| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Seong Su Kang, Eun Hee Ahn, Xia Liu, Matthew Bryson, Gary W Miller, David Weinshenker, Keqiang Y. ApoE4 inhibition of VMAT2 in the locus coeruleus exacerbates Tau pathology in Alzheimer's disease. Acta neuropathologica. vol 142. issue 1. 2021-10-19. PMID:33895869. |
our data reveal that apoe4 boosts tau neurotoxicity via vmat2 inhibition, reduces hippocampal volume, and induces cognitive dysfunction in an aep- and tau n368-dependent manner, while conversely apoe3 binds tau and protects it from cleavage. |
2021-10-19 |
2023-08-13 |
human |
| Xingyu Zhang, Li Zou, Lanxia Meng, Min Xiong, Lina Pan, Guiqin Chen, Yongfa Zheng, Jing Xiong, Zhihao Wang, Duc M Duong, Zhaohui Zhang, Xuebing Cao, Tao Wang, Li Tang, Keqiang Ye, Zhentao Zhan. Amphiphysin I cleavage by asparagine endopeptidase leads to tau hyperphosphorylation and synaptic dysfunction. eLife. vol 10. 2021-10-18. PMID:34018922. |
overexpression of amphiphysin i (1-278) in the hippocampus of tau p301s mice induces synaptic dysfunction, tau hyperphosphorylation, and cognitive deficits. |
2021-10-18 |
2023-08-13 |
mouse |
| Changhe Ren, Milian Chen, Guo Mu, Suangchun Peng, Xiangbo Liu, Cehua O. NLRP3 Inflammasome Mediates Neurodegeneration in Rats with Chronic Neuropathic Pain. Shock (Augusta, Ga.). vol 56. issue 5. 2021-10-18. PMID:34265833. |
in addition, tau hyperphosphorylation and aβ expression increase in the cortex and hippocampus of the brain. |
2021-10-18 |
2023-08-13 |
rat |
| Kurt A Jellinge. Neuropathological assessment of the Alzheimer spectrum. Journal of neural transmission (Vienna, Austria : 1996). vol 127. issue 9. 2021-10-15. PMID:32740684. |
ad is a mixed proteinopathy (amyloid and tau), frequently associated with other age-related co-pathologies, such as cerebrovascular lesions, lewy and tdp-43 pathologies, hippocampal sclerosis, or argyrophilic grain disease. |
2021-10-15 |
2023-08-13 |
Not clear |
| M D Morsy, M A Alsaleem, M S Aboonq, S O Bashir, H A Al-Dahe. Acylated Ghrelin Administration Inhibits Sleeve Gastrectomy-Induced Hippocampal Oxidative Stress, Apoptosis and Tau-Hyperphosphorylation by Activating the PI3K/Akt Pathway. Folia biologica. vol 67. issue 2. 2021-10-12. PMID:34624937. |
concomitantly, it inhibited the hippocampal activity of akt and increased the activity of glycogen synthase kinase 3β and tau protein phosphorylation. |
2021-10-12 |
2023-08-13 |
rat |
| M D Morsy, M A Alsaleem, M S Aboonq, S O Bashir, H A Al-Dahe. Acylated Ghrelin Administration Inhibits Sleeve Gastrectomy-Induced Hippocampal Oxidative Stress, Apoptosis and Tau-Hyperphosphorylation by Activating the PI3K/Akt Pathway. Folia biologica. vol 67. issue 2. 2021-10-12. PMID:34624937. |
in conclusion, ag replacement therapy after sg in rats protects them against memory deficits and hippocampal damage by suppressing tau protein phosphorylation, mediated by activating pi3k/aktinduced inhibition of glycogen synthase kinase 3β. |
2021-10-12 |
2023-08-13 |
rat |
| Paula Duarte-Guterman, Arianne Y Albert, Cindy K Barha, Liisa A M Galea, On Behalf Of The Alzheimer's Disease Neuroimaging Initiativ. Sex influences the effects of APOE genotype and Alzheimer's diagnosis on neuropathology and memory. Psychoneuroendocrinology. vol 129. 2021-10-11. PMID:33962245. |
using the adni database (n = 630 females, n = 830 males), we analyzed the effect of sex, apoe genotype (non-carriers or carriers of apoeε4 alleles), and diagnosis (cognitively normal (cn), early amci (emci), late amci (lmci), probable ad) on cognition (memory and executive function), hippocampal volume, and ad biomarkers (csf levels of amyloid beta, tau, and ptau). |
