| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Carlos M Soto-Faguás, Paula Sanchez-Molina, Carlos A Saur. Loss of presenilin function enhances tau phosphorylation and aggregation in mice. Acta neuropathologica communications. vol 9. issue 1. 2021-11-05. PMID:34593029. |
interestingly, genetic inactivation of presenilin 1 (ps1) or both ps genes in mutant human tau transgenic mice exacerbates memory deficits by accelerating phosphorylation and aggregation of tau in excitatory neurons of vulnerable ad brain regions (e.g., hippocampus, cortex and amygdala). |
2021-11-05 |
2023-08-13 |
mouse |
| Anthony R Vega, Rati Chkheidze, Vipul Jarmale, Ping Shang, Chan Foong, Marc I Diamond, Charles L White, Satwik Rajara. Deep learning reveals disease-specific signatures of white matter pathology in tauopathies. Acta neuropathologica communications. vol 9. issue 1. 2021-11-05. PMID:34674762. |
although pathology of tauopathies is characterized by abnormal tau protein aggregation in both gray and white matter regions of the brain, neuropathological investigations have generally focused on abnormalities in the cerebral cortex because the canonical aggregates that form the diagnostic criteria for these disorders predominate there. |
2021-11-05 |
2023-08-13 |
human |
| Sadhana Ravikumar, Laura E M Wisse, Sydney Lim, Ranjit Ittyerah, Long Xie, Madigan L Bedard, Sandhitsu R Das, Edward B Lee, M Dylan Tisdall, Karthik Prabhakaran, Jacqueline Lane, John A Detre, Gabor Mizsei, John Q Trojanowski, John L Robinson, Theresa Schuck, Murray Grossman, Emilio Artacho-Pérula, Maria Mercedes Iñiguez de Onzoño Martin, María Del Mar Arroyo Jiménez, Monica Muñoz, Francisco Javier Molina Romero, Maria Del Pilar Marcos Rabal, Sandra Cebada Sánchez, José Carlos Delgado González, Carlos de la Rosa Prieto, Marta Córcoles Parada, David J Irwin, David A Wolk, Ricardo Insausti, Paul A Yushkevic. Ex vivo MRI atlas of the human medial temporal lobe: characterizing neurodegeneration due to tau pathology. Acta neuropathologica communications. vol 9. issue 1. 2021-11-05. PMID:34689831. |
we found significant correlations between tau pathology and thickness in the entorhinal cortex (erc) and stratum radiatum lacunosum moleculare (srlm). |
2021-11-05 |
2023-08-13 |
human |
| Behrus Puladi, Maja Dinekov, Thomas Arzberger, Max Taubert, Christoph Köhle. The relation between tau pathology and granulovacuolar degeneration of neurons. Neurobiology of disease. vol 147. 2021-11-01. PMID:33069844. |
the entorhinal cortex, drn, and lc are among the regions that display pathological changes of tau earliest, whereas neurons with gvbs occur first in the hippocampus and have been found in oral raphe nuclei only at the most advanced gvd stage. |
2021-11-01 |
2023-08-13 |
human |
| Behrus Puladi, Maja Dinekov, Thomas Arzberger, Max Taubert, Christoph Köhle. The relation between tau pathology and granulovacuolar degeneration of neurons. Neurobiology of disease. vol 147. 2021-11-01. PMID:33069844. |
we studied the relation between tau pathology and gvd in field ca1 of the hippocampus, entorhinal cortex, dorsal (drn) and median (mrn) raphe nucleus, and locus coeruleus from elderly subjects with braak & braak stages of tau pathology ranging from 0 to vi. |
2021-11-01 |
2023-08-13 |
human |
| Jean-Christophe Delpech, Dhruba Pathak, Merina Varghese, Srinidhi Venkatesan Kalavai, Emma C Hays, Patrick R Hof, W Evan Johnson, Seiko Ikezu, Maria Medalla, Jennifer I Luebke, Tsuneya Ikez. Wolframin-1-expressing neurons in the entorhinal cortex propagate tau to CA1 neurons and impair hippocampal memory in mice. Science translational medicine. vol 13. issue 611. 2021-11-01. PMID:34524859. |
wolframin-1-expressing neurons in the entorhinal cortex propagate tau to ca1 neurons and impair hippocampal memory in mice. |
2021-11-01 |
2023-08-13 |
mouse |
