| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xinyu Huang, Kangbai Huang, Zhaowei Li, Dongyan Bai, Yan Hao, Qinglong Wu, Wei Yi, Nenggui Xu, Youcan Pan, Liang Zhan. Electroacupuncture improves cognitive deficits and insulin resistance in an OLETF rat model of Al/D-gal induced aging model via the PI3K/Akt signaling pathway. Brain research. vol 1740. 2021-09-01. PMID:32304687. |
after ea intervention, the hippocampal aβ and total tau protein levels, body weight, fpg, fins, and c-p were significantly decreased. |
2021-09-01 |
2023-08-13 |
rat |
| Md Ataur Rahman, Md Abdul Hannan, Md Jamal Uddin, Md Saidur Rahman, Md Mamunur Rashid, Bonglee Ki. Exposure to Environmental Arsenic and Emerging Risk of Alzheimer's Disease: Perspective Mechanisms, Management Strategy, and Future Directions. Toxics. vol 9. issue 8. 2021-08-31. PMID:34437506. |
alzheimer's disease (ad) is one of the most prevailing neurodegenerative diseases, characterized by memory dysfunction and the presence of hyperphosphorylated tau and amyloid β (aβ) aggregates in multiple brain regions, including the hippocampus and cortex. |
2021-08-31 |
2023-08-13 |
human |
| Zhiqun Tang, Dan Liang, Miaoying Cheng, Xinyi Su, Runhe Liu, Yiding Zhang, Hongkun W. Effects of Porphyromonas gingivalis and Its Underlying Mechanisms on Alzheimer-Like Tau Hyperphosphorylation in Sprague-Dawley Rats. Journal of molecular neuroscience : MN. vol 71. issue 1. 2021-08-27. PMID:32557144. |
the results showed that the severity of phosphorylated tau at the ad-related sites thr181 and thr231 and the number of activated astrocytes were notably greater in the hippocampus of rats with p. gingivalis injection. |
2021-08-27 |
2023-08-13 |
rat |
| L E M Wisse, S Ravikumar, R Ittyerah, S Lim, J Lane, M L Bedard, L Xie, S R Das, T Schuck, M Grossman, E B Lee, M D Tisdall, K Prabhakaran, J A Detre, G Mizsei, J Q Trojanowski, E Artacho-Pérula, M M de Iñiguez de Onzono Martin, M M Arroyo-Jiménez, M Muñoz Lopez, F J Molina Romero, M P Marcos Rabal, S Cebada Sánchez, J C Delgado González, C de la Rosa Prieto, M Córcoles Parada, D A Wolk, D J Irwin, R Insausti, P A Yushkevic. Downstream effects of polypathology on neurodegeneration of medial temporal lobe subregions. Acta neuropathologica communications. vol 9. issue 1. 2021-08-23. PMID:34289895. |
tau, tar dna-binding protein 43 (tdp-43), amyloid-β and α-synuclein pathology were rated on a scale of 0 (absent)-3 (severe) in the hippocampus and entorhinal cortex (erc) of 58 individuals with and without neurodegenerative diseases (median age 75.0 years, 60.3% male). |
2021-08-23 |
2023-08-13 |
Not clear |
| Ron Balczon, Mike T Lin, Ji Young Lee, Adeel Abbasi, Phoibe Renema, Sarah B Voth, Chun Zhou, Anna Koloteva, C Michael Francis, Neel R Sodha, Jean-Francois Pittet, Brant M Wagener, Jessica Bell, Chung-Sik Choi, Corey E Ventetuolo, Troy Steven. Pneumonia initiates a tauopathy. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 35. issue 9. 2021-08-23. PMID:34384141. |
cytotoxic amyloid and tau species were recovered from the blood and the hippocampus following pneumonia, and they were present in the extracorporeal membrane oxygenation oxygenators of patients with pneumonia, especially in those who died. |
2021-08-23 |
2023-08-13 |
mouse |
| Ron Balczon, Mike T Lin, Ji Young Lee, Adeel Abbasi, Phoibe Renema, Sarah B Voth, Chun Zhou, Anna Koloteva, C Michael Francis, Neel R Sodha, Jean-Francois Pittet, Brant M Wagener, Jessica Bell, Chung-Sik Choi, Corey E Ventetuolo, Troy Steven. Pneumonia initiates a tauopathy. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 35. issue 9. 2021-08-23. PMID:34384141. |
introduction of immunopurified blood-borne amyloid and tau into either the airways or the blood of uninfected animals acutely and chronically impaired hippocampal information processing. |
2021-08-23 |
2023-08-13 |
mouse |
| Ron Balczon, Mike T Lin, Ji Young Lee, Adeel Abbasi, Phoibe Renema, Sarah B Voth, Chun Zhou, Anna Koloteva, C Michael Francis, Neel R Sodha, Jean-Francois Pittet, Brant M Wagener, Jessica Bell, Chung-Sik Choi, Corey E Ventetuolo, Troy Steven. Pneumonia initiates a tauopathy. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 35. issue 9. 2021-08-23. PMID:34384141. |