2021-10-11 |
2023-08-13 |
Not clear |
| Jing Cai, Junyong Ruan, Xi Shao, Yuanjun Ding, Kangning Xie, Chi Tang, Zedong Yan, Erping Luo, Da Jin. Oxygen Enrichment Mitigates High-Altitude Hypoxia-Induced Hippocampal Neurodegeneration and Memory Dysfunction Associated with Attenuated Tau Phosphorylation. High altitude medicine & biology. vol 22. issue 3. 2021-10-11. PMID:34348049. |
oxygen enrichment mitigates high-altitude hypoxia-induced hippocampal neurodegeneration and memory dysfunction associated with attenuated tau phosphorylation. |
2021-10-11 |
2023-08-13 |
Not clear |
| Jing Cai, Junyong Ruan, Xi Shao, Yuanjun Ding, Kangning Xie, Chi Tang, Zedong Yan, Erping Luo, Da Jin. Oxygen Enrichment Mitigates High-Altitude Hypoxia-Induced Hippocampal Neurodegeneration and Memory Dysfunction Associated with Attenuated Tau Phosphorylation. High altitude medicine & biology. vol 22. issue 3. 2021-10-11. PMID:34348049. |
oxygen enrichment mitigates high-altitude hypoxia-induced hippocampal neurodegeneration and memory dysfunction associated with attenuated tau phosphorylation. |
2021-10-11 |
2023-08-13 |
Not clear |
| Julien Lagarde, Pauline Olivieri, Matteo Tonietto, Philippe Gervais, Claude Comtat, Fabien Caillé, Michel Bottlaender, Marie Sarazi. Distinct amyloid and tau PET signatures are associated with diverging clinical and imaging trajectories in patients with amnestic syndrome of the hippocampal type. Translational psychiatry. vol 11. issue 1. 2021-10-11. PMID:34588422. |
distinct amyloid and tau pet signatures are associated with diverging clinical and imaging trajectories in patients with amnestic syndrome of the hippocampal type. |
2021-10-11 |
2023-08-13 |
Not clear |
| Julien Lagarde, Pauline Olivieri, Matteo Tonietto, Philippe Gervais, Claude Comtat, Fabien Caillé, Michel Bottlaender, Marie Sarazi. Distinct amyloid and tau PET signatures are associated with diverging clinical and imaging trajectories in patients with amnestic syndrome of the hippocampal type. Translational psychiatry. vol 11. issue 1. 2021-10-11. PMID:34588422. |
we aimed to investigate the amyloid and tau pet imaging signatures of patients with amnestic syndrome of the hippocampal type (asht) and study their clinical and imaging progression according to their initial pet imaging status. |
2021-10-11 |
2023-08-13 |
Not clear |
| Tarek M Mohamed, Menna Allah M Youssef, Azza A Bakry, Mai M El-Kei. Alzheimer's disease improved through the activity of mitochondrial chain complexes and their gene expression in rats by boswellic acid. Metabolic brain disease. vol 36. issue 2. 2021-10-05. PMID:33159653. |
as a result, an increase in hippocampus glucose, tau protein expression, mda and glut2 in the ad group (g3) compared to control groups (g1 and g2) has been recorded. |
2021-10-05 |
2023-08-13 |
rat |
| Michelle Lima Garcez, Ricardo Chiengo Sapalo Cassoma, Francielle Mina, Tatiani Bellettini-Santos, Aline Pereira da Luz, Gustavo Luis Schiavo, Eduarda Behenck Medeiros, Ana Carolina Brunatto Falchetti Campos, Sabrina da Silva, Lisienny Campoli Tono Rempel, Amanda Valnier Steckert, Tatiana Barichello, Josiane Budn. Folic acid prevents habituation memory impairment and oxidative stress in an aging model induced by D-galactose. Metabolic brain disease. vol 36. issue 2. 2021-10-05. PMID:33219893. |
d-gal induced synaptophysin and bcl-2 decrease in the hippocampus and phosphorylated tau increase in the prefrontal cortex. |
2021-10-05 |
2023-08-13 |
rat |
