| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Junfang Zhang, Haijuan Chen, Jie Wang, Qi Huang, Xiaomeng Xu, Wenjing Wang, Wei Xu, Yihui Guan, Jun Liu, Joanna M Wardlaw, Yulei Deng, Fang Xie, Binyin L. Linking white matter hyperintensities to regional cortical thinning, amyloid deposition, and synaptic density loss in Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2024-04-22. PMID:38648354. |
we investigated the association between white matter hyperintensities (wmh) and regional cortical thickness, amyloid and tau deposition, and synaptic density in the wmh-connected cortex using multimodal images. |
2024-04-22 |
2024-04-26 |
Not clear |
| Maciej Zadrozny, Patrycja Drapich, Anna Gasiorowska-Bien, Wiktor Niewiadomski, Charles R Harrington, Claude M Wischik, Gernot Riedel, Grazyna Niewiadomsk. Neuroprotection of Cholinergic Neurons with a Tau Aggregation Inhibitor and Rivastigmine in an Alzheimer's-like Tauopathy Mouse Model. Cells. vol 13. issue 7. 2024-04-12. PMID:38607082. |
the strongest phenotypic reversal coincided with a normalization of the tau load in the cortex and hippocampus of l1, suggesting that tau accumulation underpins the loss of cholinergic markers in the basal forebrain and its projection targets. |
2024-04-12 |
2024-04-14 |
mouse |
| Masumi Sugiyama, Kenneth S Kosik, Eleni Panagioto. Mathematical topology and geometry-based classification of tauopathies. Scientific reports. vol 14. issue 1. 2024-03-30. PMID:38555402. |
neurodegenerative diseases, like alzheimer's, are associated with the presence of neurofibrillary lesions formed by tau protein filaments in the cerebral cortex. |
2024-03-30 |
2024-04-02 |
Not clear |
| Ian Cheong, Yong Du, Gwenn Smith, Jun Hua, Xu Li, Alexander Pantelya. Cerebral tau deposition in co-morbid progressive supranuclear palsy and amyotrophic lateral sclerosis: an [18F]-flortaucipir and 7T MRI study. Neuro-degenerative diseases. 2024-03-25. PMID:38527450. |
conclusion in vivo tau pet imaging of an individual with psp-als overlap demonstrated increased tau burden in the motor cortex that was not observed in psp-rs or control participants. |
2024-03-25 |
2024-03-28 |
human |
| Chaitali Anand, Justin Torok, Farras Abdelnour, Pedro D Maia, Ashish Ra. Selective vulnerability and resilience to Alzheimer's disease tauopathy as a function of genes and the connectome. bioRxiv : the preprint server for biology. 2024-03-18. PMID:38496606. |
brain regions in alzheimer's (ad) exhibit distinct vulnerability to the disease's hallmark pathology, with the entorhinal cortex and hippocampus succumbing early to tau tangles while others like primary sensory cortices remain resilient. |
2024-03-18 |
2024-03-20 |
Not clear |
| Zhongying Shao, Yanjun Lu, Aihong Xing, Xiying He, Hongyan Xie, Ming H. Effect of outer membrane vesicles of Lactobacillus pentosus on Tau phosphorylation and CDK5-Calpain pathway in mice. Experimental gerontology. 2024-03-14. PMID:38484904. |
immunohistochemistry and western blot assessments unveiled elevated levels of hyperphosphorylated tau in the cortex and hippocampus of mice treated with ad-omvs. |
2024-03-14 |
2024-03-17 |
mouse |
| Patricia Rodriguez-Rodriguez, Luis Enrique Arroyo-Garcia, Christina Tsagkogianni, Lechuan Li, Wei Wang, Ákos Végvári, Isabella Salas-Allende, Zakary Plautz, Angel Cedazo-Minguez, Subhash C Sinha, Olga Troyanskaya, Marc Flajolet, Vicky Yao, Jean-Pierre Roussari. A cell autonomous regulator of neuronal excitability modulates tau in Alzheimer's disease vulnerable neurons. Brain : a journal of neurology. 2024-03-11. PMID:38462574. |
neurons from layer ii of the entorhinal cortex (ecii) are the first to accumulate tau protein aggregates and degenerate during prodromal alzheimer's disease (ad). |
2024-03-11 |
2024-03-14 |
mouse |
| Muhammad Ali, Pierre Garcia, Laetitia P Lunkes, Alessia Sciortino, Melanie Thomas, Tony Heurtaux, Kamil Grzyb, Rashi Halder, Djalil Coowar, Alex Skupin, Luc Buée, David Blum, Manuel Buttini, Enrico Glaa. Single cell transcriptome analysis of the THY-Tau22 mouse model of Alzheimer's disease reveals sex-dependent dysregulations. Cell death discovery. vol 10. issue 1. 2024-03-07. PMID:38453894. |
