| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Iain J Hartnell, Declan Woodhouse, William Jasper, Luke Mason, Pavan Marwaha, Manon Graffeuil, Laurie C Lau, Jeanette L Norman, David S Chatelet, Luc Buee, James A R Nicoll, David Blum, Guillaume Dorothee, Delphine Boch. Glial reactivity and T cell infiltration in frontotemporal lobar degeneration with tau pathology. Brain : a journal of neurology. 2023-09-13. PMID:37703311. |
tau pathology was assessed in the cerebral cortex using antibodies directed against: tau-2 (phosphorylated and unphosphorylated tau), at8 (pser202/pthr205), at100 (pthr212/pser214), cp13 (pser202), phf1(pser396/pser404), pthr181 and pser356. |
2023-09-13 |
2023-10-07 |
mouse |
| Li Gao, Dongqing Wang, Jia Ren, Xue Tan, Jiayuan Chen, Zheng Kong, Yunan Nie, Ming Ya. Acteoside ameliorates learning and memory impairment in APP/PS1 transgenic mice by increasing Aβ degradation and inhibiting tau hyperphosphorylation. Phytotherapy research : PTR. 2023-09-04. PMID:37661763. |
we evaluated the levels of aβ40 and aβ42 in serum, cortex, and hippocampus, and aβ-related scavenging enzymes, phosphorylated gsk3β and hyperphosphorylated tau in the cortex and hippocampus of app/ps1 mice by western blotting. |
2023-09-04 |
2023-09-07 |
mouse |
| Dominic J Acri, Yanwen You, Mason D Tate, Hande Karahan, Pablo Martinez, Brianne McCord, A Daniel Sharify, Sutha John, Byungwook Kim, Luke C Dabin, Stéphanie Philtjens, H R Sagara Wijeratne, Tyler J McCray, Daniel C Smith, Stephanie J Bissel, Bruce T Lamb, Cristian A Lasagna-Reeves, Jungsu Ki. Network analysis identifies strain-dependent response to tau and tau seeding-associated genes. The Journal of experimental medicine. vol 220. issue 11. 2023-08-22. PMID:37606887. |
by measuring tau seeding activity using the cortex, we identified 19 key genes associated with tau seeding and amyloid response. |
2023-08-22 |
2023-09-07 |
mouse |
| Dario Bachmann, Andreas Buchmann, Sandro Studer, Antje Saake, Katrin Rauen, Isabelle Zuber, Esmeralda Gruber, Roger M Nitsch, Christoph Hock, Anton Gietl, Valerie Treye. Age-, sex-, and pathology-related variability in brain structure and cognition. Translational psychiatry. vol 13. issue 1. 2023-08-13. PMID:37574523. |
tau burden in entorhinal cortex was related to worse episodic memory in individuals with increased amyloid burden (centiloid >12) independently of medial temporal lobe atrophy. |
2023-08-13 |
2023-08-16 |
human |
| Eliot J Davidowitz, Patricia Lopez, Heidy Jimenez, Leslie Adrien, Peter Davies, James G Mo. Small molecule inhibitor of tau self-association in a mouse model of tauopathy: A preventive study in P301L tau JNPL3 mice. PloS one. vol 18. issue 8. 2023-08-09. PMID:37556474. |
biochemical methods were used to evaluate self-associated tau, insoluble tau aggregates, total tau, and phosphorylated tau in the hindbrain, cortex, and hippocampus. |
2023-08-09 |
2023-08-16 |
mouse |
| Eliot J Davidowitz, Patricia Lopez, Heidy Jimenez, Leslie Adrien, Peter Davies, James G Mo. Small molecule inhibitor of tau self-association in a mouse model of tauopathy: A preventive study in P301L tau JNPL3 mice. PloS one. vol 18. issue 8. 2023-08-09. PMID:37556474. |
in the cortex, the levels of insoluble tau were similar in the baseline and vehicle groups, indicating that the pathological phenotype of these mice was beginning to emerge at the study endpoint and that there was a delay in the development of the phenotype of the model as originally characterized. |
2023-08-09 |
2023-08-16 |
mouse |
| Lucia Aa Giannini, Merel O Mol, Ana Rajicic, Renee van Buuren, Lana Sarkar, Sanaz Arezoumandan, Daniel T Ohm, David J Irwin, Annemieke Jm Rozemuller, John C van Swieten, Harro Seelaa. Presymptomatic and early pathological features of MAPT-associated frontotemporal lobar degeneration. Acta neuropathologica communications. vol 11. issue 1. 2023-08-02. PMID:37533060. |
