| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Heiko Braak, Kelly Del Tredic. From the Entorhinal Region via the Prosubiculum to the Dentate Fascia: Alzheimer Disease-Related Neurofibrillary Changes in the Temporal Allocortex. Journal of neuropathology and experimental neurology. vol 79. issue 2. 2020-07-27. PMID:31913466. |
the pathological process underlying alzheimer disease (ad) unfolds predominantly in the cerebral cortex with the gradual appearance and regional progression of abnormal tau. |
2020-07-27 |
2023-08-13 |
Not clear |
| Benoit Mouzon, Corbin Bachmeier, Joseph Ojo, Christopher Acker, Scott Ferguson, Gogce Crynen, Peter Davies, Michael Mullan, William Stewart, Fiona Crawfor. Chronic White Matter Degeneration, but No Tau Pathology at One-Year Post-Repetitive Mild Traumatic Brain Injury in a Tau Transgenic Model. Journal of neurotrauma. vol 36. issue 4. 2020-07-21. PMID:29993324. |
tau immunohistochemistry and enzyme-linked immunosorbent assay data suggest, however, only transient, injury-dependent increases in phosphorylated tau in the cerebral cortex beneath the impact site and in the ca1/ca3 subregion of the hippocampus after single or r-mtbi. |
2020-07-21 |
2023-08-13 |
mouse |
| Ariana Myers, Paul McGonigl. Overview of Transgenic Mouse Models for Alzheimer's Disease. Current protocols in neuroscience. vol 89. issue 1. 2020-07-13. PMID:31532917. |
this review describes several transgenic mouse models of alzheimer's disease (ad), a devastating neurodegenerative disorder that causes progressive cognitive decline and is diagnosed postmortem by the presence of extracellular amyloid-β (aβ) plaques and intraneuronal tau neurofibrillary tangles in the cerebral cortex. |
2020-07-13 |
2023-08-13 |
mouse |
| Stavros Skouras, Jordi Torner, Patrik Andersson, Yury Koush, Carles Falcon, Carolina Minguillon, Karine Fauria, Francesc Alpiste, Kaj Blenow, Henrik Zetterberg, Juan D Gispert, José L Molinuev. Earliest amyloid and tau deposition modulate the influence of limbic networks during closed-loop hippocampal downregulation. Brain : a journal of neurology. vol 143. issue 3. 2020-07-06. PMID:32091109. |
across subjects, our main findings during hippocampal downregulation were: (i) in the absence of abnormal biomarkers, age correlated with eigenvector centrality negatively in the insula and midcingulate cortex, and positively in the inferior temporal gyrus; (ii) abnormal csf amyloid-β42 (<1098) correlated negatively with eigenvector centrality in the anterior cingulate cortex and primary motor cortex; and (iii) abnormal csf phosphorylated tau levels (>19.2) correlated with eigenvector centrality positively in the ventral striatum, anterior cingulate and somatosensory cortex, and negatively in the precuneus and orbitofrontal cortex. |
2020-07-06 |
2023-08-13 |
human |
| Lok-Kin Yeung, Rosanna K Olsen, Bryan Hong, Valentina Mihajlovic, Maria C D'Angelo, Arber Kacollja, Jennifer D Ryan, Morgan D Barens. Object-in-place Memory Predicted by Anterolateral Entorhinal Cortex and Parahippocampal Cortex Volume in Older Adults. Journal of cognitive neuroscience. vol 31. issue 5. 2020-07-01. PMID:30822207. |
the lateral portion of the entorhinal cortex is one of the first brain regions affected by tau pathology, an important biomarker for alzheimer disease. |
2020-07-01 |
2023-08-13 |
human |
| David Berron, Arturo Cardenas-Blanco, Daniel Bittner, Coraline D Metzger, Annika Spottke, Michael T Heneka, Klaus Fliessbach, Anja Schneider, Stefan J Teipel, Michael Wagner, Oliver Speck, Frank Jessen, Emrah Düze. Higher CSF Tau Levels Are Related to Hippocampal Hyperactivity and Object Mnemonic Discrimination in Older Adults. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 39. issue 44. 2020-06-29. PMID:31541019. |
the mtl subregions that are known to be affected early by tau pathology, the perirhinal-transentorhinal region (area 35) and the anterior-lateral entorhinal cortex (alec), have recently been implicated in the mnemonic discrimination of objects rather than scenes. |
2020-06-29 |
2023-08-13 |
human |
| Wei Xu, Can Zhang, Jie-Qiong Li, Chen-Chen Tan, Xi-Peng Cao, Lan Tan, Jin-Tai Y. Age-related hearing loss accelerates cerebrospinal fluid tau levels and brain atrophy: a longitudinal study. Aging. vol 11. issue 10. 2020-06-17. PMID:31118310. |
age-related hearing loss was associated with elevated cerebrospinal fluid tau levels and atrophy of entorhinal cortex. |
2020-06-17 |
2023-08-13 |
human |
| Marshall A Dalton, Cornelia McCormick, Flavia De Luca, Ian A Clark, Eleanor A Maguir. Functional connectivity along the anterior-posterior axis of hippocampal subfields in the ageing human brain. Hippocampus. vol 29. issue 11. 2020-06-12. PMID:31058404. |
compared to the young group, the older participants had significantly reduced fc between the anterior ca1-subiculum transition region and the transentorhinal cortex, two brain regions known to be disproportionately affected during the early stages of age-related tau accumulation. |
2020-06-12 |
2023-08-13 |
human |
| Anne Maass, David Berron, Theresa M Harrison, Jenna N Adams, Renaud La Joie, Suzanne Baker, Taylor Mellinger, Rachel K Bell, Kaitlin Swinnerton, Ben Inglis, Gil D Rabinovici, Emrah Düzel, William J Jagus. Alzheimer's pathology targets distinct memory networks in the ageing brain. Brain : a journal of neurology. vol 142. issue 8. 2020-05-26. PMID:31199481. |
post-mortem studies indicate that in ageing and alzheimer's disease tau tangles deposit early in the transentorhinal cortex, a region located in the anterior-temporal lobe that is critical for object memory. |
2020-05-26 |
2023-08-13 |
Not clear |
| Joonki Kim, Sharmelee Selvaraji, Sung Wook Kang, Wei Thye Lee, Christopher Li-Hsian Chen, Hyungwon Choi, Edward H Koo, Dong-Gyu Jo, Kah Leong Lim, Yun-An Lim, Thiruma V Arumuga. Cerebral transcriptome analysis reveals age-dependent progression of neuroinflammation in P301S mutant tau transgenic male mice. Brain, behavior, and immunity. vol 80. 2020-05-21. PMID:30980950. |
employing rna sequencing on ps19 transgenic mice that overexpress human mutant tau harboring the p301s mutation, we have examined the effects of age-dependent tau overexpression on transcriptomic changes of immune and inflammatory responses in the cerebral cortex. |
2020-05-21 |
2023-08-13 |
mouse |
| Joonki Kim, Sharmelee Selvaraji, Sung Wook Kang, Wei Thye Lee, Christopher Li-Hsian Chen, Hyungwon Choi, Edward H Koo, Dong-Gyu Jo, Kah Leong Lim, Yun-An Lim, Thiruma V Arumuga. Cerebral transcriptome analysis reveals age-dependent progression of neuroinflammation in P301S mutant tau transgenic male mice. Brain, behavior, and immunity. vol 80. 2020-05-21. PMID:30980950. |
our current study on p301s transgenic mice model revealed for the first time, the differences of gene expression patterns in both early and late stage of tau pathology in cerebral cortex. |
2020-05-21 |
2023-08-13 |
mouse |
| James A R Nicoll, George R Buckland, Charlotte H Harrison, Anton Page, Scott Harris, Seth Love, James W Neal, Clive Holmes, Delphine Boch. Persistent neuropathological effects 14 years following amyloid-β immunization in Alzheimer's disease. Brain : a journal of neurology. vol 142. issue 7. 2020-05-18. PMID:31157360. |
we analysed the relationships between the topographical distribution of amyloid-β removal from the cerebral cortex and tau pathology, cerebrovascular territories, plasma anti-an1792 antibody titres and late cognitive status. |
2020-05-18 |
2023-08-13 |
human |
| James A R Nicoll, George R Buckland, Charlotte H Harrison, Anton Page, Scott Harris, Seth Love, James W Neal, Clive Holmes, Delphine Boch. Persistent neuropathological effects 14 years following amyloid-β immunization in Alzheimer's disease. Brain : a journal of neurology. vol 142. issue 7. 2020-05-18. PMID:31157360. |
cortical foci cleared of plaques contained less tau than did cortex with remaining plaques, but the overall distribution of tangles was extensive (braak v/vi). |
2020-05-18 |
2023-08-13 |
human |
| Jessica L Hoffman, Sara Faccidomo, Michelle Kim, Seth M Taylor, Abigail E Agoglia, Ashley M May, Evan N Smith, L C Wong, Clyde W Hodg. Alcohol drinking exacerbates neural and behavioral pathology in the 3xTg-AD mouse model of Alzheimer's disease. International review of neurobiology. vol 148. 2020-05-11. PMID:31733664. |
multiplex immunoassay conducted on brain lysates showed that alcohol drinking upregulated primary markers of ad pathology in 3xtg-ad mice: aβ 42/40 ratio in the lateral entorhinal and prefrontal cortex and total tau expression in the lateral entorhinal cortex, medial prefrontal cortex, and amygdala at 1-month post alcohol exposure. |
2020-05-11 |
2023-08-13 |
mouse |
| Susanne Wegmann, Rachel E Bennett, Louis Delorme, Ashley B Robbins, Miwei Hu, Danny McKenzie, Molly J Kirk, Julia Schiantarelli, Nahel Tunio, Ana C Amaral, Zhanyun Fan, Samantha Nicholls, Eloise Hudry, Bradley T Hyma. Experimental evidence for the age dependence of tau protein spread in the brain. Science advances. vol 5. issue 6. 2020-04-30. PMID:31249873. |
we virally expressed human tau locally in entorhinal cortex (ec) neurons of young or old mice and monitored the cell-to-cell tau protein spread by immunolabeling. |
2020-04-30 |
2023-08-13 |
mouse |
| Carine Bossenmeyer-Pourié, A David Smith, Sylvain Lehmann, Vincent Deramecourt, Bernard Sablonnière, Jean-Michel Camadro, Grégory Pourié, Racha Kerek, Deborah Helle, Remy Umoret, Rosa-Maria Guéant-Rodriguez, Valérie Rigau, Audrey Gabelle, Jeffrey M Sequeira, Edward V Quadros, Jean-Luc Daval, Jean-Louis Guéan. N-homocysteinylation of tau and MAP1 is increased in autopsy specimens of Alzheimer's disease and vascular dementia. The Journal of pathology. vol 248. issue 3. 2020-04-08. PMID:30734924. |
compared with controls, n-homocysteinylated tau and map1 were increased and accumulated in protein aggregates and tangles in the cortex, hippocampus and cerebellum of patients and animals. |
2020-04-08 |
2023-08-13 |
mouse |
| Nicole D Anderso. State of the science on mild cognitive impairment (MCI). CNS spectrums. vol 24. issue 1. 2020-03-24. PMID:30651152. |
elevated tau can be identified in mci, particularly in the entorhinal cortex, using positron emission tomography, and analysis of signal complexity using electroencephalography or magnetoencephalography holds promise as a biomarker. |
2020-03-24 |
2023-08-13 |
Not clear |
| Passainte S Hassaan, Abeer E Dief, Teshreen M Zeitoun, Azza M Baraka, Robert M J Deacon, Amany Elshorbag. Cortical tau burden and behavioural dysfunctions in mice exposed to monosodium glutamate in early life. PloS one. vol 14. issue 8. 2020-03-09. PMID:31412065. |
intracellular hyperphosphorylated tau immunostaining was observed diffusely in the cortex and hippocampus, together with cortical atrophic neurons, extensive vacuolation and dysmorphic neuropil suggestive of spongiform neurodegeneration. |
2020-03-09 |
2023-08-13 |
mouse |
| Satoshi Tanikawa, Mishie Tanino, Lei Wang, Marin Ishikawa, Masaya Miyazaki, Masumi Tsuda, Yasuko Orba, Hirofumi Sawa, Kotarou Matoba, Nishio Nakamura, Kazuo Nagashima, William W Hall, Shinya Tanak. Autopsy findings in the early stage of amyotrophic lateral sclerosis with "dropped head" syndrome. Neuropathology : official journal of the Japanese Society of Neuropathology. vol 39. issue 5. 2020-03-06. PMID:31373095. |
phosphorylated tau positive structures in neuronal cytoplasm were found in the amygdala, entorhinal cortex and parahippocampal cortex, some of which co-expressed p-tdp-43. |
2020-03-06 |
2023-08-13 |
Not clear |
| E Orta-Salazar, A I Feria-Velasco, S Díaz-Cintr. Primary motor cortex alterations in Alzheimer disease: A study in the 3xTg-AD model. Neurologia (Barcelona, Spain). vol 34. issue 7. 2020-03-02. PMID:28433262. |
in humans and animal models, alzheimer disease (ad) is characterised by accumulation of amyloid-β peptide (aβ) and hyperphosphorylated tau protein, neuronal degeneration, and astrocytic gliosis, especially in vulnerable brain regions (hippocampus and cortex). |
2020-03-02 |
2023-08-13 |
mouse |