| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jianping Tang, Yanjun Li, Xu Liu, Guangxia Yu, Fuli Zheng, Zhenkun Guo, Yating Zhang, Wenya Shao, Siying Wu, Huangyuan L. Cobalt induces neurodegenerative damages through impairing autophagic flux by activating hypoxia-inducible factor-1α triggered ROS overproduction. The Science of the total environment. 2022-10-15. PMID:36243078. |
we first reveal cobalt as an environmental toxicant to severely induce β amyloid (aβ) deposition, tau hyperphosphorylation, and dysregulated autophagy in the hippocampus and cortex of mice. |
2022-10-15 |
2023-08-14 |
mouse |
| Yueh-Ting Tsai, Shung-Te Kao, Chin-Yi Chen. Medicinal Herbs and Their Derived Ingredients Protect against Cognitive Decline in In Vivo Models of Alzheimer's Disease. International journal of molecular sciences. vol 23. issue 19. 2022-10-14. PMID:36232612. |
therefore, mhdis listed in this review protect against aβ-induced cognitive decline by inhibiting aβ accumulation, oxidative stress, tau hyperphosphorylation, inflammation, synaptic damage, and neuronal apoptosis in the cortex and hippocampus during the early and late ad phases. |
2022-10-14 |
2023-08-14 |
Not clear |
| Yuta Katsumi, Deepti Putcha, Ryan Eckbo, Bonnie Wong, Megan Quimby, Scott McGinnis, Alexandra Touroutoglou, Bradford C Dickerso. Anterior dorsal attention network tau drives visual attention deficits in posterior cortical atrophy. Brain : a journal of neurology. 2022-10-14. PMID:36237170. |
as predicted, we found consistent and prominent localization of tau pathology in the dorsal attention network and visual network of the cerebral cortex. |
2022-10-14 |
2023-08-14 |
Not clear |
| Martina P Morawe, Fan Liao, Willi Amberg, Jeroen van Bergeijk, Rui Chang, Mary Gulino, Caitlin Hamilton, Carolin Hoft, Casey Lumpkin, Bryan Mastis, Emily McGlame, Judith Nuber, Christian Plaas, Brinda Ravikumar, Kaushambi Roy, Marion Schanzenbächer, Joseph Tierno, Viktor Lakics, Tammy Dellovade, Matthew Townsen. Pharmacological mTOR-inhibition facilitates clearance of AD-related tau aggregates in the mouse brain. European journal of pharmacology. 2022-10-03. PMID:36191631. |
rapamycin treatment reduced the burden of hyperphosphorylated and aggregated pathological tau in the cerebral cortex only when applied to young mice, prior to the emergence of pathology. |
2022-10-03 |
2023-08-14 |
mouse |
| Martina P Morawe, Fan Liao, Willi Amberg, Jeroen van Bergeijk, Rui Chang, Mary Gulino, Caitlin Hamilton, Carolin Hoft, Casey Lumpkin, Bryan Mastis, Emily McGlame, Judith Nuber, Christian Plaas, Brinda Ravikumar, Kaushambi Roy, Marion Schanzenbächer, Joseph Tierno, Viktor Lakics, Tammy Dellovade, Matthew Townsen. Pharmacological mTOR-inhibition facilitates clearance of AD-related tau aggregates in the mouse brain. European journal of pharmacology. 2022-10-03. PMID:36191631. |
nevertheless, this pulse-like mtor inhibition followed by longer intervals of re-activation was sufficient to reduce tau pathology in the cerebral cortex in p301s tau transgenic mice. |
2022-10-03 |
2023-08-14 |
mouse |
| Longfei Li, Jin Miao, Dandan Chu, Nana Jin, Yunn Chyn Tung, Chun-Ling Dai, Wen Hu, Cheng-Xin Gong, Khalid Iqbal, Fei Li. Tau antibody 77G7 targeting microtubule binding domain suppresses proteopathic tau to seed tau aggregation. CNS neuroscience & therapeutics. 2022-09-17. PMID:36114722. |
tau lesion starts in the trans-entorhinal cortex, from where it spreads to limbic regions, followed by neocortical areas. |
2022-09-17 |
2023-08-14 |
Not clear |
| Churaibhon Wisessaowapak, Luksamee Worasuttayangkurn, Kanjanamas Maliphol, Watanyoo Nakareangrit, Wanida Cholpraipimolrat, Sumontha Nookabkaew, Piyajit Watcharasit, Jutamaad Satayaviva. The 28-day repeated arsenic exposure increases tau phosphorylation in the rat brain. Environmental toxicology and pharmacology. 2022-09-11. PMID:36089238. |
