| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Roshni C Lalwani, Claude-Henry Volmar, Claes Wahlestedt, Keith A Webster, Lina A Shehade. Contextualizing the Role of Osteopontin in the Inflammatory Responses of Alzheimer's Disease. Biomedicines. vol 11. issue 12. 2023-12-23. PMID:38137453. |
tau and aβ complexes spread from the entorhinal cortex of the brain to interconnected regions, where they bind pattern recognition receptors on microglia and astroglia to trigger inflammation and neurotoxicity that ultimately lead to neurodegeneration and clinical ad. |
2023-12-23 |
2023-12-25 |
Not clear |
| Chao Qi, Bert M Verheijen, Yasumasa Kokubo, Yang Shi, Stephan Tetter, Alexey G Murzin, Asa Nakahara, Satoru Morimoto, Marc Vermulst, Ryogen Sasaki, Eleonora Aronica, Yoshifumi Hirokawa, Kiyomitsu Oyanagi, Akiyoshi Kakita, Benjamin Ryskeldi-Falcon, Mari Yoshida, Masato Hasegawa, Sjors H W Scheres, Michel Goeder. Tau filaments from amyotrophic lateral sclerosis/parkinsonism-dementia complex adopt the CTE fold. Proceedings of the National Academy of Sciences of the United States of America. vol 120. issue 51. 2023-12-15. PMID:38100415. |
here, we used electron cryo-microscopy to determine the structures of tau filaments from the cerebral cortex of three cases of als/pdc from guam and eight cases from kii, as well as from the spinal cord of two of the guam cases. |
2023-12-15 |
2023-12-18 |
Not clear |
| Joseph Giorgio, Jenna N Adams, Anne Maass, William J Jagust, Michael Breakspea. Amyloid induced hyperexcitability in default mode network drives medial temporal hyperactivity and early tau accumulation. Neuron. 2023-12-14. PMID:38096815. |
in early alzheimer's disease (ad) β-amyloid (aβ) deposits throughout association cortex and tau appears in the entorhinal cortex (ec). |
2023-12-14 |
2023-12-17 |
Not clear |
| Justin Torok, Pedro D Maia, Chaitali Anand, Ashish Ra. Cellular underpinnings of the selective vulnerability to tauopathic insults in Alzheimer's disease. bioRxiv : the preprint server for biology. 2023-12-11. PMID:38076913. |
recent work has identified certain subpopulations of neurons in a few focal regions of interest, such as the entorhinal cortex, that are selectively vulnerable to tau pathology in ad. |
2023-12-11 |
2023-12-17 |
mouse |
| Kaitlyn M Dybing, Cecelia J Vetter, Desarae A Dempsey, Soumilee Chaudhuri, Andrew J Saykin, Shannon L Risache. Traumatic brain injury and Alzheimer's Disease biomarkers: A systematic review of findings from amyloid and tau positron emission tomography (PET). medRxiv : the preprint server for health sciences. 2023-12-11. PMID:38077068. |
evidence for increased tau was strongest in the medial temporal lobe, entorhinal cortex, precuneus, and frontal, temporal, parietal, and occipital lobes. |
2023-12-11 |
2023-12-17 |
human |
| Matthew Rowan, Annie Goettemoeller, Emmie Banks, Katharine McCann, Prateek Kumar, Kelly South, Viktor Olah, Christina Ramelow, Duc Duong, Nicholas Seyfried, Srikant Rangaraju, David Weinshenke. Entorhinal cortex vulnerability to human APP expression promotes hyperexcitability and tau pathology. Research square. 2023-11-21. PMID:37987015. |
entorhinal cortex vulnerability to human app expression promotes hyperexcitability and tau pathology. |
2023-11-21 |
2023-11-29 |
mouse |
| Cassandra Morrison, Mahsa Dadar, Farooq Kamal, D Louis Collin. Differences in AD-related pathology profiles across APOE groups. The journals of gerontology. Series A, Biological sciences and medical sciences. 2023-11-07. PMID:37935216. |
linear mixed models examined the relationship between apoe profiles and brain changes (i.e., regional wmhs, ventricle size, hippocampal and entorhinal cortex volume, amyloid level, and phosphorylated tau measures), while controlling for age, sex, education, and diagnostic status at baseline and over time. |
