| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xi Chen, Kaitlin E Cassady, Jenna N Adams, Theresa M Harrison, Suzanne L Baker, William J Jagus. Regional Tau Effects on Prospective Cognitive Change in Cognitively Normal Older Adults. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 41. issue 2. 2021-03-25. PMID:33219003. |
studies suggest that tau deposition starts in the anterolateral entorhinal cortex (ec) with normal aging, and that the presence of β-amyloid (aβ) facilitates its spread to neocortex, which may reflect the beginning of alzheimer's disease (ad). |
2021-03-25 |
2023-08-13 |
Not clear |
| Hiroyuki Shimada, Shinobu Minatani, Jun Takeuchi, Akitoshi Takeda, Joji Kawabe, Yasuhiro Wada, Aya Mawatari, Yasuyoshi Watanabe, Hitoshi Shimada, Makoto Higuchi, Tetsuya Suhara, Takami Tomiyama, Yoshiaki Ito. Heavy Tau Burden with Subtle Amyloid β Accumulation in the Cerebral Cortex and Cerebellum in a Case of Familial Alzheimer's Disease with APP Osaka Mutation. International journal of molecular sciences. vol 21. issue 12. 2021-03-19. PMID:32580499. |
heavy tau burden with subtle amyloid β accumulation in the cerebral cortex and cerebellum in a case of familial alzheimer's disease with app osaka mutation. |
2021-03-19 |
2023-08-13 |
Not clear |
| Hiroyuki Shimada, Shinobu Minatani, Jun Takeuchi, Akitoshi Takeda, Joji Kawabe, Yasuhiro Wada, Aya Mawatari, Yasuyoshi Watanabe, Hitoshi Shimada, Makoto Higuchi, Tetsuya Suhara, Takami Tomiyama, Yoshiaki Ito. Heavy Tau Burden with Subtle Amyloid β Accumulation in the Cerebral Cortex and Cerebellum in a Case of Familial Alzheimer's Disease with APP Osaka Mutation. International journal of molecular sciences. vol 21. issue 12. 2021-03-19. PMID:32580499. |
scatter plot analysis of the two tracers revealed that fad (osaka) exhibits a distinguishing pattern with a heavy tau burden and subtle aβ accumulation in the cerebral cortex and cerebellum. |
2021-03-19 |
2023-08-13 |
Not clear |
| Yanchao Liu, Shujuan Zhang, Xiaoguang Li, Enjie Liu, Xin Wang, Qiuzhi Zhou, Jinwang Ye, Jian-Zhi Wan. Peripheral inflammation promotes brain tau transmission via disrupting blood-brain barrier. Bioscience reports. vol 40. issue 2. 2021-03-16. PMID:32043530. |
in the ad patients, the abnormal tau accumulation first appeared in entorhinal cortex (ec) and then propagated to the hippocampus with microglia activation and inflammation, but the mechanism is elusive. |
2021-03-16 |
2023-08-13 |
human |
| Yanchao Liu, Shujuan Zhang, Xiaoguang Li, Enjie Liu, Xin Wang, Qiuzhi Zhou, Jinwang Ye, Jian-Zhi Wan. Peripheral inflammation promotes brain tau transmission via disrupting blood-brain barrier. Bioscience reports. vol 40. issue 2. 2021-03-16. PMID:32043530. |
by intraperitoneal injection of lipopolysaccharide (lps) with brain medial entorhinal cortex (mec)-specific overexpressing p301l human tau (p301l-htau), we found that both acute and chronic administration of lps remarkably promoted p301l-htau transmission from mec to the hippocampal subsets. |
2021-03-16 |
2023-08-13 |
human |
| Isabel Castanho, Tracey K Murray, Eilis Hannon, Aaron Jeffries, Emma Walker, Emma Laing, Hedley Baulf, Joshua Harvey, Lauren Bradshaw, Andrew Randall, Karen Moore, Paul O'Neill, Katie Lunnon, David A Collier, Zeshan Ahmed, Michael J O'Neill, Jonathan Mil. Transcriptional Signatures of Tau and Amyloid Neuropathology. Cell reports. vol 30. issue 6. 2021-03-08. PMID:32049030. |
systems-level analyses identify discrete co-expression networks associated with the progressive accumulation of tau that are enriched for genes and pathways previously implicated in ad pathology and overlap with co-expression networks identified in human ad cortex. |
2021-03-08 |
2023-08-13 |
mouse |
| Wei Sun, Yuchun Tang, Yuchuan Qiao, Xinting Ge, Mara Mather, John M Ringman, Yonggang Sh. A probabilistic atlas of locus coeruleus pathways to transentorhinal cortex for connectome imaging in Alzheimer's disease. NeuroImage. vol 223. 2021-03-01. PMID:32861791. |
