| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tapasi Roy, Abhishek Chatterjee, Snehasikta Swarnaka. Rotenone induced neurodegeneration is mediated via cytoskeleton degradation and necroptosis. Biochimica et biophysica acta. Molecular cell research. 2022-12-29. PMID:36581087. |
we further observed an increased expression, as well as activity of matrix metalloproteinase9 (mmp9) in rotenone exposed n2a cells; suggesting the involvement of inflammation upon rotenone exposure. |
2022-12-29 |
2023-08-14 |
Not clear |
| Martina Trentini, Ilaria Zanolla, Federica Zanotti, Elena Tiengo, Danilo Licastro, Simeone Dal Monego, Luca Lovatti, Barbara Zava. Apple Derived Exosomes Improve Collagen Type I Production and Decrease MMPs during Aging of the Skin through Downregulation of the NF-κB Pathway as Mode of Action. Cells. vol 11. issue 24. 2022-12-23. PMID:36552714. |
adnvs also reduce extracellular matrix degradation by increasing collagen synthesis (col3a1, col1a2, col8a1 and col6a1) and downregulating metalloproteinase production (mmp1, mmp8 and mmp9). |
2022-12-23 |
2023-08-14 |
Not clear |
| Dapeng Chen, Marek A Mirski, Shuo Chen, Alese P Devin, Caroline R Haddaway, Emily R Caton, Wayne A Bryden, Michael McLoughli. Human exhaled air diagnostic markers for respiratory tract infections in subjects receiving mechanical ventilation. Journal of breath research. 2022-12-21. PMID:36542858. |
the results showed that three truncated proteoforms, collagen type vi alpha three chain protein (co6a3), matrix metalloproteinase-9 (mmp9), and putative homeodomain transcription factor ii (phtf2) were independently associated with rti with the p-values of 2.0e-5, 1.1e-4, and 1.7e-3, respectively, using multiple logistic regression. |
2022-12-21 |
2023-08-14 |
human |
| Yi-Kai Wang, Shi-Jie Li, Lu-Lu Zhou, Duan Li, Li-Wei Gu. GALNT3 protects against vascular calcification by reducing oxidative stress and apoptosis of smooth muscle cells. European journal of pharmacology. vol 939. 2022-12-16. PMID:36473594. |
moreover, overexpression of galnt3 significantly down-regulated the expression of the oxidative stress markers nox2 and nox4, up-regulated total antioxidant capacity, decreased the expression of pro-inflammatory factors il-1β, tnf-α and il-8, matrix metalloproteinases mmp2 and mmp9, as well as reduced the apoptosis of cells in phosphate induced hasmcs. |
2022-12-16 |
2023-08-14 |
mouse |
| Xuli Gao, Shenyang Shen, Qiaohua Niu, Weilan Miao, Yuting Han, Ziwei Hao, Ning An, Yingyu Yang, Yu Zhang, Han Zhang, Kenneth B Storey, Hui Chan. Differential bone metabolism and protein expression in mice fed a high-fat diet versus Daurian ground squirrels following natural pre-hibernation fattening. Journal of Zhejiang University. Science. B. vol 23. issue 12. 2022-12-15. PMID:36518056. |
western blots were used to analyze protein expression levels related to bone metabolism (runt-related transcription factor 2 (runx2), osteocalcin (ocn), alkaline phosphatase (alp), osteoprotegerin (opg), receptor activator of nuclear factor-κb ligand (rankl), cathepsin k, matrix metallopeptidase 9 (mmp9), patched protein homolog 1 (ptch1), phosphorylated β-catenin (p-β-catenin), and glycogen synthase kinase-3β (gsk-3β)). |
2022-12-15 |
2023-08-14 |
mouse |
| Hongcan Huang, Jing Xie, Jieya Wei, Siqun Xu, Demao Zhang, Xuedong Zho. Fibroblast growth factor 8 (FGF8) up-regulates gelatinase expression in chondrocytes through nuclear factor-κB p65. Journal of bone and mineral metabolism. 2022-12-13. PMID:36512085. |
gelatinases, namely mmp2 and mmp9, are involved in the natural turnover of articular cartilage, as well as the loss of the cartilage matrix in osteoarthritis (oa). |
2022-12-13 |
2023-08-14 |
Not clear |
| Fan Shuyuan, Feng Xiao Yan, Li Kun, Li Bin, Diao Yunpen. Transcriptomics-based study of the protective effect of ethyl gallate on intestinal ischemia-reperfusion injury in mice. Chemistry & biodiversity. 2022-12-13. PMID:36513607. |
