| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Amane Tateno, Tsuyoshi Nogami, Takeshi Sakayori, Ken Yamamoto, Yoshiro Okub. Depression as a Prodromal Symptom of Neurodegenerative Diseases. Journal of Nippon Medical School = Nippon Ika Daigaku zasshi. vol 90. issue 2. 2023-05-31. PMID:37258256. |
the severity of depression was significantly associated with greater inferior temporal tau and marginally associated with greater entorhinal cortex tau, and depression was associated with significantly greater mean cortical tau deposition. |
2023-05-31 |
2023-08-14 |
human |
| Carlos G Ardanaz, Amaia Ezkurdia, Arantza Bejarano, Beatriz Echarte, Cristian Smerdou, Eva Martisova, Iván Martínez-Valbuena, María-Rosario Luquin, María J Ramírez, Maite Sola. JNK3 Overexpression in the Entorhinal Cortex Impacts on the Hippocampus and Induces Cognitive Deficiencies and Tau Misfolding. ACS chemical neuroscience. 2023-05-26. PMID:37236204. |
jnk3 overexpression in the entorhinal cortex impacts on the hippocampus and induces cognitive deficiencies and tau misfolding. |
2023-05-26 |
2023-08-14 |
human |
| Sarah Barker, Bindu D Paul, Andrew A Piepe. Increased Risk of Aging-Related Neurodegenerative Disease after Traumatic Brain Injury. Biomedicines. vol 11. issue 4. 2023-05-16. PMID:37189772. |
disease-specific mechanistic links with tbi that are reviewed include tar dna binding protein 43 and motor cortex lesions in als and ftd; alpha-synuclein, dopaminergic cell death, and synergistic toxin exposure in pd; and brain insulin resistance, amyloid beta pathology, and tau pathology in ad. |
2023-05-16 |
2023-08-14 |
Not clear |
| Junjiao Zhang, Jianing Jin, Dongning Su, Tao Feng, Huiqing Zha. Tau-PET imaging in Parkinson's disease: a systematic review and meta-analysis. Frontiers in neurology. vol 14. 2023-05-15. PMID:37181568. |
pathological tau accumulates in the cerebral cortex of parkinson's disease (pd), resulting in cognitive deterioration. |
2023-05-15 |
2023-08-14 |
Not clear |
| Wenqiang Chen, Qian Huang, Ekaterina Katie Lazdon, Antonio Gomes, Marisa Wong, Emily Stephens, Tabitha Grace Royal, Dan Frenkel, Weikang Cai, C Ronald Kah. Loss of insulin signaling in astrocytes exacerbates Alzheimer-like phenotypes in a 5xFAD mouse model. Proceedings of the National Academy of Sciences of the United States of America. vol 120. issue 21. 2023-05-15. PMID:37186836. |
this was associated with increased tau (t231) phosphorylation, increased aβ plaque size, and increased association of astrocytes with plaques in the cerebral cortex as assessed using tissue clarity of the brain in the igirko/5xfad mice. |
2023-05-15 |
2023-08-14 |
mouse |
| Chao Qi, Bert M Verheijen, Yasumasa Kokubo, Yang Shi, Stephan Tetter, Alexey G Murzin, Asa Nakahara, Satoru Morimoto, Marc Vermulst, Ryogen Sasaki, Eleonora Aronica, Yoshifumi Hirokawa, Kiyomitsu Oyanagi, Akiyoshi Kakita, Benjamin Ryskeldi-Falcon, Mari Yoshida, Masato Hasegawa, Sjors H W Scheres, Michel Goeder. Tau Filaments from Amyotrophic Lateral Sclerosis/Parkinsonism-Dementia Complex (ALS/PDC) adopt the CTE Fold. bioRxiv : the preprint server for biology. 2023-05-10. PMID:37162924. |
here we used electron cryo-microscopy (cryo-em) to determine the structures of tau filaments from the cerebral cortex of three cases of als/pdc from guam and eight cases from kii, as well as from the spinal cord of two of the guam cases. |
2023-05-10 |
2023-08-14 |
Not clear |
| F A Concepcion, N A Ekstrom, M N Khan, O O Estes, N P Poolo. Progressive Dysregulation of Tau Phosphorylation in an Animal Model of Temporal Lobe Epilepsy. Neuroscience. 2023-05-04. PMID:37142182. |
in somatosensory cortex, outside of the seizure onset zone, no changes in tau expression or phosphorylation were seen at the later time point. |
2023-05-04 |
2023-08-14 |
human |
