| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Guanghong Sui, Caixia Yang, Lu Wang, Xiangyang Xiong, Mengtian Guo, Zheng Chen, Feng Wan. Exogenous IGF-1 improves tau pathology and neuronal pyroptosis in high-fat diet mice with cognitive dysfunction. Metabolic brain disease. vol 36. issue 7. 2021-09-14. PMID:34269982. |
inhibition of the signaling pathway using axl1717 or znpp ix re-deteriorated cognitive function, tau pathology and neuronal pyroptosis in hippocampus. |
2021-09-14 |
2023-08-13 |
mouse |
| Mohamed A Salem, Barbara Budzyńska, Joanna Kowalczyk, Nesrine S El Sayed, Suzan M Mansou. Tadalafil and bergapten mitigate streptozotocin-induced sporadic Alzheimer's disease in mice via modulating neuroinflammation, PI3K/Akt, Wnt/β-catenin, AMPK/mTOR signaling pathways. Toxicology and applied pharmacology. vol 429. 2021-09-14. PMID:34428446. |
administration of tad or bg at doses of 20 and 25 mg/kg, respectively, for 21 consecutive days attenuated stz-induced hippocampal insult, preserved neuronal integrity, and improved cognitive function in the morris water maze and object recognition tests paralleled by reduction in aβ expression by 79 and 89% and tau hyperphosphorylation by 60 and 61%, respectively. |
2021-09-14 |
2023-08-13 |
mouse |
| Liangyu Peng, Xin Fang, Fangxia Xu, Shuai Liu, Yue Qian, Xiangdan Gong, Xin Zhao, Zhengliang Ma, Tianjiao Xia, Xiaoping G. Amelioration of Hippocampal Insulin Resistance Reduces Tau Hyperphosphorylation and Cognitive Decline Induced by Isoflurane in Mice. Frontiers in aging neuroscience. vol 13. 2021-09-14. PMID:34512303. |
amelioration of hippocampal insulin resistance reduces tau hyperphosphorylation and cognitive decline induced by isoflurane in mice. |
2021-09-14 |
2023-08-13 |
mouse |
| Liangyu Peng, Xin Fang, Fangxia Xu, Shuai Liu, Yue Qian, Xiangdan Gong, Xin Zhao, Zhengliang Ma, Tianjiao Xia, Xiaoping G. Amelioration of Hippocampal Insulin Resistance Reduces Tau Hyperphosphorylation and Cognitive Decline Induced by Isoflurane in Mice. Frontiers in aging neuroscience. vol 13. 2021-09-14. PMID:34512303. |
we investigated if alleviation of hippocampal ir by the antidiabetic agent metformin could reduce tau hyperphosphorylation and cognitive decline induced by isoflurane in mice. |
2021-09-14 |
2023-08-13 |
mouse |
| Liangyu Peng, Xin Fang, Fangxia Xu, Shuai Liu, Yue Qian, Xiangdan Gong, Xin Zhao, Zhengliang Ma, Tianjiao Xia, Xiaoping G. Amelioration of Hippocampal Insulin Resistance Reduces Tau Hyperphosphorylation and Cognitive Decline Induced by Isoflurane in Mice. Frontiers in aging neuroscience. vol 13. 2021-09-14. PMID:34512303. |
the effects of prolonged (6 h) isoflurane anesthesia on hippocampal ir, hippocampal tau hyperphosphorylation, and hippocampus-dependent cognitive function were evaluated in wild type (wt) adult mice and the high-fat diet plus streptozotocin (hfd/stz) mouse model of t2dm. |
2021-09-14 |
2023-08-13 |
mouse |
| Liangyu Peng, Xin Fang, Fangxia Xu, Shuai Liu, Yue Qian, Xiangdan Gong, Xin Zhao, Zhengliang Ma, Tianjiao Xia, Xiaoping G. Amelioration of Hippocampal Insulin Resistance Reduces Tau Hyperphosphorylation and Cognitive Decline Induced by Isoflurane in Mice. Frontiers in aging neuroscience. vol 13. 2021-09-14. PMID:34512303. |
isoflurane also induced hippocampal tau hyperphosphorylation and metformin reversed this effect. |
2021-09-14 |
2023-08-13 |
mouse |
| Liangyu Peng, Xin Fang, Fangxia Xu, Shuai Liu, Yue Qian, Xiangdan Gong, Xin Zhao, Zhengliang Ma, Tianjiao Xia, Xiaoping G. Amelioration of Hippocampal Insulin Resistance Reduces Tau Hyperphosphorylation and Cognitive Decline Induced by Isoflurane in Mice. Frontiers in aging neuroscience. vol 13. 2021-09-14. PMID:34512303. |
