| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Akira Ooki, Taroh Satoh, Kei Muro, Atsuo Takashima, Shigenori Kadowaki, Daisuke Sakai, Takashi Ichimura, Seiichiro Mitani, Toshihiro Kudo, Keisho Chin, Shigehisa Kitano, Dung Thai, Marianna Zavodovskaya, JieJane Liu, Narikazu Boku, Kensei Yamaguch. A phase 1b study of andecaliximab in combination with S-1 plus platinum in Japanese patients with gastric adenocarcinoma. Scientific reports. vol 12. issue 1. 2022-06-30. PMID:35773363. |
andecaliximab (adx) is a monoclonal antibody that inhibits matrix metalloproteinase 9 (mmp9), an extracellular enzyme involved in matrix remodeling, tumor growth, and metastasis. |
2022-06-30 |
2023-08-14 |
Not clear |
| Xin Zhang, Xuebing Zhou, Ming Gao, You Lyu, Ying Wang, Chunyu Yang, Yingshi Piao, Xiangshan Re. [Cordycepin inhibits the proliferation and migration of human gastric cancer cells by suppressing lipid metabolism via AMPK and MAPK activation]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 38. issue 6. 2022-06-22. PMID:35732609. |
the proliferation ability of mgc-803 and hgc-27 cells was detected by mtt assay and edu assay; the colony formation ability of cells was detected by colony formation assay; both wound healing assay and cell migration assay were applied to detect the cell migration ability of mgc-803 and hgc-27 cells; the chromatin agglutination was detected by hoechst 33342 staining; the apoptosis of gastric cancer cells was detected by annexin v-fitc/pi double labeling combined with flow cytometry; western blot was used to measure the protein expression levels of lipid metabolism-related proteins including sterol regulatory element binding transcription factor 1 (srebf1), fatty acid synthase (fasn), and acetyl coa carboxylase 1 (acc1), epithelial-mesenchymal transition (emt)-related proteins including e-cadherin, vimentin, snail, slug, matrix metalloproteinase 2 (mmp2), mmp9, ampk, and phosphorylated ampk (p-ampk), mapk signaling pathway-related proteins including jnk, phosphorylated jnk (p-jnk), p38 mapk, and p-p38 mapk, and apoptosis-related proteins including cleaved caspase-9 (c-caspase-9), c-caspase-3, and cleaved poly (adp-ribose) polymerase (c-parp). |
2022-06-22 |
2023-08-14 |
human |
| Tianyue Wang, Xinyu Jiang, Yanmin Ruan, Jun Zhuang, Yuanjun Yi. Based on network pharmacology and in vitro experiments to prove the effective inhibition of myocardial fibrosis by Buyang Huanwu decoction. Bioengineered. vol 13. issue 5. 2022-06-21. PMID:35726821. |
after screening, interleukin (il)-6, il-1β, and matrix metallopeptidase 9 (mmp9) were selected for |
2022-06-21 |
2023-08-14 |
Not clear |
| Sujan Chatterjee, Debajyoti Patra, Pujita Ghosh, Soumi Banerjee, Kaustav Dutta Chowdhury, Pratip Chakraborty, Anupam Basu, Gobinda Chandra Sadhukha. Activity of ROCKII not ROCKI promotes pulmonary metastasis of melanoma cells via modulating Smad2/3-MMP9 and FAK-Src- VEGF signalling. Cellular signalling. 2022-06-19. PMID:35718242. |
inhibition by kd-025 indicated dual wielding role of rockii as it is associated with the regulation of mmp9 activity responsible for extra-cellular matrix (ecm) degradation as well as angiogenic invasion as an effect of src-fak-stat3 interaction dependent vegf switching. |
2022-06-19 |
2023-08-14 |
mouse |
| Xiaoling Xu, Xinmei Lan, Shuhua Fu, Qian Zhang, Fu Gui, Qifang Jin, Lin Xie, Yu Xion. Dickkopf-1 exerts protective effects by inhibiting PANoptosis and retinal neovascularization in diabetic retinopathy. Biochemical and biophysical research communications. vol 617. issue Pt 2. 2022-06-12. PMID:35691117. |
furthermore, retinal neovascularization and acellular vessel in dr rats were also considerably abolished after dkk1 injection, accompanied by reduced expression levels of retinal vascular endothelial growth factor (vegf), matrix metalloproteinase-2 (mmp2) and matrix metalloproteinase-9 (mmp9). |
2022-06-12 |
2023-08-14 |
rat |
| Chang Liu, Di Zhang, Zhengfang Lu, Jiang Man, Zhen Zhang, Xiaojuan Fu, Kefei Cui, Jianping Wan. Metformin protects against pericyte apoptosis and promotes neurogenesis through suppressing JNK p38 MAPK signalling activation in ischemia/reperfusion injury. Neuroscience letters. 2022-06-06. PMID:35660649. |
