| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shaozhen Yan, Chaojie Zheng, Manish D Paranjpe, Yanxiao Li, Weihua Li, Xiuying Wang, Tammie L S Benzinger, Jie Lu, Yun Zho. Sex modifies APOE ε4 dose effect on brain tau deposition in cognitively impaired individuals. Brain : a journal of neurology. vol 144. issue 10. 2021-12-09. PMID:33876815. |
we observed a significant apoe ε4 dosage × sex interaction effect on tau deposition in the lateral temporal, posterior cingulate, medial temporal, inferior temporal, entorhinal cortex, amygdala, parahippocampal gyrus regions after adjusting for age and education level (p < 0.05). |
2021-12-09 |
2023-08-13 |
Not clear |
| Shaozhen Yan, Chaojie Zheng, Manish D Paranjpe, Yanxiao Li, Weihua Li, Xiuying Wang, Tammie L S Benzinger, Jie Lu, Yun Zho. Sex modifies APOE ε4 dose effect on brain tau deposition in cognitively impaired individuals. Brain : a journal of neurology. vol 144. issue 10. 2021-12-09. PMID:33876815. |
the medial temporal, entorhinal cortex, amygdala and parahippocampal gyrus regions retained a significant apoe ε4 dosage × sex interaction effect on tau deposition after adjusting for global cortical amyloid-β (p < 0.05). |
2021-12-09 |
2023-08-13 |
Not clear |
| Shaozhen Yan, Chaojie Zheng, Manish D Paranjpe, Yanxiao Li, Weihua Li, Xiuying Wang, Tammie L S Benzinger, Jie Lu, Yun Zho. Sex modifies APOE ε4 dose effect on brain tau deposition in cognitively impaired individuals. Brain : a journal of neurology. vol 144. issue 10. 2021-12-09. PMID:33876815. |
female heterozygotes exhibited significantly increased tau deposition compared to male heterozygotes in the orbitofrontal, posterior cingulate, lateral temporal, inferior temporal, entorhinal cortex, amygdala and parahippocampal gyrus (p < 0.05). |
2021-12-09 |
2023-08-13 |
Not clear |
| Lu Zhang, Yasuko Toyoshima, Akari Takeshima, Hiroshi Shimizu, Itsuro Tomita, Osamu Onodera, Hitoshi Takahashi, Akiyoshi Kakit. Progressive supranuclear palsy: Neuropathology of patients with a short disease duration due to unexpected death. Neuropathology : official journal of the Japanese Society of Neuropathology. vol 41. issue 3. 2021-11-25. PMID:33205528. |
there was also a tendency for tau deposition to be more predominant in neuronal cells in the brainstem and cerebellum and in glial cells in the cerebral cortex and subcortical gray matter. |
2021-11-25 |
2023-08-13 |
Not clear |
| So Tando, Takashi Kasai, Ikuko Mizuta, Hisashi Takahashi, Takeshi Yaoi, Kozo Saito, Tomohito Hojo, Toshiki Mizuno, Masato Hasegawa, Kyoko Ito. An autopsy case of corticobasal syndrome due to asymmetric degeneration of the motor cortex and substantia nigra with TDP-43 proteinopathy, associated with Alzheimer's disease pathology. Neuropathology : official journal of the Japanese Society of Neuropathology. vol 41. issue 3. 2021-11-25. PMID:33537992. |
phosphorylated tdp-43 (p-tdp-43) immunohistochemistry revealed widespread deposits of dystrophic neurites (dns), glial cytoplasmic inclusions (gcis), and neuronal cytoplasmic inclusions (ncis), which were most remarkable in layers ii/iii of the motor cortex and predominant on the left hemisphere of the frontal cortex, these neuropathology being consistent with frontotemporal lobar degeneration with tdp-43 (ftld-tdp) type a. interestingly, neuronal loss in the substantia nigra was more severe on the left than the right side, with a few phosphorylated tau (p-tau) and p-tdp-43 deposits. |
2021-11-25 |
2023-08-13 |
Not clear |
| So Tando, Takashi Kasai, Ikuko Mizuta, Hisashi Takahashi, Takeshi Yaoi, Kozo Saito, Tomohito Hojo, Toshiki Mizuno, Masato Hasegawa, Kyoko Ito. An autopsy case of corticobasal syndrome due to asymmetric degeneration of the motor cortex and substantia nigra with TDP-43 proteinopathy, associated with Alzheimer's disease pathology. Neuropathology : official journal of the Japanese Society of Neuropathology. vol 41. issue 3. 2021-11-25. PMID:33537992. |
it is highly likely that asymmetric tdp-43 pathology rather than symmetric tau pathology contributed to the laterality of degeneration of the cerebral cortex, substantia nigra, and pyramidal tract, which led us to suggest that tdp-43 proteinopathy might be a primary cause. |
