| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jack C de la Torr. Deciphering Alzheimer's Disease Pathogenic Pathway: Role of Chronic Brain Hypoperfusion on p-Tau and mTOR. Journal of Alzheimer's disease : JAD. vol 79. issue 4. 2021-09-15. PMID:33459641. |
new biomolecular findings reveal the interplay of cbh in increasing tau phosphorylation (p-tau) in the hippocampus and cortex of ad mice, damaging fast axonal transport, increasing signaling of mammalian target of rapamycin (mtor), impairing learning-memory function, and promoting the formation of neurofibrillary tangles, a neuropathologic hallmark of ad. |
2021-09-15 |
2023-08-13 |
mouse |
| Lei Huang, Yang Zhang, Yongwei Wang, Yajia La. Relationship Between Chronic Noise Exposure, Cognitive Impairment, and Degenerative Dementia: Update on the Experimental and Epidemiological Evidence and Prospects for Further Research. Journal of Alzheimer's disease : JAD. vol 79. issue 4. 2021-09-15. PMID:33459723. |
experimental studies have indicated that long-term exposure to noise might accelerate cognitive dysfunction, amyloid-β deposition, and tau hyperphosphorylation in different brain regions such as the hippocampus and cortex. |
2021-09-15 |
2023-08-13 |
Not clear |
| Parul Gupta, Shubhangini Tiwari, Abhishek Singh, Amit Pal, Amit Mishra, Sarika Sing. Rivastigmine attenuates the Alzheimer's disease related protein degradation and apoptotic neuronal death signalling. The Biochemical journal. vol 478. issue 7. 2021-09-13. PMID:33660768. |
the known inhibitory effect of rivastigmine on cognition and acetylcholinesterase activity was observed in both cortex and hippocampus and further its effect on tau level, amyloid aggregation, biochemical alterations, endoplasmic reticulum (er) stress, calcium homeostasis, proteasome activity and apoptosis was estimated. |
2021-09-13 |
2023-08-13 |
rat |
| Xin Wang, En-Jie Liu, Qian Liu, Shi-Hong Li, Ting Li, Qiu-Zhi Zhou, Yan-Chao Liu, Huaqiu Zhang, Jian-Zhi Wan. Tau Acetylation in Entorhinal Cortex Induces its Chronic Hippocampal Propagation and Cognitive Deficits in Mice. Journal of Alzheimer's disease : JAD. vol 77. issue 1. 2021-09-08. PMID:32804150. |
tau acetylation in entorhinal cortex induces its chronic hippocampal propagation and cognitive deficits in mice. |
2021-09-08 |
2023-08-13 |
mouse |
| Yuhan Ma, Jing Wang, Dihui Xu, Yabing Chen, Xiaodong Ha. Chronic MC-LR exposure promoted Aβ and p-tau accumulation via regulating Akt/GSK-3β signal pathway. The Science of the total environment. vol 794. 2021-09-06. PMID:34323745. |
in this study, we observed β-amyloid (aβ) accumulation and tau hyperphosphorylation (p-tau) at sites of ser396 and thr205 in mouse hippocampus and cortex, alzheimer's disease (ad) like changes, after chronic exposure to mc-lr at different concentrations (1, 7.5, 15 and 30 μg/l) for 180 days. |
2021-09-06 |
2023-08-13 |
mouse |
| Md Ataur Rahman, Md Abdul Hannan, Md Jamal Uddin, Md Saidur Rahman, Md Mamunur Rashid, Bonglee Ki. Exposure to Environmental Arsenic and Emerging Risk of Alzheimer's Disease: Perspective Mechanisms, Management Strategy, and Future Directions. Toxics. vol 9. issue 8. 2021-08-31. PMID:34437506. |
alzheimer's disease (ad) is one of the most prevailing neurodegenerative diseases, characterized by memory dysfunction and the presence of hyperphosphorylated tau and amyloid β (aβ) aggregates in multiple brain regions, including the hippocampus and cortex. |
2021-08-31 |
2023-08-13 |
human |
| L E M Wisse, S Ravikumar, R Ittyerah, S Lim, J Lane, M L Bedard, L Xie, S R Das, T Schuck, M Grossman, E B Lee, M D Tisdall, K Prabhakaran, J A Detre, G Mizsei, J Q Trojanowski, E Artacho-Pérula, M M de Iñiguez de Onzono Martin, M M Arroyo-Jiménez, M Muñoz Lopez, F J Molina Romero, M P Marcos Rabal, S Cebada Sánchez, J C Delgado González, C de la Rosa Prieto, M Córcoles Parada, D A Wolk, D J Irwin, R Insausti, P A Yushkevic. Downstream effects of polypathology on neurodegeneration of medial temporal lobe subregions. Acta neuropathologica communications. vol 9. issue 1. 2021-08-23. PMID:34289895. |