| Lin Chen, Peter C M van Zijl, Zhiliang Wei, Hanzhang Lu, Wenzhen Duan, Philip C Wong, Tong Li, Jiadi X. Early detection of Alzheimer's disease using creatine chemical exchange saturation transfer magnetic resonance imaging. NeuroImage. vol 236. 2021-10-28. PMID:33878375. |
the results on wild type (wt) mice and two age-matched ad models, namely tauopathy (tau) and aβ amyloidosis (app), indicated that crcest contrasts of the cortex and corpus callosum in the app and tau mice were significantly reduced compared to wt counterpart at an early stage (6-7 months) (p < 0.011). |
2021-10-28 |
2023-08-13 |
mouse |
| Che-Yu Hsu, Kuan-Ting Lee, Tzu-Yu Sun, Chun-I Sze, Shenq-Shyang Huang, Li-Jin Hsu, Nan-Shan Chan. WWOX and Its Binding Proteins in Neurodegeneration. Cells. vol 10. issue 7. 2021-10-28. PMID:34359949. |
gradual loss of wwox protein in the hippocampus and cortex starting from middle age may slowly induce aggregation of a protein cascade that ultimately causes accumulation of extracellular amyloid beta plaques and intracellular tau tangles, along with reduction in inhibitory gabaergic interneurons, in ad patients over 70 years old. |
2021-10-28 |
2023-08-13 |
mouse |
| Ayman A Soubh, Amira A El-Gazar, Eman A Mohamed, Azza S Awad, Hanan S El-Abha. Further insights for the role of Morin in mRTBI: Implication of non-canonical Wnt/PKC-α and JAK-2/STAT-3 signaling pathways. International immunopharmacology. vol 100. 2021-10-27. PMID:34560511. |
the results obtained has shown that all the chosen regimens opposed the upregulated dementia markers (aβ1-40,p(thr231)tau) and inflammatory protein contents/expression of p(ser53s6)nf-κbp65, tnf-α, il-6,and il-1β and the elevated gfap in immune stained cortex sections. |
2021-10-27 |
2023-08-13 |
Not clear |
| Amy F T Arnsten, Dibyadeep Datta, Kelly Del Tredici, Heiko Braa. Hypothesis: Tau pathology is an initiating factor in sporadic Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17. issue 1. 2021-10-25. PMID:33075193. |
this postulate rests on extensive data demonstrating that in human brains tau pathology appears about a decade before the formation of aβ plaques (aβps), especially targeting glutamate projection neurons in the association cortex. |
2021-10-25 |
2023-08-13 |
human |
| Amy F T Arnsten, Dibyadeep Datta, Kelly Del Tredici, Heiko Braa. Hypothesis: Tau pathology is an initiating factor in sporadic Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17. issue 1. 2021-10-25. PMID:33075193. |
this hypothesis could be testable in the aged monkey association cortex that naturally expresses characteristics capable of promoting and sustaining abnormal tau phosphorylation and aβ production. |
2021-10-25 |
2023-08-13 |
human |
| Luis Aragão Gomes, Valerie Uytterhoeven, Diego Lopez-Sanmartin, Sandra O Tomé, Thomas Tousseyn, Rik Vandenberghe, Mathieu Vandenbulcke, Christine A F von Arnim, Patrik Verstreken, Dietmar Rudolf Tha. Maturation of neuronal AD-tau pathology involves site-specific phosphorylation of cytoplasmic and synaptic tau preceding conformational change and fibril formation. Acta neuropathologica. vol 141. issue 2. 2021-10-25. PMID:33427938. |
ic- and in-tau were observed in all analyzed regions of the human brain, including early affected regions in nonad cases (entorhinal cortex) and late affected regions in symptomatic ad cases (cerebellum), indicating that tau pathology initiation follows similar processes when propagating into previously unaffected regions. |
2021-10-25 |
2023-08-13 |
human |
| Meijuan Zhu, Yanhua Zhao, Yongjun Zheng, Diansan Su, Xiangrui Wan. Relative Higher Hematocrit Attenuates the Cerebral Excitatory Amino Acid Elevation Induced by Deep Hypothermic Circulatory Arrest in Rats. Therapeutic hypothermia and temperature management. vol 3. issue 3. 2021-10-21. PMID:24066268. |
