver regeneration and health. Biological chemistry. vol 402. issue 9. 2021-12-06. PMID:33908220. |
these include β1 integrin-dependent mechanotransduction in liver sinusoidal endothelial cells (lsecs), triggering mechanically-induced activation of the vascular endothelial growth factor receptor-3 (vegfr3) and matrix metalloproteinase-9 (mmp9) as well as release of growth-promoting angiocrine signals. |
2021-12-06 |
2023-08-13 |
Not clear |
| Licui Ye, Xia Meng, Rui Xiang, Wen Li, Jingyi Wan. Investigating function of long noncoding RNA of HOTAIRM1 in progression of SKOV3 ovarian cancer cells. Drug development research. vol 82. issue 8. 2021-12-06. PMID:33939846. |
also, silencing of hotairm1 resulted in a suppressed expression of wnt pathway-related proteins and also expression of its downstream target gene, matrix metalloproteinase 9(mmp9). |
2021-12-06 |
2023-08-13 |
Not clear |
| Santosh K Yadav, Paras K Mishr. Intracellular matrix metalloproteinase-9 mediates epigenetic modifications and autophagy to regulate differentiation in human cardiac stem cells. Stem cells (Dayton, Ohio). vol 39. issue 4. 2021-12-04. PMID:33438302. |
previously, we have reported that intracellular matrix metalloproteinase-9 (mmp9), a collagenase, mediates cell death in hcscs. |
2021-12-04 |
2023-08-13 |
human |
| Lei Gong, Juan Chen, Xijiao Jian. Circ_0005033 is an oncogene in laryngeal squamous cell carcinoma and regulates cell progression and Cisplatin sensitivity via miR-107/IGF1R axis. Anti-cancer drugs. 2021-11-30. PMID:34845162. |
allied with that, cleaved-caspase 3/8/9 expression was elevated via death receptor-mediated and mitochondrial pathways, and expression of matrix metalloproteinase-2 (mmp2), mmp9, cyclin d1 and proliferating cell nuclear antigen was decreased. |
2021-11-30 |
2023-08-13 |
Not clear |
| Veysel Suzan, Hakan Yavuzer, Rabia Bag Soytas, Bahar Bektan Kanat, Pinar Arman, Tugce Emiroglu Gedik, Damla Unal, Oguz Atar, Ibrahim Murat Bolayirli, Alper Doventa. The relationship between primary sarcopenia and SARC-F, serum MMP9, TIMP1 levels, and MMP9/TIMP1 ratio in the geriatric patients. European geriatric medicine. vol 12. issue 6. 2021-11-29. PMID:34106445. |
the purpose of this study is to evaluate the relationship between serum mmp9 (matrix metalloproteinase), timp1 (tissue inhibitor of metalloproteinase) levels and mmp9/timp1 ratio and primary sarcopenia in geriatric patients, and compare the diagnostic accuracy of such biomarkers with that of the sarc-f score. |
2021-11-29 |
2023-08-13 |
Not clear |
| Yu Mao, Yajie Huo, Jing Li, Yanli Zhao, Yuan Wang, Ling Sun, Zhiqiang Kan. circRPS28 (hsa_circ_0049055) is a novel contributor for papillary thyroid carcinoma by regulating cell growth and motility via functioning as ceRNA for miR-345-5p to regulate frizzled family receptor 8 (FZD8). Endocrine journal. vol 68. issue 11. 2021-11-29. PMID:34108309. |
these effects paralleled with low b-cell lymphoma (bcl)-2 level and high bcl-2-associated x protein (bax), matrix metalloproteinase-2 (mmp2), and mmp9 levels, as analyzed by western blotting. |
2021-11-29 |
2023-08-13 |
mouse |
| Songtao Dong, Zhongyuan Chen, Li Wang, Yankai Liu, Dimitrios Stagos, Xiukun Lin, Ming Li. Marine Bromophenol Bis(2,3,6-Tribromo-4,5-Dihydroxybenzyl)ether Inhibits Angiogenesis in Human Umbilical Vein Endothelial Cells and Reduces Vasculogenic Mimicry in Human Lung Cancer A549 Cells. Marine drugs. vol 19. issue 11. 2021-11-28. PMID:34822512. |
the present study illustrated that btde had anti-angiogenesis effect in vitro through inhibiting human umbilical vein endothelial cells migration, invasion, tube formation, and the activity of matrix metalloproteinases 9 (mmp9), and in vivo btde also blocked intersegmental vessel formation in zebrafish embryos. |
2021-11-28 |
2023-08-13 |
human |