the data showed that met alleviated bbb disruption by reducing pdgfrβ/ matrix metalloproteinase-9 (mmp9) positive cells, relieving zonula occludens-1 (zo-1) drop away and increasing pericyte coverage through remarkably reducing the percentage of pdgfrβ/caspase-3 positive cells. |
2022-06-06 |
2023-08-14 |
mouse |
| Marwah Suliman Maashi, Shatha G Felemban, Hibah Ali Almasmoum, Mostafa Jarahia. Nicaraven-loaded electrospun wound dressings promote diabetic wound healing via proangiogenic and immunomodulatory functions: a preclinical investigation. Drug delivery and translational research. 2022-06-01. PMID:35648292. |
gene expression study showed that the developed wound dressings reduced the tissue expression levels of glutathione peroxidase, nfkβ, and matrix metalloproteinase 9 (mmp9) genes. |
2022-06-01 |
2023-08-13 |
rat |
| Trinh T T Phan, Yu-Chun Lin, Yu-Ting Chou, Chien-Wei Wu, Lih-Yuan Li. Tumor suppressor p53 restrains cancer cell dissemination by modulating mitochondrial dynamics. Oncogenesis. vol 11. issue 1. 2022-05-19. PMID:35589683. |
upon p53 loss, exaggerated mitochondrial fragmentation stimulates the activation of the extracellular signal-regulated kinase 1/2 (erk1/2) signaling resulting in epithelial-to-mesenchymal transition (emt)-like changes in cell morphology, accompanied by accelerated matrix metalloproteinase 9 (mmp9) expression and invasive cell migration. |
2022-05-19 |
2023-08-13 |
Not clear |
| Rui Wang, Hongliu Liu, Mingqiang Dong, Dan Huang, Jun Y. Exosomal hsa_circ_0000519 modulates the NSCLC cell growth and metastasis via miR-1258/RHOV axis. Open medicine (Warsaw, Poland). vol 17. issue 1. 2022-05-18. PMID:35582196. |
circ_0000519 knockdown suppressed the cell growth by decreasing the colony-formation ability and cyclin d1 expression and inhibited cell metastasis via reducing migration, invasion, and levels of vimentin and matrix metalloproteinase 9 (mmp9). |
2022-05-18 |
2023-08-13 |
Not clear |
| Michael R McLeod, Jonathan G Heywood, Sarah M Thomas, William J Richardson, Adi D Dubas. Control of Fibrotic Gene Expression in Cardiac Myocytes and Fibroblasts via the Rap1 GTPase. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35552696. |
interestingly, expression of wt or 63e rap1a in cardiac fibroblasts caused a dramatic increase in inflammatory markers (such as tnf, il6, nfkb1a) and matrix remodeling enzymes (mmp3 and mmp9), genes which have been shown to play a role in increasing collagen turnover, reducing ecm rigidity/stiffness and repair of damaged myocardial tissue. |
2022-05-13 |
2023-08-13 |
Not clear |
| Nelson A Cook, Katie D Finnegan, Caleb L Lines, Sam J Reyes, Shawn M Ellerbroe. Matrix Metalloproteinase-9 Promotes Membrane Protrusive Activity in Ovarian Cancer Cells. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35554315. |
matrix metalloproteinase-9 (mmp9) is an extracellular endopeptidase associated with ovarian cancer development and progression. |
2022-05-13 |
2023-08-13 |
Not clear |
| Luyao Zhang, Xiang Li, Xiaozhou Feng, Tolga Berkman, Ruining Ma, Shibin Du, Shaogen Wu, Congcong Huang, Akwasi Amponsah, Alex Bekker, Yuan-Xiang Ta. E74-like factor 1 contributes to nerve trauma-induced nociceptive hypersensitivity via transcriptionally activating matrix metalloprotein-9 in dorsal root ganglion neurons. Pain. 2022-05-04. PMID:35507368. |
preventing this increase through drg microinjection of adeno-associated virus 5-expressing elf1 shrna attenuated the cci-induced upregulation of matrix metallopeptidase 9 (mmp9) in injured drg and induction and maintenance of nociceptive hypersensitivities, without changing locomotor functions and basal responses to acute mechanical, heat and cold stimuli. |
2022-05-04 |
2023-08-13 |
mouse |
| Han-Jie Yang, Tian Liu, Yang Xion. Anti-cancer effect of LINC00478 in bladder cancer correlates with KDM1A-dependent MMP9 demethylation. Cell death discovery. vol 8. issue 1. 2022-05-03. PMID:35504875. |
