| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Carlos M Soto-Faguás, Paula Sanchez-Molina, Carlos A Saur. Loss of presenilin function enhances tau phosphorylation and aggregation in mice. Acta neuropathologica communications. vol 9. issue 1. 2021-11-05. PMID:34593029. |
interestingly, genetic inactivation of presenilin 1 (ps1) or both ps genes in mutant human tau transgenic mice exacerbates memory deficits by accelerating phosphorylation and aggregation of tau in excitatory neurons of vulnerable ad brain regions (e.g., hippocampus, cortex and amygdala). |
2021-11-05 |
2023-08-13 |
mouse |
| Sadhana Ravikumar, Laura E M Wisse, Sydney Lim, Ranjit Ittyerah, Long Xie, Madigan L Bedard, Sandhitsu R Das, Edward B Lee, M Dylan Tisdall, Karthik Prabhakaran, Jacqueline Lane, John A Detre, Gabor Mizsei, John Q Trojanowski, John L Robinson, Theresa Schuck, Murray Grossman, Emilio Artacho-Pérula, Maria Mercedes Iñiguez de Onzoño Martin, María Del Mar Arroyo Jiménez, Monica Muñoz, Francisco Javier Molina Romero, Maria Del Pilar Marcos Rabal, Sandra Cebada Sánchez, José Carlos Delgado González, Carlos de la Rosa Prieto, Marta Córcoles Parada, David J Irwin, David A Wolk, Ricardo Insausti, Paul A Yushkevic. Ex vivo MRI atlas of the human medial temporal lobe: characterizing neurodegeneration due to tau pathology. Acta neuropathologica communications. vol 9. issue 1. 2021-11-05. PMID:34689831. |
when focusing on cases with low levels of tdp-43 pathology, we found strong associations between tau pathology and thickness in the erc, srlm and the subiculum/cornu ammonis 1 (ca1) subfields of the hippocampus, consistent with early braak stages. |
2021-11-05 |
2023-08-13 |
human |
| Sanila Amber, Sumera, Fatima J Mirza, Muhammad Asif, Deeba Hassan, Touqeer Ahmed, Saadia Zahi. Amyloid-beta Induced Neurotoxicity Impairs Cognition and Adult Hippocampal Neurogenesis in a Mouse Model for Alzheimer's Disease. Current Alzheimer research. vol 17. issue 11. 2021-11-04. PMID:33357181. |
in the past few years, impaired adult hippocampal neurogenesis emerged as a contributing hallmark of ad pathophysiology along with amyloid beta (aβ) and tau hyper phosphorylation-induced neurotoxicity. |
2021-11-04 |
2023-08-13 |
mouse |
| Jing-Hua Zhang, Jin-Feng Zhang, Jun Song, Yu Bai, Lan Deng, Chun-Peng Feng, Xin-Yao Xu, Hong-Xia Guo, Yi Wang, Xin Gao, Yan Gu, Chuan Jin, Jun-Fu Zheng, Zhong Zhen, Hao S. Effects of Berberine on Diabetes and Cognitive Impairment in an Animal Model: The Mechanisms of Action. The American journal of Chinese medicine. vol 49. issue 6. 2021-11-04. PMID:34137676. |
serum and hippocampal [formula: see text]-amyloid peptide (a[formula: see text], tau and phosphorylated tau protein deposition in the hippocampi were measured. |
2021-11-04 |
2023-08-13 |
rat |
| Jing-Hua Zhang, Jin-Feng Zhang, Jun Song, Yu Bai, Lan Deng, Chun-Peng Feng, Xin-Yao Xu, Hong-Xia Guo, Yi Wang, Xin Gao, Yan Gu, Chuan Jin, Jun-Fu Zheng, Zhong Zhen, Hao S. Effects of Berberine on Diabetes and Cognitive Impairment in an Animal Model: The Mechanisms of Action. The American journal of Chinese medicine. vol 49. issue 6. 2021-11-04. PMID:34137676. |
berberine also effectively decreased the expression of hippocampal tau protein, phosphorylated tau, and increased insulin receptor antibodies. |
2021-11-04 |
2023-08-13 |
rat |
| Jing-Hua Zhang, Jin-Feng Zhang, Jun Song, Yu Bai, Lan Deng, Chun-Peng Feng, Xin-Yao Xu, Hong-Xia Guo, Yi Wang, Xin Gao, Yan Gu, Chuan Jin, Jun-Fu Zheng, Zhong Zhen, Hao S. Effects of Berberine on Diabetes and Cognitive Impairment in an Animal Model: The Mechanisms of Action. The American journal of Chinese medicine. vol 49. issue 6. 2021-11-04. PMID:34137676. |
moreover, berberine downregulated the abnormal phosphorylation of a[formula: see text] and tau protein and improved hippocampal insulin signaling. |
2021-11-04 |
2023-08-13 |
rat |