the 59-year-old prodromal p301l carrier (ftld-cdr = 0.5) had highest tau burden in anterior cingulate, anterior temporal, middle/superior frontal, and fronto-insular cortex, and amygdala. |
2023-08-02 |
2023-08-14 |
Not clear |
| Kaiming Guo, Wenting Huang, Kun Chen, Pengkai Huang, Wenshuo Peng, Ruiqing Shi, Tao He, Mulan Zhang, Hao Wang, Jian Hu, Xinshi Wang, Yangping Shentu, Huiqin Xu, Li Li. Fibroblast growth factor 10 ameliorates neurodegeneration in mouse and cellular models of Alzheimer's disease via reducing tau hyperphosphorylation and neuronal apoptosis. Aging cell. 2023-07-28. PMID:37503695. |
additionally, fgf10 treatment reduced tau hyperphosphorylation and neuronal apoptosis, thereby mitigating neuronal cell damage and synaptic deficits in the cortex and hippocampus of 3xtg-ad mice, as well as appswe-transfected ht22 cells. |
2023-07-28 |
2023-08-14 |
mouse |
| Kaiming Guo, Wenting Huang, Kun Chen, Pengkai Huang, Wenshuo Peng, Ruiqing Shi, Tao He, Mulan Zhang, Hao Wang, Jian Hu, Xinshi Wang, Yangping Shentu, Huiqin Xu, Li Li. Fibroblast growth factor 10 ameliorates neurodegeneration in mouse and cellular models of Alzheimer's disease via reducing tau hyperphosphorylation and neuronal apoptosis. Aging cell. 2023-07-28. PMID:37503695. |
similarly, endogenous fgf10 overexpression ameliorated tau hyperphosphorylation and neuronal apoptosis in the cortex and hippocampus of 3xtg-ad mice. |
2023-07-28 |
2023-08-14 |
mouse |
| Carlos M Hernandez, Rachel E Barkey, Kristen M Craven, Karin A Pedemonte, Bernadette Alisantosa, Jonathan O Sanchez, Jane M Flin. Transfusion with Blood Plasma from Young Mice Affects rTg4510 Transgenic Tau Mice Modeling of Alzheimer's Disease. Brain sciences. vol 13. issue 6. 2023-06-28. PMID:37371321. |
we found that tau mice injected with plasma had lower expression of phosphorylated tau (ptau) in the brain, accompanied by fewer tau tangles in the cortex and ca1 region of the hippocampus and smaller tau tangles in the cortex, when compared to tau mice injected with saline. |
2023-06-28 |
2023-08-14 |
mouse |
| Minji Kim, Hiroaki Sekiya, Gary Yao, Nicholas B Martin, Monica Castanedes-Casey, Dennis W Dickson, Tae Hyun Hwang, Shunsuke Kog. Diagnosis of Alzheimer Disease and Tauopathies on Whole-Slide Histopathology Images Using a Weakly Supervised Deep Learning Algorithm. Laboratory investigation; a journal of technical methods and pathology. vol 103. issue 6. 2023-06-26. PMID:36889541. |
three sections (a: motor cortex; b: cingulate gyrus and superior frontal gyrus; and c: corpus striatum) that had been immunostained for phosphorylated tau were scanned and converted to wsis. |
2023-06-26 |
2023-12-23 |
Not clear |
| Tiziana Petrozziello, Sommer S Huntress, Ayleen L Castillo-Torres, James P Quinn, Theresa R Connors, Corinne A Auger, Alexandra N Mills, Spencer E Kim, Sophia Liu, Farah Mahmood, Adel Boudi, Muzhou Wu, Ellen Sapp, Pia Kivisäkk, Shekar R Sunderesh, Mahmoud A Pouladi, Steven E Arnold, Bradley T Hyman, H Diana Rosas, Marian DiFiglia, Ricardo Mouro Pinto, Kimberly Kegel-Gleason, Ghazaleh Sadri-Vakil. Age-dependent increase in tau phosphorylation at serine 396 in Huntington's disease pre-frontal cortex. medRxiv : the preprint server for health sciences. 2023-06-19. PMID:37333415. |
age-dependent increase in tau phosphorylation at serine 396 in huntington's disease pre-frontal cortex. |
2023-06-19 |
2023-08-14 |
mouse |
| Juan D Rodríguez-Callejas, Eberhard Fuchs, Claudia Perez-Cru. Atrophic astrocytes in aged marmosets present tau hyperphosphorylation, RNA oxidation, and DNA fragmentation. Neurobiology of aging. vol 129. 2023-06-11. PMID:37302213. |
these astrocytes also show oxidative damage to rna and increased nuclear plaques in the cortex and tau hyperphosphorylation (at100). |
2023-06-11 |
2023-08-14 |
marmoset |