tau, tar dna-binding protein 43 (tdp-43), amyloid-β and α-synuclein pathology were rated on a scale of 0 (absent)-3 (severe) in the hippocampus and entorhinal cortex (erc) of 58 individuals with and without neurodegenerative diseases (median age 75.0 years, 60.3% male). |
2021-08-23 |
2023-08-13 |
Not clear |
| Audrey J Weber, Jeremy H Herskowit. Perspectives on ROCK2 as a Therapeutic Target for Alzheimer's Disease. Frontiers in cellular neuroscience. vol 15. 2021-08-21. PMID:33790742. |
recent studies indicate that dysregulation of autophagy contributes to the development of misfolded tau aggregates among entorhinal cortex (ec) excitatory neurons in early alzheimer's disease (ad). |
2021-08-21 |
2023-08-13 |
Not clear |
| Toshiki Uchihar. Neurofibrillary changes undergoing morphological and biochemical changes - How does tau with the profile shift of from four repeat to three repeat spread in Alzheimer brain? Neuropathology : official journal of the Japanese Society of Neuropathology. vol 40. issue 5. 2021-08-18. PMID:32698244. |
the concept of the hierarchal spread of neurofibrillary tangles (nfts) from the hippocampus to the cortex in alzheimer's disease (ad)/aging brains, initially proposed by braak and braak, revolutionized our understanding by putatively explaining that tau lesions are being unidirectionally extended along neural connections. |
2021-08-18 |
2023-08-13 |
human |
| David Wallon, Susana Boluda, Anne Rovelet-Lecrux, Manon Thierry, Julien Lagarde, Laetitia Miguel, Magalie Lecourtois, Antoine Bonnevalle, Marie Sarazin, Michel Bottlaender, Mathieu Mula, Serge Marty, Natsuko Nakamura, Catherine Schramm, François Sellal, Thérèse Jonveaux, Camille Heitz, Isabelle Le Ber, Stéphane Epelbaum, Eloi Magnin, Aline Zarea, Stéphane Rousseau, Olivier Quenez, Didier Hannequin, Florence Clavaguera, Dominique Campion, Charles Duyckaerts, Gaël Nicola. Clinical and neuropathological diversity of tauopathy in MAPT duplication carriers. Acta neuropathologica. vol 142. issue 2. 2021-08-16. PMID:34095977. |
amyloid imaging was negative but tau imaging showed significant deposits mainly in both mesiotemporal cortex. |
2021-08-16 |
2023-08-13 |
human |
| Seong Su Kang, Eun Hee Ahn, Keqiang Y. Delta-secretase cleavage of Tau mediates its pathology and propagation in Alzheimer's disease. Experimental & molecular medicine. vol 52. issue 8. 2021-08-10. PMID:32859953. |
the spread of tau deposits is first initiated in the lc and is transported in a stepwise manner from the entorhinal cortex to the hippocampus and then to associative regions of the neocortex as the disease progresses. |
2021-08-10 |
2023-08-13 |
Not clear |
| Amelia Strom, Leonardo Iaccarino, Lauren Edwards, Orit H Lesman-Segev, David N Soleimani-Meigooni, Julie Pham, Suzanne L Baker, Susan Landau, William J Jagust, Bruce L Miller, Howard J Rosen, Maria Luisa Gorno-Tempini, Gil D Rabinovici, Renaud La Joi. Cortical hypometabolism reflects local atrophy and tau pathology in symptomatic Alzheimer's disease. Brain : a journal of neurology. 2021-08-10. PMID:34373896. |
exploratory analyses across the cortex confirmed overall associations between hypometabolism and local tau pathology and thickness and revealed associations between medial temporal degeneration and hypometabolism in retrosplenial, orbitofrontal, and anterior cingulate cortices. |
2021-08-10 |
2023-08-13 |
human |
| Tosha Williams, Zachary Sorrentino, Mary Weinrich, Benoit I Giasson, Paramita Chakrabart. Differential cross-seeding properties of tau and α-synuclein in mouse models of tauopathy and synucleinopathy. Brain communications. vol 2. issue 2. 2021-08-07. PMID:33094280. |