in contrast, the infection did not impair long-term potentiation in tau knockout mice and the amyloid- and tau-dependent disruption in hippocampal signaling was less severe in tau knockout mice. |
2021-08-23 |
2023-08-13 |
mouse |
| Eva Dávila-Bouziguet, Arnau Casòliba-Melich, Georgina Targa-Fabra, Lorena Galera-López, Andrés Ozaita, Rafael Maldonado, Jesús Ávila, José M Delgado-García, Agnès Gruart, Eduardo Soriano, Marta Pascua. Functional protection in J20/VLW mice: a model of non-demented with Alzheimer's disease neuropathology. Brain : a journal of neurology. 2021-08-23. PMID:34424282. |
we demonstrate that j20/vlw mice (accumulating amyloid-β and hyperphosphorylated tau) exhibit preserved hippocampal rhythmic activity and cognition, as opposed to j20 and vlw animals, which show significant alterations. |
2021-08-23 |
2023-08-13 |
mouse |
| Eva Dávila-Bouziguet, Arnau Casòliba-Melich, Georgina Targa-Fabra, Lorena Galera-López, Andrés Ozaita, Rafael Maldonado, Jesús Ávila, José M Delgado-García, Agnès Gruart, Eduardo Soriano, Marta Pascua. Functional protection in J20/VLW mice: a model of non-demented with Alzheimer's disease neuropathology. Brain : a journal of neurology. 2021-08-23. PMID:34424282. |
furthermore, we show that the overexpression of mutant human tau in coexistence with amyloid-β accumulation renders a particular hyperphosphorylated tau signature in hippocampal interneurons. |
2021-08-23 |
2023-08-13 |
mouse |
| Eva Dávila-Bouziguet, Arnau Casòliba-Melich, Georgina Targa-Fabra, Lorena Galera-López, Andrés Ozaita, Rafael Maldonado, Jesús Ávila, José M Delgado-García, Agnès Gruart, Eduardo Soriano, Marta Pascua. Functional protection in J20/VLW mice: a model of non-demented with Alzheimer's disease neuropathology. Brain : a journal of neurology. 2021-08-23. PMID:34424282. |
moreover, they suggest that a differential tau phosphorylation pattern in hippocampal interneurons prevents the loss of gabaergic septohippocampal innervation and alterations in local field potentials, thereby avoiding cognitive deficits. |
2021-08-23 |
2023-08-13 |
mouse |
| Isabella Hoi Kei Leung, Kathryn Mary Broadhouse, Loren Mowszowski, Haley M LaMonica, Jake Robert Palmer, Ian B Hickie, Sharon L Naismith, Shantel Leigh Duff. Association between lifetime depression history, hippocampal volume and memory in non-amnestic mild cognitive impairment. The European journal of neuroscience. vol 54. issue 3. 2021-08-20. PMID:33765347. |
hippocampal subfield volume loss in older adults with amnestic mild cognitive impairment (amci) and depression history are associated with amyloid beta and tau pathology, thereby increasing the risk for alzheimer's disease (ad). |
2021-08-20 |
2023-08-13 |
Not clear |
| Yanning Li, Gehua Wen, Runtao Ding, Xinghua Ren, Chenchen Jing, Lin Liu, Jun Yao, Guohua Zhang, Yan Lu, Baoman Li, Xu W. Effects of Single-Dose and Long-Term Ketamine Administration on Tau Phosphorylation-Related Enzymes GSK-3β, CDK5, PP2A, and PP2B in the Mouse Hippocampus. Journal of molecular neuroscience : MN. vol 70. issue 12. 2021-08-19. PMID:32705526. |
effects of single-dose and long-term ketamine administration on tau phosphorylation-related enzymes gsk-3β, cdk5, pp2a, and pp2b in the mouse hippocampus. |
2021-08-19 |
2023-08-13 |
mouse |
| Yanning Li, Gehua Wen, Runtao Ding, Xinghua Ren, Chenchen Jing, Lin Liu, Jun Yao, Guohua Zhang, Yan Lu, Baoman Li, Xu W. Effects of Single-Dose and Long-Term Ketamine Administration on Tau Phosphorylation-Related Enzymes GSK-3β, CDK5, PP2A, and PP2B in the Mouse Hippocampus. Journal of molecular neuroscience : MN. vol 70. issue 12. 2021-08-19. PMID:32705526. |
in the present study, we administered a single ketamine injection and long-term (6 months) ketamine injections in c57bl/6 mice, to investigate the effects of different doses of ketamine on the expression levels of tau protein and its phosphorylation, the expression levels and activities of the related protein phosphokinases gsk-3β and cdk5, and the expression levels and activities of the related protein phosphatases pp2a and pp2b in the mouse hippocampus. |
2021-08-19 |
2023-08-13 |
mouse |