in iiri mouse intestinal tissue, expression of the differential protein matrix metalloproteinase 9 (mmp9), as well as its co-protein nf-κb-p65, was significantly increased, while eg inhibited the expression of mmp9 and nf-κb-p65. |
2022-12-13 |
2023-08-14 |
mouse |
| Savannah A Lynn, Flavie Soubigou, Jennifer M Dewing, Amanda Smith, Joanna Ballingall, Thea Sass, Isabela Nica, Catrin Watkins, Bhaskar Gupta, Hussein Almuhtaseb, Stephen C Lash, Ho Ming Yuen, Angela Cree, Tracey A Newman, Andrew J Lotery, J Arjuna Ratnayak. An Exploratory Study Provides Insights into MMP9 and Aβ Levels in the Vitreous and Blood across Different Ages and in a Subset of AMD Patients. International journal of molecular sciences. vol 23. issue 23. 2022-12-11. PMID:36498929. |
matrix metalloproteinase-9 (mmp9) and total amyloid-beta (aβ) are prospective biomarkers of ocular ageing and retinopathy. |
2022-12-11 |
2023-08-14 |
Not clear |
| Chunyan Chen, Ping Fan, Lirong Zhang, Kaige Xue, Jiaheng Hu, Juan Huang, Weitian Lu, Jin Xu, Shiye Xu, Guoping Qiu, Jianhua Ran, Shengwei Ga. Bumetanide Rescues Aquaporin-4 Depolarization via Suppressing β-Dystroglycan Cleavage and Provides Neuroprotection in Rat Retinal Ischemia-Reperfusion Injury. Neuroscience. 2022-12-09. PMID:36493910. |
β-dystroglycan (β-dg) is responsible for aqp4 polarization and can be cleaved by matrix metalloproteinase-9 (mmp9). |
2022-12-09 |
2023-08-14 |
rat |
| Yun-Yun Yang, Xiao-Lu Jiao, Huahui Yu, Lin-Yi Li, Juan Li, Xiao-Ping Zhang, Yan-Wen Qi. Angiopoietin-like protein 8 deficiency attenuates thoracic aortic aneurysm/dissection development in β-aminopropionitrile monofumarate-induced model mice. Biochimica et biophysica acta. Molecular basis of disease. 2022-12-09. PMID:36494038. |
in addition, the protein levels of proinflammatory cytokines and matrix metalloproteinase 9 (mmp9) and ers proteins were decreased in the aorta wall. |
2022-12-09 |
2023-08-14 |
mouse |
| Negar Noorbakhsh, Hamid Galehdari, Mohammad Shafie. The Effect of Sialic Acid on MiR-320a and Let-7e Expression in Human Glial Cell Line. Basic and clinical neuroscience. vol 13. issue 3. 2022-12-02. PMID:36457880. |
matrix metalloproteinases 9 (mmp9) is one factor that changes the exposure of different concentrations of sialic acid solution. |
2022-12-02 |
2023-08-14 |
human |
| Yongbin Jing, Mingkun Jia, Jinpeng Zhuang, Dong Han, Changlong Zhou, Jinglong Ya. TLR9 Exerts an Oncogenic Role in Promoting Osteosarcoma Progression Depending on the Regulation of NF-κB Signaling Pathway. Biological & pharmaceutical bulletin. vol 45. issue 12. 2022-11-30. PMID:36450527. |
furthermore, tlr9 overexpression could enhance the migration and invasion activities of the os cells by the upregulation of matrix metalloproteinases 2 (mmp2) and mmp9, and the opposite result was observed in tlr9-silenced cells. |
2022-11-30 |
2023-08-14 |
Not clear |
| Wenliang Tan, Yong Yang, Huogeng Bao, Xinjun Kang, Hong Zeng, Lang Hong, Liang Sha. MicroRNA-22-3p Restrains the Proliferation, Phenotypic Transformation, and Migration of Vascular Smooth Muscle Cells by Manipulating TOMM40. International heart journal. vol 63. issue 6. 2022-11-30. PMID:36450556. |
after mir-22-3p-inhibitor, oe-tomm40, and sh-tomm40 were transfected into vsmcs, cell counting kit (cck) -8 assay, scratch test, and western blot analysis were implemented to measure the vsmc proliferation, migration, and matrix metallopeptidase 9 (mmp9), α-smooth muscle actin (sma), smooth muscle-myosin heavy chain (sm-mhc), and osteopontin (opn) expressions, respectively. |
2022-11-30 |
2023-08-14 |
human |
| Jen-Fu Yang, Tzu-Min Chen, Hsin-Han Chang, Yu-Ling Tsai, Wen-Chiuan Tsai, Wen-Yen Huang, Cheng-Hsiang Lo, Chun-Shu Lin, Po-Chien Shen, Ying Che. Guggulsterone inhibits migration and invasion through proteasomal and lysosomal degradation in human glioblastoma cells. European journal of pharmacology. 2022-11-27. PMID:36436590. |