in m20 mice, unilateral hippocampal injection of α-synuclein fibrils or tau fibrils induced robust bilateral phosphorylated α-synuclein pathology, while tau + α-synuclein copolymer injection resulted in restricted phosphorylated α-synuclein pathology predominantly in the ipsilateral cortex. |
2021-08-07 |
2023-08-13 |
mouse |
| Lei Zhang, Yankai Jiang, Jie Zhu, Huazheng Liang, Xiangyang He, Jiahong Qian, Hai Lin, Yubo Tao, Keqing Zh. Quantitative Assessment of Hippocampal Tau Pathology in AD and PART. Journal of molecular neuroscience : MN. vol 70. issue 11. 2021-07-29. PMID:32372343. |
in ad cases, tau pathology was high in both ca1 and subiculum, followed by ca2/3, entorhinal cortex (ec), ca4, and dentate gyrus (dg). |
2021-07-29 |
2023-08-13 |
Not clear |
| Jonathan D Cherry, Katharine J Babcock, Lee E Goldstei. Repetitive Head Trauma Induces Chronic Traumatic Encephalopathy by Multiple Mechanisms. Seminars in neurology. vol 40. issue 4. 2021-07-26. PMID:32674181. |
the defining diagnostic lesion of cte consists of patchy perivascular accumulations of hyperphosphorylated tau protein that localize in the sulcal depths of the cerebral cortex. |
2021-07-26 |
2023-08-13 |
Not clear |
| Ann C McKe. The Neuropathology of Chronic Traumatic Encephalopathy: The Status of the Literature. Seminars in neurology. vol 40. issue 4. 2021-07-26. PMID:32712946. |
cte is characterized by the buildup of hyperphosphorylated tau (p-tau) in neurofibrillary tangles (nfts), neurites, and, sometimes, astrocytes, surrounding small blood vessels in a patchy distribution at the sulcal depths of the cerebral cortex. |
2021-07-26 |
2023-08-13 |
Not clear |
| Jinsu Park, Meenu Madan, Srinivasulu Chigurupati, Seung Hyun Baek, Yoonsuk Cho, Mohamed R Mughal, Amin Yu, Sic L Chan, Jogi V Pattisapu, Mark P Mattson, Dong-Gyu J. Neuronal Aquaporin 1 Inhibits Amyloidogenesis by Suppressing the Interaction Between Beta-Secretase and Amyloid Precursor Protein. The journals of gerontology. Series A, Biological sciences and medical sciences. vol 76. issue 1. 2021-07-15. PMID:32154567. |
aqp1 accumulation was observed in vulnerable neurons in the cerebral cortex of ad patients, and in neurons affected by the aβ or tau pathology in the 3xtg-ad and 5xfad mice. |
2021-07-15 |
2023-08-13 |
mouse |
| Qing Xia, XinYu Yang, JiaBin Shi, ZiJie Liu, YaHui Peng, WenJing Wang, BoWen Li, Yu Zhao, JiaYing Xiao, Lei Huang, DaYong Wang, Xu Ga. The Protective A673T Mutation of Amyloid Precursor Protein (APP) in Alzheimer's Disease. Molecular neurobiology. vol 58. issue 8. 2021-07-15. PMID:33914267. |
alzheimer's disease is a progressive neurodegenerative disorder characterized by extracellular amyloid beta peptides and neurofibrillary tangles consisted of intracellular hyperphosphorylated tau in the hippocampus and cerebral cortex. |
2021-07-15 |
2023-08-13 |
Not clear |
| Kimberly L Fiock, Jodi D Smith, John F Crary, Marco M Heft. β-amyloid and tau pathology in the aging feline brain. The Journal of comparative neurology. vol 528. issue 1. 2021-07-01. PMID:31273784. |
in 75% of these cases (3/4), tau deposition was limited to entorhinal cortex, while one case showed diffuse positive staining throughout the hippocampal formation and neocortex. |
2021-07-01 |
2023-08-13 |
human |
| Jacob W Vogel, Alexandra L Young, Neil P Oxtoby, Ruben Smith, Rik Ossenkoppele, Olof T Strandberg, Renaud La Joie, Leon M Aksman, Michel J Grothe, Yasser Iturria-Medina, Michael J Pontecorvo, Michael D Devous, Gil D Rabinovici, Daniel C Alexander, Chul Hyoung Lyoo, Alan C Evans, Oskar Hansso. Four distinct trajectories of tau deposition identified in Alzheimer's disease. Nature medicine. vol 27. issue 5. 2021-06-23. PMID:33927414. |
alzheimer's disease (ad) is characterized by the spread of tau pathology throughout the cerebral cortex. |
2021-06-23 |
2023-08-13 |
Not clear |