| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Emile Verhulst, Delphine Garnier, Ingrid De Meester, Brigitte Bauvoi. Validating Cell Surface Proteases as Drug Targets for Cancer Therapy: What Do We Know, and Where Do We Go? Cancers. vol 14. issue 3. 2022-02-15. PMID:35158891. |
several members, most notably dipeptidyl peptidase 4 (dpp4/cd26) and its related family member fibroblast activation protein (fap), aminopeptidase n (apn/cd13), a disintegrin and metalloprotease 17 (adam17/tace), and matrix metalloproteinases (mmps) mmp2 and mmp9, are often overexpressed in cancers and have been associated with tumour dysfunction. |
2022-02-15 |
2023-08-13 |
human |
| Chia-Yu Hung, Chih-Han Chang, Tzu-Jung Lin, Hsin-Hui Yi, Nian-Zhen Tsai, Yu-Ru Chen, Yng-Tay Che. AQP4 Attenuated TRAF6/NFκB Activation in Acrylamide-Induced Neurotoxicity. Molecules (Basel, Switzerland). vol 27. issue 3. 2022-02-15. PMID:35164330. |
matrix metalloproteinase (mmp9) expression was higher in the acr-treated group than in the control group. |
2022-02-15 |
2023-08-13 |
rat |
| Woobeen Jo, Min Kim, Jiyoung Oh, Chu-Sook Kim, Chanho Park, Sora Yoon, Changhu Lee, Sahee Kim, Dougu Nam, Jiyoung Par. MicroRNA-29 Ameliorates Fibro-Inflammation and Insulin Resistance in HIF1α-Deficient Obese Adipose Tissue by Inhibiting Endotrophin Generation. Diabetes. 2022-02-15. PMID:35167651. |
herein, we identified that several endotrophin-containing peptides (pre-endotrophins) were generated from the col6a3 chain in a stepwise manner for the efficient production of mature endotrophin, partly through the action of hypoxia-induced matrix metalloproteinases (mmps), including mmp2, mmp9, and mmp16. |
2022-02-15 |
2023-08-13 |
mouse |
| Sana Abdul Khaliq, Zobia Umair, Mi-Ock Baek, Seung Joo Chon, Mee-Sup Yoo. C-Peptide Promotes Cell Migration by Controlling Matrix Metallopeptidase-9 Activity Through Direct Regulation of β-Catenin in Human Endometrial Stromal Cells. Frontiers in cell and developmental biology. vol 10. 2022-02-07. PMID:35127683. |
c-peptide was also observed to increase matrix metallopeptidase-9 (mmp9) activity by increasing mmp9 expression and decreasing the expression of metallopeptidase inhibitor 1 (timp1) and timp3. |
2022-02-07 |
2023-08-13 |
human |
| Elizabeth Quinla. Recovery from amblyopia in the adult mouse through dark exposure, light reintroduction and perisynaptic proteolysis. Journal of vision. vol 22. issue 3. 2022-02-04. PMID:35120209. |
the reactivation of plasticity triggered by de/lrx is mediated by an increase in the activity of a matrix metalloproteinase (mmp9), that is perisynaptic, specific to thalamocortical synapses, and results in degradation of trans-synaptic adhesion proteins. |
2022-02-04 |
2023-08-13 |
mouse |
| Alexandria N Early, Erica M Weekman, Tiffany L Sudduth, Brittani R Price, Abigail E Woolums, Danielle Hawthorne, Charles E Seaks, Donna M Wilcoc. Elucidating the neurodegnerative sequelae leading to VCID pathology. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109152. |
i hypothesize that hyperhomocysteinemia initiates a pro-inflammatory cascade that increases the activity of matrix metalloproteinase 9 (mmp9) causing perivascular astrocytes to dissociate from their vessels, leading to blood brain barrier dysfunction and the progression toward vcid pathology. |
2022-02-03 |
2023-08-13 |
Not clear |
| Briliant Adhi Prabowo, Elisabete Fernandes, Paulo Freita. A pump-free microfluidic device for fast magnetic labeling of ischemic stroke biomarkers. Analytical and bioanalytical chemistry. 2022-01-28. PMID:35088131. |
this research proposes a low-cost and simple operation microfluidic chip to enhance the magnetic labeling efficiency of two ischemic stroke biomarkers: cellular fibronectin (c-fn) and matrix metallopeptidase 9 (mmp9). |
2022-01-28 |
2023-08-13 |
Not clear |
