| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Guoliang Fang, Jiexiu Zhao, Pengfei Li, Liang Li, Tao Yu, Xingya Yang, Zihong He, Ye Tia. Long-term treadmill exercise inhibits neuronal cell apoptosis and reduces tau phosphorylation in the cerebral cortex and hippocampus of aged rats. Science bulletin. vol 62. issue 11. 2023-01-20. PMID:36659268. |
long-term treadmill exercise inhibits neuronal cell apoptosis and reduces tau phosphorylation in the cerebral cortex and hippocampus of aged rats. |
2023-01-20 |
2023-08-14 |
rat |
| Anish Kapadia, Krish Billimoria, Prarthna Desai, James T Grist, Chris Heyn, Pejman Maralani, Sean Symons, Fulvio Zaccagn. Hypoperfusion Precedes Tau Deposition in the Entorhinal Cortex: A Retrospective Evaluation of ADNI-2 Data. Journal of clinical neurology (Seoul, Korea). 2023-01-17. PMID:36647226. |
hypoperfusion precedes tau deposition in the entorhinal cortex: a retrospective evaluation of adni-2 data. |
2023-01-17 |
2023-08-14 |
Not clear |
| Anish Kapadia, Krish Billimoria, Prarthna Desai, James T Grist, Chris Heyn, Pejman Maralani, Sean Symons, Fulvio Zaccagn. Hypoperfusion Precedes Tau Deposition in the Entorhinal Cortex: A Retrospective Evaluation of ADNI-2 Data. Journal of clinical neurology (Seoul, Korea). 2023-01-17. PMID:36647226. |
tau deposition in the entorhinal cortex is the earliest pathological feature of alzheimer's disease (ad). |
2023-01-17 |
2023-08-14 |
Not clear |
| Nikhil Dave, Jessica M Judd, Annika Decker, Wendy Winslow, Patrick Sarette, Oscar Villarreal Espinosa, Savannah Tallino, Samantha K Bartholomew, Alina Bilal, Jessica Sandler, Ian McDonough, Joanna K Winstone, Erik A Blackwood, Christopher Glembotski, Timothy Karr, Ramon Velazque. Dietary choline intake is necessary to prevent systems-wide organ pathology and reduce Alzheimer's disease hallmarks. Aging cell. 2023-01-16. PMID:36642814. |
tissue analyses showed cardiac and liver pathology, elevated soluble and insoluble amyloid-β and thioflavin s structures, and tau hyperphosphorylation at various pathological epitopes in the hippocampus and cortex of 3xtg-ad ch- mice. |
2023-01-16 |
2023-08-14 |
mouse |
| Arunkumar Subramanian, T Tamilanban, Abdulrhman Alsayari, Gobinath Ramachawolran, Ling Shing Wong, Mahendran Sekar, Siew Hua Gan, Vetriselvan Subramaniyan, Suresh V Chinni, Nur Najihah Izzati Mat Rani, Nagaraja Suryadevara, Shadma Waha. Trilateral association of autophagy, mTOR and Alzheimer's disease: Potential pathway in the development for Alzheimer's disease therapy. Frontiers in pharmacology. vol 13. 2023-01-09. PMID:36618946. |
alzheimer's disease (ad) is the chief cause of progressive dementia, and it is characterized by irreparable loss of cognitive abilities, forming senile plaques having amyloid beta (aβ) aggregates and neurofibrillary tangles with considerable amounts of tau in affected hippocampus and cortex regions of human brains. |
2023-01-09 |
2023-08-14 |
human |
| Zheng Liang, Xiaokang Gong, Runjia Ye, Yang Zhao, Jin Yu, Yanna Zhao, Jian Ba. Long-Term High-Fat Diet Consumption Induces Cognitive Decline Accompanied by Tau Hyper-Phosphorylation and Microglial Activation in Aging. Nutrients. vol 15. issue 1. 2023-01-08. PMID:36615907. |
compared with the nd group, the hfd-fed mice showed tau hyperphosphorylation at ps214 in the hippocampus and at ps422 and ps396 in the cortex, which was accompanied by gsk-3β activation. |
2023-01-08 |
2023-08-14 |
mouse |
| Yuek Ling Chai, Nathan Hao Ping Liang, Joyce R Chong, Narayanaswamy Venketasubramanian, Boon Yeow Tan, Saima Hilal, Christopher P Chen, Mitchell K P La. Serum Cathepsin D Is a Potential Biomarker for Alzheimer's Disease Dementia and Cognitive Decline. Journal of Alzheimer's disease : JAD. 2022-12-24. PMID:36565119. |
the lysosomal protease cathepsin d (catd) has been reported to be upregulated in postmortem alzheimer's disease (ad) cortex, where it colocalized with neurofibrillary tangles and correlated with levels of phosphorylated tau, suggesting pathophysiological links between catd and neurodegeneration. |