| Seyed Hani Hojjati, Tracy A Butler, Gloria C Chiang, Christian Habeck, Arindam RoyChoudhury, Farnia Feiz, Jacob Shteingart, Siddharth Nayak, Sindy Ozoria, Antonio Fernández, Yaakov Stern, José A Luchsinger, Davangere P Devanand, Qolamreza R Razligh. Distinct and joint effects of low and high levels of Aβ and tau deposition on cortical thickness. NeuroImage. Clinical. vol 38. 2023-04-27. PMID:37104927. |
alzheimer's disease (ad) is defined by the presence of amyloid-β (aβ),tau, and neurodegeneration (atn framework) in the human cerebral cortex. |
2023-04-27 |
2023-08-14 |
human |
| Asgeir Kobro-Flatmoen, Claudia Battistin, Rajeevkumar Raveendran Nair, Christiana Bjorkli, Belma Skender, Cliff Kentros, Gunnar Gouras, Menno P Witte. Lowering levels of reelin in entorhinal cortex layer II-neurons results in lowered levels of intracellular amyloid-β. Brain communications. vol 5. issue 2. 2023-04-24. PMID:37091586. |
projection neurons in the anteriolateral part of entorhinal cortex layer ii are the predominant cortical site for hyper-phosphorylation of tau and formation of neurofibrillary tangles in prodromal alzheimer's disease. |
2023-04-24 |
2023-08-14 |
rat |
| Isaline Mees, Rebecca Nisbet, Anthony Hannan, Thibault Renoi. Implications of Tau Dysregulation in Huntington's Disease and Potential for New Therapeutics. Journal of Huntington's disease. 2023-04-24. PMID:37092231. |
tau hyperphosphorylation, the main feature of tau pathology, has also been investigated and our own published results suggest that the protein phosphorylation machinery is dysregulated in the early stages of hd in r6/1 transgenic mice, primarily in the cortex and striatum. |
2023-04-24 |
2023-08-14 |
mouse |
| Courtney K Walker, Kelsey M Greathouse, Jennifer J Tuscher, Eric B Dammer, Audrey J Weber, Evan Liu, Kendall A Curtis, Benjamin D Boros, Cameron D Freeman, Jung Vin Seo, Raksha Ramdas, Cheyenne Hurst, Duc M Duong, Marla Gearing, Charles F Murchison, Jeremy J Day, Nicholas T Seyfried, Jeremy H Herskowit. Cross-Platform Synaptic Network Analysis of Human Entorhinal Cortex Identifies TWF2 as a Modulator of Dendritic Spine Length. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2023-04-13. PMID:37055180. |
collectively, this study describes alterations in dendritic spine density and morphology as well as synaptic proteins and phosphorylated tau from the entorhinal cortex of preclinical and advanced stage ad patients. |
2023-04-13 |
2023-08-14 |
human |
| Mingqi Liu, Jinhao Huang, Tao Liu, Jiangyuan Yuan, Chuanxiang Lv, Zhuang Sha, Chenrui Wu, Weiwei Jiang, Xuanhui Liu, Meng Nie, Yupeng Chen, Shiying Dong, Yu Qian, Chuang Gao, Yibing Fan, Di Wu, Rongcai Jian. Exogenous interleukin 33 enhances the brain's lymphatic drainage and toxic protein clearance in acute traumatic brain injury mice. Acta neuropathologica communications. vol 11. issue 1. 2023-04-06. PMID:37024941. |
we verified that exogenous il-33 could improve the motor and memory skills of tbi mice and demonstrated that in the acute phase, it increased the exchange of cerebrospinal and interstitial fluid, reversed the dysregulation and depolarization of aquaporin-4 in the cortex and hippocampus, improved the drainage of mlvs to deep cervical lymph nodes, and reduced tau accumulation and glial activation. |
2023-04-06 |
2023-08-14 |
mouse |
| Laura J Mahady, Sylvia E Perez, Michael Malek-Ahmadi, Elliott J Mufso. Oligomeric, phosphorylated, and truncated tau and spliceosome pathology within the entorhinal-hippocampal connectome across stages of Alzheimer's disease. The Journal of comparative neurology. 2023-03-29. PMID:36989381. |
here, we used quantitative immunohistochemistry to determine the density of posttranslational oligomeric (toc1 and tnt1), phosphorylated (at8), and late truncated (tauc3) tau epitopes within the mtl subfields including entorhinal cortex (ec) layer ii, subiculum, cornu ammonis (ca) subfields, and dentate gyrus (dg) in subjects who died with a clinical diagnosis of no cognitive impairment (nci), mild cognitive impairment (mci), and ad. |
2023-03-29 |
2023-08-14 |