| Jing-Hua Zhang, Jin-Feng Zhang, Jun Song, Yu Bai, Lan Deng, Chun-Peng Feng, Xin-Yao Xu, Hong-Xia Guo, Yi Wang, Xin Gao, Yan Gu, Chuan Jin, Jun-Fu Zheng, Zhong Zhen, Hao S. Effects of Berberine on Diabetes and Cognitive Impairment in an Animal Model: The Mechanisms of Action. The American journal of Chinese medicine. vol 49. issue 6. 2021-11-04. PMID:34137676. |
the reduction of neuronal injury, a[formula: see text] deposition, abnormal phosphorylation of tau protein, and neuronal apoptosis in the hippocampus were observed as the related mechanisms of action. |
2021-11-04 |
2023-08-13 |
rat |
| Austin T Marckx, Katja E Fritschle, Laurent Calvier, Joachim Her. Reelin changes hippocampal learning in aging and Alzheimer's disease. Behavioural brain research. vol 414. 2021-11-04. PMID:34333070. |
additionally, we hypothesized that reelin deficiency in the presence of mutated human microtubule associated protein tau (mapt) would further impair hippocampal function. |
2021-11-04 |
2023-08-13 |
mouse |
| Behrus Puladi, Maja Dinekov, Thomas Arzberger, Max Taubert, Christoph Köhle. The relation between tau pathology and granulovacuolar degeneration of neurons. Neurobiology of disease. vol 147. 2021-11-01. PMID:33069844. |
the entorhinal cortex, drn, and lc are among the regions that display pathological changes of tau earliest, whereas neurons with gvbs occur first in the hippocampus and have been found in oral raphe nuclei only at the most advanced gvd stage. |
2021-11-01 |
2023-08-13 |
human |
| Behrus Puladi, Maja Dinekov, Thomas Arzberger, Max Taubert, Christoph Köhle. The relation between tau pathology and granulovacuolar degeneration of neurons. Neurobiology of disease. vol 147. 2021-11-01. PMID:33069844. |
we studied the relation between tau pathology and gvd in field ca1 of the hippocampus, entorhinal cortex, dorsal (drn) and median (mrn) raphe nucleus, and locus coeruleus from elderly subjects with braak & braak stages of tau pathology ranging from 0 to vi. |
2021-11-01 |
2023-08-13 |
human |
| Jean-Christophe Delpech, Dhruba Pathak, Merina Varghese, Srinidhi Venkatesan Kalavai, Emma C Hays, Patrick R Hof, W Evan Johnson, Seiko Ikezu, Maria Medalla, Jennifer I Luebke, Tsuneya Ikez. Wolframin-1-expressing neurons in the entorhinal cortex propagate tau to CA1 neurons and impair hippocampal memory in mice. Science translational medicine. vol 13. issue 611. 2021-11-01. PMID:34524859. |
wolframin-1-expressing neurons in the entorhinal cortex propagate tau to ca1 neurons and impair hippocampal memory in mice. |
2021-11-01 |
2023-08-13 |
mouse |
| Zhiyong Zhao, Lei Zhang, Qingqing Wen, Wanrong Luo, Weihao Zheng, Tingting Liu, Yi Zhang, Keqing Zhu, Dan W. The effect of beta-amyloid and tau protein aggregations on magnetic susceptibility of anterior hippocampal laminae in Alzheimer's diseases. NeuroImage. vol 244. 2021-11-01. PMID:34537383. |
the effect of beta-amyloid and tau protein aggregations on magnetic susceptibility of anterior hippocampal laminae in alzheimer's diseases. |
2021-11-01 |
2023-08-13 |
Not clear |
| Zhiyong Zhao, Lei Zhang, Qingqing Wen, Wanrong Luo, Weihao Zheng, Tingting Liu, Yi Zhang, Keqing Zhu, Dan W. The effect of beta-amyloid and tau protein aggregations on magnetic susceptibility of anterior hippocampal laminae in Alzheimer's diseases. NeuroImage. vol 244. 2021-11-01. PMID:34537383. |
the present study aims to investigate layer-specific magnetic susceptibility in the hippocampus of ad patients using high-resolution ex-vivo mri, and elucidate its relationship with beta amyloid (aβ) and tau protein histology. |
2021-11-01 |
2023-08-13 |
Not clear |
| Zhiyong Zhao, Lei Zhang, Qingqing Wen, Wanrong Luo, Weihao Zheng, Tingting Liu, Yi Zhang, Keqing Zhu, Dan W. The effect of beta-amyloid and tau protein aggregations on magnetic susceptibility of anterior hippocampal laminae in Alzheimer's diseases. NeuroImage. vol 244. 2021-11-01. PMID:34537383. |