interestingly, we found an increase in tau phosphorylation at the tau 1 region (189-207) and s202 in the hippocampus, s404 in the cerebral cortex, and s396 and s404 in the cerebellum of arsenic-treated rats. |
2022-09-11 |
2023-08-14 |
rat |
| Pengfang Zheng, Xiaojun She, Chunping Wang, Yingwen Zhu, Bo Fu, Kefeng Ma, Honglian Yang, Xiujie Gao, Xiaofang Li, Fangshan Wu, Bo Cu. Around-the-Clock Noise Induces AD-like Neuropathology by Disrupting Autophagy Flux Homeostasis. Cells. vol 11. issue 17. 2022-09-09. PMID:36078149. |
the levels of phosphorylated tau, amyloid-β (aβ), and neuroinflammation in the cortex and hippocampus were assessed and autophagosome (ap) aggregation was observed by transmission electron microscopy. |
2022-09-09 |
2023-08-14 |
rat |
| Lucia A A Giannini, Daniel T Ohm, Annemieke J M Rozemuller, Laynie Dratch, EunRan Suh, Vivianna M van Deerlin, John Q Trojanowski, Edward B Lee, John C van Swieten, Murray Grossman, Harro Seelaar, David J Irwi. Isoform-specific patterns of tau burden and neuronal degeneration in MAPT-associated frontotemporal lobar degeneration. Acta neuropathologica. 2022-09-06. PMID:36066634. |
in contrast, the regions with the highest tau burden differed in isoform groups (3r: striatum; 3r + 4r: striatum, inferior parietal lobule, middle frontal cortex, anterior cingulate cortex; 4r: transentorhinal cortex, anterior temporal cortex, fusiform gyrus). |
2022-09-06 |
2023-08-14 |
Not clear |
| Zhen-Kai Ngian, Yow-Yong Tan, Ching-Thong Choo, Wei-Qi Lin, Chao-Yong Leow, Shan-Jie Mah, Mitchell Kim-Peng Lai, Christopher Li-Hsian Chen, Chin-Tong On. Truncated Tau caused by intron retention is enriched in Alzheimer's disease cortex and exhibits altered biochemical properties. Proceedings of the National Academy of Sciences of the United States of America. vol 119. issue 37. 2022-09-06. PMID:36067305. |
truncated tau caused by intron retention is enriched in alzheimer's disease cortex and exhibits altered biochemical properties. |
2022-09-06 |
2023-08-14 |
Not clear |
| Moorthi Ponnusamy, Shuai Wang, Melike Yuksel, Mitchell T Hansen, Danielle M Blazier, Joseph D McMillan, Xiaolin Zhang, Eric B Dammer, Lisa Collier, Gopal Thinakara. Loss of forebrain BIN1 attenuates hippocampal pathology and neuroinflammation in a tauopathy model. Brain : a journal of neurology. 2022-09-04. PMID:36059072. |
the loss of forebrain bin1 expression in ps19 mice exacerbated tau pathology in the somatosensory cortex, thalamus, spinal cord, and sciatic nerve, accelerated disease progression, and caused early death. |
2022-09-04 |
2023-08-14 |
mouse |
| Moorthi Ponnusamy, Shuai Wang, Melike Yuksel, Mitchell T Hansen, Danielle M Blazier, Joseph D McMillan, Xiaolin Zhang, Eric B Dammer, Lisa Collier, Gopal Thinakara. Loss of forebrain BIN1 attenuates hippocampal pathology and neuroinflammation in a tauopathy model. Brain : a journal of neurology. 2022-09-04. PMID:36059072. |
intriguingly, the loss of bin1 also mitigated tau neuropathology in select regions, including the hippocampus, entorhinal/piriform cortex, and amygdala, thus attenuating hippocampal synapse loss, neuronal death, neuroinflammation, and brain atrophy. |
2022-09-04 |
2023-08-14 |
mouse |
| Philip S Insel, Christina B Young, Paul S Aisen, Keith A Johnson, Reisa A Sperling, Elizabeth C Mormino, Michael C Donohu. Tau positron emission tomography in preclinical Alzheimer's disease. Brain : a journal of neurology. 2022-08-13. PMID:35962782. |
the focus of early tau accumulation on the medial temporal lobe has resulted from the observation that the entorhinal cortex is the initial site to show abnormal levels of tau with age. |
2022-08-13 |
2023-08-14 |
human |
| Philip S Insel, Christina B Young, Paul S Aisen, Keith A Johnson, Reisa A Sperling, Elizabeth C Mormino, Michael C Donohu. Tau positron emission tomography in preclinical Alzheimer's disease. Brain : a journal of neurology. 2022-08-13. PMID:35962782. |