there was also concomitant decreased expression of focal adhesion complex, matrix metalloproteinase-2 (mmp2), mmp9 and cathepsin b. |
2022-11-27 |
2023-08-14 |
human |
| Nannan Kang, Xue Liang, Buxi Fan, Chen Zhao, Beiyu Shen, Xuemei Ji, Yu Li. Endothelial-Specific Molecule 1 Inhibition Lessens Productive Angiogenesis and Tumor Metastasis to Overcome Bevacizumab Resistance. Cancers. vol 14. issue 22. 2022-11-26. PMID:36428773. |
furthermore, tnfα induced the upregulation of esm1, which promotes metastasis and angiogenesis and regulates matrix metalloprotease-9 (mmp9), vascular endothelial growth factor (vegf), and delta-like ligand-4 molecules (dll4). |
2022-11-26 |
2023-08-14 |
mouse |
| Agathe Quesnel, Nathan Coles, Tuomo M Polvikoski, George S Karagiannis, Claudio Angione, Meez Islam, Ahmad A Khundakar, Panagiota S Filippo. The diagnostic and prognostic potential of the EGFR/MUC4/MMP9 axis in glioma patients. Scientific reports. vol 12. issue 1. 2022-11-18. PMID:36400876. |
interactions between mucin 4 (muc4) and the epidermal growth factor receptor (egfr) are involved in carcinogenesis, and may lead to matrix metalloproteinase-9 (mmp9) overexpression, exacerbating cancer cell invasiveness. |
2022-11-18 |
2023-08-14 |
Not clear |
| Guiyue Cai, Ruitao Zou, Huizhi Yang, Jiahao Xie, Xiaoxuan Chen, Chunchan Zheng, Sujun Luo, Na Wei, Shuang Liu, Rongyi Che. Circ_0084043-miR-134-5p axis regulates PCDH9 to suppress melanoma. Frontiers in oncology. vol 12. 2022-11-17. PMID:36387162. |
ectopic expression or knock down (kd) of pcdh9 with a lentivirus vector, we explored its effects on the proliferation, invasion, and apoptosis of melanoma and verified its regulatory effect on ras-related c3 botulinum toxin substrate 1 (rac1), proline-rich tyrosine kinase 2 (pyk2), cyclin d1, matrix metalloproteinase 2 (mmp2), and mmp9. |
2022-11-17 |
2023-08-14 |
human |
| Haowen Yin, Yuanyuan Liu, Hao Yue, Yingying Tian, Ping Dong, Changhu Xue, Yun-Tao Zhao, Zifang Zhao, Jingfeng Wan. DHA- and EPA-Enriched Phosphatidylcholine Suppress Human Lung Carcinoma 95D Cells Metastasis via Activating the Peroxisome Proliferator-Activated Receptor γ. Nutrients. vol 14. issue 21. 2022-11-11. PMID:36364935. |
furthermore, critical factors related to invasion, including matrix metallopeptidase 9 (mmp9), heparanase (hpa), and vascular endothelial growth factor (vegf), were drastically downregulated through the pparγ/nf-κb signaling pathway. |
2022-11-11 |
2023-08-14 |
human |
| Mingyue Jiang, You Sun, Kyung Son. Ginsenoside compound K suppresses tumor growth in the 22Rv1 xenograft model and inhibits androgenic responses via the transcriptional mechanism in human prostate cancer cells. The FEBS journal. 2022-11-09. PMID:36349420. |
gck downregulated epithelial-mesenchymal transition (emt) markers such as vimentin and matrix metalloproteinase 9 (mmp9), whereas e-cadherin was significantly increased in gck-stimulated lncap and 22rv1 cells. |
2022-11-09 |
2023-08-14 |
mouse |
| Longxiang Huang, Zhenni Wei, Xiaohui Wang, Chunlin Lan, Yihua Zhu, Qin Y. AZD6738 Decreases Intraocular Pressure and Inhibits Fibrotic Response in Trabecular Meshwork through CHK1/P53 Pathway. Biochemical pharmacology. 2022-11-08. PMID:36347274. |
further, we demonstrated that azd6738 reduces cell viability and migration, and inhibit the expression of fibrosis-related factors including fibronectin (fn), α-smooth muscle actin (α-sma), laminin subunit beta 1 (lamb1), matrix metallopeptidase (mmp) family including mmp2 and mmp9, collagen Ⅰ (col1), and collagen Ⅳ (col4), reduce gap junctions, altered cytoskeleton and nitric oxide production in tgf-β1-induced human trabecular meshwork cells (htmcs) through the chk1/p53 pathway, which were affected aqueous humor (ah) production and outflow pathway. |
2022-11-08 |
2023-08-14 |
mouse |