according to the latest braak staging of alzheimer's disease (ad), tau pathology occurs earliest in the brain in the locus coeruleus (lc) of the brainstem, then propagates to the transentorhinal cortex (tec), and later to other neocortical regions. |
2021-03-01 |
2023-08-13 |
human |
| Amy F T Arnsten, Dibyadeep Datta, Shannon Leslie, Sheng-Tao Yang, Min Wang, Angus C Nair. Alzheimer's-like pathology in aging rhesus macaques: Unique opportunity to study the etiology and treatment of Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. 2021-02-26. PMID:31871209. |
in particular, tau pathology in the association cortex is poorly replicated in mouse models. |
2021-02-26 |
2023-08-13 |
mouse |
| Amy F T Arnsten, Dibyadeep Datta, Shannon Leslie, Sheng-Tao Yang, Min Wang, Angus C Nair. Alzheimer's-like pathology in aging rhesus macaques: Unique opportunity to study the etiology and treatment of Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. 2021-02-26. PMID:31871209. |
for example, aging monkeys can help reveal how synapses in the prefrontal association cortex are uniquely regulated compared to the primary sensory cortex in ways that render them vulnerable to calcium dysregulation and tau phosphorylation, resulting in the selective localization of tau pathology observed in ad. |
2021-02-26 |
2023-08-13 |
mouse |
| Amy F T Arnsten, Dibyadeep Datta, Shannon Leslie, Sheng-Tao Yang, Min Wang, Angus C Nair. Alzheimer's-like pathology in aging rhesus macaques: Unique opportunity to study the etiology and treatment of Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. 2021-02-26. PMID:31871209. |
these data may help explain why circuits with aggressive tau pathology (e.g., entorhinal cortex) may degenerate prior to producing significant amyloid pathology. |
2021-02-26 |
2023-08-13 |
mouse |
| Tharick A Pascoal, Joseph Therriault, Andrea L Benedet, Melissa Savard, Firoza Z Lussier, Mira Chamoun, Cécile Tissot, Muhammad Naveed Iqbal Qureshi, Min Su Kang, Sulantha Mathotaarachchi, Jenna Stevenson, Robert Hopewell, Gassan Massarweh, Jean-Paul Soucy, Serge Gauthier, Pedro Rosa-Net. 18F-MK-6240 PET for early and late detection of neurofibrillary tangles. Brain : a journal of neurology. vol 143. issue 9. 2021-02-16. PMID:32671408. |
sixty-eight per cent of the cognitively unimpaired elderly amyloid-β-positive and 37% of the cognitively unimpaired elderly amyloid-β-negative subjects displayed tau deposition, at least in the transentorhinal cortex (braak i). |
2021-02-16 |
2023-08-13 |
human |
| Tharick A Pascoal, Joseph Therriault, Andrea L Benedet, Melissa Savard, Firoza Z Lussier, Mira Chamoun, Cécile Tissot, Muhammad Naveed Iqbal Qureshi, Min Su Kang, Sulantha Mathotaarachchi, Jenna Stevenson, Robert Hopewell, Gassan Massarweh, Jean-Paul Soucy, Serge Gauthier, Pedro Rosa-Net. 18F-MK-6240 PET for early and late detection of neurofibrillary tangles. Brain : a journal of neurology. vol 143. issue 9. 2021-02-16. PMID:32671408. |
tau deposition solely in the transentorhinal cortex was associated with an elevated prevalence of amyloid-β, neurodegeneration, and cognitive impairment (p < 0.0001). |
2021-02-16 |
2023-08-13 |
human |
| Panwen Liu, Lingyu Cui, Bo Liu, Weiwei Liu, Toshihiko Hayashi, Kazunori Mizuno, Shunji Hattori, Yuko Ushiki-Kaku, Satoshi Onodera, Takashi Ikejim. Silibinin ameliorates STZ-induced impairment of memory and learning by up- regulating insulin signaling pathway and attenuating apoptosis. Physiology & behavior. vol 213. 2021-01-22. PMID:31669775. |
moreover, silibinin significantly decreased stz-induced tau hyperphosphorylation (ser404) in hippocampus and cerebral cortex, markedly inhibited apoptosis of neurons induced by stz, and up-regulated insulin signal transduction pathway. |
2021-01-22 |
2023-08-13 |
rat |
