| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Amaryllis A Tsiknia, Steven D Edland, Erin E Sundermann, Emilie T Reas, James B Brewer, Douglas Galasko, Sarah J Bank. Sex differences in plasma p-tau181 associations with Alzheimer's disease biomarkers, cognitive decline, and clinical progression. Molecular psychiatry. 2022-06-29. PMID:35768637. |
linear regressions tested for an effect of sex on plasma p-tau181 levels and for plasma p-tau181 × sex interactions on csf p-tau181, as well as entorhinal cortex tau, cortical amyloid-β (aβ) deposition, and brain glucose metabolism, quantified using pet imaging. |
2022-06-29 |
2023-08-14 |
human |
| Amaryllis A Tsiknia, Steven D Edland, Erin E Sundermann, Emilie T Reas, James B Brewer, Douglas Galasko, Sarah J Bank. Sex differences in plasma p-tau181 associations with Alzheimer's disease biomarkers, cognitive decline, and clinical progression. Molecular psychiatry. 2022-06-29. PMID:35768637. |
despite similar plasma p-tau181 levels between sexes, women had lower brain glucose metabolism, greater brain aβ and entorhinal cortex tau deposition, higher csf p-tau181 and faster cognitive decline in relation to higher baseline plasma p-tau181 levels compared with men. |
2022-06-29 |
2023-08-14 |
human |
| Petrice M Cogswell, Heather J Wiste, Michelle M Mielke, Christopher G Schwarz, Stephen D Weigand, Val J Lowe, Terry M Therneau, David S Knopman, Jonathan Graff-Radford, Prashanthi Vemuri, Matthew L Senjem, Jeffrey L Gunter, Alicia Algeciras-Schimnich, Ronald C Petersen, Clifford R Jac. CSF phosphorylated tau as an indicator of subsequent tau accumulation. Neurobiology of aging. vol 117. 2022-06-28. PMID:35764037. |
we evaluated the relationship between baseline csf p-tau181 and the rate of tau pet change in the temporal meta-roi and entorhinal cortex (erc) and how it varied by amyloid level (csf aβ42 or amyloid pet) among 143 individuals from the mayo clinic study of aging and mayo alzheimer disease research center. |
2022-06-28 |
2023-08-14 |
human |
| Karl Sjölin, Kim Kultima, Anders Larsson, Eva Freyhult, Christina Zjukovskaja, Kanar Alkass, Joachim Burma. Distribution of five clinically important neuroglial proteins in the human brain. Molecular brain. vol 15. issue 1. 2022-06-28. PMID:35765081. |
highly myelinated areas of the cns had tenfold higher mbp concentration than cerebral cortex, whereas tau showed an inverse pattern. |
2022-06-28 |
2023-08-14 |
human |
| Sonia Podvin, Zhenze Jiang, Ben Boyarko, Leigh-Ana Rossitto, Anthony O'Donoghue, Robert A Rissman, Vivian Hoo. Dysregulation of Neuropeptide and Tau Peptide Signatures in Human Alzheimer's Disease Brain. ACS chemical neuroscience. 2022-06-27. PMID:35758417. |
notably, tau peptide signatures differed in the ad compared to age-matched control human brain cortex synaptosomes. |
2022-06-27 |
2023-08-14 |
human |
| Sonia Podvin, Zhenze Jiang, Ben Boyarko, Leigh-Ana Rossitto, Anthony O'Donoghue, Robert A Rissman, Vivian Hoo. Dysregulation of Neuropeptide and Tau Peptide Signatures in Human Alzheimer's Disease Brain. ACS chemical neuroscience. 2022-06-27. PMID:35758417. |
unique tau peptides were derived from the tau protein through proteolysis using similar and differential cleavage sites in the ad brain cortex compared to the control. |
2022-06-27 |
2023-08-14 |
human |
| Sonia Podvin, Zhenze Jiang, Ben Boyarko, Leigh-Ana Rossitto, Anthony O'Donoghue, Robert A Rissman, Vivian Hoo. Dysregulation of Neuropeptide and Tau Peptide Signatures in Human Alzheimer's Disease Brain. ACS chemical neuroscience. 2022-06-27. PMID:35758417. |
overall, these results demonstrate that dysregulation of neuropeptides and tau peptides occurs in ad brain cortex synaptosomes compared to age-matched controls, involving differential cleavage site properties for proteolytic processing of precursor proteins. |
2022-06-27 |
2023-08-14 |
human |
