| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Seong Su Kang, Eun Hee Ahn, Keqiang Y. Delta-secretase cleavage of Tau mediates its pathology and propagation in Alzheimer's disease. Experimental & molecular medicine. vol 52. issue 8. 2021-08-10. PMID:32859953. |
the spread of tau deposits is first initiated in the lc and is transported in a stepwise manner from the entorhinal cortex to the hippocampus and then to associative regions of the neocortex as the disease progresses. |
2021-08-10 |
2023-08-13 |
Not clear |
| Elisa García-Lara, Samuel Aguirre, Núria Clotet, Xenia Sawkulycz, Clara Bartra, Lidia Almenara-Fuentes, Cristina Suñol, Rubén Corpas, Peter Olah, Florin Tripon, Andrei Crauciuc, Mark Slevin, Coral Sanfeli. Antibody Protection against Long-Term Memory Loss Induced by Monomeric C-Reactive Protein in a Mouse Model of Dementia. Biomedicines. vol 9. issue 7. 2021-08-09. PMID:34356892. |
here, we showed that a single hippocampal administration of mcrp in mice induced memory loss, lasting at least 6 months, along with neurodegenerative changes detected by increased levels of hyperphosphorylated tau protein and a decrease of the neuroplasticity marker |
2021-08-09 |
2023-08-13 |
mouse |
| Tosha Williams, Zachary Sorrentino, Mary Weinrich, Benoit I Giasson, Paramita Chakrabart. Differential cross-seeding properties of tau and α-synuclein in mouse models of tauopathy and synucleinopathy. Brain communications. vol 2. issue 2. 2021-08-07. PMID:33094280. |
unilateral hippocampal injection of tau fibrils or α-synuclein fibrils, and to a lesser extent tau + α-synuclein copolymer fibrils prepared from co-incubating individual recombinant monomers, induced robust phosphorylated tau pathology in ps19 mice relative to control mice. |
2021-08-07 |
2023-08-13 |
mouse |
| Tosha Williams, Zachary Sorrentino, Mary Weinrich, Benoit I Giasson, Paramita Chakrabart. Differential cross-seeding properties of tau and α-synuclein in mouse models of tauopathy and synucleinopathy. Brain communications. vol 2. issue 2. 2021-08-07. PMID:33094280. |
in m20 mice, unilateral hippocampal injection of α-synuclein fibrils or tau fibrils induced robust bilateral phosphorylated α-synuclein pathology, while tau + α-synuclein copolymer injection resulted in restricted phosphorylated α-synuclein pathology predominantly in the ipsilateral cortex. |
2021-08-07 |
2023-08-13 |
mouse |
| Fernanda Dos Santos Petry, Juliana Bender Hoppe, Caroline Peres Klein, Bernardo Gindri Dos Santos, Régis Mateus Hözer, Felippo Bifi, Cristiane Matté, Christianne Gazzana Salbego, Vera Maria Treis Trindad. Genistein attenuates amyloid-beta-induced cognitive impairment in rats by modulation of hippocampal synaptotoxicity and hyperphosphorylation of Tau. The Journal of nutritional biochemistry. vol 87. 2021-08-04. PMID:33065257. |
genistein attenuates amyloid-beta-induced cognitive impairment in rats by modulation of hippocampal synaptotoxicity and hyperphosphorylation of tau. |
2021-08-04 |
2023-08-13 |
rat |
| José Gulfo, Joana Pérez de San Román, Angelo Ledda, Felix Junyent, María J Ramírez, Francisco J Gil-Bea, Montserrat Esteve, Mar Gras. Corticosteroid-binding-globulin (CBG)-deficient mice show high pY216-GSK3β and phosphorylated-Tau levels in the hippocampus. PloS one. vol 16. issue 2. 2021-08-04. PMID:33592009. |
we used cbg-/- mice, which display low total-corticosterone and high free-corticosterone blood levels at the nadir of corticosterone secretion (morning) and at rest to evaluate the hippocampus for total- and free-corticosterone levels; 11β-hydroxysteroid dehydrogenase expression and activity; the expression of key proteins involved in glucocorticoid activity and insulin signaling; microtubule-associated protein tau phosphorylation, and neuronal and synaptic function markers. |
2021-08-04 |
2023-08-13 |
mouse |
