| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wen Hu, Feng Wu, Yanchong Zhang, Cheng-Xin Gong, Khalid Iqbal, Fei Li. Expression of Tau Pathology-Related Proteins in Different Brain Regions: A Molecular Basis of Tau Pathogenesis. Frontiers in aging neuroscience. vol 9. 2020-10-01. PMID:29021756. |
the tau pathology starts from the entorhinal cortex (ec), spreads to the hippocampus and frontal and temporal cortices, and finally to all isocortex areas, but the cerebellum is spared from tau lesions. |
2020-10-01 |
2023-08-13 |
human |
| Wen Hu, Feng Wu, Yanchong Zhang, Cheng-Xin Gong, Khalid Iqbal, Fei Li. Expression of Tau Pathology-Related Proteins in Different Brain Regions: A Molecular Basis of Tau Pathogenesis. Frontiers in aging neuroscience. vol 9. 2020-10-01. PMID:29021756. |
in the rat brain, the expression level of tau with three microtubule-binding repeats (3r-tau) was comparable in the hippocampus, ec, fc, parietal-temporal cortex (ptc), occipital-temporal cortex (otc), striatum, thalamus, olfactory bulb (ob) and cerebellum. |
2020-10-01 |
2023-08-13 |
human |
| Jin Miao, Ruirui Shi, Longfei Li, Feng Chen, Yan Zhou, Yunn Chyn Tung, Wen Hu, Cheng-Xin Gong, Khalid Iqbal, Fei Li. Pathological Tau From Alzheimer's Brain Induces Site-Specific Hyperphosphorylation and SDS- and Reducing Agent-Resistant Aggregation of Tau Frontiers in aging neuroscience. vol 11. 2020-10-01. PMID:30890929. |
in the present study, we injected hyperphosphorylated and oligomeric tau isolated from ad brain (ad p-tau) into hippocampus of human tau transgenic mice and found that in addition to tau aggregation/pathology, tau was hyperphosphorylated at ser202/thr205, thr212, ser214, thr217, ser262, and ser422 in ad p-tau injected hippocampus and at ser422 in the contralateral hippocampus and in the ipsilateral cortex. |
2020-10-01 |
2023-08-13 |
mouse |
| Marianna Alves, Aidan Kenny, Gioacchino de Leo, Edward H Beamer, Tobias Enge. Tau Phosphorylation in a Mouse Model of Temporal Lobe Epilepsy. Frontiers in aging neuroscience. vol 11. 2020-10-01. PMID:31780921. |
the discovery of tau pathology and aggregates in the cortex of temporal lobe epilepsy (tle) patients has focused interest on hyperphosphorylation of tau as a potential mechanism contributing to increased states of hyperexcitability and cognitive decline. |
2020-10-01 |
2023-08-13 |
mouse |
| Rufus O Akinyemi, Louise M Allan, Arthur Oakley, Rajesh N Kalari. Hippocampal Neurodegenerative Pathology in Post-stroke Dementia Compared to Other Dementias and Aging Controls. Frontiers in neuroscience. vol 11. 2020-09-30. PMID:29311794. |
we quantified markers of amyloid β (total aβ, aβ-40, aβ-42, and soluble aβ) and hyperphosphorylated tau in the hippocampal formation and entorhinal cortex of 94 subjects consisting of normal controls ( |
2020-09-30 |
2023-08-13 |
human |
| Scott A Ferguson, Benoit C Mouzon, Cillian Lynch, Carlyn Lungmus, Alexander Morin, Gogce Crynen, Benjamin Carper, Gayle Bieler, Elliott J Mufson, William Stewart, Michael Mullan, Fiona Crawfor. Negative Impact of Female Sex on Outcomes from Repetitive Mild Traumatic Brain Injury in hTau Mice Is Age Dependent: A Chronic Effects of Neurotrauma Consortium Study. Frontiers in aging neuroscience. vol 9. 2020-09-30. PMID:29311903. |
pathologically, increases in iba-1 and gfap staining typically seen in this model of r-mtbi showed the expected increases with both injury and age, but phosphorylated tau stained with cp13 in the hippocampus (reduced in female sham mice compared to males) and phf1 in the cortex (reduced in female tbi mice compared to male tbi mice) showed the only histological signs of sex-dependent differences in these mice. |
2020-09-30 |
2023-08-13 |
mouse |
| Camille Pernègre, Antoine Duquette, Nicole Lecler. Tau Secretion: Good and Bad for Neurons. Frontiers in neuroscience. vol 13. 2020-09-30. PMID:31293374. |
in alzheimer's disease (ad), neurofibrillary tangles (nfts), lesions composed of hyperphosphorylated and aggregated tau, spread from the transentorhinal cortex to the hippocampal formation and neocortex. |
2020-09-30 |
2023-08-13 |
Not clear |
| Atsuko Katsumoto, Hideyuki Takeuchi, Fumiaki Tanak. Tau Pathology in Chronic Traumatic Encephalopathy and Alzheimer's Disease: Similarities and Differences. Frontiers in neurology. vol 10. 2020-09-30. PMID:31551922. |
hyperphosphorylated tau deposition usually begins in the perivascular area of the sulci in the cerebral cortex, then spreads unevenly in the cortex in cte, while ad shows diffuse distribution of hyperphosphorylated tau in the cortical areas. |
2020-09-30 |
2023-08-13 |
Not clear |
| Gustavo Alves Andrade Dos Santos, Paulo Celso Pard. Biomarkers in Alzheimer's disease: Evaluation of platelets, hemoglobin and vitamin B12. Dementia & neuropsychologia. vol 14. issue 1. 2020-09-28. PMID:32206196. |
currently, the most likely hypotheses as the cause of alzheimer's disease are deposition of amyloid beta peptide in the cerebral cortex and hyperphosphorylation of tau protein. |
2020-09-28 |
2023-08-13 |
Not clear |
| Verner Knott, Nicola Wright, Dhrasti Shah, Ashley Baddeley, Hayley Bowers, Sara de la Salle, Alain Labell. Change in the Neural Response to Auditory Deviance Following Cognitive Therapy for Hallucinations in Patients With Schizophrenia. Frontiers in psychiatry. vol 11. 2020-09-28. PMID:32595542. |
although not showing consistent changes in the frequency of avhs, cbtv (vs. tau) improved patients' appraisal (p = 0.001) of and behavioral/emotional responses to avhs, and increased both mmn generation (p = 0.001) and auditory cortex current density (p = 0.002) in response to tone pitch deviants. |
2020-09-28 |
2023-08-13 |
Not clear |
| Isidro Ferrer, Pol Andrés-Benito, Julia Sala-Jarque, Vanessa Gil, José Antonio Del Ri. Capacity for Seeding and Spreading of Argyrophilic Grain Disease in a Wild-Type Murine Model; Comparisons With Primary Age-Related Tauopathy. Frontiers in molecular neuroscience. vol 13. 2020-09-28. PMID:32670019. |
agd has a characteristic pattern progressively involving the entorhinal cortex, amygdala, hippocampus, dentate gyrus, presubiculum, subiculum, hypothalamic nuclei, temporal cortex, and neocortex and brainstem, thus suggesting that argyrophilic grain pathology is a natural model of tau propagation. |
2020-09-28 |
2023-08-13 |
mouse |
| M A Berezutsky, N A Durnova, T A Andronova, O V Sinichkin. [Alzheimer's disease: experimental and clinical researches of Chinese herbal medicine neurobiological effects (a review).] Advances in gerontology = Uspekhi gerontologii. vol 33. issue 2. 2020-09-22. PMID:32593241. |
various neurobiological effects of various herbal decoctions in the cells of hippocampus were demonstrated - the inhibition of amyloid β peptides aggregation, increasing of neurons quantity with normal morphology and decreasing of apoptotic cells, decreasing of inducible nitric oxide synthase (inos) production, decreasing of reactive expression level of rage and increasing reactive expression level of lrp-1, decreasing of tau protein phosphorylation at thr231 and ser422, inhibition of expression of gsk-3β and cdk-5, decreasing of activation and inflammation of microglia, production of 15 types of n-glycans in the cerebral cortex layers, which are absent in experimental animals. |
2020-09-22 |
2023-08-13 |
mouse |
| Patrizia Vannini, Federico d'Oleire Uquillas, Heidi I L Jacobs, Jorge Sepulcre, Jennifer Gatchel, Rebecca E Amariglio, Bernard Hanseeuw, Kathryn V Papp, Trey Hedden, Dorene M Rentz, Alvaro Pascual-Leone, Keith A Johnson, Reisa A Sperlin. Decreased meta-memory is associated with early tauopathy in cognitively unimpaired older adults. NeuroImage. Clinical. vol 24. 2020-09-21. PMID:31795044. |
decreased episodic fok was related to tauopathy in the medial temporal lobe regions, including the entorhinal cortex and temporal pole, whereas decreased semantic fok was related to increased tau in regions associated with the semantic knowledge network. |
2020-09-21 |
2023-08-13 |
human |
