| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Amir Abbas Tahami Monfared, Michael J Byrnes, Leigh Ann White, Quanwu Zhan. Alzheimer's Disease: Epidemiology and Clinical Progression. Neurology and therapy. 2022-03-14. PMID:35286590. |
factors shown to increase risk include lower mini-mental state examination (mmse) score, higher alzheimer's disease assessment scale (adas-cog) score, positive apoe4 status, white matter hyperintensities volume, entorhinal cortex atrophy, cerebrospinal fluid (csf) total tau, csf neurogranin levels, dependency in instrumental activities of daily living (iadl), and being female. |
2022-03-14 |
2023-08-13 |
Not clear |
| Sha Sha, Xiao-Na Xing, Tao Wang, Ying Li, Rong-Wei Zhang, Xue-Li Shen, Yun-Peng Cao, Le Q. DNA vaccines targeting amyloid-β oligomer ameliorate cognitive deficits of aged APP/PS1/tau triple-transgenic mouse models of Alzheimer's disease. Neural regeneration research. vol 17. issue 10. 2022-03-09. PMID:35259854. |
our results showed that the p(aβ3-10)10-mt vaccine effectively reduced aβ oligomer levels and plaque deposition in the cerebral cortex and hippocampus, decreased the levels tau protein variants, reduced synaptic loss, protected synaptic function, reduced neuron loss, and ameliorated memory impairment without causing any cerebral hemorrhaging. |
2022-03-09 |
2023-08-13 |
mouse |
| Li-Fan Lin, Yun-Ting Jhao, Chuang-Hsin Chiu, Lu-Han Sun, Ta-Kai Chou, Chyng-Yann Shiue, Cheng-Yi Cheng, Kuo-Hsing M. Bezafibrate Exerts Neuroprotective Effects in a Rat Model of Sporadic Alzheimer's Disease. Pharmaceuticals (Basel, Switzerland). vol 15. issue 2. 2022-02-26. PMID:35215222. |
stz-icv administration induced significant cognitive impairment and substantial neuronal loss, tau pathology, glucose hypometabolism, and microgliosis in the cortex and hippocampus, while bezafibrate effectively attenuated these abnormalities. |
2022-02-26 |
2023-08-13 |
mouse |
| Tomohiro Umeda, Rumi Uekado, Keiko Shigemori, Hiroshi Eguchi, Takami Tomiyam. Nasal Rifampicin Halts the Progression of Tauopathy by Inhibiting Tau Oligomer Propagation in Alzheimer Brain Extract-Injected Mice. Biomedicines. vol 10. issue 2. 2022-02-25. PMID:35203506. |
rifampicin treatment inhibited the spreading of tau oligomers from the injection site to other brain regions and neurofibrillary tangle formation in the entorhinal cortex. |
2022-02-25 |
2023-08-13 |
mouse |
| Tammy T Tran, Caroline L Speck, Michela Gallagher, Arnold Bakke. Lateral entorhinal cortex dysfunction in amnestic mild cognitive impairment. Neurobiology of aging. vol 112. 2022-02-19. PMID:35182842. |
specifically, the lateral entorhinal cortex shows significant accumulation of tau neurofibrillary tangles in the amnestic mild cognitive impairment (amci) phase of alzheimer's disease. |
2022-02-19 |
2023-08-13 |
human |
| Ilie Cosmin Stancu, Chritica Lodder, Pablo Botella Lucena, Sarah Vanherle, Manuel Gutiérrez de Ravé, Dick Terwel, Astrid Bottelbergs, Ilse Dewachte. The NLRP3 inflammasome modulates tau pathology and neurodegeneration in a tauopathy model. Glia. 2022-02-17. PMID:35174546. |
tau pathology in hippocampus and cortex was significantly decreased in tau.nlrp3-/- versus tau.nlrp3+/+ mice. |
2022-02-17 |
2023-08-13 |
mouse |
| Ilie Cosmin Stancu, Chritica Lodder, Pablo Botella Lucena, Sarah Vanherle, Manuel Gutiérrez de Ravé, Dick Terwel, Astrid Bottelbergs, Ilse Dewachte. The NLRP3 inflammasome modulates tau pathology and neurodegeneration in a tauopathy model. Glia. 2022-02-17. PMID:35174546. |
nlrp3 deficiency significantly decreased prion-like seeding and propagation of tau pathology, reflected in decreased tau pathology in ipsi- and contralateral hippocampus and cortex in tau.nlrp3-/- following tau seeding. |
2022-02-17 |
2023-08-13 |
mouse |
| Dibyadeep Datta, SueAnn Mentone, Yury Morozov, Christopher H van Dyck, Amy F T Arnste. Subcellular localization of PDE4D and HCN1 in rhesus macaque entorhinal cortex layer II: Signature of vulnerability in Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109064. |