high-performance liquid chromatography was used to determine the concentration of glutamate (glu), aspartate (asp), glycine (gly), gamma-aminobutyric acid (gaba), and taurine (tau) in the cerebral cortex, hippocampus, and thalamus. |
2021-10-21 |
2023-08-12 |
rat |
| Vivek Kumar Sharma, Thakur Gurjeet Singh, Shareen Singh, Nikhil Garg, Sonia Dhima. Apoptotic Pathways and Alzheimer's Disease: Probing Therapeutic Potential. Neurochemical research. vol 46. issue 12. 2021-10-21. PMID:34386919. |
the well-characterized pathological features of ad, including extracellular plaques of amyloid-beta, intracellular hyperphosphorylated tangles of tau protein (nfts), inflammation, mitochondrial dysfunction, oxidative stress, and excitotoxic cell death, also instigate an abnormal apoptotic cascade in susceptible brain regions (cerebral cortex, hippocampus). |
2021-10-21 |
2023-08-13 |
Not clear |
| Changhe Ren, Milian Chen, Guo Mu, Suangchun Peng, Xiangbo Liu, Cehua O. NLRP3 Inflammasome Mediates Neurodegeneration in Rats with Chronic Neuropathic Pain. Shock (Augusta, Ga.). vol 56. issue 5. 2021-10-18. PMID:34265833. |
in addition, tau hyperphosphorylation and aβ expression increase in the cortex and hippocampus of the brain. |
2021-10-18 |
2023-08-13 |
rat |
| Jia-Ying Lu, Yi-Min Sun, Tzu-Chen Yen, Chuan-Tao Zuo, Jian Wan. Multimodal Imaging in a Patient With Alzheimer Disease and Parkinsonism Because of a Presenilin-1 Mutation. Clinical nuclear medicine. vol 46. issue 9. 2021-10-15. PMID:33883498. |
her main findings on pet included diffuse tau accumulation in the cerebral cortex and left putamen, increased cerebellar amyloid deposits, asymmetrically reduced dopamine transporter binding, and mild hypermetabolism in the putamen. |
2021-10-15 |
2023-08-13 |
Not clear |
| Simona Sacchini, Josué Díaz-Delgado, Antonio Espinosa de Los Monteros, Yania Paz, Yara Bernaldo de Quirós, Eva Sierra, Manuel Arbelo, Pedro Herráez, Antonio Fernánde. Amyloid-beta peptide and phosphorylated tau in the frontopolar cerebral cortex and in the cerebellum of toothed whales: aging versus hypoxia. Biology open. vol 9. issue 11. 2021-10-13. PMID:33037014. |
amyloid-beta peptide and phosphorylated tau in the frontopolar cerebral cortex and in the cerebellum of toothed whales: aging versus hypoxia. |
2021-10-13 |
2023-08-13 |
Not clear |
| Jing Li, Junxiang Wang, Yuan-Liang Wang, Zhousong Luo, Chunyan Zheng, Guangxia Yu, Siying Wu, Fuli Zheng, Huangyuan L. NOX2 activation contributes to cobalt nanoparticles-induced inflammatory responses and Tau phosphorylation in mice and microglia. Ecotoxicology and environmental safety. vol 225. 2021-10-05. PMID:34492628. |
moreover, both total unphosphorylated tau and phosphorylated tau (ptau; t231 and s262) expressions in the hippocampus and cortex were upregulated, unveiling tau phosphorylation. |
2021-10-05 |
2023-08-13 |
mouse |
| Sharay E Setti, Miranda N Ree. Network activity changes in the pathophysiology of Alzheimer's disease: the role of aging and early entorhinal cortex dysfunction. Metabolic brain disease. 2021-09-30. PMID:34591222. |
also unknown is what impact activity alterations in the entorhinal cortex (ec) has on the spread of ad pathology such as pathological tau through the brain as ad progresses. |
2021-09-30 |
2023-08-13 |
Not clear |
| Ryan A Wirt, Lauren A Crew, Andrew A Ortiz, Adam M McNeela, Emmanuel Flores, Jefferson W Kinney, James M Hyma. Altered theta rhythm and hippocampal-cortical interactions underlie working memory deficits in a hyperglycemia risk factor model of Alzheimer's disease. Communications biology. vol 4. issue 1. 2021-09-24. PMID:34480097. |
consistent with previous investigations, we found increases in phosphorylated tau in stz animals' hippocampus and cortex, which might account for the observed oscillatory and cognitive changes. |
2021-09-24 |
2023-08-13 |
human |