our findings show hippocampal ir and tau hyperphosphorylation contribute to acute isoflurane-induced cognitive dysfunction. |
2021-09-14 |
2023-08-13 |
mouse |
| Parul Gupta, Shubhangini Tiwari, Abhishek Singh, Amit Pal, Amit Mishra, Sarika Sing. Rivastigmine attenuates the Alzheimer's disease related protein degradation and apoptotic neuronal death signalling. The Biochemical journal. vol 478. issue 7. 2021-09-13. PMID:33660768. |
the known inhibitory effect of rivastigmine on cognition and acetylcholinesterase activity was observed in both cortex and hippocampus and further its effect on tau level, amyloid aggregation, biochemical alterations, endoplasmic reticulum (er) stress, calcium homeostasis, proteasome activity and apoptosis was estimated. |
2021-09-13 |
2023-08-13 |
rat |
| Lauren E McCollum, Sandhitsu R Das, Long Xie, Robin de Flores, Jieqiong Wang, Sharon X Xie, Laura E M Wisse, Paul A Yushkevich, David A Wol. Oh brother, where art tau? Amyloid, neurodegeneration, and cognitive decline without elevated tau. NeuroImage. Clinical. vol 31. 2021-09-13. PMID:34119903. |
β-amyloid and tau status were determined by csf assays, while neurodegeneration status was based on hippocampal volume on mri. |
2021-09-13 |
2023-08-13 |
human |
| David S Priemer, Rebecca D Folkert. Dementia in the Forensic Setting: Diagnoses Obtained Using a Condensed Protocol at the Office of Chief Medical Examiner, New York City. Journal of neuropathology and experimental neurology. vol 80. issue 8. 2021-09-13. PMID:34388235. |
others included age-related tau astrogliopathy, hippocampal sclerosis of aging, progressive supranuclear palsy, multiple system atrophy, amyotrophic lateral sclerosis, argyrophilic grain disease, and creutzfeldt-jakob disease. |
2021-09-13 |
2023-08-13 |
Not clear |
| Jamie M Walker, Yelena Fudym, Kurt Farrell, Megan A Iida, Kevin F Bieniek, Sudha Seshadri, Charles L White, John F Crary, Timothy E Richardso. Asymmetry of Hippocampal Tau Pathology in Primary Age-Related Tauopathy and Alzheimer Disease. Journal of neuropathology and experimental neurology. vol 80. issue 5. 2021-09-09. PMID:33860327. |
asymmetry of hippocampal tau pathology in primary age-related tauopathy and alzheimer disease. |
2021-09-09 |
2023-08-13 |
Not clear |
| Xin Wang, En-Jie Liu, Qian Liu, Shi-Hong Li, Ting Li, Qiu-Zhi Zhou, Yan-Chao Liu, Huaqiu Zhang, Jian-Zhi Wan. Tau Acetylation in Entorhinal Cortex Induces its Chronic Hippocampal Propagation and Cognitive Deficits in Mice. Journal of Alzheimer's disease : JAD. vol 77. issue 1. 2021-09-08. PMID:32804150. |
tau acetylation in entorhinal cortex induces its chronic hippocampal propagation and cognitive deficits in mice. |
2021-09-08 |
2023-08-13 |
mouse |
| Israa M Abd El-Fatah, Heba M A Abdelrazek, Sherehan M Ibrahim, Dalaal M Abdallah, Hanan S El-Abha. Dimethyl fumarate abridged tauo-/amyloidopathy in a D-Galactose/ovariectomy-induced Alzheimer's-like disease: Modulation of AMPK/SIRT-1, AKT/CREB/BDNF, AKT/GSK-3β, adiponectin/Adipo1R, and NF-κB/IL-1β/ROS trajectories. Neurochemistry international. vol 148. 2021-09-08. PMID:34052296. |
mechanistically, dmf suppressed the hippocampal contents of ad-surrogate markers; viz., apolipoprotein (apo)-e1, bace1, aβ42, and hyperphosphorylated tau. |
2021-09-08 |
2023-08-13 |
rat |
| Yuhan Ma, Jing Wang, Dihui Xu, Yabing Chen, Xiaodong Ha. Chronic MC-LR exposure promoted Aβ and p-tau accumulation via regulating Akt/GSK-3β signal pathway. The Science of the total environment. vol 794. 2021-09-06. PMID:34323745. |