| José Gulfo, Joana Pérez de San Román, Angelo Ledda, Felix Junyent, María J Ramírez, Francisco J Gil-Bea, Montserrat Esteve, Mar Gras. Corticosteroid-binding-globulin (CBG)-deficient mice show high pY216-GSK3β and phosphorylated-Tau levels in the hippocampus. PloS one. vol 16. issue 2. 2021-08-04. PMID:33592009. |
our results revealed that at the nadir of corticosterone secretion in the resting state the cbg-/- mouse hippocampus exhibited slightly elevated levels of free-corticosterone, diminished fk506 binding protein 5 expression, increased corticosterone downstream effectors and altered mapk and pi3k pathway with increased py216-gsk3β and phosphorylated tau. |
2021-08-04 |
2023-08-13 |
mouse |
| Sujin Kim, Yunkwon Nam, Min-Joo Ham, Chisoo Park, Minho Moon, Doo-Han Yo. Neurological Mechanisms of Animal-Assisted Intervention in Alzheimer's Disease: A Hypothetical Review. Frontiers in aging neuroscience. vol 13. 2021-08-03. PMID:34335229. |
this review postulates potential neurological mechanisms of emotional or social interaction through aai in countering ad-related pathologies, such as aβ deposition, tau hyperphosphorylation, neuroinflammation, and impaired adult hippocampal neurogenesis (ahn), and proposes insights for future research by organizing accumulated previous evidence. |
2021-08-03 |
2023-08-13 |
Not clear |
| Mara A Guzmán-Ruiz, Amor Herrera-González, Adriana Jiménez, Alan Candelas-Juárez, Crystal Quiroga-Lozano, Claudia Castillo-Díaz, Erika Orta-Salazar, Diana Organista-Juárez, Sofía Díaz-Cintra, Rosalinda Guevara-Guzmá. Protective effects of intracerebroventricular adiponectin against olfactory impairments in an amyloid β BMC neuroscience. vol 22. issue 1. 2021-07-31. PMID:33653273. |
studies have demonstrated that apn administration decreases aβ neurotoxicity and tau hyperphosphorylation in the hipp, reducing cognitive impairment. |
2021-07-31 |
2023-08-13 |
rat |
| Lei Zhang, Yankai Jiang, Jie Zhu, Huazheng Liang, Xiangyang He, Jiahong Qian, Hai Lin, Yubo Tao, Keqing Zh. Quantitative Assessment of Hippocampal Tau Pathology in AD and PART. Journal of molecular neuroscience : MN. vol 70. issue 11. 2021-07-29. PMID:32372343. |
quantitative assessment of hippocampal tau pathology in ad and part. |
2021-07-29 |
2023-08-13 |
Not clear |
| Lei Zhang, Yankai Jiang, Jie Zhu, Huazheng Liang, Xiangyang He, Jiahong Qian, Hai Lin, Yubo Tao, Keqing Zh. Quantitative Assessment of Hippocampal Tau Pathology in AD and PART. Journal of molecular neuroscience : MN. vol 70. issue 11. 2021-07-29. PMID:32372343. |
to quantitatively assess the distribution pattern of hippocampal tau pathology in alzheimer's disease (ad) and primary age-related tauopathy (part), we investigated the distribution of phosphorylated tau protein (at8) in 6 anatomically defined subregions of the hippocampal formation and developed a mathematical algorithm to compare the patterns of tau deposition in part and ad. |
2021-07-29 |
2023-08-13 |
Not clear |
| Karlo Toljan, Jan Homola. Circadian changes in Alzheimer's disease: Neurobiology, clinical problems, and therapeutic opportunities. Handbook of clinical neurology. vol 179. 2021-07-28. PMID:34225969. |
the understanding of alzheimer's disease (ad) pathophysiology is an active area of research, and the traditional focus on hippocampus, amyloid and tau protein, and memory impairment has been expanded with components like neuroinflammation, insulin resistance, and circadian rhythm alterations. |
2021-07-28 |
2023-08-13 |
Not clear |
| Rodrigo A Quntanilla, Carola Tapia-Monsalve. The Role of Mitochondrial Impairment in Alzheimer´s Disease Neurodegeneration: The Tau Connection. Current neuropharmacology. vol 18. issue 11. 2021-07-26. PMID:32448104. |
more importantly, tau protein contributes to the physiological regulation of mitochondria through the opening/interaction with mptp in hippocampal neurons. |
2021-07-26 |
2023-08-13 |
mouse |
| Mamen Regalado-Reyes, Ruth Benavides-Piccione, Isabel Fernaud-Espinosa, Javier DeFelipe, Gonzalo León-Espinos. Effect of Phosphorylated Tau on Cortical Pyramidal Neuron Morphology during Hibernation. Cerebral cortex communications. vol 1. issue 1. 2021-07-24. PMID:34296096. |