| Nathalie Bodd Halaas, Kristi Henjum, Kaj Blennow, Shams Dakhil, Ane-Victoria Idland, Lars Ng Nilsson, Donatas Sederevicius, Didac Vidal-Piñeiro, Kristine B Walhovd, Torgeir Brunn Wyller, Henrik Zetterberg, Leiv Otto Watne, Anders M Fjel. CSF sTREM2 and Tau Work Together in Predicting Increased Temporal Lobe Atrophy in Older Adults. Cerebral cortex (New York, N.Y. : 1991). vol 30. issue 4. 2021-08-18. PMID:31812991. |
high baseline strem2 was associated with accelerated cortical thinning in the temporal cortex of the left hemisphere, as well as bilateral hippocampal atrophy, independently of age, aβ42, and tau. |
2021-08-18 |
2023-08-13 |
human |
| Nathalie Bodd Halaas, Kristi Henjum, Kaj Blennow, Shams Dakhil, Ane-Victoria Idland, Lars Ng Nilsson, Donatas Sederevicius, Didac Vidal-Piñeiro, Kristine B Walhovd, Torgeir Brunn Wyller, Henrik Zetterberg, Leiv Otto Watne, Anders M Fjel. CSF sTREM2 and Tau Work Together in Predicting Increased Temporal Lobe Atrophy in Older Adults. Cerebral cortex (New York, N.Y. : 1991). vol 30. issue 4. 2021-08-18. PMID:31812991. |
in conclusion, increased csf strem2 was associated with accelerated cortical and hippocampal atrophy in cognitively unimpaired older participants, particularly in individuals with tau pathology. |
2021-08-18 |
2023-08-13 |
human |
| Toshiki Uchihar. Neurofibrillary changes undergoing morphological and biochemical changes - How does tau with the profile shift of from four repeat to three repeat spread in Alzheimer brain? Neuropathology : official journal of the Japanese Society of Neuropathology. vol 40. issue 5. 2021-08-18. PMID:32698244. |
the concept of the hierarchal spread of neurofibrillary tangles (nfts) from the hippocampus to the cortex in alzheimer's disease (ad)/aging brains, initially proposed by braak and braak, revolutionized our understanding by putatively explaining that tau lesions are being unidirectionally extended along neural connections. |
2021-08-18 |
2023-08-13 |
human |
| Toshiki Uchihar. Neurofibrillary changes undergoing morphological and biochemical changes - How does tau with the profile shift of from four repeat to three repeat spread in Alzheimer brain? Neuropathology : official journal of the Japanese Society of Neuropathology. vol 40. issue 5. 2021-08-18. PMID:32698244. |
surprisingly, this profile shift from 4r to 3r tau is shared with the hierarchal spread of nft around the hippocampus, which is hardly explained by a simple mechanism such as propagation of a single tau molecule. |
2021-08-18 |
2023-08-13 |
human |
| Hiroki Takeuchi, Keiko Imamura, Bin Ji, Kayoko Tsukita, Takako Enami, Keizo Takao, Tsuyoshi Miyakawa, Masato Hasegawa, Naruhiko Sahara, Nobuhisa Iwata, Makoto Inoue, Hideo Hara, Takeshi Tabira, Maiko Ono, John Q Trojanowski, Virginia M-Y Lee, Ryosuke Takahashi, Tetsuya Suhara, Makoto Higuchi, Haruhisa Inou. Nasal vaccine delivery attenuates brain pathology and cognitive impairment in tauopathy model mice. NPJ vaccines. vol 5. issue 1. 2021-08-16. PMID:32219000. |
in vivo imaging and postmortem neuropathological assays demonstrated the suppression of phosphorylated tau accumulation, neurotoxic gliosis, and neuronal loss in the hippocampus of immunized mice. |
2021-08-16 |
2023-08-13 |
mouse |
| Yosra Nadhimi, Daniel A Llan. Does hearing loss lead to dementia? A review of the literature. Hearing research. vol 402. 2021-08-13. PMID:32814645. |
the data suggest that noise-exposure produces a toxic milieu in the hippocampus consisting of a spike in glucocorticoid levels, elevations of mediators of oxidative stress and excitotoxicity, which as a consequence induce cessation of neurogenesis, synaptic loss and tau hyperphosphorylation. |
2021-08-13 |
2023-08-13 |
human |
| Christina N Rogers Flattery, Rebecca F Rosen, Aaron S Farberg, Jeromy M Dooyema, Patrick R Hof, Chet C Sherwood, Lary C Walker, Todd M Preus. Quantification of neurons in the hippocampal formation of chimpanzees: comparison to rhesus monkeys and humans. Brain structure & function. vol 225. issue 8. 2021-08-11. PMID:32909100. |
we also sought evidence of aβ deposition and hyperphosphorylated tau in the hippocampus and adjacent neocortex. |
2021-08-11 |
2023-08-13 |
human |