anatomical studies in ad subjects and rhesus macaques show earliest signs of tau pathology in the stellate cell islands in entorhinal cortex (erc) layer ii. |
2022-02-03 |
2023-08-13 |
human |
| Giulia Quattrini, Lorenzo Pini, Ilaria Boscolo Galazzo, Francesca B Pizzini, Michela Pievan. Microstructural alterations of the locus coeruleus-entorhinal cortex pathway in Alzheimer's disease and behavioral variant frontotemporal dementia. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109188. |
in ad, the lc may be the earliest site of tau pathology, which subsequently spreads to the entorhinal cortex (ec) through axonal pathways; in ftd, pathology might follow the opposite pattern, spreading from the frontal/temporal areas to the lc. |
2022-02-03 |
2023-08-13 |
Not clear |
| Limin Wu, Brian T Kalish, Benjamin Finander, Tian Cao, Gina Jin, Taha Yahya, Emily S Levy, Bharti Kukreja, Eliza Sophie LaRovere, Joon Yong Chung, Eng H Lo, Alexander Brown-Whalen, Joseph El Khoury, David L Kaplan, Michael J Whale. Repetitive mild closed head injury in adolescent mice is associated with impaired proteostasis, neuroinflammation, and tauopathy. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2022-02-02. PMID:35105673. |
at 6 months, injured il-1 receptor 1 (il-1r1) knockout mice, which are protected from post-injury cognitive deficits, had decreased accumulation of pro-il-1β and misfolded tau in cortex and cerebellum, suggesting that il-1r1 is upstream of inflammasome priming (defined as increase in pro-il-1β) and abnormal tau phosphorylation. |
2022-02-02 |
2023-08-13 |
mouse |
| Steven G Fagan, Sibylle Bechet, Kumlesh K De. Fingolimod Rescues Memory and Improves Pathological Hallmarks in the 3xTg-AD Model of Alzheimer's Disease. Molecular neurobiology. 2022-01-15. PMID:35031916. |
finally, treatment with fingolimod was shown to reduce phosphorylated tau and app levels in the hippocampus and cortex. |
2022-01-15 |
2023-08-13 |
mouse |
| Xi-Chen Zhu, Lu Liu, Wen-Zhuo Dai, Tao M. Crry silencing alleviates Alzheimer's disease injury by regulating neuroinflammatory cytokines and the complement system. Neural regeneration research. vol 17. issue 8. 2022-01-12. PMID:35017447. |
we also found that crry protein expression in the hippocampus and cortex was significantly elevated in p301s mice (a mouse model widely used for investigating tau pathology) compared with that in wild-type mice. |
2022-01-12 |
2023-08-13 |
mouse |
| Jianfeng Wu, Wenhui Zhu, Yi Su, Jie Gui, Natasha Lepore, Eric M Reiman, Richard J Caselli, Paul M Thompson, Kewei Chen, Yalin Wan. Predicting Tau Accumulation in Cerebral Cortex with Multivariate MRI Morphometry Measurements, Sparse Coding, and Correntropy. Proceedings of SPIE--the International Society for Optical Engineering. vol 12088. 2021-12-28. PMID:34961803. |
predicting tau accumulation in cerebral cortex with multivariate mri morphometry measurements, sparse coding, and correntropy. |
2021-12-28 |
2023-08-13 |
human |
| Murat Bilgel, Alisa Bannerjee, Andrea Shafer, Yang An, Susan M Resnic. Vascular risk is not associated with PET measures of Alzheimer's disease neuropathology among cognitively normal older adults. Neuroimage. Reports. vol 1. issue 4. 2021-12-20. PMID:34927122. |
as expected, aβ positive participants had greater tau in the entorhinal cortex (ec) and inferior temporal gyrus (itg) (difference in means = 0.09, p < 0.05 for each region), and 10-year cvd risk was positively correlated with white matter lesion burden (r = 0.24, p = 0.03). |
2021-12-20 |
2023-08-13 |
human |
| YouJin Lee, Morgan R Miller, Marty A Fernandez, Elizabeth L Berg, Adriana M Prada, Qing Ouyang, Michael Schmidt, Jill L Silverman, Tracy L Young-Pearse, Eric M Morro. Early lysosome defects precede neurodegeneration with amyloid-β and tau aggregation in NHE6-null rat brain. Brain : a journal of neurology. 2021-12-20. PMID:34928329. |
importantly, we subsequently observe biochemical and in situ evidence of both aβ and tau aggregation in the aged nhe6-null hippocampus and cortex (but not in the cerebellum). |
2021-12-20 |
2023-08-13 |
mouse |
| Seraphina K Solders, Vitaly L Galinsky, Alexandra L Clark, Scott F Sorg, Alexandra J Weigand, Mark W Bondi, Lawrence R Fran. Diffusion MRI tractography of the locus coeruleus-transentorhinal cortex connections using GO-ESP. Magnetic resonance in medicine. 2021-12-11. PMID:34792198. |
tau pathology is hypothesized to propagate in a prion-like manner along the lc-transentorhinal cortex (tec) white matter (wm) pathway, leading to atrophy of the entorhinal cortex and adjacent cortical regions in a progressive and stereotypical manner. |
2021-12-11 |
2023-08-13 |
Not clear |
| Chen Chen, Junfeng Lu, Weijia Peng, Marvin Sh Mak, Yang Yang, Zeyu Zhu, Shuyi Wang, Jiawei Hou, Xin Zhou, Wenjun Xin, Yafang Hu, Karl Wah Keung Tsim, Yifan Han, Qinyu Liu, Rongbiao P. Acrolein, an endogenous aldehyde induces Alzheimer's disease-like pathologies in mice: A new sporadic AD animal model. Pharmacological research. vol 175. 2021-12-11. PMID:34838693. |
1) olfactory dysfunctions, cognitive impairments and psychological symptoms in c57bl/6 mice; 2) increased levels of aβ1-42 and tau phosphorylation (s396/t231) in cortex and hippocampus; 3) astrocytes and microglia proliferation; 4) reduced levels of postsynaptic density 95(psd95) and synapsin1, as well as the density of dendritic spines in the ca1 and dg neurons of the hippocampus; 5) high-frequency stimulation failed to induce the long-term potentiation (ltp) in the hippocampus after exposure to acrolein for 4 weeks; 6) decreased blood oxygen level-dependent (bold) signal in the olfactory bulb and induced high t2 signals in the hippocampus, which matched to the clinical observation in the brain of ad patients, and 7) activated rhoa/rock2/ p-cofilin-associated pathway in hippocampus of acrolein-treated mice, which may be the causes of synaptic damage and neuroinflammation in acrolein mice model. |
2021-12-11 |
2023-08-13 |
mouse |
| Zhao-Yan Cheng, Yu-Hui Hu, Qing-Peng Xia, Chen Wang, Ling H. DRD1 agonist A-68930 improves mitochondrial dysfunction and cognitive deficits in a streptozotocin-induced mouse model. Brain research bulletin. vol 175. 2021-12-10. PMID:34284074. |
moreover, our mechanism researches revealed that the drd1 signaling induced by a-68930 significantly rescued stz-induced mitochondrial biogenesis deficit, mitochondrial dysfunction, aβ overexpression, and tau phosphorylation in mice hippocampus and cortex and sh-sy5y cells, which may be mediated through stimulating ampk/pgc-1α pathway. |
2021-12-10 |
2023-08-13 |
mouse |
| David Berron, Jacob W Vogel, Philip S Insel, Joana B Pereira, Long Xie, Laura E M Wisse, Paul A Yushkevich, Sebastian Palmqvist, Niklas Mattsson-Carlgren, Erik Stomrud, Ruben Smith, Olof Strandberg, Oskar Hansso. Early stages of tau pathology and its associations with functional connectivity, atrophy and memory. Brain : a journal of neurology. vol 144. issue 9. 2021-12-09. PMID:33725124. |
first, event-based modelling revealed that the entorhinal cortex and brodmann area 35 show the earliest signs of tau accumulation followed by the anterior and posterior hippocampus, brodmann area 36 and the parahippocampal cortex. |
2021-12-09 |
2023-08-13 |
human |
| David Berron, Jacob W Vogel, Philip S Insel, Joana B Pereira, Long Xie, Laura E M Wisse, Paul A Yushkevich, Sebastian Palmqvist, Niklas Mattsson-Carlgren, Erik Stomrud, Ruben Smith, Olof Strandberg, Oskar Hansso. Early stages of tau pathology and its associations with functional connectivity, atrophy and memory. Brain : a journal of neurology. vol 144. issue 9. 2021-12-09. PMID:33725124. |
second, in cognitively unimpaired individuals, increased tau load was related to local atrophy in the entorhinal cortex, brodmann area 35 and the anterior hippocampus and tau load in several anterior medial temporal lobe subregions was associated with distant atrophy of the posterior hippocampus. |
2021-12-09 |
2023-08-13 |
human |