| Huomei Hou, Fen Ning, Joy Yue Zhang, Qinsheng Lu, Min Zhang, Peihuang Wu, Miaojuan Chen, Gendie E Las. Angiopoietin 2 stimulates trophoblast invasion via a mechanism associated with JNK signaling. Molecular human reproduction. vol 27. issue 3. 2021-11-26. PMID:33629098. |
ang-2 increased expression of matrix metalloproteinase (mmp)2 and mmp9, altered the cytoskeleton of htr-8/svneo cells and also induced phosphorylation of tie2, jnk and c-jun. |
2021-11-26 |
2023-08-13 |
human |
| Huimin Pei, Shaokang Wu, Lijun Zheng, Hanxun Wang, Xiangrong Zhan. Identification of the active compounds and their mechanisms of medicinal and edible Shanzha based on network pharmacology and molecular docking. Journal of food biochemistry. 2021-11-26. PMID:34825377. |
the key targets were prostaglandin-endoperoxide synthase 2 (ptgs2), serine/threonine-protein kinase mtor (mtor), heat shock protein hsp 90-alpha (hsp90aa1), mitogen-activated protein kinase 1 (mapk1), mapk3, e3 ubiquitin-protein ligase mdm2 (mdm2), receptor tyrosine-protein kinase erbb-2 (erbb2), caspase-3 (casp3), matrix metalloproteinase-9 (mmp9), estrogen receptor (esr1), tumor necrosis factor (tnf), phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (pik3ca), and peroxisome proliferator-activated receptor gamma (pparg), which played the vital roles in tnf, prostate cancer, thyroid hormone, hepatitis b and estrogen signaling pathway. |
2021-11-26 |
2023-08-13 |
Not clear |
| Wei-Wei Guo, Ming-Ming Feng, Shuang-Feng Li, Li-Hui We. Circular RNA circ_0023404 serves as a miR-636 sponge to promote malignant behaviors in cervical cancer cells through upregulation of CYP2S1. The Kaohsiung journal of medical sciences. 2021-11-26. PMID:34825467. |
protein levels of cyclin d1, matrix metallopeptidase 9 (mmp9), bcl-2-associated x protein (bax), and cyp2s1 were examined by western blot assay. |
2021-11-26 |
2023-08-13 |
Not clear |
| Shohreh Azadi, Mohammad Tafazzoli Shadpour, Majid E Warkian. Characterizing the effect of substrate stiffness on the extravasation potential of breast cancer cells using a 3D microfluidic model. Biotechnology and bioengineering. vol 118. issue 2. 2021-11-25. PMID:33111314. |
we further investigated the secreted level of matrix metalloproteinase 9 (mmp9) and identified that there is a positive correlation between substrate stiffening, mmp9 concentration, and extravasation of cancer cells. |
2021-11-25 |
2023-08-13 |
Not clear |
| Jingrong Huang, Li Zhao, Chengxian Gong, Yi Wang, Yinzong Qu, Chunyan Ji, Jianmei Yan. Shikonin Promotes Apoptosis and Attenuates Migration and Invasion of Human Esophageal Cancer Cells by Inhibiting Tumor Necrosis Factor Receptor-Associated Protein 1 Expression and AKT/mTOR Signaling Pathway. Evidence-based complementary and alternative medicine : eCAM. vol 2021. 2021-11-24. PMID:34812264. |
shrna-trap1 enhanced the inhibitory effect of shikonin on matrix metalloproteinase (mmp)2 and mmp9 expression. |
2021-11-24 |
2023-08-13 |
human |
| Xingmei Luo, Jing Wu, Guofeng W. PPARγ activation suppresses the expression of MMP9 by downregulating NF-κB post intracerebral hemorrhage. Neuroscience letters. vol 752. 2021-11-22. PMID:33636289. |
we have previously reported that rosiglitazone, an agonist of pparγ, was effective to prevent microglia from apoptosis and ameliorate neuronal injuries post intracerebral hemorrhage (ich) with suppression of matrix metalloproteinase-9 (mmp9) expression. |
2021-11-22 |
2023-08-13 |
Not clear |
| Prabhavathi Maddineni, Ramesh B Kasetti, Bindu Kodati, Sam Yacoub, Gulab S Zod. Sodium 4-Phenylbutyrate Reduces Ocular Hypertension by Degrading Extracellular Matrix Deposition via Activation of MMP9. International journal of molecular sciences. vol 22. issue 18. 2021-11-19. PMID:34576258. |
sodium 4-phenylbutyrate reduces ocular hypertension by degrading extracellular matrix deposition via activation of mmp9. |
2021-11-19 |
2023-08-13 |
mouse |