| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Susan C Schwerin, Mitali Chatterjee, Elizabeth B Hutchinson, Francis T Djankpa, Regina C Armstrong, Joseph T McCabe, Daniel P Perl, Sharon L Julian. Expression of GFAP and Tau Following Blast Exposure in the Cerebral Cortex of Ferrets. Journal of neuropathology and experimental neurology. vol 80. issue 2. 2021-06-22. PMID:33421075. |
expression of gfap and tau following blast exposure in the cerebral cortex of ferrets. |
2021-06-22 |
2023-08-13 |
human |
| Susan C Schwerin, Mitali Chatterjee, Elizabeth B Hutchinson, Francis T Djankpa, Regina C Armstrong, Joseph T McCabe, Daniel P Perl, Sharon L Julian. Expression of GFAP and Tau Following Blast Exposure in the Cerebral Cortex of Ferrets. Journal of neuropathology and experimental neurology. vol 80. issue 2. 2021-06-22. PMID:33421075. |
changes in forms of tau, including phosphorylated tau, and the isoforms 3r and 4r were noted using immunohistochemistry and western blot in specific regions of the cerebral cortex. |
2021-06-22 |
2023-08-13 |
human |
| Shengyi Yang, Huanhuan Zhou, Guiping Wang, Xiao-Hong Zhong, Qi-Liang Shen, Xue-Jing Zhang, Ru-Yi Li, Li-Hua Chen, Ya-Han Zhang, Zhongxiao Wa. Quercetin is protective against short-term dietary advanced glycation end products intake induced cognitive dysfunction in aged ICR mice. Journal of food biochemistry. vol 44. issue 4. 2021-06-21. PMID:32065675. |
key markers involved in aβ, tau, and neuroinflammation from hippocampus and cortex were measured via western blot. |
2021-06-21 |
2023-08-13 |
mouse |
| Kimberly L Fiock, Martin E Smalley, John F Crary, Anca M Pasca, Marco M Heft. Increased Tau Expression Correlates with Neuronal Maturation in the Developing Human Cerebral Cortex. eNeuro. vol 7. issue 3. 2021-06-18. PMID:32393582. |
increased tau expression correlates with neuronal maturation in the developing human cerebral cortex. |
2021-06-18 |
2023-08-13 |
human |
| Anshua Ghosh, Keiko Mizuno, Sachin S Tiwari, Petroula Proitsi, Beatriz Gomez Perez-Nievas, Elizabeth Glennon, Rocio T Martinez-Nunez, K Peter Gies. Alzheimer's disease-related dysregulation of mRNA translation causes key pathological features with ageing. Translational psychiatry. vol 10. issue 1. 2021-06-18. PMID:32546772. |
modelling this cyfip2 reduction in mice, we find age-dependent aβ accumulation in the thalamus, development of tau pathology in entorhinal cortex and hippocampus, as well as gliosis and synapse loss in the hippocampus, together with deficits in memory formation. |
2021-06-18 |
2023-08-13 |
mouse |
| Jonathan D Cherry, Camille D Esnault, Zachary H Baucom, Yorghos Tripodis, Bertrand R Huber, Victor E Alvarez, Thor D Stein, Dennis W Dickson, Ann C McKe. Tau isoforms are differentially expressed across the hippocampus in chronic traumatic encephalopathy and Alzheimer's disease. Acta neuropathologica communications. vol 9. issue 1. 2021-06-07. PMID:33980303. |
while the neuropathologic hallmark of cte is found in the cortex, hippocampal tau has proven to be an important neuropathologic feature to examine the extent of disease severity. |
2021-06-07 |
2023-08-13 |
Not clear |
| Helen C Murray, Birger Victor Dieriks, Molly E V Swanson, Praju Vikas Anekal, Clinton Turner, Richard L M Faull, Leonardo Belluscio, Alan Koretsky, Maurice A Curti. The unfolded protein response is activated in the olfactory system in Alzheimer's disease. Acta neuropathologica communications. vol 8. issue 1. 2021-05-31. PMID:32665027. |
we used immunohistochemistry to label two markers of upr activation (p-perk and p-eif2α) concomitantly with neuronal markers (neun and pgp9.5) and pathology markers (beta-amyloid and tau) in the olfactory bulb, piriform cortex, entorhinal cortex and the ca1 region of the hippocampus in ad and normal cases. |
2021-05-31 |
2023-08-13 |
Not clear |