morphological alterations have been described in hippocampal dendritic spines during hibernation-a state of inactivity and metabolic depression that occurs via a transient neuronal tau hyperphosphorylation. |
2021-07-24 |
2023-08-13 |
Not clear |
| Wei Chen, Lingfei Jiang, Yueqiang Hu, Nong Tang, Ni Liang, Xing-Feng Li, Ye-Wen Chen, Hongling Qin, Lin W. Ferritin reduction is essential for cerebral ischemia-induced hippocampal neuronal death through p53/SLC7A11-mediated ferroptosis. Brain research. vol 1752. 2021-07-22. PMID:33333054. |
the morris water maze (mwm) test and tau hyperphosphorylation test were performed on hippocampal neurons to establish a mcao model. |
2021-07-22 |
2023-08-13 |
rat |
| Ida Cariati, Laura Masuelli, Roberto Bei, Virginia Tancredi, Claudio Frank, Giovanna D'Arcangel. Neurodegeneration in Niemann-Pick Type C Disease: An Updated Review on Pharmacological and Non-Pharmacological Approaches to Counteract Brain and Cognitive Impairment. International journal of molecular sciences. vol 22. issue 12. 2021-07-20. PMID:34202978. |
in addition, different pathological similarities, including degeneration of hippocampal and cortical neurons, hyperphosphorylated tau, and neurofibrillary tangle formation, have been identified between npc disease and other neurodegenerative pathologies. |
2021-07-20 |
2023-08-13 |
Not clear |
| Yanyan Kong, Lin Huang, Weihao Li, Xuanting Liu, Yinping Zhou, Cuiping Liu, Shibo Zhang, Fang Xie, Zhengwei Zhang, Donglang Jiang, Weiyan Zhou, Ruiqing Ni, Chencheng Zhang, Bomin Sun, Jiao Wang, Yihui Gua. The Synaptic Vesicle Protein 2A Interacts With Key Pathogenic Factors in Alzheimer's Disease: Implications for Treatment. Frontiers in cell and developmental biology. vol 9. 2021-07-20. PMID:34277597. |
we found that the expression of sv2a was down-regulated in the hippocampus of ad patients, yet the relation of sv2a to other hallmarks of ad pathology such as amyloid precursor protein (app), β-amyloid (aβ), and tau protein is not thoroughly clear. |
2021-07-20 |
2023-08-13 |
Not clear |
| Wenjin Yang, Gaoyi Li, Ke Cao, Peng Ma, Yijun Guo, Wusong Tong, Jian Wa. Exogenous insulin-like growth factor 1 attenuates acute ischemic stroke-induced spatial memory impairment via modulating inflammatory response and tau phosphorylation. Neuropeptides. vol 83. 2021-07-16. PMID:32863068. |
additionally, igf-1 attenuated tau phosphorylation in ischemic hippocampus. |
2021-07-16 |
2023-08-13 |
rat |
| Qing Xia, XinYu Yang, JiaBin Shi, ZiJie Liu, YaHui Peng, WenJing Wang, BoWen Li, Yu Zhao, JiaYing Xiao, Lei Huang, DaYong Wang, Xu Ga. The Protective A673T Mutation of Amyloid Precursor Protein (APP) in Alzheimer's Disease. Molecular neurobiology. vol 58. issue 8. 2021-07-15. PMID:33914267. |
alzheimer's disease is a progressive neurodegenerative disorder characterized by extracellular amyloid beta peptides and neurofibrillary tangles consisted of intracellular hyperphosphorylated tau in the hippocampus and cerebral cortex. |
2021-07-15 |
2023-08-13 |
Not clear |
| Shi-Dong Chen, Yu-Yuan Huang, Xue-Ning Shen, Yu Guo, Lan Tan, Qiang Dong, Jin-Tai Y. Longitudinal plasma phosphorylated tau 181 tracks disease progression in Alzheimer's disease. Translational psychiatry. vol 11. issue 1. 2021-07-14. PMID:34120152. |
a longitudinal increase of plasma p-tau181 was associated with abnormal cerebrospinal fluid biomarker levels (low aβ42, high phosphorylated tau, and high total tau, all p < 0.001), amyloid accumulation (p < 0.001) and hypometabolism (p = 0.002) on positron emission tomography, atrophy in structure imaging (small hippocampal (p = 0.030), middle temporal (p = 0.008), and whole brain (p = 0.027) volume, and large ventricular volume (p = 0.008)), and deteriorated cognitive performance (global cognition and memory, language, executive function, and visuospatial function, all p < 0.050) at baseline. |
2021-07-14 |
2023-08-13 |
human |