| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Md Sahab Uddin, Anna Stachowiak, Abdullah Al Mamun, Nikolay T Tzvetkov, Shinya Takeda, Atanas G Atanasov, Leandro B Bergantin, Mohamed M Abdel-Daim, Adrian M Stankiewic. Autophagy and Alzheimer's Disease: From Molecular Mechanisms to Therapeutic Implications. Frontiers in aging neuroscience. vol 10. 2021-04-09. PMID:29441009. |
it is characterized by a progressive and irreversible loss of cognitive abilities and formation of senile plaques, composed mainly of amyloid \xce\xb2 (a\xce\xb2), and neurofibrillary tangles (nfts), composed of tau protein, in the hippocampus and cortex of afflicted humans. |
2021-04-09 |
2023-08-13 |
Not clear |
| Xiaoqing Zhang, Juan Li, Li Ma, Hui Xu, Yun Cao, Wei Liang, Jia Ma, Z Peter Wang, Yuyun L. BMP4 overexpression induces the upregulation of APP/Tau and memory deficits in Alzheimer's disease. Cell death discovery. vol 7. issue 1. 2021-04-02. PMID:33723239. |
moreover, their hippocampal tissues exhibited high expression levels of ad-related proteins, including app, a\xce\xb2, psen-1, tau, p-tau (thr181), and p-tau (thr231). |
2021-04-02 |
2023-08-13 |
mouse |
| Julie Pilliod, Alexandre Desjardins, Camille Pern\\xc3\\xa8gre, H\\xc3\\xa9l\\xc3\\xa8ne Jamann, Catherine Larochelle, Edward A Fon, Nicole Lecler. Clearance of intracellular tau protein from neuronal cells via VAMP8-induced secretion. The Journal of biological chemistry. vol 295. issue 51. 2021-04-01. PMID:33454017. |
increased tau secretion by vamp8 was also observed in murine hippocampal slices. |
2021-04-01 |
2023-08-13 |
Not clear |
| Ali H Abu Almaaty, Rehab M Mosaad, Mohamed K Hassan, Elham H A Ali, Ghada A Mahmoud, Hassan Ahmed, Nahla Anber, Saad Alkahtani, Mohamed M Abdel-Daim, Lotfi Aleya, Seddik Hamma. Urtica dioica extracts abolish scopolamine-induced neuropathies in rats. Environmental science and pollution research international. vol 28. issue 14. 2021-03-31. PMID:33405105. |
furthermore, cortical tau and hippocampal hsp70 were modulated by ud extracts particularly nr compared to the scop group. |
2021-03-31 |
2023-08-13 |
rat |
| Thuy Trang Nguyen, Qui Thanh Hoai Ta, Thi Thuy Dung Nguyen, Thi Thuy Le, Van Giau V. Role of Insulin Resistance in the Alzheimer's Disease Progression. Neurochemical research. vol 45. issue 7. 2021-03-29. PMID:32314178. |
insulin resistance or dysfunction of insulin signaling is a universal feature of t2d, the main culprit for altered glucose metabolism and its interdependence on cell death pathways, forming the basis of linking t2d with ad as it may exacerbate a\xce\xb2 accumulation, tau hyperphosphorylation and devastates glucose transportation, energy metabolism, hippocampal framework and promulgate inflammatory pathways. |
2021-03-29 |
2023-08-13 |
Not clear |
| Amira M Abo-Youssef, Waleed A Khallaf, Mahmoud M Khattab, Basim A S Messih. The anti-Alzheimer effect of telmisartan in a hyperglycemic ovariectomized rat model; role of central angiotensin and estrogen receptors. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 142. 2021-03-29. PMID:32450287. |
furthermore, it improved cognitive impairment and suppressed hippocampal amyloidogenic markers including amyloid-beta level, phosphorylated tau protein and beta site amyloid precursor protein cleaving enzyme 1 expression, while elevated levels of insulin degrading enzyme and recovered permeability of blood brain barrier (bbb). |
2021-03-29 |
2023-08-13 |
rat |
| Aurelie Joly-Amado, Jordan Hunter, Zainuddin Quadri, Frank Zamudio, Patricia V Rocha-Rangel, Deanna Chan, Anisha Kesarwani, Kevin Nash, Daniel C Lee, Dave Morgan, Marcia N Gordon, Maj-Linda B Selenic. CCL2 Overexpression in the Brain Promotes Glial Activation and Accelerates Tau Pathology in a Mouse Model of Tauopathy. Frontiers in immunology. vol 11. 2021-03-29. PMID:32508844. |