| Jing Li, Junxiang Wang, Yuan-Liang Wang, Zhousong Luo, Chunyan Zheng, Guangxia Yu, Siying Wu, Fuli Zheng, Huangyuan L. NOX2 activation contributes to cobalt nanoparticles-induced inflammatory responses and Tau phosphorylation in mice and microglia. Ecotoxicology and environmental safety. vol 225. 2021-10-05. PMID:34492628. |
moreover, both total unphosphorylated tau and phosphorylated tau (ptau; t231 and s262) expressions in the hippocampus and cortex were upregulated, unveiling tau phosphorylation. |
2021-10-05 |
2023-08-13 |
mouse |
| Jiaojiao Huang, Xuemin Peng, Rongping Fan, Kun Dong, Xiaoli Shi, Shujun Zhang, Xuefeng Yu, Yan Yan. Disruption of Circadian Clocks Promotes Progression of Alzheimer's Disease in Diabetic Mice. Molecular neurobiology. vol 58. issue 9. 2021-10-04. PMID:34018152. |
we also found that the hyperphosphorylated tau protein exhibited more disruptive daily oscillations in db/db mice hippocampus under the 6:18 light/dark cycle. |
2021-10-04 |
2023-08-13 |
mouse |
| Marco Bucci, Konstantinos Chiotis, Agneta Nordber. Alzheimer's disease profiled by fluid and imaging markers: tau PET best predicts cognitive decline. Molecular psychiatry. 2021-10-01. PMID:34593971. |
agreement between csf (amyloid-β-1-42(a), phosphorylated-tau181(t), total-tau(n)), and imaging (amyloid-β pet (florbetaben and florbetapir)(a), tau pet (flortaucipir)(t), hippocampal volume (mri)(n)) positivity in atn was assessed with cohen's kappa. |
2021-10-01 |
2023-08-13 |
human |
| Sharay E Setti, Miranda N Ree. Network activity changes in the pathophysiology of Alzheimer's disease: the role of aging and early entorhinal cortex dysfunction. Metabolic brain disease. 2021-09-30. PMID:34591222. |
this review focuses on evidence in the literature that describes how one potential age-related change, that of glutamate-mediated increases in neuronal activity, may ultimately increase the risk of developing ad and promote the spread of tau pathology in ad-affected brains from the ec to later regions such as the hippocampus and prefrontal cortex. |
2021-09-30 |
2023-08-13 |
Not clear |
| Alberto Fernández, Lucía Vaquero, Ricardo Bajo, Pilar Zuluag. Apolipoprotein E ɛ4-related effects on cognition are limited to the Alzheimer's disease spectrum. GeroScience. 2021-09-30. PMID:34591236. |
our analyses included apoe4 genotype, neuropsychological variables, amyloid-βeta (aβ) and tau markers, fdg-pet values, and hippocampal volumetry data derived from the healthy controls sample of the adni database. |
2021-09-30 |
2023-08-13 |
human |
| Nils Richter, Gérard N Bischof, Julian Dronse, Nils Nellessen, Bernd Neumaier, Karl-Josef Langen, Alexander Drzezga, Gereon R Fink, Thilo van Eimeren, Juraj Kukolja, Oezguer A Onu. Entorhinal Tau Predicts Hippocampal Activation and Memory Deficits in Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 78. issue 4. 2021-09-29. PMID:33164934. |
entorhinal tau predicts hippocampal activation and memory deficits in alzheimer's disease. |
2021-09-29 |
2023-08-13 |
Not clear |
| Nils Richter, Gérard N Bischof, Julian Dronse, Nils Nellessen, Bernd Neumaier, Karl-Josef Langen, Alexander Drzezga, Gereon R Fink, Thilo van Eimeren, Juraj Kukolja, Oezguer A Onu. Entorhinal Tau Predicts Hippocampal Activation and Memory Deficits in Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 78. issue 4. 2021-09-29. PMID:33164934. |
recent findings indicate that tau accumulation may drive hippocampal hyperactivity in cognitively normal aging, but it remains to be elucidated how tau accumulation is related to neural activation in ad. |
2021-09-29 |
2023-08-13 |
Not clear |