| Nandan Wu, Shuilian Chen, Qian Luo, Zihua Jiang, Xiao Wang, Yan Li, Jin Qiu, Keming Yu, Ying Yang, Jing Zhuan. Kruppel-like factor 2 acts as a tumor suppressor in human retinoblastoma. Experimental eye research. 2022-01-25. PMID:35074341. |
in addition, klf2 overexpression contributed to suppressing rb cell migration and invasion by downregulating matrix metallopeptidase 9 (mmp9). |
2022-01-25 |
2023-08-13 |
human |
| Monika Matusiak, Dominika Oziębło, Monika Ołdak, Emilia Rejmak, Leszek Kaczmarek, Piotr Henryk Skarżyński, Henryk Skarżyńsk. Prospective cohort study reveals MMP-9, a neuroplasticity regulator, as a prediction marker of cochlear implantation outcome in prelingual deafness treatment. Molecular neurobiology. 2022-01-21. PMID:35061219. |
to address this issue, we investigated genetic variants of matrix metalloproteinase 9 (mmp9) and brain-derived neurotrophic factor (bdnf) and plasma levels of mmp-9, bdnf, and pro-bdnf that have all been implicated in neuroplasticity after sensory deprivation in the auditory pathway. |
2022-01-21 |
2023-08-13 |
Not clear |
| Zhenglei Xu, Zeming Chen, Minsi Peng, Zhuliang Zhang, Weixiang Luo, Ruiyue Shi, Lisheng Wang, Yingcai Hon. MicroRNA MiR-490-5p suppresses pancreatic cancer through regulating epithelial-mesenchymal transition via targeting MAGI2 antisense RNA 3. Bioengineered. vol 13. issue 2. 2022-01-19. PMID:35043728. |
the mrna expressions of mir-490-5p, magi2 antisense rna 3 (magi2-as3), matrix metalloproteinase (mmp)2, mmp9, n-cadherin, and e-cadherin were detected by quantitative real-time pcr, while the protein expressions of these genes except mir-490-5p were measured by western blot analysis. |
2022-01-19 |
2023-08-13 |
Not clear |
| A Ramesova, B Vesela, E Svandova, H Lesot, E Matalov. Caspase-9 inhibition decreases expression of Mmp9 during chondrogenesis. Histochemistry and cell biology. 2022-01-09. PMID:34999953. |
the expression of several chondrogenesis-related genes was shown to be altered, some of which may impact chondrogenic differentiation (bmp4, bmp7, sp7, gli1), mineral deposition (alp, itgam) or the remodelling of the extracellular matrix (col1a2, mmp9) related to endochondral ossification. |
2022-01-09 |
2023-08-13 |
mouse |
| Akie Kimura Yoshikawa, Kensei Yamaguchi, Kei Muro, Atsuo Takashima, Takashi Ichimura, Daisuke Sakai, Shigenori Kadowaki, Keisho Chin, Toshihiro Kudo, Seiichiro Mitani, Shigehisa Kitano, Dung Thai, Marianna Zavodovskaya, JieJane Liu, Narikazu Boku, Taroh Sato. Safety and tolerability of andecaliximab as monotherapy and in combination with an anti-PD-1 antibody in Japanese patients with gastric or gastroesophageal junction adenocarcinoma: a phase 1b study. Journal for immunotherapy of cancer. vol 10. issue 1. 2022-01-07. PMID:34992093. |
matrix metalloproteinase 9 (mmp9) is implicated in protumorigenic processes. |
2022-01-07 |
2023-08-13 |
Not clear |
| Carine Jiguet-Jiglaire, Sebastien Boissonneau, Emilie Denicolai, Victoria Hein, Romain Lasseur, Josep Garcia, Sylvie Romain, Romain Appay, Thomas Graillon, Warren Mason, Antoine F Carpentier, Alba A Brandes, L 'Houcine Ouafik, Wolfgang Wick, Ania Baaziz, Julien P Gigan, Rafael J Argüello, Dominique Figarella-Branger, Olivier Chinot, Emeline Taboure. Plasmatic MMP9 released from tumor-infiltrating neutrophils is predictive for bevacizumab efficacy in glioblastoma patients: an AVAglio ancillary study. Acta neuropathologica communications. vol 10. issue 1. 2022-01-04. PMID:34980260. |
we previously identified matrix metalloproteinase 2 (mmp2) and mmp9 plasma levels as candidate biomarkers of bevacizumab activity in patients with recurrent glioblastoma. |
2022-01-04 |
2023-08-13 |
Not clear |
| Li Jia, Bin Lei, Huaijun Gao, Lin Jia, Dan Luo, Jianjun Han, Bingxin Ji. miR-130b suppresses the invasion and migration of prostate cancer via inhibiting DLL1 and regulating the PI3K/Akt pathways. Experimental and therapeutic medicine. vol 23. issue 1. 2022-01-03. PMID:34976140. |
