| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| b' Sanna-Kaisa Herukka, Corina Pennanen, Hilkka Soininen, Tuula Pirttil\\xc3\\xa. CSF Abeta42, tau and phosphorylated tau correlate with medial temporal lobe atrophy. Journal of Alzheimer\'s disease : JAD. vol 14. issue 1. 2008-08-18. PMID:18525127.' |
tau and phospho-tau correlated inversely with hippocampal volumes and left entorhinal cortex volume in the whole study group. |
2008-08-18 |
2023-08-12 |
human |
| Scott A Yuzwa, Matthew S Macauley, Julia E Heinonen, Xiaoyang Shan, Rebecca J Dennis, Yuan He, Garrett E Whitworth, Keith A Stubbs, Ernest J McEachern, Gideon J Davies, David J Vocadl. A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo. Nature chemical biology. vol 4. issue 8. 2008-08-13. PMID:18587388. |
thiamet-g also efficiently reduced phosphorylation of tau at thr231, ser396 and ser422 in both rat cortex and hippocampus, which reveals the rapid and dynamic relationship between o-glcnac and phosphorylation of tau in vivo. |
2008-08-13 |
2023-08-12 |
human |
| A M Fjell, K B Walhovd, I Amlien, A Bjørnerud, I Reinvang, L Gjerstad, T Cappelen, F Willoch, P Due-Tønnessen, R Grambaite, A Skinningsrud, V Stenset, T Fladb. Morphometric changes in the episodic memory network and tau pathologic features correlate with memory performance in patients with mild cognitive impairment. AJNR. American journal of neuroradiology. vol 29. issue 6. 2008-07-10. PMID:18544670. |
the purpose of this study was to ask these 2 questions: 1) can levels of csf tau proteins and amyloid beta 42 peptide explain thinning of the cerebral cortex in patients with mci? |
2008-07-10 |
2023-08-12 |
Not clear |
| Paloma Navarro, Rosa Guerrero, Eva Gallego, Jesus Avila, Rosario Luquin, Pedro J Garcia Ruiz, Marina P Sanche. Memory and exploratory impairment in mice that lack the Park-2 gene and that over-express the human FTDP-17 mutant Tau. Behavioural brain research. vol 189. issue 2. 2008-07-09. PMID:18346797. |
however, the presence of both mutations simultaneously causes a tau neuropathology, involving reactive astrocytosis, neuron loss in the cortex and hippocampus, and lesions in nigrostriatal and motor neurons. |
2008-07-09 |
2023-08-12 |
mouse |
| Kimiko Obi, Haruhiko Akiyama, Hiromi Kondo, Yoko Shimomura, Masato Hasegawa, Takeshi Iwatsubo, Yoshikuni Mizuno, Hideki Mochizuk. Relationship of phosphorylated alpha-synuclein and tau accumulation to Abeta deposition in the cerebral cortex of dementia with Lewy bodies. Experimental neurology. vol 210. issue 2. 2008-06-20. PMID:18164295. |
relationship of phosphorylated alpha-synuclein and tau accumulation to abeta deposition in the cerebral cortex of dementia with lewy bodies. |
2008-06-20 |
2023-08-12 |
Not clear |
| Gustavo Basurto-Islas, Jose Luna-Muñoz, Angela L Guillozet-Bongaarts, Lester I Binder, Raul Mena, Francisco García-Sierr. Accumulation of aspartic acid421- and glutamic acid391-cleaved tau in neurofibrillary tangles correlates with progression in Alzheimer disease. Journal of neuropathology and experimental neurology. vol 67. issue 5. 2008-06-20. PMID:18431250. |
glutamic acid391 tau truncation was prominent in the entorhinal cortex, whereas d421 truncation was prominent in the subiculum, suggesting that nfts composed of either d421- or e391-truncated tau may be formed mutually exclusively in these areas. |
2008-06-20 |
2023-08-12 |
Not clear |
| Rosa Guerrero, Paloma Navarro, Eva Gallego, Jesus Avila, Justo G de Yebenes, Marina P Sanche. Park2-null/tau transgenic mice reveal a functional relationship between parkin and tau. Journal of Alzheimer's disease : JAD. vol 13. issue 2. 2008-06-10. PMID:18376058. |
aggregates of phosphorylated tau in neurons and reactive gliosis are quite abundant in cortex and hippocampus of these mice. |
2008-06-10 |
2023-08-12 |
mouse |
| Abraham Fishe. M1 muscarinic agonists target major hallmarks of Alzheimer's disease--the pivotal role of brain M1 receptors. Neuro-degenerative diseases. vol 5. issue 3-4. 2008-05-15. PMID:18322400. |