| Anika Wuestefeld, Hannah Baumeister, Jenna N Adams, Robin de Flores, Carl Hodgetts, Negar Mazloum-Farzaghi, Rosanna K Olsen, Vyash Puliyadi, Tammy T Tran, Arnold Bakker, Kelsey L Canada, Marshall A Dalton, Ana M Daugherty, Renaud La Joie, Lei Wang, Madigan Bedard, Esther Buendia, Amanda Denning, David J Irwin, Ranjit Ittyerah, Edward B Lee, Sydney Lim, Maria Mercedes Iñiguez de Onzoño Martin, Monica Munoz Lopez, Theresa Schuck, Winifred Trotman, Alicia Vela, Paul Yushkevich, Katrin Amunts, Jean C Augustinack, Song-Lin Ding, Ricardo Insausti, Olga Kedo, David Berron, Laura E M Wiss. Comparison of histological delineations of medial temporal lobe cortices by four independent neuroanatomy laboratories. bioRxiv : the preprint server for biology. 2023-06-09. PMID:37292729. |
the medial temporal lobe (mtl) cortex, located adjacent to the hippocampus, is crucial for memory and prone to the accumulation of certain neuropathologies such as alzheimer's disease neurofibrillary tau tangles. |
2023-06-09 |
2023-08-14 |
human |
| Karol Andrea Arizaca Maquera, Justin Ralph Welden, Giorgi Margvelani, Sandra C Miranda Sardón, Samantha Hart, Noémie Robil, Alvaro Gonzalo Hernandez, Pierre de la Grange, Peter T Nelson, Stefan Stam. Alzheimer's disease pathogenetic progression is associated with changes in regulated retained introns and editing of circular RNAs. Frontiers in molecular neuroscience. vol 16. 2023-06-02. PMID:37266374. |
a decisive factor in the disease occurs when neurofibrillary tangles (nft) composed of microtubule associated protein tau (mapt) form in the entorhinal cortex and then spread throughout the brain. |
2023-06-02 |
2023-08-14 |
Not clear |
| Jiang Li, Shaofeng Xu, Ling Wang, Xiaoliang Wan. PHPB Attenuated Cognitive Impairment in Type 2 Diabetic KK-Ay Mice by Modulating SIRT1/Insulin Signaling Pathway and Inhibiting Generation of AGEs. Pharmaceuticals (Basel, Switzerland). vol 16. issue 2. 2023-06-01. PMID:37259448. |
the results showed that phpb markedly ameliorated the spatial learning ability of kk-ay mice in the morris water maze and decreased ad-like pathologic changes (tau hyperphosphorylation) in the cortex. |
2023-06-01 |
2023-08-14 |
mouse |
| Amane Tateno, Tsuyoshi Nogami, Takeshi Sakayori, Ken Yamamoto, Yoshiro Okub. Depression as a Prodromal Symptom of Neurodegenerative Diseases. Journal of Nippon Medical School = Nippon Ika Daigaku zasshi. vol 90. issue 2. 2023-05-31. PMID:37258256. |
the severity of depression was significantly associated with greater inferior temporal tau and marginally associated with greater entorhinal cortex tau, and depression was associated with significantly greater mean cortical tau deposition. |
2023-05-31 |
2023-08-14 |
human |
| Carlos G Ardanaz, Amaia Ezkurdia, Arantza Bejarano, Beatriz Echarte, Cristian Smerdou, Eva Martisova, Iván Martínez-Valbuena, María-Rosario Luquin, María J Ramírez, Maite Sola. JNK3 Overexpression in the Entorhinal Cortex Impacts on the Hippocampus and Induces Cognitive Deficiencies and Tau Misfolding. ACS chemical neuroscience. 2023-05-26. PMID:37236204. |
jnk3 overexpression in the entorhinal cortex impacts on the hippocampus and induces cognitive deficiencies and tau misfolding. |
2023-05-26 |
2023-08-14 |
human |
| Sarah Barker, Bindu D Paul, Andrew A Piepe. Increased Risk of Aging-Related Neurodegenerative Disease after Traumatic Brain Injury. Biomedicines. vol 11. issue 4. 2023-05-16. PMID:37189772. |
disease-specific mechanistic links with tbi that are reviewed include tar dna binding protein 43 and motor cortex lesions in als and ftd; alpha-synuclein, dopaminergic cell death, and synergistic toxin exposure in pd; and brain insulin resistance, amyloid beta pathology, and tau pathology in ad. |
2023-05-16 |
2023-08-14 |
Not clear |
| Junjiao Zhang, Jianing Jin, Dongning Su, Tao Feng, Huiqing Zha. Tau-PET imaging in Parkinson's disease: a systematic review and meta-analysis. Frontiers in neurology. vol 14. 2023-05-15. PMID:37181568. |
pathological tau accumulates in the cerebral cortex of parkinson's disease (pd), resulting in cognitive deterioration. |
2023-05-15 |
2023-08-14 |
Not clear |