to address this question, ccl2 was delivered via recombinant adeno-associated virus serotype 9 into both cortex and hippocampus of a mouse model with tau pathology (rtg4510). |
2021-03-29 |
2023-08-13 |
mouse |
| Matthew R Barron, Jane Gartlon, Lee A Dawson, Peter J Atkinson, Marie-Christine Pardo. Increasing Tau 4R Tau Levels Exacerbates Hippocampal Tau Hyperphosphorylation in the hTau Model of Tauopathy but Also Tau Dephosphorylation Following Acute Systemic Inflammation. Frontiers in immunology. vol 11. 2021-03-25. PMID:32194553. |
increasing tau 4r tau levels exacerbates hippocampal tau hyperphosphorylation in the htau model of tauopathy but also tau dephosphorylation following acute systemic inflammation. |
2021-03-25 |
2023-08-13 |
mouse |
| Yanchao Liu, Shujuan Zhang, Xiaoguang Li, Enjie Liu, Xin Wang, Qiuzhi Zhou, Jinwang Ye, Jian-Zhi Wan. Peripheral inflammation promotes brain tau transmission via disrupting blood-brain barrier. Bioscience reports. vol 40. issue 2. 2021-03-16. PMID:32043530. |
in the ad patients, the abnormal tau accumulation first appeared in entorhinal cortex (ec) and then propagated to the hippocampus with microglia activation and inflammation, but the mechanism is elusive. |
2021-03-16 |
2023-08-13 |
human |
| Yanchao Liu, Shujuan Zhang, Xiaoguang Li, Enjie Liu, Xin Wang, Qiuzhi Zhou, Jinwang Ye, Jian-Zhi Wan. Peripheral inflammation promotes brain tau transmission via disrupting blood-brain barrier. Bioscience reports. vol 40. issue 2. 2021-03-16. PMID:32043530. |
by intraperitoneal injection of lipopolysaccharide (lps) with brain medial entorhinal cortex (mec)-specific overexpressing p301l human tau (p301l-htau), we found that both acute and chronic administration of lps remarkably promoted p301l-htau transmission from mec to the hippocampal subsets. |
2021-03-16 |
2023-08-13 |
human |
| Shouchao Wei, Wanjuan Peng, Yingren Mai, Kanglan Li, Wei Wei, Li Hu, Shaoping Zhu, Haihong Zhou, Wanxin Jie, Zhuangsheng Wei, Chenyao Kang, Ruikai Li, Zhou Liu, Bin Zhao, Zhiyou Ca. Outer membrane vesicles enhance tau phosphorylation and contribute to cognitive impairment. Journal of cellular physiology. vol 235. issue 5. 2021-03-08. PMID:31663118. |
more important, further study showed that omvs induced tau phosphorylation by activating glycogen synthase kinase 3\xce\xb2 (gsk-3\xce\xb2) in the hippocampus. |
2021-03-08 |
2023-08-13 |
Not clear |
| C\\xc3\\xa9sar Espino de la Fuente-Mu\\xc3\\xb1oz, M\\xc3\\xb3nica Rosas-Lemus, Perla Moreno-Castilla, Federico Berm\\xc3\\xbadez-Rattoni, Salvador Uribe-Carvajal, Clorinda Aria. Age-Dependent Decline in Synaptic Mitochondrial Function Is Exacerbated in Vulnerable Brain Regions of Female 3xTg-AD Mice. International journal of molecular sciences. vol 21. issue 22. 2021-03-04. PMID:33227902. |
accumulation of toxic compounds, such as tau and a\xce\xb2, that occurred in the 3xtg-ad mouse model seemed to participate in the worsening of this decline in the hippocampus. |
2021-03-04 |
2023-08-13 |
mouse |
| Sarah Houben, M\\xc3\\xa9gane Homa, Zehra Yilmaz, Karelle Leroy, Jean-Pierre Brion, Kunie And. Tau Pathology and Adult Hippocampal Neurogenesis: What Tau Mouse Models Tell us? Frontiers in neurology. vol 12. 2021-03-03. PMID:33643196. |
tau pathology and adult hippocampal neurogenesis: what tau mouse models tell us? |
2021-03-03 |
2023-08-13 |
mouse |
| Daria Pawlik, Antoine Leuzy, Olof Strandberg, Ruben Smit. Compensating for choroid plexus based off-target signal in the hippocampus using NeuroImage. vol 221. 2021-03-02. PMID:32711062. |
compensating for choroid plexus based off-target signal in the hippocampus using the hippocampus is affected by tau pathology early in alzheimer's disease (ad) development. |
2021-03-02 |
2023-08-13 |
Not clear |
| Daria Pawlik, Antoine Leuzy, Olof Strandberg, Ruben Smit. Compensating for choroid plexus based off-target signal in the hippocampus using NeuroImage. vol 221. 2021-03-02. PMID:32711062. |