we further analyzed the expression of linc00478 and matrix metalloprotein 9 (mmp9) in bladder cancer tissues and cell lines and observed a significant decline in linc00478 expression and an elevation in mmp9 expression. |
2022-05-03 |
2023-08-13 |
Not clear |
| Min-Yun Cai, Yue-Li Xu, Hua Rong, Hai Yan. Low Level of PALMD Contributes to the Metastasis of Uveal Melanoma. Frontiers in oncology. vol 12. 2022-05-02. PMID:35494064. |
furthermore, the levels of matrix metallopeptidase (mmp) 2 and mmp9 increased after transfection of sirnas specifically targeting palmd, whereas the levels of mmp2 and mmp9 were decreased after palmd overexpression. |
2022-05-02 |
2023-08-13 |
Not clear |
| Anil Kumar Rana, Supriya Sharma, Shiv Kumar Saini, Damanpreet Sing. Rutin protects hemorrhagic stroke development via supressing oxidative stress and inflammatory events in a zebrafish model. European journal of pharmacology. 2022-04-26. PMID:35469838. |
the treatment increased the expression of tight junction protein claud5a and decreased the mrna level of matrix metalloproteases (mmp2 and mmp9). |
2022-04-26 |
2023-08-13 |
zebrafish |
| Feiran Qi, Yan Liu, Kunlin Zhang, Yanzhenzi Zhang, Ke Xu, Mei Zhou, Huinan Zhao, Shuolin Zhu, Jianxin Chen, Ping Li, Jie D. Artificial Intelligence Uncovers Natural MMP Inhibitor Crocin as a Potential Treatment of Thoracic Aortic Aneurysm and Dissection. Frontiers in cardiovascular medicine. vol 9. 2022-04-25. PMID:35463768. |
bioinformatics analysis of pathological studies indicated "extracellular matrix organization" as the most significant functional pathway related to taad, in which matrix metallopeptidase (mmp) 2 and mmp9 ranked above other proteases. |
2022-04-25 |
2023-08-13 |
mouse |
| Attia Ahmed Attia, Afrah Fatthi Salama, Jayda G Eldiasty, Sahar Abd El-Razik Mosallam, Sabry Ali El-Naggar, Mohammed Abu El-Magd, Hebatala M Nasser, Alaa Elmetwall. Amygdalin potentiates the anti-cancer effect of Sorafenib on Ehrlich ascites carcinoma and ameliorates the associated liver damage. Scientific reports. vol 12. issue 1. 2022-04-21. PMID:35444229. |
the hepatic expression of the antioxidant-related gene [nuclear factor erythroid-2-related factor 2 (nrf2)], the migration-related gene [matrix metalloprotease 9 (mmp9)], and the angiogenesis-related gene [vascular endothelial growth factor (vegf)] were evaluated by qpcr. |
2022-04-21 |
2023-08-13 |
mouse |
| Anmin Ren, Qian Gan, Wanlin Han, Donghuo Gong, Jiasheng Cai, Xinkai Q. Endothelial GATA5 positively regulates angiogenesis via cathepsin S-mediated Angpt2/Flk1 and MMP2/9 signaling pathways. Biochemical and biophysical research communications. vol 609. 2022-04-16. PMID:35429678. |
in addition, we observed a decrease in the angpt2 and flk1, and the matrix metalloproteinase (mmp) family proteins: mmp2 and mmp9 while gata5 was decreased. |
2022-04-16 |
2023-08-13 |
mouse |
| Marta Wołosowicz, Bartłomiej Łukaszuk, Irena Kasacka, Adrian Chabowsk. Diverse Impact of N-Acetylcysteine or Alpha-Lipoic Acid Supplementation during High-Fat Diet Regime on Matrix Metalloproteinase-2 and Matrix Metalloproteinase-9 in Visceral and Subcutaneous Adipose Tissue. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 56. issue 2. 2022-04-14. PMID:35420738. |
despite years of studies, there is no data explaining the mechanism of action of n-acetylcysteine (nac) or alpha-lipoic acid (ala) on matrix metalloproteinase-2 (mmp2) and matrix metalloproteinase-9 (mmp9) in visceral and subcutaneous adipose tissue of hfd-fed rats. |
2022-04-14 |
2023-08-13 |
rat |
| Ying Li, Xin Zhang, Dan He, Zhijie Ma, Ke Xue, Haiyan L. 45S5 Bioglass® works synergistically with siRNA to downregulate the expression of matrix metalloproteinase-9 in diabetic wounds. Acta biomaterialia. 2022-04-14. PMID:35421617. |
the present study is the first to demonstrate that ion products of 45s5 bioglass® (bg) can work with small interfering rna of mmp9 (mmp9-sirna) to reduce mmp-9 expression in tissue-forming cells and enhance the synthesis of extracellular matrix proteins (ecms). |
2022-04-14 |
2023-08-13 |
rat |