2021-11-25 |
2023-08-13 |
Not clear |
| Sarah Helena Nies, Hideyuki Takahashi, Charlotte S Herber, Anita Huttner, Alison Chase, Stephen M Strittmatte. Spreading of Alzheimer tau seeds is enhanced by aging and template matching with limited impact of amyloid-β. The Journal of biological chemistry. vol 297. issue 4. 2021-11-25. PMID:34480901. |
the density and spreading of tau inclusions triggered by human tau seed were unaltered in the hippocampus and cortex of appswe/psen1Δe9 transgenic and app |
2021-11-25 |
2023-08-13 |
mouse |
| Amy F T Arnsten, Dibyadeep Datta, Todd M Preus. Studies of aging nonhuman primates illuminate the etiology of early-stage Alzheimer's-like neuropathology: An evolutionary perspective. American journal of primatology. vol 83. issue 11. 2021-11-24. PMID:33960505. |
the expression of nmdar-nr2b (glun2b)-the subunit that fluxes high levels of calcium-increases over the cortical hierarchy and with the expansion of association cortex in primate evolution, consistent with patterns of tau pathology. |
2021-11-24 |
2023-08-13 |
mouse |
| Shinobu Kawakatsu, Ryota Kobayashi, Hiroshi Hayashi, Daichi Morioka, Aya Utsunomiya, Takanobu Kabasawa, Rintaro Ohe, Koichi Otan. Clinicopathological heterogeneity of Alzheimer's disease with pure Alzheimer's disease pathology: Cases associated with dementia with Lewy bodies, very early-onset dementia, and primary progressive aphasia. Neuropathology : official journal of the Japanese Society of Neuropathology. 2021-11-24. PMID:34816507. |
the distribution of tau and astrocytic pathologies in the cerebral cortex, basal ganglia, brain stem, and cerebellum may explain the various symptoms of atypical pure ad patients. |
2021-11-24 |
2023-08-13 |
Not clear |
| Yasufumi Sakakibara, Yu Hirota, Kyoko Ibaraki, Kimi Takei, Sachie Chikamatsu, Yoko Tsubokawa, Takashi Saito, Takaomi C Saido, Michiko Sekiya, Koichi M Iijim. Widespread Reduced Density of Noradrenergic Locus Coeruleus Axons in the App Knock-In Mouse Model of Amyloid-β Amyloidosis. Journal of Alzheimer's disease : JAD. vol 82. issue 4. 2021-11-23. PMID:34180416. |
amyloid-β (aβ) pathology in the cortex in ad is thought to exacerbate the age-related loss of lc neurons, which may lead to cortical tau pathology. |
2021-11-23 |
2023-08-13 |
mouse |
| Jacob Ziontz, Jenna N Adams, Theresa M Harrison, Suzanne L Baker, William J Jagus. Hippocampal Connectivity with Retrosplenial Cortex is Linked to Neocortical Tau Accumulation and Memory Function. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 41. issue 42. 2021-11-23. PMID:34531286. |
hippocampal connectivity with retrosplenial cortex is linked to neocortical tau accumulation and memory function. |
2021-11-23 |
2023-08-13 |
human |
| Jacob Ziontz, Jenna N Adams, Theresa M Harrison, Suzanne L Baker, William J Jagus. Hippocampal Connectivity with Retrosplenial Cortex is Linked to Neocortical Tau Accumulation and Memory Function. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 41. issue 42. 2021-11-23. PMID:34531286. |
functional connectivity between hippocampus (hc) and retrosplenial cortex (rsc), a key region of the medial parietal lobe, was associated with tau in medial parietal lobe. |
2021-11-23 |
2023-08-13 |
human |
| Jacob Ziontz, Jenna N Adams, Theresa M Harrison, Suzanne L Baker, William J Jagus. Hippocampal Connectivity with Retrosplenial Cortex is Linked to Neocortical Tau Accumulation and Memory Function. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 41. issue 42. 2021-11-23. PMID:34531286. |
by contrast, connectivity between entorhinal cortex (ec) and rsc did not correlate with medial parietal lobe tau. |
2021-11-23 |
2023-08-13 |
human |
| Bo-Wen Chen, Kai-Wen Zhang, Si-Jia Chen, Chun Yang, Peng-Gao L. Vitamin A Deficiency Exacerbates Gut Microbiota Dysbiosis and Cognitive Deficits in Amyloid Precursor Protein/Presenilin 1 Transgenic Mice. Frontiers in aging neuroscience. vol 13. 2021-11-19. PMID:34790112. |
our results show that vad aggravated the behavioral learning and memory deficits, reduced the retinol concentration in the liver and the serum, decreased the transcription of vitamin a (va)-related receptors and va-related enzymes in the cortex, increased amyloid-β peptides (aβ40 and aβ42) in the brain and gut, upregulate the translation of beta-site app-cleaving enzyme 1 (bace1) and phosphorylated tau in the cortex, and downregulate the expression of brain-derived neurotrophic factor (bdnf) and γ-aminobutyric acid (gaba) receptors in the cortex. |