human |
| Kangshuai Du, Yunxiao Dou, Kui Chen, Yanxin Zha. Activation of TRPV4 induces intraneuronal tau hyperphosphorylation via cholesterol accumulation. Experimental neurology. 2023-03-29. PMID:36990137. |
our data indicated that trpv4 activation increased tau phosphorylation in the cortex and hippocampus of p301s tauopathy mouse model and aggravated its cognitive decline. |
2023-03-29 |
2023-08-14 |
mouse |
| Patricia Grandizoli Saletti, Pablo M Casillas-Espinosa, Christos Panagiotis Lisgaras, Wenzhu Bi Mowrey, Qianyun Li, Wei Liu, Rhys D Brady, Idrish Ali, Juliana Silva, Glenn Yamakawa, Matt Hudson, Crystal Li, Emma Baine, Lisa Coles, James C Cloyd, Nigel C Jones, Sandy R Shultz, Solomon L Moshé, Terence J O'Brien, Aristea S Galanopoulo. TAU phosphorylation patterns in the rat cerebral cortex after traumatic brain injury and sodium selenate effects: An EpiBioS4Rx Project 2 study. Journal of neurotrauma. 2023-03-23. PMID:36950806. |
tau phosphorylation patterns in the rat cerebral cortex after traumatic brain injury and sodium selenate effects: an epibios4rx project 2 study. |
2023-03-23 |
2023-08-14 |
rat |
| Katrine Sjaastad Hanssen, Menno P Witter, Axel Sandvig, Ioanna Sandvig, Asgeir Kobro-Flatmoe. Dissection and culturing of adult lateral entorhinal cortex layer II neurons from APP/PS1 Alzheimer model mice. Journal of neuroscience methods. 2023-03-22. PMID:36948358. |
the first cortical neurons affected in ad reside in layer ii of the lateralmost part of the entorhinal cortex, and they undergo early accumulation of intracellular amyloid-β, form subsequent tau pathology, and start degenerating pre-symptomatically. |
2023-03-22 |
2023-08-14 |
mouse |
| Kaitlin M Stouffer, Claire Chen, Sue Kulason, Eileen Xu, Menno P Witter, Can Ceritoglu, Marilyn S Albert, Susumu Mori, Juan Troncoso, Daniel J Tward, Michael I Mille. Early amygdala and ERC atrophy linked to 3D reconstruction of rostral neurofibrillary tau tangle pathology in Alzheimer's disease. NeuroImage. Clinical. vol 38. 2023-03-19. PMID:36934675. |
previous research has emphasized the unique impact of alzheimer's disease (ad) pathology on the medial temporal lobe (mtl), a reflection that tau pathology is particularly striking in the entorhinal and transentorhinal cortex (erc, tec) early in the course of disease. |
2023-03-19 |
2023-08-14 |
Not clear |
| Lindsay A Welikovitch, Simon Dujardin, Amy R Dunn, Analiese R Fernandes, Anita Khasnavis, Lori B Chibnik, Catherine C Kaczorowski, Bradley T Hyma. Rate of tau propagation is a heritable disease trait in genetically diverse mouse strains. iScience. vol 26. issue 2. 2023-02-09. PMID:36756365. |
using an aav-based model system, p301l-mutant human tau (htau) was introduced into the entorhinal cortex of mice derived from 18 distinct lines. |
2023-02-09 |
2023-08-14 |
mouse |
| Amber M Tetlow, Brianna M Jackman, Mohammed M Alhadidy, Patricia Muskus, David G Morgan, Marcia N Gordo. Neural atrophy produced by AAV tau injections into hippocampus and anterior cortex of middle-aged mice. Neurobiology of aging. vol 124. 2023-02-05. PMID:36739619. |
neural atrophy produced by aav tau injections into hippocampus and anterior cortex of middle-aged mice. |
2023-02-05 |
2023-08-14 |
mouse |
| Md Rejaul Hoq, Sakshibeedu R Bharath, Grace I Hallinan, Anllely Fernandez, Frank S Vago, Kadir A Ozcan, Daoyi Li, Holly J Garringer, Ruben Vidal, Bernardino Ghetti, Wen Jian. Cross-β helical filaments of Tau and TMEM106B in Gray and White Matter of Multiple System Tauopathy with presenile Dementia. bioRxiv : the preprint server for biology. 2023-01-30. PMID:36711790. |
cryogenic electron microscopy (cryo-em) studies have unveiled the structure of tau and tmem106b, from the cerebral cortex, in several neurodegenerative diseases; however, whether tau and tmem106b filaments from the gray and white matter share a common fold requires additional investigation. |
2023-01-30 |
2023-08-14 |
Not clear |