in triple transgenic ad mice, af267b reduced cognitive deficits and decreased abeta(42) and tau pathologies in the cortex and hippocampus (not amygdala), via m1 machr activation of protein kinase c and a disintegrin and metalloproteinase domain 17 (adam17 or tace) and decreased beta-site amyloid precursor protein-cleaving enzyme 1 and glycogen synthase kinase 3beta, respectively. |
2008-05-15 |
2023-08-12 |
mouse |
| Dick Terwel, David Muyllaert, Ilse Dewachter, Peter Borghgraef, Sophie Croes, Herman Devijver, Fred Van Leuve. Amyloid activates GSK-3beta to aggravate neuronal tauopathy in bigenic mice. The American journal of pathology. vol 172. issue 3. 2008-05-09. PMID:18258852. |
extensive and remarkable parallels were observed between these strains including 1) aggravation of tauopathy with highly fibrillar tangles in the hippocampus and cortex; 2) prolonged survival correlated to alleviated brainstem tauopathy; 3) development of severe cognitive and behavioral defects in young adults before the onset of amyloid deposition or tauopathy; and 4) presence of pathological phospho-epitopes of tau, including the characteristic gsk-3beta motif at s396/s404. |
2008-05-09 |
2023-08-12 |
mouse |
| Cyntia Tremblay, Mireille Pilote, Alix Phivilay, Vincent Emond, David A Bennett, Frédéric Calo. Biochemical characterization of Abeta and tau pathologies in mild cognitive impairment and Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 12. issue 4. 2008-03-25. PMID:18198424. |
interestingly, soluble/insoluble total tau ratio, phf_{tau} and insoluble abeta_{42} concentrations in the cortex correlated strongly with global cognition scores proximate to death and with immunohistochemical and histological quantification of abeta and tau pathologies. |
2008-03-25 |
2023-08-12 |
human |
| Abraham Fishe. M1 muscarinic agonists target major hallmarks of Alzheimer's disease--an update. Current Alzheimer research. vol 4. issue 5. 2008-03-21. PMID:18220527. |
in 3x transgenic-ad mice that recapitulate the major pathologies and cognitive deficits of ad, chronic af267b treatment rescued cognitive deficits and decreased abeta42 and tau pathologies in the cortex and hippocampus (not amygdala), via m1 machr-activation of adam17/tace and decreased bace1 steady state levels and inhibition of gsk3beta, extending findings from above. |
2008-03-21 |
2023-08-12 |
mouse |
| Tetsuya Kimura, Shunji Yamashita, Tetsuya Fukuda, Jun-Mi Park, Miyuki Murayama, Tatsuya Mizoroki, Yuji Yoshiike, Naruhiko Sahara, Akihiko Takashim. Hyperphosphorylated tau in parahippocampal cortex impairs place learning in aged mice expressing wild-type human tau. The EMBO journal. vol 26. issue 24. 2008-03-07. PMID:18007595. |
hyperphosphorylated tau in parahippocampal cortex impairs place learning in aged mice expressing wild-type human tau. |
2008-03-07 |
2023-08-12 |
mouse |
| Tetsuya Kimura, Shunji Yamashita, Tetsuya Fukuda, Jun-Mi Park, Miyuki Murayama, Tatsuya Mizoroki, Yuji Yoshiike, Naruhiko Sahara, Akihiko Takashim. Hyperphosphorylated tau in parahippocampal cortex impairs place learning in aged mice expressing wild-type human tau. The EMBO journal. vol 26. issue 24. 2008-03-07. PMID:18007595. |
taken together, the accumulation of hyperphosphorylated tau and synapse loss in aged mice, leading to inhibition of neural activity in parahippocampal areas, including the entorhinal cortex, may underlie place learning impairment. |
2008-03-07 |
2023-08-12 |
mouse |
| Tetsuya Kimura, Shunji Yamashita, Tetsuya Fukuda, Jun-Mi Park, Miyuki Murayama, Tatsuya Mizoroki, Yuji Yoshiike, Naruhiko Sahara, Akihiko Takashim. Hyperphosphorylated tau in parahippocampal cortex impairs place learning in aged mice expressing wild-type human tau. The EMBO journal. vol 26. issue 24. 2008-03-07. PMID:18007595. |
thus, the accumulation of hyperphosphorylated tau that occurs before nft formation in entorhinal cortex may contribute to the memory problems seen in alzheimer's disease (ad). |
2008-03-07 |
2023-08-12 |
mouse |
| Tristan Bolmont, Florence Clavaguera, Melanie Meyer-Luehmann, