| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nils Richter, Gérard N Bischof, Julian Dronse, Nils Nellessen, Bernd Neumaier, Karl-Josef Langen, Alexander Drzezga, Gereon R Fink, Thilo van Eimeren, Juraj Kukolja, Oezguer A Onu. Entorhinal Tau Predicts Hippocampal Activation and Memory Deficits in Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 78. issue 4. 2021-09-29. PMID:33164934. |
entorhinal tau predicts hippocampal activation and memory deficits in alzheimer's disease. |
2021-09-29 |
2023-08-13 |
Not clear |
| Nils Richter, Gérard N Bischof, Julian Dronse, Nils Nellessen, Bernd Neumaier, Karl-Josef Langen, Alexander Drzezga, Gereon R Fink, Thilo van Eimeren, Juraj Kukolja, Oezguer A Onu. Entorhinal Tau Predicts Hippocampal Activation and Memory Deficits in Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 78. issue 4. 2021-09-29. PMID:33164934. |
recent findings indicate that tau accumulation may drive hippocampal hyperactivity in cognitively normal aging, but it remains to be elucidated how tau accumulation is related to neural activation in ad. |
2021-09-29 |
2023-08-13 |
Not clear |
| Giuseppina Amadoro, Valentina Latina, Bijorn Omar Balzamino, Rosanna Squitti, Monica Varano, Pietro Calissano, Alessandra Micer. Nerve Growth Factor-Based Therapy in Alzheimer's Disease and Age-Related Macular Degeneration. Frontiers in neuroscience. vol 15. 2021-09-29. PMID:34566573. |
according to the cholinergic hypothesis, an early and progressive synaptic and neuronal loss in a vulnerable population of basal forebrain involved in memory and learning processes leads to degeneration of cortical and hippocampal projections followed by cognitive impairment with accumulation of misfolded/aggregated aβ and tau protein. |
2021-09-29 |
2023-08-13 |
Not clear |
| Anastasie Maté de Gérando, Marie d'Orange, Emma Augustin, Charlène Joséphine, Gwénaelle Aurégan, Mylène Gaudin-Guérif, Martine Guillermier, Anne-Sophie Hérard, Lev Stimmer, Fanny Petit, Pauline Gipchtein, Caroline Jan, Carole Escartin, Erwan Selingue, Kévin Carvalho, David Blum, Emmanuel Brouillet, Philippe Hantraye, Marie-Claude Gaillard, Gilles Bonvento, Alexis-Pierre Bemelmans, Karine Cambo. Neuronal tau species transfer to astrocytes and induce their loss according to tau aggregation state. Brain : a journal of neurology. vol 144. issue 4. 2021-09-24. PMID:33842937. |
using stereological counting of astrocytes, we report that, as for neurons, soluble tau species are highly toxic to some subpopulations of astrocytes in the hippocampus, whereas the accumulation of tau aggregates does not affect their survival. |
2021-09-24 |
2023-08-13 |
mouse |
| Ryan A Wirt, Lauren A Crew, Andrew A Ortiz, Adam M McNeela, Emmanuel Flores, Jefferson W Kinney, James M Hyma. Altered theta rhythm and hippocampal-cortical interactions underlie working memory deficits in a hyperglycemia risk factor model of Alzheimer's disease. Communications biology. vol 4. issue 1. 2021-09-24. PMID:34480097. |
it is thought that chronic hyperglycemia leads to neuroinflammation and tau hyperphosphorylation in the hippocampus leading to cognitive decline, but effects on hippocampal network activity are unknown. |
2021-09-24 |
2023-08-13 |
human |
| Ryan A Wirt, Lauren A Crew, Andrew A Ortiz, Adam M McNeela, Emmanuel Flores, Jefferson W Kinney, James M Hyma. Altered theta rhythm and hippocampal-cortical interactions underlie working memory deficits in a hyperglycemia risk factor model of Alzheimer's disease. Communications biology. vol 4. issue 1. 2021-09-24. PMID:34480097. |
consistent with previous investigations, we found increases in phosphorylated tau in stz animals' hippocampus and cortex, which might account for the observed oscillatory and cognitive changes. |
2021-09-24 |
2023-08-13 |
human |