| Masahiko Takaya, Kazunari Ishii, Kazumasa Saigoh, Osamu Shirakaw. Longitudinal study of primary progressive aphasia in a patient with pathologically diagnosed Alzheimer's disease: a case report. Journal of medical case reports. vol 15. issue 1. 2021-05-27. PMID:34034805. |
alzheimer's disease is a neurodegenerative disease involving the deposition of pathologic amyloid-β and tau protein in the cerebral cortex. |
2021-05-27 |
2023-08-13 |
Not clear |
| Paola C Bello-Medina, Fernando Hernández-Quiroz, Marcel Pérez-Morales, Diego A González-Franco, Guadalupe Cruz-Pauseno, Jaime García-Mena, Sofía Díaz-Cintra, Gustavo Pacheco-Lópe. Spatial Memory and Gut Microbiota Alterations Are Already Present in Early Adulthood in a Pre-clinical Transgenic Model of Alzheimer's Disease. Frontiers in neuroscience. vol 15. 2021-05-18. PMID:33994914. |
the irreversible and progressive neurodegenerative alzheimer's disease (ad) is characterized by cognitive decline, extracellular β-amyloid peptide accumulation, and tau neurofibrillary tangles in the cortex and hippocampus. |
2021-05-18 |
2023-08-13 |
mouse |
| Yuqian Guo, Limei Wang, Jiangli Lu, Jianlin Jiao, Yi Yang, Hongbin Zhao, Zhang Liang, Hong Zhen. Ginsenoside Rg1 improves cognitive capability and affects the microbiota of large intestine of tree shrew model for Alzheimer's disease. Molecular medicine reports. vol 23. issue 4. 2021-05-17. PMID:33649817. |
immunohistochemical analysis revealed that rg1 decreased the expression of amyloid β, tau phosphorylated at serine 404 and pro-apoptotic factor bax, while increasing the expression of bcl-2 in the hippocampus and cortex. |
2021-05-17 |
2023-08-13 |
Not clear |
| Max Mo, Marie E Jönsson, Miranda A Mathews, Daniel Johnstone, Yazi D Ke, Lars M Ittner, Bernard W Balleine, Teri M Furlong, Aaron J Cam. K369I Tau Mice Demonstrate a Shift Towards Striatal Neuron Burst Firing and Goal-directed Behaviour. Neuroscience. vol 449. 2021-05-14. PMID:32949670. |
k369i mutant tau transgenic mice (k3 mice) recapitulate neural and behavioural symptoms of ftld, including tau aggregates in the cortex, alterations to nigrostriatum, memory deficits and parkinsonism. |
2021-05-14 |
2023-08-13 |
mouse |
| Michael G Friedrich, Amanda Skora, Sarah E Hancock, Todd W Mitchell, Paul L Else, Roger J W Truscot. Tau Is Truncated in Five Regions of the Normal Adult Human Brain. International journal of molecular sciences. vol 22. issue 7. 2021-05-10. PMID:33805376. |
antibodies to the c-terminal and n-terminal regions of tau were employed to examine tau cleavage in five human brain regions: the entorhinal cortex, prefrontal cortex, motor cortex, hippocampus, and cerebellum. |
2021-05-10 |
2023-08-13 |
human |
| Yasuhisa Ano, Rena Ohya, Yuta Takaichi, Terukatsu Washinuma, Kazuyuki Uchida, Akihiko Takashima, Hiroyuki Nakayam. β-Lactolin, a Whey-Derived Lacto-Tetrapeptide, Prevents Alzheimer's Disease Pathologies and Cognitive Decline. Journal of Alzheimer's disease : JAD. vol 73. issue 4. 2021-05-06. PMID:31929163. |
in addition, intake of β-lactolin and whey digestion rich in β-lactolin improved behavioral abnormality and reduced the ratio of phosphorylated tau to total tau in the cortex in ps19 tauopathy mice. |
2021-05-06 |
2023-08-13 |
mouse |
| Magdalena Gąssowska-Dobrowolska, Agnieszka Kolasa-Wołosiuk, Magdalena Cieślik, Agnieszka Dominiak, Kristina Friedland, Agata Adamczy. Alterations in Tau Protein Level and Phosphorylation State in the Brain of the Autistic-Like Rats Induced by Prenatal Exposure to Valproic Acid. International journal of molecular sciences. vol 22. issue 6. 2021-04-30. PMID:33809910. |
our results indicated that maternal exposure to vpa induces: (1) decrease the level of α/β-tubulin along with tau accumulation in the hippocampus and cerebral cortex; (2) excessive tau phosphorylation and activation of tau-kinases: cdk5, erk1/2, and p70s6k in the cerebral cortex; (3) up-regulation of mtor kinase-dependent signalling in the hippocampus and cerebral cortex of adolescent rat offspring. |