while the entorhinal cortex plays a central role in the early appearance of tau, it may be the inferior temporal cortex that is the critical region for rapid tau accumulation in preclinical alzheimer's disease. |
2022-08-13 |
2023-08-14 |
human |
| Heather McCann, Anita Y Bahar, Karim Burkhardt, Andrew J Gardner, Glenda M Halliday, Grant L Iverson, Claire E Shepher. Prevalence of chronic traumatic encephalopathy in the Sydney Brain Bank. Brain communications. vol 4. issue 4. 2022-08-11. PMID:35950093. |
the tau-immunopositive neurons and astrocytes that are considered pathognomonic for chronic traumatic encephalopathy are morphologically indistinguishable from alzheimer-related neurofibrillary tangles and ageing-related tau astrogliopathy, respectively, although they are found in different spatial distributions throughout the cortex. |
2022-08-11 |
2023-08-14 |
Not clear |
| Victor Montal, Ibai Diez, Chan-Mi Kim, William Orwig, Elisenda Bueichekú, Raquel Gutiérrez-Zúñiga, Alexandre Bejanin, Jordi Pegueroles, Oriol Dols-Icardo, Patrizia Vannini, Georges El-Fakhri, Keith A Johnson, Reisa A Sperling, Juan Fortea, Jorge Sepulcr. Network Tau spreading is vulnerable to the expression gradients of Science translational medicine. vol 14. issue 655. 2022-07-27. PMID:35895837. |
network tau spreading is vulnerable to the expression gradients of a key hallmark of alzheimer's disease (ad) pathology is the intracellular accumulation of tau protein in the form of neurofibrillary tangles across large-scale networks of the human brain cortex. |
2022-07-27 |
2023-08-14 |
human |
| Alexandria B Marciante, John Howard, Mia N Kelly, Juan Santiago Moreno, Latoya L Allen, Elisa J Gonzalez-Rothi, Gordon S Mitchel. Dose-dependent Phosphorylation of Endogenous Tau by Intermittent Hypoxia in Rat Brain. Journal of applied physiology (Bethesda, Md. : 1985). 2022-07-21. PMID:35861520. |
we hypothesized cih characteristic of moderate sleep apnea would increase dysregulation of phosphorylated tau (phospho-tau) species in sprague-dawley rat hippocampus and pre-frontal cortex. |
2022-07-21 |
2023-08-14 |
human |
| Fei Yan, Ju Liu, Mei-Xiang Chen, Ying Zhang, Sheng-Jiao Wei, Hai Jin, Jing Nie, Xiao-Long Fu, Jing-Shan Shi, Shao-Yu Zhou, Feng Ji. Icariin ameliorates memory deficits through regulating brain insulin signaling and glucose transporters in 3×Tg-AD mice. Neural regeneration research. vol 18. issue 1. 2022-07-08. PMID:35799540. |
we performed behavioral tests, pathological examination, and western blot assay, and found that memory deficits of the model mice were obviously improved, neuronal and synaptic damage in the cerebral cortex was substantially mitigated, and amyloid-β accumulation and tau hyperphosphorylation were considerably reduced after 5 months of intragastric administration of icariin at a dose of 60 mg/kg body weight per day. |
2022-07-08 |
2023-08-14 |
mouse |
| Lin Wang, Bi-Qiang Zhou, Ying-Hong Li, Qian-Qian Jiang, Wei-Hong Cong, Ke-Ji Chen, Xiao-Min Wen, Zheng-Zhi W. Lactoferrin modification of berberine nanoliposomes enhances the neuroprotective effects in a mouse model of Alzheimer's disease. Neural regeneration research. vol 18. issue 1. 2022-07-08. PMID:35799547. |
lactoferrin-modified berberine nanoliposomes inhibited acetylcholinesterase activity and apoptosis in the hippocampus, reduced tau over-phosphorylation in the cerebral cortex, and improved mouse behavior. |
2022-07-08 |
2023-08-14 |
mouse |
| Amaryllis A Tsiknia, Steven D Edland, Erin E Sundermann, Emilie T Reas, James B Brewer, Douglas Galasko, Sarah J Bank. Sex differences in plasma p-tau181 associations with Alzheimer's disease biomarkers, cognitive decline, and clinical progression. Molecular psychiatry. 2022-06-29. PMID:35768637. |
linear regressions tested for an effect of sex on plasma p-tau181 levels and for plasma p-tau181 × sex interactions on csf p-tau181, as well as entorhinal cortex tau, cortical amyloid-β (aβ) deposition, and brain glucose metabolism, quantified using pet imaging. |
2022-06-29 |
2023-08-14 |
human |