| Zeran Li, Fabiana H G Farias, Umber Dube, Jorge L Del-Aguila, Kathie A Mihindukulasuriya, Maria Victoria Fernandez, Laura Ibanez, John P Budde, Fengxian Wang, Allison M Lake, Yuetiva Deming, James Perez, Chengran Yang, Jorge A Bahena, Wei Qin, Joseph L Bradley, Richard Davenport, Kristy Bergmann, John C Morris, Richard J Perrin, Bruno A Benitez, Joseph D Dougherty, Oscar Harari, Carlos Cruchag. The TMEM106B FTLD-protective variant, rs1990621, is also associated with increased neuronal proportion. Acta neuropathologica. vol 139. issue 1. 2021-01-19. PMID:31456032. |
apart from amyloid β deposition and tau neurofibrillary tangles, alzheimer's disease (ad) is a neurodegenerative disorder characterized by neuronal loss and astrocytosis in the cerebral cortex. |
2021-01-19 |
2023-08-13 |
Not clear |
| José J Jarero-Basulto, Martha C Rivera-Cervantes, Deisy Gasca-Martínez, Francisco García-Sierra, Yadira Gasca-Martínez, Carlos Beas-Zárat. Current Evidence on the Protective Effects of Recombinant Human Erythropoietin and Its Molecular Variants against Pathological Hallmarks of Alzheimer's Disease. Pharmaceuticals (Basel, Switzerland). vol 13. issue 12. 2020-12-26. PMID:33255969. |
ad is a degenerative disorder of the brain, characterized by an aberrant accumulation of amyloid β (aβ) and hyperphosphorylated tau (tau-p) proteins in the extracellular and intracellular space, respectively, leading to inflammation, oxidative stress, excitotoxicity, and other neuronal alterations that compromise cell viability, causing neurodegeneration in the hippocampus and the cerebral cortex. |
2020-12-26 |
2023-08-13 |
human |
| Seiko Ikezu, Kaitlin L Ingraham Dixie, Lacin Koro, Takashi Watanabe, Kozo Kaibuchi, Tsuneya Ikez. Tau-tubulin kinase 1 and amyloid-β peptide induce phosphorylation of collapsin response mediator protein-2 and enhance neurite degeneration in Alzheimer disease mouse models. Acta neuropathologica communications. vol 8. issue 1. 2020-12-23. PMID:32019603. |
the accumulation of phosphorylated tau protein (ptau) in the entorhinal cortex (ec) is the earliest tau pathology in alzheimer's disease (ad). |
2020-12-23 |
2023-08-13 |
mouse |
| Eva-Lotta von Rüden, Christina Zellinger, Julia Gedon, Andreas Walker, Vera Bierling, Cornelia A Deeg, Stefanie M Hauck, Heidrun Potschk. Regulation of Alzheimer's disease-associated proteins during epileptogenesis. Neuroscience. vol 424. 2020-12-10. PMID:31705965. |
the analysis also revealed a regulation of the microtubule associated protein tau in parahippocampal cortex tissue during the latency phase. |
2020-12-10 |
2023-08-13 |
rat |
| Natalia Dos Santos Tramontin, Sabrina da Silva, Rychard Arruda, Kellen Simon Ugioni, Paula Bortuluzzi Canteiro, Gustavo de Bem Silveira, Carolini Mendes, Paulo Cesar Lock Silveira, Alexandre Pastoris Mulle. Gold Nanoparticles Treatment Reverses Brain Damage in Alzheimer's Disease Model. Molecular neurobiology. vol 57. issue 2. 2020-11-25. PMID:31612296. |
oa increases tau phosphorylation in the cortex and hippocampus, while aunp treatment maintained it as normal. |
2020-11-25 |
2023-08-13 |
rat |
| Guy Griebel, Jeanne Stemmelin, Mati Lopez-Grancha, Denis Boulay, Gerald Boquet, Franck Slowinski, Philippe Pichat, Sandra Beeské, Shinji Tanaka, Akiko Mori, Masatake Fujimura, Junichi Eguch. The selective GSK3 inhibitor, SAR502250, displays neuroprotective activity and attenuates behavioral impairments in models of neuropsychiatric symptoms of Alzheimer's disease in rodents. Scientific reports. vol 9. issue 1. 2020-11-13. PMID:31792284. |
in p301l human tau transgenic mice, sar502250 attenuated tau hyperphosphorylation in the cortex and spinal cord. |
2020-11-13 |
2023-08-13 |
mouse |
| Arnaud Charil, Sergey Shcherbinin, Sudeepti Southekal, Michael D Devous, Mark Mintun, Melissa E Murray, Bradley B Miller, Adam J Schwar. Tau Subtypes of Alzheimer's Disease Determined in vivo Using Flortaucipir PET Imaging. Journal of Alzheimer's disease : JAD. vol 71. issue 3. 2020-11-05. PMID:31476153. |
worse performance on delayed recall was associated with increased hippocampal tau signal, and worse performance on the trail making test b-a was associated with lower values of the hippocampus to cortex ratio. |
2020-11-05 |
2023-08-13 |
human |