| Vishaal Rajani, Qi Yua. Noradrenergic Modulation of the Piriform Cortex: A Possible Avenue for Understanding Pre-Clinical Alzheimer's Disease Pathogenesis. Frontiers in cellular neuroscience. vol 16. 2022-06-20. PMID:35722616. |
in a recent animal model, lc pretangle tau leads to lc fiber degeneration in the piriform cortex (pc), a cortical area associated with olfactory dysfunction in both human ad and rodent models. |
2022-06-20 |
2023-08-14 |
human |
| Md Ataur Rahman, M D Hasanur Rahman, A N M Mamun-Or-Rashid, Hongik Hwang, Sooyoung Chung, Bonglee Kim, Hyewhon Rhi. Autophagy Modulation in Aggresome Formation: Emerging Implications and Treatments of Alzheimer's Disease. Biomedicines. vol 10. issue 5. 2022-05-28. PMID:35625764. |
alzheimer's disease (ad) is one of the most prevailing neurodegenerative diseases in the world, which is characterized by memory dysfunction and the formation of tau and amyloid β (aβ) aggregates in multiple brain regions, including the hippocampus and cortex. |
2022-05-28 |
2023-08-13 |
Not clear |
| Michelle M Mielke, Jeffrey L Dage, Ryan D Frank, Alicia Algeciras-Schimnich, David S Knopman, Val J Lowe, Guojun Bu, Prashanthi Vemuri, Jonathan Graff-Radford, Clifford R Jack, Ronald C Peterse. Performance of plasma phosphorylated tau 181 and 217 in the community. Nature medicine. 2022-05-26. PMID:35618838. |
continuous, unadjusted plasma p-tau181 and p-tau217 predicted abnormal amyloid positron-emission tomography (pet) (area under the receiver operating characteristic curve (auroc) = 0.81-0.86) and tau pet entorhinal cortex (auroc > 0.80), but was less predictive of a tau pet temporal region of interest (auroc < 0.70). |
2022-05-26 |
2023-08-13 |
human |
| Anna Mietelska-Porowska, Justyna Domańska, Andrew Want, Angelika Więckowska-Gacek, Dominik Chutorański, Maciej Koperski, Urszula Wojd. Induction of Brain Insulin Resistance and Alzheimer's Molecular Changes by Western Diet. International journal of molecular sciences. vol 23. issue 9. 2022-05-14. PMID:35563135. |
ad is the main cause of progressive dementia characterized by the deposition of amyloid-β (aβ) plaques and neurofibrillary tangles consisting of the hyperphosphorylated tau (p-tau) protein in the brain, starting from the entorhinal cortex and the hippocampus. |
2022-05-14 |
2023-08-13 |
mouse |
| Anna Mietelska-Porowska, Justyna Domańska, Andrew Want, Angelika Więckowska-Gacek, Dominik Chutorański, Maciej Koperski, Urszula Wojd. Induction of Brain Insulin Resistance and Alzheimer's Molecular Changes by Western Diet. International journal of molecular sciences. vol 23. issue 9. 2022-05-14. PMID:35563135. |
in this study, we report that wd-derived impairment in insulin signaling induces tau and aβ brain pathology in wild-type c57bl/6 mice, and that the entorhinal cortex is more sensitive than the hippocampus to the impairment of brain insulin signaling. |
2022-05-14 |
2023-08-13 |
mouse |
| Nan-Shan Chan. The strength of WWOX binding with protein partners correlates with cancer suppression and potentially with inhibition of Alzheimer's disease progression. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35552574. |
gradual loss of wwox protein in the hippocampus and cortex starting from middle age may slowly induce aggregation of a protein cascade that ultimately causes accumulation of extracellular amyloid beta plaques and intracellular tau tangles, along with reduction in inhibitory gabaergic interneurons, in ad patients over 70 years old. |
2022-05-13 |
2023-08-13 |
mouse |
| Wha Jin Lee, Jesse A Brown, Hye Ryun Kim, Renaud La Joie, Hanna Cho, Chul Hyoung Lyoo, Gil D Rabinovici, Joon-Kyung Seong, William W Seele. Regional Aβ-tau interactions promote onset and acceleration of Alzheimer's disease tau spreading. Neuron. 2022-04-20. PMID:35443153. |
first, we show that the lateral entorhinal cortex, an early site of tau neurofibrillary tangle formation, is subject to remote, connectivity-mediated amyloid-beta/tau interactions linked to initial tau spreading. |