for this purpose, reverse transcription-pcr was performed to evaluate the mrna levels of dll1, phosphoinositide-3 kinase (pi3k), protein kinase b (akt) and matrix metalloproteinase (mmp)9, and western blot analysis was carried out to detect the protein expression levels of dll1, phosphorylated (p)-pi3k, p-akt and mmp9. |
2022-01-03 |
2023-08-13 |
Not clear |
| Ming-Xiao Zhang, Qing-Xin Tian, Jian-Long Li. [The myocardial protective effect of propofol on rats with experimental myocardial infarction and its mechanism]. Sheng li xue bao : [Acta physiologica Sinica]. vol 73. issue 6. 2021-12-28. PMID:34961861. |
furthermore, after myocardial infarction, the administration of propofol significantly improved the diastolic strain rate, down-regulated the mrna expression levels of myocardial hypertrophy markers, atrial natriuretic peptide and β-myosin heavy chain, and reversed the up-regulation of matrix metalloproteinase 2 (mmp2), mmp9 and tissue inhibitor of metalloproteinase-2 (timp-2) induced by myocardial infarction. |
2021-12-28 |
2023-08-13 |
rat |
| Christos Koutsakis, Anastasia-Gerasimoula Tavianatou, Dimitris Kokoretsis, Georgios Baroutas, Nikos K Karamano. Sulfated Hyaluronan Modulates the Functional Properties and Matrix Effectors Expression of Breast Cancer Cells with Different Estrogen Receptor Status. Biomolecules. vol 11. issue 12. 2021-12-24. PMID:34944559. |
additionally, sha downregulates matrix remodeling enzymes such as the matrix metalloproteinases mt1-mmp, mmp2, and mmp9. |
2021-12-24 |
2023-08-13 |
Not clear |
| Sheng-Yu Lee, Tzu-Yun Wang, Ru-Band Lu, Liang-Jen Wang, Cheng-Ho Chang, Yung-Chih Chiang, Chih-Chuan Pan, Kuo-Wang Tsa. Plasma BDNF and Cytokines Correlated with Protein Biomarkers for Bipolar II Disorder. Journal of personalized medicine. vol 11. issue 12. 2021-12-24. PMID:34945756. |
we have previously identified five candidate proteins (matrix metallopeptidase 9 (mmp9), phenylalanyl-trna synthetase subunit beta (farsb), peroxiredoxin 2 (prdx2), carbonic anhydrase 1 (ca-1), and proprotein convertase subtilisin/kexin type 9 (pcsk9)) as potential biomarkers for bipolar ii disorder (bd-ii). |
2021-12-24 |
2023-08-13 |
human |
| Maximilian Bellut, Lena Papp, Michael Bieber, Peter Kraft, Guido Stoll, Michael K Schuhman. NLPR3 inflammasome inhibition alleviates hypoxic endothelial cell death in vitro and protects blood-brain barrier integrity in murine stroke. Cell death & disease. vol 13. issue 1. 2021-12-21. PMID:34930895. |
moreover, inflammasome inhibition reduced the secretion of pro-inflammatory chemokines, cytokines, and matrix metalloproteinase-9 (mmp9) in ec. |
2021-12-21 |
2023-08-13 |
mouse |
| Venkatesh Gunasekaran, Jinu Avarachan, Anitta Augustine, Abdul Khayum, Arivukkarasu . 3-O-Acetyl-11-keto-β-boswellic acid ameliorates acquired, consolidated and recognitive memory deficits through the regulation of hippocampal PPAR γ, MMP9 and MMP2 genes in dementia model. Heliyon. vol 7. issue 12. 2021-12-20. PMID:34926858. |
further, gene expression study reveals akba ameliorates the memory impairment via activating pparγ and its downstream regulators, matrix metalloproteinase 2 (mmp2) and matrix metalloproteinase 9 (mmp9) genes in hippocampus. |
2021-12-20 |
2023-08-13 |
rat |
| M Dolores Martín-de-Saavedra, Marc Dos Santos, Lorenza Culotta, Olga Varea, Benjamin P Spielman, Euan Parnell, Marc P Forrest, Ruoqi Gao, Sehyoun Yoon, Emmarose McCoig, Hiba A Jalloul, Kristoffer Myczek, Natalia Khalatyan, Elizabeth A Hall, Liam S Turk, Antonio Sanz-Clemente, Davide Comoletti, Stefan F Lichtenthaler, Jeffrey S Burgdorf, Maria V Barbolina, Jeffrey N Savas, Peter Penze. Shed CNTNAP2 ectodomain is detectable in CSF and regulates Ca Neuron. 2021-12-18. PMID:34921780. |
cntnap2 undergoes activity-dependent es via mmp9 (matrix metalloprotease 9), and cntnap2-ecto levels are reduced in the hcsf of individuals with autism spectrum disorder. |
2021-12-18 |
2023-08-13 |
human |