2021-04-30 |
2023-08-13 |
rat |
| Philip S Insel, Elizabeth C Mormino, Paul S Aisen, Wesley K Thompson, Michael C Donohu. Neuroanatomical spread of amyloid β and tau in Alzheimer's disease: implications for primary prevention. Brain communications. vol 2. issue 1. 2021-04-28. PMID:32140682. |
early elevation in tau pet uptake was found in the inferior temporal lobe, amygdala, banks of the superior temporal sulcus, entorhinal cortex, middle temporal lobe, inferior parietal lobe and the fusiform gyrus. |
2021-04-28 |
2023-08-13 |
human |
| Eero Vuoksimaa, Linda K McEvoy, Dominic Holland, Carol E Franz, William S Kreme. Modifying the minimum criteria for diagnosing amnestic MCI to improve prediction of brain atrophy and progression to Alzheimer's disease. Brain imaging and behavior. vol 14. issue 3. 2021-04-27. PMID:30511118. |
cn, avlt+, and avlt- groups differed significantly on baseline brain (hippocampus, entorhinal cortex) and cerebrospinal fluid (amyloid, tau, p-tau) biomarkers, with the avlt- group being most abnormal. |
2021-04-27 |
2023-08-13 |
human |
| Md Sahab Uddin, Anna Stachowiak, Abdullah Al Mamun, Nikolay T Tzvetkov, Shinya Takeda, Atanas G Atanasov, Leandro B Bergantin, Mohamed M Abdel-Daim, Adrian M Stankiewic. Autophagy and Alzheimer's Disease: From Molecular Mechanisms to Therapeutic Implications. Frontiers in aging neuroscience. vol 10. 2021-04-09. PMID:29441009. |
it is characterized by a progressive and irreversible loss of cognitive abilities and formation of senile plaques, composed mainly of amyloid β (aβ), and neurofibrillary tangles (nfts), composed of tau protein, in the hippocampus and cortex of afflicted humans. |
2021-04-09 |
2023-08-13 |
Not clear |
| Aurelie Joly-Amado, Jordan Hunter, Zainuddin Quadri, Frank Zamudio, Patricia V Rocha-Rangel, Deanna Chan, Anisha Kesarwani, Kevin Nash, Daniel C Lee, Dave Morgan, Marcia N Gordon, Maj-Linda B Selenic. CCL2 Overexpression in the Brain Promotes Glial Activation and Accelerates Tau Pathology in a Mouse Model of Tauopathy. Frontiers in immunology. vol 11. 2021-03-29. PMID:32508844. |
to address this question, ccl2 was delivered via recombinant adeno-associated virus serotype 9 into both cortex and hippocampus of a mouse model with tau pathology (rtg4510). |
2021-03-29 |
2023-08-13 |
mouse |
| Anna Fracassi, Michela Marcatti, Olga Zolochevska, Natalie Tabor, Randall Woltjer, Sandra Moreno, Giulio Taglialatel. Oxidative Damage and Antioxidant Response in Frontal Cortex of Demented and Nondemented Individuals with Alzheimer's Neuropathology. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 41. issue 3. 2021-03-29. PMID:33239403. |
alzheimer's disease (ad) is characterized by progressive neurodegeneration in the cerebral cortex, histopathologically hallmarked by amyloid β (aβ) extracellular plaques and intracellular neurofibrillary tangles, constituted by hyperphosphorylated tau protein. |
2021-03-29 |
2023-08-13 |
human |
| Kun Leng, Emmy Li, Rana Eser, Antonia Piergies, Rene Sit, Michelle Tan, Norma Neff, Song Hua Li, Roberta Diehl Rodriguez, Claudia Kimie Suemoto, Renata Elaine Paraizo Leite, Alexander J Ehrenberg, Carlos A Pasqualucci, William W Seeley, Salvatore Spina, Helmut Heinsen, Lea T Grinberg, Martin Kampman. Molecular characterization of selectively vulnerable neurons in Alzheimer's disease. Nature neuroscience. vol 24. issue 2. 2021-03-29. PMID:33432193. |
to identify and characterize selectively vulnerable neuronal populations, we used single-nucleus rna sequencing to profile the caudal entorhinal cortex and the superior frontal gyrus-brain regions where neurofibrillary inclusions and neuronal loss occur early and late in ad, respectively-from postmortem brains spanning the progression of ad-type tau neurofibrillary pathology. |
2021-03-29 |
2023-08-13 |
Not clear |