2022-04-20 |
2023-08-13 |
human |
| Megumi Asada-Utsugi, Kengo Uemura, Takashi Ayaki, Maiko T Uemura, Sumio Minamiyama, Ryota Hikiami, Toshifumi Morimura, Akemi Shodai, Takatoshi Ueki, Ryosuke Takahashi, Ayae Kinoshita, Makoto Urushitan. Failure of DNA double-strand break repair by tau mediates Alzheimer's disease pathology in vitro. Communications biology. vol 5. issue 1. 2022-04-14. PMID:35418705. |
first, immunohistochemistry reveals the frequent coexistence of dsb and phosphorylated tau in the cortex of ad patients. |
2022-04-14 |
2023-08-13 |
mouse |
| Shuo Chen, Diana Acosta, Liangping Li, Jiawen Liang, Yuzhou Chang, Cankun Wang, Julie Fitzgerald, Cody Morrison, Chris N Goulbourne, Yoshi Nakano, Nancy C Hernandez Villegas, Lalitha Venkataraman, Cris Brown, Geidy E Serrano, Erica Bell, Trina Wemlinger, Min Wu, Olga N Kokiko-Cochran, Phillip Popovich, Xena E Flowers, Lawrence S Honig, Jean Paul Vonsattel, Douglas W Scharre, Thomas G Beach, Qin Ma, Jeff Kuret, Sulev Kõks, Fumihiko Urano, Karen E Duff, Hongjun F. Wolframin is a novel regulator of tau pathology and neurodegeneration. Acta neuropathologica. 2022-04-07. PMID:35389045. |
tau protein aggregates have been found in wolframin (wfs1)-expressing excitatory neurons in the entorhinal cortex, one of the earliest affected regions in ad. |
2022-04-07 |
2023-08-13 |
mouse |
| Hiroaki Miyahara, Akio Akagi, Yuichi Riku, Jun Sone, Yasushi Otsuka, Motoko Sakai, Satoshi Kuru, Masato Hasegawa, Mari Yoshida, Akiyoshi Kakita, Yasushi Iwasak. Independent distribution between tauopathy secondary to subacute sclerotic panencephalitis and measles virus: An immunohistochemical analysis in autopsy cases including cases treated with aggressive antiviral therapies. Brain pathology (Zurich, Switzerland). 2022-04-04. PMID:35373453. |
neurofibrillary tangles characterized by a combination of 3- and 4-repeat tau were observed mainly in the oculomotor nuclei, locus coeruleus, and limbic cortex. |
2022-04-04 |
2023-08-13 |
human |
| Simon Dujardin, Analiese Fernandes, Riley Bannon, Caitlin Commins, Mark De Los Santos, Tarun V Kamath, Mansuo Hayashi, Bradley T Hyma. Tau propagation is dependent on the genetic background of mouse strains. Brain communications. vol 4. issue 2. 2022-03-30. PMID:35350555. |
we virally expressed human tau locally in the hippocampus and the entorhinal cortex neurons and monitored the cell-to-cell tau protein spread by immunolabelling. |
2022-03-30 |
2023-08-13 |
mouse |
| Prokopis C Prokopiou, Nina Engels-Domínguez, Kathryn V Papp, Matthew R Scott, Aaron P Schultz, Christoph Schneider, Michelle E Farrell, Rachel F Buckley, Yakeel T Quiroz, Georges El Fakhri, Dorene M Rentz, Reisa A Sperling, Keith A Johnson, Heidi I L Jacob. Lower novelty-related locus coeruleus function is associated with Aβ-related cognitive decline in clinically healthy individuals. Nature communications. vol 13. issue 1. 2022-03-24. PMID:35322012. |
the locus coeruleus (lc), one of the initial subcortical regions harboring pretangle hyperphosphorylated tau, has widespread connections to the cortex modulating cognition. |
2022-03-24 |
2023-08-13 |
human |
| Anam Islam, Takashi Saito, Takaomi Saido, Afia B Al. Presubiculum principal cells are preserved from degeneration in knock-in APP/TAU mouse models of Alzheimer's disease. Seminars in cell & developmental biology. 2022-03-16. PMID:35292192. |
the presubiculum (prs) is an integral component of the perforant pathway that has recently been recognised as a relatively unscathed region in clinical alzheimer's disease (ad), despite neighbouring components of the perforant pathway, ca1 and the entorhinal cortex, responsible for formation of episodic memory and storage, showing severe hallmarks of ad including, amyloid-beta (aβ) plaques, tau tangles and marked gliosis. |
2022-03-16 |
2023-08-13 |
mouse |