2021-11-19 |
2023-08-13 |
mouse |
| Christine W Fung, Jia Guo, Hongjun Fu, Helen Y Figueroa, Elisa E Konofagou, Karen E Duf. Atrophy associated with tau pathology precedes overt cell death in a mouse model of progressive tauopathy. Science advances. vol 6. issue 42. 2021-11-17. PMID:33067235. |
tau pathology in alzheimer's disease (ad) first develops in the entorhinal cortex (ec), then spreads to the hippocampus, followed by the neocortex. |
2021-11-17 |
2023-08-13 |
mouse |
| Tiziana Petrozziello, Ana C Amaral, Simon Dujardin, Sali M K Farhan, James Chan, Bianca A Trombetta, Pia Kivisäkk, Alexandra N Mills, Evan A Bordt, Spencer E Kim, Patrick M Dooley, Caitlin Commins, Theresa R Connors, Derek H Oakley, Anubrata Ghosal, Teresa Gomez-Isla, Bradley T Hyman, Steven E Arnold, Tara Spires-Jones, Merit E Cudkowicz, James D Berry, Ghazaleh Sadri-Vakil. Novel genetic variants in MAPT and alterations in tau phosphorylation in amyotrophic lateral sclerosis post-mortem motor cortex and cerebrospinal fluid. Brain pathology (Zurich, Switzerland). 2021-11-15. PMID:34779076. |
novel genetic variants in mapt and alterations in tau phosphorylation in amyotrophic lateral sclerosis post-mortem motor cortex and cerebrospinal fluid. |
2021-11-15 |
2023-08-13 |
Not clear |
| Tiziana Petrozziello, Ana C Amaral, Simon Dujardin, Sali M K Farhan, James Chan, Bianca A Trombetta, Pia Kivisäkk, Alexandra N Mills, Evan A Bordt, Spencer E Kim, Patrick M Dooley, Caitlin Commins, Theresa R Connors, Derek H Oakley, Anubrata Ghosal, Teresa Gomez-Isla, Bradley T Hyman, Steven E Arnold, Tara Spires-Jones, Merit E Cudkowicz, James D Berry, Ghazaleh Sadri-Vakil. Novel genetic variants in MAPT and alterations in tau phosphorylation in amyotrophic lateral sclerosis post-mortem motor cortex and cerebrospinal fluid. Brain pathology (Zurich, Switzerland). 2021-11-15. PMID:34779076. |
recently, we have demonstrated that phosphorylated tau at s396 (ptau-s396) is mislocalized to synapses in als motor cortex (mctx) and contributes to mitochondrial dysfunction. |
2021-11-15 |
2023-08-13 |
Not clear |
| Marta Perez-Rando, Simon Dujardin, Rachel E Bennett, Caitlin Commins, Tara Nibhanupudy, Bradley T Hyma. Synaptic and metabolic gene expression alterations in neurons that are recipients of proteopathic tau seeds. Acta neuropathologica communications. vol 8. issue 1. 2021-11-10. PMID:33076986. |
we utilized high resolution multi-color in situ hybridization technology, rnascope, in a well-established tau transgenic animal, and found that a subset of neurons in the cortex do not appear to express the transgene, but do develop phospho-tau positive inclusions, consistent with having received tau seeds. |
2021-11-10 |
2023-08-13 |
mouse |
| Yang Gao, Xiao-Qing Wang, Shuai Ma, Yong-Cai Dong, Ya-Zhen Shan. Flavonoids from Stem and Leaf of Scutellaria Baicalensis Georgi Inhibit the Phosphorylation on Multi-sites of Tau Protein Induced by Okadaic Acid and the Regulative Mechanism of Protein Kinases in Rats. Combinatorial chemistry & high throughput screening. vol 24. issue 7. 2021-11-09. PMID:32875975. |
the present study aims to investigate the effect of flavonoids from stem and leaf of scutellaria baicalensis georgi (ssf) on multi-sites phosphorylation of tau protein in the cerebral cortex and hippocampus of rats induced by okadaic acid (oa) and the regulative mechanism of the protein kinases. |
2021-11-09 |
2023-08-13 |
rat |
| Benjamin B Tournier, Cristina Barca, Aïda B Fall, Yesica Gloria, Léa Meyer, Kelly Ceyzériat, Philippe Mille. Spatial reference learning deficits in absence of dysfunctional working memory in the TgF344-AD rat model of Alzheimer's disease. Genes, brain, and behavior. vol 20. issue 5. 2021-11-09. PMID:33150709. |
these behavioral phenomena were observed at an age when tau accumulation are absent, and where amyloid deposits are predominant in the hippocampus and the entorhinal cortex. |
2021-11-09 |
2023-08-13 |
human |