to gain insights into early ad-associated molecular changes and their sex dependency for tau pathology in the cortex, we performed single-cell rna-seq in the thy-tau22 ad mouse model. |
2024-03-07 |
2024-03-10 |
mouse |
| Danira Toral-Rios, Justin M Long, Jason D Ulrich, Jinsheng Yu, Michael R Strickland, Xianlin Han, David M Holtzman, Anil G Cashikar, Steven M Pau. Cholesterol 25-hydroxylase mediates neuroinflammation and neurodegeneration in a mouse model of tauopathy. The Journal of experimental medicine. vol 221. issue 4. 2024-03-05. PMID:38442267. |
here, we show that in the absence of ch25h and the resultant reduction in 25-hc, there is strikingly reduced age-dependent neurodegeneration and neuroinflammation in the hippocampus and entorhinal/piriform cortex of ps19 mice, which express the p301s mutant human tau transgene. |
2024-03-05 |
2024-03-08 |
mouse |
| Anika Wuestefeld, Hannah Baumeister, Jenna N Adams, Robin de Flores, Carl J Hodgetts, Negar Mazloum-Farzaghi, Rosanna K Olsen, Vyash Puliyadi, Tammy T Tran, Arnold Bakker, Kelsey L Canada, Marshall A Dalton, Ana M Daugherty, Renaud La Joie, Lei Wang, Madigan L Bedard, Esther Buendia, Eunice Chung, Amanda Denning, María Del Mar Arroyo-Jiménez, Emilio Artacho-Pérula, David J Irwin, Ranjit Ittyerah, Edward B Lee, Sydney Lim, María Del Pilar Marcos-Rabal, Maria Mercedes Iñiguez de Onzoño Martin, Monica Munoz Lopez, Carlos de la Rosa Prieto, Theresa Schuck, Winifred Trotman, Alicia Vela, Paul Yushkevich, Katrin Amunts, Jean C Augustinack, Song-Lin Ding, Ricardo Insausti, Olga Kedo, David Berron, Laura E M Wiss. Comparison of histological delineations of medial temporal lobe cortices by four independent neuroanatomy laboratories. Hippocampus. 2024-02-28. PMID:38415962. |
the medial temporal lobe (mtl) cortex, located adjacent to the hippocampus, is crucial for memory and prone to the accumulation of certain neuropathologies such as alzheimer's disease neurofibrillary tau tangles. |
2024-02-28 |
2024-03-01 |
human |
| Malin Wennström, Nina Schultz, Paula Mille Gallardo, The Netherlands Brain Bank, Geidy E Serrano, Thomas G Beach, Suchira Bose, Oskar Hansso. The Relationship between p-tau217, p-tau231, and p-tau205 in the Human Brain Is Affected by the Cellular Environment and Alzheimer's Disease Pathology. Cells. vol 13. issue 4. 2024-02-23. PMID:38391945. |
to investigate if the three p-tau variants are found to the same degree in different tau structures and if their co-localization is affected by the diagnosis and presence of aß plaques, we immunostained sections of the entorhinal cortex (ec) and inferior temporal gyrus (itg) from non-demented controls (nc), patients with alzheimer's disease (ad), and primary age-related tauopathy (part) against p-tau217, p-tau231, and p-tau205 together with methoxi-x04. |
2024-02-23 |
2024-02-25 |
human |
| Osborne F X Almeid. Early and specific detection of Alzheimer's disease: more than a (virtual) reality? Brain communications. vol 6. issue 1. 2024-02-13. PMID:38347943. |
this scientific commentary refers to 'path integration deficits are associated with phosphorylated tau accumulation in the entorhinal cortex', by koike |
2024-02-13 |
2024-02-15 |
Not clear |
| Riki Koike, Yoshiyuki Soeda, Atsushi Kasai, Yusuke Fujioka, Shinsuke Ishigaki, Akihiro Yamanaka, Yuta Takaichi, James K Chambers, Kazuyuki Uchida, Hirohisa Watanabe, Akihiko Takashim. Path integration deficits are associated with phosphorylated tau accumulation in the entorhinal cortex. Brain communications. vol 6. issue 1. 2024-02-13. PMID:38347945. |
path integration deficits are associated with phosphorylated tau accumulation in the entorhinal cortex. |
2024-02-13 |
2024-02-15 |
mouse |
| Riki Koike, Yoshiyuki Soeda, Atsushi Kasai, Yusuke Fujioka, Shinsuke Ishigaki, Akihiro Yamanaka, Yuta Takaichi, James K Chambers, Kazuyuki Uchida, Hirohisa Watanabe, Akihiko Takashim. Path integration deficits are associated with phosphorylated tau accumulation in the entorhinal cortex. Brain communications. vol 6. issue 1. 2024-02-13. PMID:38347945. |