we manually segmented each sample into seven layers, including four layers in the cornu ammonis1 (ca1) and three layers in the dentate gyrus (dg), and then evaluated ad-related alterations of susceptibility and t2* values and their correlations with aβ and tau in each hippocampal layer. |
2021-11-01 |
2023-08-13 |
Not clear |
| D G Coughlin, R Ittyerah, C Peterson, J S Phillips, S Miller, K Rascovsky, D Weintraub, A D Siderowf, J E Duda, H I Hurtig, D A Wolk, C T McMillan, P A Yushkevich, M Grossman, E B Lee, J Q Trojanowski, D J Irwi. Hippocampal subfield pathologic burden in Lewy body diseases vs. Alzheimer's disease. Neuropathology and applied neurobiology. vol 46. issue 7. 2021-10-28. PMID:32892355. |
here we use digital histological methods to test the association between hippocampal syn pathology and the distribution of tau and amyloid-beta (aβ) pathology in lbd and contrast with ad subjects. |
2021-10-28 |
2023-08-13 |
human |
| Bin Wu, Haiqing Cai, Shen Tang, Yilu Xu, Qianqian Shi, Lancheng Wei, Ling Meng, Ning Zhang, Xinhang Wang, Deqiang Xiao, Yunfeng Zou, Xiaobo Yang, Xiyi Li, Cailing L. Methionine-Mediated Protein Phosphatase 2A Catalytic Subunit (PP2Ac) Methylation Ameliorates the Tauopathy Induced by Manganese in Cell and Animal Models. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. vol 17. issue 4. 2021-10-28. PMID:32959271. |
we show that mn-induced neurotoxicity is characterized by pp2ac demethylation accompanied by abnormally decreased lcmt-1 and increased pme-1, which are associated with tau hyperphosphorylation and spatial learning and memory deficits, and that the poor availability of sam in the hippocampus is likely to determine the loss of pp2ac methylation. |
2021-10-28 |
2023-08-13 |
rat |
| Che-Yu Hsu, Kuan-Ting Lee, Tzu-Yu Sun, Chun-I Sze, Shenq-Shyang Huang, Li-Jin Hsu, Nan-Shan Chan. WWOX and Its Binding Proteins in Neurodegeneration. Cells. vol 10. issue 7. 2021-10-28. PMID:34359949. |
gradual loss of wwox protein in the hippocampus and cortex starting from middle age may slowly induce aggregation of a protein cascade that ultimately causes accumulation of extracellular amyloid beta plaques and intracellular tau tangles, along with reduction in inhibitory gabaergic interneurons, in ad patients over 70 years old. |
2021-10-28 |
2023-08-13 |
mouse |
| Meijuan Zhu, Yanhua Zhao, Yongjun Zheng, Diansan Su, Xiangrui Wan. Relative Higher Hematocrit Attenuates the Cerebral Excitatory Amino Acid Elevation Induced by Deep Hypothermic Circulatory Arrest in Rats. Therapeutic hypothermia and temperature management. vol 3. issue 3. 2021-10-21. PMID:24066268. |
high-performance liquid chromatography was used to determine the concentration of glutamate (glu), aspartate (asp), glycine (gly), gamma-aminobutyric acid (gaba), and taurine (tau) in the cerebral cortex, hippocampus, and thalamus. |
2021-10-21 |
2023-08-12 |
rat |
| Vivek Kumar Sharma, Thakur Gurjeet Singh, Shareen Singh, Nikhil Garg, Sonia Dhima. Apoptotic Pathways and Alzheimer's Disease: Probing Therapeutic Potential. Neurochemical research. vol 46. issue 12. 2021-10-21. PMID:34386919. |
the well-characterized pathological features of ad, including extracellular plaques of amyloid-beta, intracellular hyperphosphorylated tangles of tau protein (nfts), inflammation, mitochondrial dysfunction, oxidative stress, and excitotoxic cell death, also instigate an abnormal apoptotic cascade in susceptible brain regions (cerebral cortex, hippocampus). |
2021-10-21 |
2023-08-13 |
Not clear |
| Troy T Rohn, Polina Kokoulin. Caspase-cleaved TAR DNA-binding protein-43 in Pick's disease. International journal of physiology, pathophysiology and pharmacology. vol 1. issue 1. 2021-10-20. PMID:20411029. |
co-localization of tdpccp with phf-1, a general marker for pick bodies, as well as with an antibody to caspase-cleaved tau (tauc3) was evident within the hippocampus. |
2021-10-20 |
2023-08-12 |
Not clear |