2023-11-07 |
2023-11-20 |
human |
| Brian N Lee, Junwen Wang, Molly A Hall, Dokyoon Kim, Shana D Stites, Li She. Sex modifies effects of imaging and CSF biomarkers on cognitive and functional outcomes: a study of Alzheimer's disease. Neurobiology of aging. vol 133. 2023-11-01. PMID:37913627. |
multiple magnetic resonance imaging (whole brain, entorhinal cortex, middle temporal gyrus, fusiform gyrus, hippocampus), position emission tomography (av45), and csf (p-tau, tau) biomarkers were differentially associated with cognitive and functional outcomes. |
2023-11-01 |
2023-11-08 |
human |
| Dibyadeep Datta, Isabella Perone, Yury M Morozov, Jon Arellano, Alvaro Duque, Pasko Rakic, Christopher H van Dyck, Amy F T Arnste. Localization of PDE4D, HCN1 channels, and mGluR3 in rhesus macaque entorhinal cortex may confer vulnerability in Alzheimer's disease. Cerebral cortex (New York, N.Y. : 1991). 2023-10-24. PMID:37874022. |
alzheimer's disease cortical tau pathology initiates in the layer ii cell clusters of entorhinal cortex, but it is not known why these specific neurons are so vulnerable. |
2023-10-24 |
2023-11-08 |
monkey |
| Dibyadeep Datta, Isabella Perone, Yury M Morozov, Jon Arellano, Alvaro Duque, Pasko Rakic, Christopher H van Dyck, Amy F T Arnste. Localization of PDE4D, HCN1 channels, and mGluR3 in rhesus macaque entorhinal cortex may confer vulnerability in Alzheimer's disease. Cerebral cortex (New York, N.Y. : 1991). 2023-10-24. PMID:37874022. |
aging macaques exhibit the same qualitative pattern of tau pathology as humans, including initial pathology in layer ii entorhinal cortex clusters, and thus can inform etiological factors driving selective vulnerability. |
2023-10-24 |
2023-11-08 |
monkey |
| Dibyadeep Datta, Isabella Perone, Yury M Morozov, Jon Arellano, Alvaro Duque, Pasko Rakic, Christopher H van Dyck, Amy F T Arnste. Localization of PDE4D, HCN1 channels, and mGluR3 in rhesus macaque entorhinal cortex may confer vulnerability in Alzheimer's disease. Cerebral cortex (New York, N.Y. : 1991). 2023-10-24. PMID:37874022. |
as layer ii entorhinal cortex stellate cells do not express calbindin, even when young, they may be particularly vulnerable to magnified calcium actions and ensuing tau pathology. |
2023-10-24 |
2023-11-08 |
monkey |
| Kayo Yukawa, Satomi Yamamoto-Mcguire, Louis Cafaro, Christine Hong, Fredrik Kamme, Tsuneya Ikezu, Seiko Ikez. Antisense oligonucleotide-based targeting of Tau-tubulin kinase 1 prevents hippocampal accumulation of phosphorylated tau in PS19 tauopathy mice. Acta neuropathologica communications. vol 11. issue 1. 2023-10-20. PMID:37853497. |
tau tubulin kinase-1 (ttbk1), a neuron-specific tau kinase, is highly expressed in the entorhinal cortex and hippocampal regions, where early tau pathology evolves in alzheimer's disease (ad). |
2023-10-20 |
2023-11-08 |
mouse |
| Aruna Sharma, Lianyuan Feng, Dafin F Muresanu, Z Ryan Tian, José Vicente Lafuente, Anca D Buzoianu, Ala Nozari, Lars Wiklund, Hari Shanker Sharm. Spinal cord injury induced exacerbation of Alzheimer's disease like pathophysiology is reduced by topical application of nanowired cerebrolysin with monoclonal antibodies to amyloid beta peptide, p-tau and tumor necrosis factor alpha. International review of neurobiology. vol 172. 2023-10-13. PMID:37833015. |
after 48 h of spinal cord injury elevation of amyloid beta peptide, phosphorylated tau (p-tau) and tumor necrosis factor-alpha (tnf-α) was seen in t9 and t12 segments of spinal cord in cerebral cortex, hippocampus and brain stem regions associated with microglial activation as seen by upregulation of iba1 and cd86. |
2023-10-13 |
2023-10-15 |