at 6 months of age, ps19 mice showed a significant accumulation of phosphorylated tau only in the entorhinal cortex, associated with impaired path integration without impairments in spatial cognition. |
2024-02-13 |
2024-02-15 |
mouse |
| Riki Koike, Yoshiyuki Soeda, Atsushi Kasai, Yusuke Fujioka, Shinsuke Ishigaki, Akihiro Yamanaka, Yuta Takaichi, James K Chambers, Kazuyuki Uchida, Hirohisa Watanabe, Akihiko Takashim. Path integration deficits are associated with phosphorylated tau accumulation in the entorhinal cortex. Brain communications. vol 6. issue 1. 2024-02-13. PMID:38347945. |
these data are consistent with the idea that path integration deficit is caused by the accumulation of phosphorylated tau in the entorhinal cortex. |
2024-02-13 |
2024-02-15 |
mouse |
| Chan Chen, Ramhari Kumbhar, Hu Wang, Xiuli Yang, Kundlik Gadhave, Cyrus Rastegar, Yasuyoshi Kimura, Adam Behensky, Sumasri Kotha, Grace Kuo, Sruthi Katakam, Deok Jeong, Liang Wang, Anthony Wang, Rong Chen, Shu Zhang, Lingtao Jin, Creg J Workman, Dario A A Vignali, Olga Pletinkova, Hongpeng Jia, Weiyi Peng, David W Nauen, Philip C Wong, Javier Redding-Ochoa, Juan C Troncoso, Mingyao Ying, Valina L Dawson, Ted M Dawson, Xiaobo Ma. Lymphocyte-Activation Gene 3 Facilitates Pathological Tau Neuron-to-Neuron Transmission. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2024-02-08. PMID:38327094. |
propagation of tau pathology and behavioral deficits induced by injection of tau pff in the hippocampus and overlying cortex are attenuated in mice lacking lag3 selectively in neurons. |
2024-02-08 |
2024-02-10 |
mouse |
| Veronica Astillero-Lopez, Sandra Villar-Conde, Melania Gonzalez-Rodriguez, Alicia Flores-Cuadrado, Isabel Ubeda-Banon, Daniel Saiz-Sanchez, Alino Martinez-Marco. Proteomic analysis identifies HSP90AA1, PTK2B, and ANXA2 in the human entorhinal cortex in Alzheimer's disease: Potential role in synaptic homeostasis and Aβ pathology through microglial and astroglial cells. Brain pathology (Zurich, Switzerland). 2024-01-22. PMID:38247340. |
the entorhinal cortex (ec) is among the earliest areas affected by tau accumulation along with volume reduction and neurodegeneration. |
2024-01-22 |
2024-01-24 |
human |
| Kurt A Jellinge. The enigma of depression in corticobasal degeneration, a frequent but poorly understood co-morbidity. Journal of neural transmission (Vienna, Austria : 1996). 2024-01-12. PMID:38216704. |
this 4-repeat (4r) tauopathy is morphologically featured by asymmetric frontoparietal atrophy, neuronal loss, and gliosis in cortex and subcortex including substantia nigra, ballooned/achromatic neurons with filamentous 4r tau aggregates in cortex and striatum, widespread thread-like structures, pathognomonic "astroglial plaques", "tufted astrocytes", and numerous "coiled bodies" (in astrocytes and oligodendroglia) in cerebral white matter. |
2024-01-12 |
2024-01-15 |
Not clear |
| Nisha Rani, Kylie H Alm, Caitlin A Corona-Long, Caroline L Speck, Anja Soldan, Corinne Pettigrew, Yuxin Zhu, Marilyn Albert, Arnold Bakke. Tau PET burden in Brodmann areas 35 and 36 is associated with individual differences in cognition in non-demented older adults. Frontiers in aging neuroscience. vol 15. 2024-01-01. PMID:38161595. |
the accumulation of neurofibrillary tau tangles, a neuropathological hallmark of alzheimer's disease (ad), occurs in medial temporal lobe (mtl) regions early in the disease process, with some of the earliest deposits localized to subregions of the entorhinal cortex. |
2024-01-01 |
2024-01-05 |
Not clear |
| Nisha Rani, Kylie H Alm, Caitlin A Corona-Long, Caroline L Speck, Anja Soldan, Corinne Pettigrew, Yuxin Zhu, Marilyn Albert, Arnold Bakke. Tau PET burden in Brodmann areas 35 and 36 is associated with individual differences in cognition in non-demented older adults. Frontiers in aging neuroscience. vol 15. 2024-01-01. PMID:38161595. |
although functional specialization of entorhinal cortex subregions has been reported, few studies have considered functional associations with localized tau accumulation. |
2024-01-01 |
2024-01-05 |
Not clear |