| Nobuya Kitaguchi, Harutsugu Tatebe, Kazuyoshi Sakai, Kazunori Kawaguchi, Shinji Matsunaga, Tomoko Kitajima, Hiroshi Tomizawa, Masao Kato, Satoshi Sugiyama, Nobuo Suzuki, Masao Mizuno, Hajime Takechi, Shigeru Nakai, Yoshiyuki Hiki, Hiroko Kushimoto, Midori Hasegawa, Yukio Yuzawa, Takahiko Tokud. Influx of Tau and Amyloid-β Proteins into the Blood During Hemodialysis as a Therapeutic Extracorporeal Blood Amyloid-β Removal System for Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 69. issue 3. 2020-09-18. PMID:31156161. |
furthermore, histopathological analysis revealed similar, not significantly less, cerebral cortex phosphorylated tau accumulation between the 17 patients who underwent hemodialysis and the 16 age-matched subjects who did not, although both groups showed sparse accumulation. |
2020-09-18 |
2023-08-13 |
human |
| Gustavo A Rodriguez, Geoffrey M Barrett, Karen E Duff, S Abid Hussain. Chemogenetic attenuation of neuronal activity in the entorhinal cortex reduces Aβ and tau pathology in the hippocampus. PLoS biology. vol 18. issue 8. 2020-09-17. PMID:32822389. |
chemogenetic attenuation of neuronal activity in the entorhinal cortex reduces aβ and tau pathology in the hippocampus. |
2020-09-17 |
2023-08-13 |
mouse |
| S A Krivopalov, B G Yushkov, M Yu Bykova, K N Zabegalo. [Gender differences in the pool of free amino acid neurotransmitters in Krushinsky-Molodkina rats]. Biomeditsinskaia khimiia. vol 66. issue 2. 2020-09-08. PMID:32420892. |
the content of asp, glu, gaba, gly, and tau of the medulla oblongata, hippocampus and cerebral cortex were determined using high-performance liquid chromatography (hplc) in intact km rats, km rats exposed to a series of epileptiform seizures, and wistar rats (control group). |
2020-09-08 |
2023-08-13 |
rat |
| S A Krivopalov, B G Yushkov, M Yu Bykova, K N Zabegalo. [Gender differences in the pool of free amino acid neurotransmitters in Krushinsky-Molodkina rats]. Biomeditsinskaia khimiia. vol 66. issue 2. 2020-09-08. PMID:32420892. |
the changes observed in male rats after the set of seizures included the increase in gaba concentration and a decrease in the gly level in all investigated brain parts, as well as the decrease of the tau content in the cortex and hippocampus. |
2020-09-08 |
2023-08-13 |
rat |
| Christopher D Morrone, Paolo Bazzigaluppi, Tina L Beckett, Mary E Hill, Margaret M Koletar, Bojana Stefanovic, JoAnne McLauri. Regional differences in Alzheimer's disease pathology confound behavioural rescue after amyloid-β attenuation. Brain : a journal of neurology. vol 143. issue 1. 2020-08-18. PMID:31782760. |
reduction of amyloid-β peptide in the entorhinal cortex had no effect on entorhinal tau pathology or entorhinal-hippocampal neuronal network dysfunction, as measured by an impairment in hippocampal response to entorhinal stimulation. |
2020-08-18 |
2023-08-13 |
rat |
| Sarah Gourmaud, Haochang Shou, David J Irwin, Kimberly Sansalone, Leah M Jacobs, Timothy H Lucas, Eric D Marsh, Kathryn A Davis, Frances E Jensen, Delia M Talo. Alzheimer-like amyloid and tau alterations associated with cognitive deficit in temporal lobe epilepsy. Brain : a journal of neurology. vol 143. issue 1. 2020-08-18. PMID:31834353. |
we examined these pathways, as well as amyloid-β and tau pathologies in the hippocampus and temporal lobe cortex of drug-resistant temporal lobe epilepsy patients who underwent temporal lobe resection (n = 19), in comparison with age- and region-matched samples from neurologically normal autopsy cases (n = 22). |
2020-08-18 |
2023-08-13 |
Not clear |
| J Cummings, K Blennow, K Johnson, M Keeley, R J Bateman, J L Molinuevo, J Touchon, P Aisen, B Vella. Anti-Tau Trials for Alzheimer's Disease: A Report from the EU/US/CTAD Task Force. The journal of prevention of Alzheimer's disease. vol 6. issue 3. 2020-07-30. PMID:31062825. |
both neuropathological and imaging studies indicate that tau first appears in the entorhinal cortex and then spreads to the neocortex. |
2020-07-30 |
2023-08-13 |
Not clear |