Not clear |
| Felix Carbonell, Carolann McNicoll, Alex P Zijdenbos, Barry J Bedel. Spatial association between distributed β-amyloid and tau varies with cognition. bioRxiv : the preprint server for biology. 2023-10-09. PMID:37808643. |
the most distinctive spatial association pattern was characterized by a spread of β-amyloid covering large areas of the cortex and localized tau in the entorhinal cortex. |
2023-10-09 |
2023-10-15 |
human |
| Hongli Li, Bo-Lin Xiang, Xiao Li, Cong Li, Yu Li, Ying Miao, Guo-Lan Ma, Yu-Hua Ma, Jia-Qi Chen, Qing-Yu Zhang, Long-Bao Lv, Ping Zheng, Rui Bi, Yong-Gang Ya. Cognitive Deficits and Alzheimer's Disease-Like Pathologies in the Aged Chinese Tree Shrew. Molecular neurobiology. 2023-10-09. PMID:37814108. |
moreover, the aged tree shrews exhibited several age-related phenotypes that are associated with ad, including increased levels of amyloid-β (aβ) accumulation and phosphorylated tau protein, synaptic and neuronal loss, and reactive gliosis in the cortex and the hippocampal tissues. |
2023-10-09 |
2023-10-15 |
Not clear |
| Manuel Schweighauser, Alexey G Murzin, Jennifer Macdonald, Isabelle Lavenir, R Anthony Crowther, Sjors H W Scheres, Michel Goeder. Cryo-EM structures of tau filaments from the brains of mice transgenic for human mutant P301S Tau. Acta neuropathologica communications. vol 11. issue 1. 2023-10-05. PMID:37798679. |
the filament core from the cerebral cortex of line ps19 extends from residues g271-p364 of tau. |
2023-10-05 |
2023-10-07 |
mouse |
| Aida Muntsant, Maria Del Mar Castillo-Ruiz, Lydia Giménez-Llor. Survival Bias, Non-Lineal Behavioral and Cortico-Limbic Neuropathological Signatures in 3xTg-AD Mice for Alzheimer's Disease from Premorbid to Advanced Stages and Compared to Normal Aging. International journal of molecular sciences. vol 24. issue 18. 2023-09-28. PMID:37762098. |
the underlying temporal and spatial progression of aβ and tau pathologies pointed to a relevant cortico-limbic substrate roadmap: premorbid intracellular aβ immunoreactivity and pser202/pthr205 tau phosphorylation in the amygdala and ventral hippocampus, and the entorhinal cortex and ventral hippocampus as the areas most affected by aβ plaques. |
2023-09-28 |
2023-10-07 |
mouse |
| Meixiang Huang, Carolyn Tallon, Xiaolei Zhu, Kaitlyn D J Huizar, Silvia Picciolini, Ajit G Thomas, Lukas Tenora, Wathsala Liyanage, Francesca Rodà, Alice Gualerzi, Rangaramanujam M Kannan, Marzia Bedoni, Rana Rais, Barbara S Slushe. Microglial-Targeted nSMase2 Inhibitor Fails to Reduce Tau Propagation in PS19 Mice. Pharmaceutics. vol 15. issue 9. 2023-09-28. PMID:37765332. |
the progression of alzheimer's disease (ad) correlates with the propagation of hyperphosphorylated tau (ptau) from the entorhinal cortex to the hippocampus and neocortex. |
2023-09-28 |
2023-10-07 |
mouse |
| Feng Han, JiaQie Lee, Xi Chen, Jacob Ziontz, Tyler Ward, Susan M Landau, Suzanne L Baker, Theresa M Harrison, William J Jagus. Global brain activity and its coupling with cerebrospinal fluid flow is related to tau pathology. bioRxiv : the preprint server for biology. 2023-09-25. PMID:37745434. |
cortical tau deposits first in the entorhinal cortex and hippocampus and then propagates to neocortex in an aβ-dependent manner. |
2023-09-25 |
2023-10-07 |
human |
| Feng Han, JiaQie Lee, Xi Chen, Jacob Ziontz, Tyler Ward, Susan M Landau, Suzanne L Baker, Theresa M Harrison, William J Jagus. Global brain activity and its coupling with cerebrospinal fluid flow is related to tau pathology. bioRxiv : the preprint server for biology. 2023-09-25. PMID:37745434. |
tau also tends to accumulate earlier in higher-order association cortex than in lower-order primary sensory-motor cortex. |
2023-09-25 |
2023-10-07 |
human |