in this study, we observed β-amyloid (aβ) accumulation and tau hyperphosphorylation (p-tau) at sites of ser396 and thr205 in mouse hippocampus and cortex, alzheimer's disease (ad) like changes, after chronic exposure to mc-lr at different concentrations (1, 7.5, 15 and 30 μg/l) for 180 days. |
2021-09-06 |
2023-08-13 |
mouse |
| Yilin Shen, Haixia Hu, Cui Fan, Quan Wang, Tianyuan Zou, Bin Ye, Mingliang Xian. Sensorineural hearing loss may lead to dementia-related pathological changes in hippocampal neurons. Neurobiology of disease. vol 156. 2021-09-03. PMID:34082124. |
these results suggest that hearing loss alone causes neuronal degeneration, inhibition of neurogenesis, increased tau protein phosphorylation, and increased neuroinflammation in the hippocampus. |
2021-09-03 |
2023-08-13 |
mouse |
| Jing Yan, Ailin Luo, Rao Sun, Xiaole Tang, Yilin Zhao, Jie Zhang, Biyun Zhou, Hua Zheng, Honghui Yu, Shiyong L. Resveratrol Mitigates Hippocampal Tau Acetylation and Cognitive Deficit by Activation SIRT1 in Aged Rats following Anesthesia and Surgery. Oxidative medicine and cellular longevity. vol 2020. 2021-09-02. PMID:33381265. |
resveratrol mitigates hippocampal tau acetylation and cognitive deficit by activation sirt1 in aged rats following anesthesia and surgery. |
2021-09-02 |
2023-08-13 |
rat |
| Jing Yan, Ailin Luo, Rao Sun, Xiaole Tang, Yilin Zhao, Jie Zhang, Biyun Zhou, Hua Zheng, Honghui Yu, Shiyong L. Resveratrol Mitigates Hippocampal Tau Acetylation and Cognitive Deficit by Activation SIRT1 in Aged Rats following Anesthesia and Surgery. Oxidative medicine and cellular longevity. vol 2020. 2021-09-02. PMID:33381265. |
in the present study, our findings showed that tau acetylation mediated by sirt1 deficiency resulted in tau hyperphosphorylation in the hippocampus of the aged pocd model and consequently contributed to cognitive impairment. |
2021-09-02 |
2023-08-13 |
rat |
| Jing Yan, Ailin Luo, Rao Sun, Xiaole Tang, Yilin Zhao, Jie Zhang, Biyun Zhou, Hua Zheng, Honghui Yu, Shiyong L. Resveratrol Mitigates Hippocampal Tau Acetylation and Cognitive Deficit by Activation SIRT1 in Aged Rats following Anesthesia and Surgery. Oxidative medicine and cellular longevity. vol 2020. 2021-09-02. PMID:33381265. |
interestingly, pretreatment with resveratrol almost restored the expression of sirt1, reduced the levels of acetylated tau and hyperphosphorylated tau in the hippocampus, and improved the cognitive performance in the behavioral tests. |
2021-09-02 |
2023-08-13 |
rat |
| Ghada A Badawi, Mustafa M Shokr, Hala F Zaki, Ahmed F Mohame. Pentoxifylline prevents epileptic seizure via modulating HMGB1/RAGE/TLR4 signalling pathway and improves memory in pentylenetetrazol kindling rats. Clinical and experimental pharmacology & physiology. vol 48. issue 8. 2021-09-02. PMID:33899956. |
furthermore, ptx reversed ptz hippocampal neuronal loss by decreasing protein expression of amyloid-β peptide (aβ), tau and β site-amyloid precursor protein cleavage enzyme 1 (bace1), associated with a marked reduction in expression of inflammatory mediators such as hmgb1, tl4, and rage proteins. |
2021-09-02 |
2023-08-13 |
rat |
| Xinyu Huang, Kangbai Huang, Zhaowei Li, Dongyan Bai, Yan Hao, Qinglong Wu, Wei Yi, Nenggui Xu, Youcan Pan, Liang Zhan. Electroacupuncture improves cognitive deficits and insulin resistance in an OLETF rat model of Al/D-gal induced aging model via the PI3K/Akt signaling pathway. Brain research. vol 1740. 2021-09-01. PMID:32304687. |
aβ and total tau in the hippocampus and cerebrospinal fluid (csf) were detected using western blotting (wb) and enzyme-linked immunosorbent assay (elisa). |
2021-09-01 |
2023-08-13 |
rat |