2022-12-24 |
2023-08-14 |
Not clear |
| Zhiwei Wu, Yiwen Yang, Ziyang Song, Mengya Ma, Mengmeng Feng, Yuanqing Liu, Hanqi Xing, Yue Chang, Hui Da. PICALM rs3851179 Variants Modulate Left Postcentral Cortex Thickness, CSF Amyloid β42, and Phosphorylated Tau in the Elderly. Brain sciences. vol 12. issue 12. 2022-12-23. PMID:36552141. |
picalm rs3851179 variants modulate left postcentral cortex thickness, csf amyloid β42, and phosphorylated tau in the elderly. |
2022-12-23 |
2023-08-14 |
Not clear |
| Zhiwei Wu, Yiwen Yang, Ziyang Song, Mengya Ma, Mengmeng Feng, Yuanqing Liu, Hanqi Xing, Yue Chang, Hui Da. PICALM rs3851179 Variants Modulate Left Postcentral Cortex Thickness, CSF Amyloid β42, and Phosphorylated Tau in the Elderly. Brain sciences. vol 12. issue 12. 2022-12-23. PMID:36552141. |
to explore the effects of picalm and ad continuum stage on cortex thickness, csf aβ, and tau, 188 cognitively normal controls, 261 mci patients, and 140 early load patients were recruited, and each group was divided into rs3851179 a-carriers and gg-carriers. |
2022-12-23 |
2023-08-14 |
Not clear |
| Wei-En Wang, Rob Chen, Robin Perry Mayrand, Malek Adjouadi, Ruogu Fang, Steven T DeKosky, Ranjan Duara, Stephen A Coombes, David E Vaillancour. Association of longitudinal cognitive decline with diffusion MRI in Gray Matter, Amyloid, and Tau deposition. Neurobiology of aging. vol 121. 2022-12-01. PMID:36455492. |
when the 3 groups were combined, increasing amyloid burden was associated with reduced extracellular free-water in the entorhinal cortex and hippocampus in those with amyloid-negative status whereas increasing tau burden was associated with increased extracellular free-water regardless of amyloid status. |
2022-12-01 |
2023-08-14 |
human |
| Alessandra Dos Santos, Fernanda Cardoso Teixeira, Daniel Schuch da Silva, Tayná Amaral Veleda, Julia Eisenhart de Mello, Karina Pereira Luduvico, Rejane Giacomelli Tavares, Francieli Moro Stefanello, Wilson Cunico Filho, Roselia Maria Spanevell. Thiazolidin-4-one prevents against memory deficits, increase in phosphorylated tau protein, oxidative damage and cholinergic dysfunction in Alzheimer disease model: comparison with donepezil drug. Brain research bulletin. 2022-11-28. PMID:36442692. |
memory, acetylcholinesterase (ache) activity, phosphorylated tau protein levels and oxidative stress were analyzed in the cerebral cortex, hippocampus, and cerebellum. |
2022-11-28 |
2023-08-14 |
rat |
| Shuai Zhao, Ziqi Fan, Xinyi Zhang, Zheyu Li, Ting Shen, Kaicheng Li, Yaping Yan, Yunfeng Yuan, Jiali Pu, Jun Tian, Zhirong Liu, Yanxing Chen, Baorong Zhan. Metformin Attenuates Tau Pathology in Tau-Seeded PS19 Mice. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. 2022-11-24. PMID:36422837. |
brain extracts containing tau aggregates were unilaterally injected into the hippocampus and the overlying cerebral cortex of ps19 mice. |
2022-11-24 |
2023-08-14 |
mouse |
| Daniel Ferreira, Rosaleena Mohanty, Melissa E Murray, Agneta Nordberg, Kejal Kantarci, Eric Westma. The hippocampal sparing subtype of Alzheimer's disease assessed in neuropathology and in vivo tau positron emission tomography: a systematic review. Acta neuropathologica communications. vol 10. issue 1. 2022-11-15. PMID:36376963. |
in contrast, tau pet did identify ad participants with tracer retention in the association cortex while completely sparing the hippocampus. |
2022-11-15 |
2023-08-14 |
human |
| Daniel Ferreira, Rosaleena Mohanty, Melissa E Murray, Agneta Nordberg, Kejal Kantarci, Eric Westma. The hippocampal sparing subtype of Alzheimer's disease assessed in neuropathology and in vivo tau positron emission tomography: a systematic review. Acta neuropathologica communications. vol 10. issue 1. 2022-11-15. PMID:36376963. |