| María Florencia Zappa Villar, Juliette López Hanotte, Rosana Crespo, Joaquín Pardo, Paula Cecilia Reggian. Insulin-like growth factor 1 gene transfer for sporadic Alzheimer's disease: New evidence for trophic factor mediated hippocampal neuronal and synaptic recovery-based behavior improvement. Hippocampus. vol 31. issue 10. 2021-09-21. PMID:34324234. |
this approach enhanced igf1 signaling in the hippocampus and dampened sad phosphorylated tau. |
2021-09-21 |
2023-08-13 |
rat |
| María Florencia Zappa Villar, Juliette López Hanotte, Rosana Crespo, Joaquín Pardo, Paula Cecilia Reggian. Insulin-like growth factor 1 gene transfer for sporadic Alzheimer's disease: New evidence for trophic factor mediated hippocampal neuronal and synaptic recovery-based behavior improvement. Hippocampus. vol 31. issue 10. 2021-09-21. PMID:34324234. |
we conclude that exogenous activation of igf1 signaling pathway, 1 week after intracerebroventricular stz administration, protects hippocampal immature neurons, dampens phosphorylated tau levels, improves synaptic function and therefore performs therapeutically on the sad stz model. |
2021-09-21 |
2023-08-13 |
rat |
| Christopher J Harris, Nora E Gray, Maya Caruso, Marguex Hunter, Martina Ralle, Joseph F Quin. Copper Modulation and Memory Impairment due to Hippocampal Tau Pathology Journal of Alzheimer's disease : JAD. vol 78. issue 1. 2021-09-20. PMID:32250309. |
copper modulation and memory impairment due to hippocampal tau pathology background:environmental copper has been implicated in the pathogenesis of alzheimer’s disease based on evidence that: 1) brain copper levels increase with age, 2) copper promotes misfolding and toxicity of amyloid-β in vitro, 3) copper-modulating interventions reduce amyloid pathology in animal models. |
2021-09-20 |
2023-08-13 |
mouse |
| Cihao Jiang, Yi Zhang, Xiaolu Tang, Chenchen Jing, Shasha Qiu, Baolin Li, Yanning L. IL-6 and IL-1β upregulation and tau protein phosphorylation in response to chronic alcohol exposure in the mouse hippocampus. Neuroreport. vol 32. issue 10. 2021-09-20. PMID:34029285. |
il-6 and il-1β upregulation and tau protein phosphorylation in response to chronic alcohol exposure in the mouse hippocampus. |
2021-09-20 |
2023-08-13 |
mouse |
| Cihao Jiang, Yi Zhang, Xiaolu Tang, Chenchen Jing, Shasha Qiu, Baolin Li, Yanning L. IL-6 and IL-1β upregulation and tau protein phosphorylation in response to chronic alcohol exposure in the mouse hippocampus. Neuroreport. vol 32. issue 10. 2021-09-20. PMID:34029285. |
as inflammatory cytokines have been shown to regulate tau phosphorylation, in the present study, the aim was to determine whether cognitive impairment caused by chronic alcohol exposure is associated with neuroinflammation and tau hyperphosphorylation in the hippocampus. |
2021-09-20 |
2023-08-13 |
mouse |
| Cihao Jiang, Yi Zhang, Xiaolu Tang, Chenchen Jing, Shasha Qiu, Baolin Li, Yanning L. IL-6 and IL-1β upregulation and tau protein phosphorylation in response to chronic alcohol exposure in the mouse hippocampus. Neuroreport. vol 32. issue 10. 2021-09-20. PMID:34029285. |
immunohistochemical and western blot assays were used to assess the expression levels of il-1β and il-6, as well as tau protein and its phosphorylation status in the hippocampus. |
2021-09-20 |
2023-08-13 |
mouse |
| Cihao Jiang, Yi Zhang, Xiaolu Tang, Chenchen Jing, Shasha Qiu, Baolin Li, Yanning L. IL-6 and IL-1β upregulation and tau protein phosphorylation in response to chronic alcohol exposure in the mouse hippocampus. Neuroreport. vol 32. issue 10. 2021-09-20. PMID:34029285. |
our results showed that chronic alcohol exposure impaired the spatial recognition ability of mice upregulated the expression of il-1β and il-6 in the serum and hippocampus and increased the phosphorylation of tau protein in the hippocampus. |