accurate quantification of hippocampal tau signal using the tau-pet tracer |
2021-03-02 |
2023-08-13 |
Not clear |
| Keith A Josephs, Peter R Martin, Stephen D Weigand, Nirubol Tosakulwong, Marina Buciuc, Melissa E Murray, Leonard Petrucelli, Matthew L Senjem, Anthony J Spychalla, David S Knopman, Bradley F Boeve, Ronald C Petersen, Joseph E Parisi, Dennis W Dickson, Clifford R Jack, Jennifer L Whitwel. Protein contributions to brain atrophy acceleration in Alzheimer's disease and primary age-related tauopathy. Brain : a journal of neurology. vol 143. issue 11. 2021-03-01. PMID:33150361. |
alzheimer's disease is characterized by the presence of amyloid-\xce\xb2 and tau deposition in the brain, hippocampal atrophy and increased rates of hippocampal atrophy over time. |
2021-03-01 |
2023-08-13 |
Not clear |
| Keith A Josephs, Peter R Martin, Stephen D Weigand, Nirubol Tosakulwong, Marina Buciuc, Melissa E Murray, Leonard Petrucelli, Matthew L Senjem, Anthony J Spychalla, David S Knopman, Bradley F Boeve, Ronald C Petersen, Joseph E Parisi, Dennis W Dickson, Clifford R Jack, Jennifer L Whitwel. Protein contributions to brain atrophy acceleration in Alzheimer's disease and primary age-related tauopathy. Brain : a journal of neurology. vol 143. issue 11. 2021-03-01. PMID:33150361. |
tdp-43, tau and amyloid-\xce\xb2 have all been linked to hippocampal atrophy. |
2021-03-01 |
2023-08-13 |
Not clear |
| Keith A Josephs, Peter R Martin, Stephen D Weigand, Nirubol Tosakulwong, Marina Buciuc, Melissa E Murray, Leonard Petrucelli, Matthew L Senjem, Anthony J Spychalla, David S Knopman, Bradley F Boeve, Ronald C Petersen, Joseph E Parisi, Dennis W Dickson, Clifford R Jack, Jennifer L Whitwel. Protein contributions to brain atrophy acceleration in Alzheimer's disease and primary age-related tauopathy. Brain : a journal of neurology. vol 143. issue 11. 2021-03-01. PMID:33150361. |
tdp-43 and tau have also been linked to hippocampal atrophy in cases of primary age-related tauopathy, a pathological entity with features that strongly overlap with those of alzheimer's disease. |
2021-03-01 |
2023-08-13 |
Not clear |
| Keith A Josephs, Peter R Martin, Stephen D Weigand, Nirubol Tosakulwong, Marina Buciuc, Melissa E Murray, Leonard Petrucelli, Matthew L Senjem, Anthony J Spychalla, David S Knopman, Bradley F Boeve, Ronald C Petersen, Joseph E Parisi, Dennis W Dickson, Clifford R Jack, Jennifer L Whitwel. Protein contributions to brain atrophy acceleration in Alzheimer's disease and primary age-related tauopathy. Brain : a journal of neurology. vol 143. issue 11. 2021-03-01. PMID:33150361. |
at present, it is unclear whether and how tdp-43 and tau are associated with early or late hippocampal atrophy in alzheimer's disease and primary age-related tauopathy, whether either protein is also associated with faster rates of atrophy of other brain regions and whether there is evidence for protein-associated acceleration/deceleration of atrophy rates. |
2021-03-01 |
2023-08-13 |
Not clear |
| Laetitia Degiorgis, Meltem Karatas, Marion Sourty, Emilie Faivre, Julien Lamy, Vincent Noblet, Thomas Bienert, Marco Reisert, Dominik von Elverfeldt, Luc Bu\\xc3\\xa9e, David Blum, Anne-Laurence Boutillier, Jean-Paul Armspach, Fr\\xc3\\xa9d\\xc3\\xa9ric Blanc, Laura-Adela Harsa. Brain network remodelling reflects tau-related pathology prior to memory deficits in Thy-Tau22 mice. Brain : a journal of neurology. vol 143. issue 12. 2021-03-01. PMID:33184651. |
disrupted ventral hip-amg functional pathway and altered dynamic functional connectivity were consistent with high pathological tau deposition and astrogliosis in both hippocampus and amygdala, and significant microglial reactivity in amygdalar nuclei. |
2021-03-01 |
2023-08-13 |
mouse |