based on the accumulating data, we suggest two possible pathways of tau spread: (1) a canonical pathway with early involvement of transentorhinal cortex and subsequent involvement of limbic regions and association cortices, and (2) a less common pathway that affects association cortices with limbic involvement observed at end stages of the disease or not at all. |
2022-11-15 |
2023-08-14 |
human |
| Meaghan Morris, Abhay Moghekar, Haidan Guo, Olga Pletnikova, Javier Redding-Ochoa, Marilyn Albert, Susan M Resnick, Liam Che. Ubiquitin-positive astrogliopathy clinically mimicking Parkinson's disease. Acta neuropathologica communications. vol 10. issue 1. 2022-11-15. PMID:36376970. |
these glial aggregates affected the basal ganglia, cortex, and cerebellum, and were negative for tau, alpha-synuclein, tdp-43, fus, and p62. |
2022-11-15 |
2023-08-14 |
Not clear |
| Yi Dong, Yuanjing Li, Keke Liu, Xiaolei Han, Rui Liu, Yifei Ren, Lin Cong, Qinghua Zhang, Tingting Hou, Lin Song, Shi Tang, Lin Shi, Yishan Luo, Grégoria Kalpouzos, Erika J Laukka, Bengt Winblad, Yongxiang Wang, Yifeng Du, Chengxuan Qi. Anosmia, mild cognitive impairment, and biomarkers of brain aging in older adults. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2022-11-07. PMID:36341691. |
in the subsamples, we measured plasma amyloid beta (aβ)40, aβ42, total tau, and neurofilament light chain (nfl; n = 1054); and quantified hippocampal, entorhinal cortex, and white matter hyperintensity (wmh) volumes, and alzheimer's disease (ad)-signature cortical thickness (n = 917). |
2022-11-07 |
2023-08-14 |
human |
| Yi Dong, Yuanjing Li, Keke Liu, Xiaolei Han, Rui Liu, Yifei Ren, Lin Cong, Qinghua Zhang, Tingting Hou, Lin Song, Shi Tang, Lin Shi, Yishan Luo, Grégoria Kalpouzos, Erika J Laukka, Bengt Winblad, Yongxiang Wang, Yifeng Du, Chengxuan Qi. Anosmia, mild cognitive impairment, and biomarkers of brain aging in older adults. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2022-11-07. PMID:36341691. |
in the subsamples, anosmia was significantly associated with higher plasma total tau and nfl concentrations, smaller hippocampal and entorhinal cortex volumes, and greater wmh volume, and marginally with lower ad-signature cortical thickness. |
2022-11-07 |
2023-08-14 |
human |
| Hideomi Hamasaki, Norihisa Maeda, Naokazu Sasagasako, Hiroyuki Honda, Masahiro Shijo, Shin-Ichiro Mori, Kaoru Yagita, Hajime Arahata, Toru Iwak. Neuropathology of classic myotonic dystrophy type 1 is characterized by both early initiation of primary age-related tauopathy of the hippocampus and unique 3-repeat tauopathy of the brainstem. Journal of neuropathology and experimental neurology. 2022-11-04. PMID:36331500. |
all patients, including those of presenile age, showed numerous neurofibrillary tangles (nfts) of both 3-repeat and 4-repeat tau in the limbic area and mild involvement in the cerebral cortex. |
2022-11-04 |
2023-08-14 |
Not clear |
| Pardeep Yadav, Yeon-Hee Lee, Hrithika Panday, Shubham Kant, Neha Bajwa, Ritika Parashar, Saurabh Kumar Jha, Niraj Kumar Jha, Parma Nand, Sang-Soo Lee, Abhimanyu Kumar Jh. Implications of Microorganisms in Alzheimer's Disease. Current issues in molecular biology. vol 44. issue 10. 2022-10-26. PMID:36286029. |
ad is manifested with hyperphosphorylated tau protein levels and amyloid beta (aβ) peptide buildup in the hippocampus and cortex regions of the brain. |
2022-10-26 |
2023-08-14 |
Not clear |
| Ankur Kumar, Bhupender Nehra, Dilpreet Singh, Dileep Kuma, Pooja A Chawl. Recent advances in the development of nitrogen-containing heterocyclic Anti-Alzheimer's agents. Current topics in medicinal chemistry. 2022-10-24. PMID:36278462. |
alzheimer's disease is usually triggered by numerous associated factors, including depleted amount of acetylcholine (ach), excessive aggregation of β-amyloid peptide (aβ), tau hyperphosphorylation with neurofibrillary tangle formation as well as deposition of feeble plaques in a specific portion of the brain (hippocampus and cortex). |
2022-10-24 |
2023-08-14 |
Not clear |