2021-09-20 |
2023-08-13 |
mouse |
| Cihao Jiang, Yi Zhang, Xiaolu Tang, Chenchen Jing, Shasha Qiu, Baolin Li, Yanning L. IL-6 and IL-1β upregulation and tau protein phosphorylation in response to chronic alcohol exposure in the mouse hippocampus. Neuroreport. vol 32. issue 10. 2021-09-20. PMID:34029285. |
the present results indicate that hippocampal il-1β, il-6, and phosphorylated tau proteins may be involved in the neurotoxic mechanism of chronic alcohol exposure by mediating synaptic dysfunction. |
2021-09-20 |
2023-08-13 |
mouse |
| Akinori Futamura, Sotaro Hieda, Yukiko Mori, Azusa Sugimoto, Hideyo Kasai, Takeshi Kuroda, Satoshi Yano, Kensaku Kasuga, Hidetomo Murakami, Takeshi Ikeuchi, Kenjiro On. Cingulate Island Sign in Single Photon Emission Computed Tomography: Clinical Biomarker Correlations in Lewy Body Disease and Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 79. issue 3. 2021-09-17. PMID:33361600. |
our results showed cis was not related to csf biomarkers in lbd and high csf tau levels were related to clinical disease severity and hippocampal atrophy. |
2021-09-17 |
2023-08-13 |
Not clear |
| Jack C de la Torr. Deciphering Alzheimer's Disease Pathogenic Pathway: Role of Chronic Brain Hypoperfusion on p-Tau and mTOR. Journal of Alzheimer's disease : JAD. vol 79. issue 4. 2021-09-15. PMID:33459641. |
new biomolecular findings reveal the interplay of cbh in increasing tau phosphorylation (p-tau) in the hippocampus and cortex of ad mice, damaging fast axonal transport, increasing signaling of mammalian target of rapamycin (mtor), impairing learning-memory function, and promoting the formation of neurofibrillary tangles, a neuropathologic hallmark of ad. |
2021-09-15 |
2023-08-13 |
mouse |
| Lei Huang, Yang Zhang, Yongwei Wang, Yajia La. Relationship Between Chronic Noise Exposure, Cognitive Impairment, and Degenerative Dementia: Update on the Experimental and Epidemiological Evidence and Prospects for Further Research. Journal of Alzheimer's disease : JAD. vol 79. issue 4. 2021-09-15. PMID:33459723. |
experimental studies have indicated that long-term exposure to noise might accelerate cognitive dysfunction, amyloid-β deposition, and tau hyperphosphorylation in different brain regions such as the hippocampus and cortex. |
2021-09-15 |
2023-08-13 |
Not clear |
| Anastasia Noël, Bénédicte Foveau, Andréa C LeBlan. Caspase-6-cleaved Tau fails to induce Tau hyperphosphorylation and aggregation, neurodegeneration, glial inflammation, and cognitive deficits. Cell death & disease. vol 12. issue 3. 2021-09-14. PMID:33649324. |
intraneuronal hippocampal tau hyperphosphorylation at s202/t205, s422, and t231, and tau conformational change were absent in both ctc and cto brains. |
2021-09-14 |
2023-08-13 |
mouse |
| Anastasia Noël, Bénédicte Foveau, Andréa C LeBlan. Caspase-6-cleaved Tau fails to induce Tau hyperphosphorylation and aggregation, neurodegeneration, glial inflammation, and cognitive deficits. Cell death & disease. vol 12. issue 3. 2021-09-14. PMID:33649324. |
a slight accumulation of tau phosphorylated at s396/404 and s202 was observed in cornu ammonis 1 (ca1) hippocampal neuron soma of ctc compared to cto brains. |
2021-09-14 |
2023-08-13 |
mouse |
| Guanghong Sui, Caixia Yang, Lu Wang, Xiangyang Xiong, Mengtian Guo, Zheng Chen, Feng Wan. Exogenous IGF-1 improves tau pathology and neuronal pyroptosis in high-fat diet mice with cognitive dysfunction. Metabolic brain disease. vol 36. issue 7. 2021-09-14. PMID:34269982. |
during in vitro experiment, high-fat diet mice showed cognitive dysfunction, significant hyperphosphorylation of tau protein and neuronal pyroptosis in hippocampus compared with the sham mice. |
2021-09-14 |
2023-08-13 |
mouse |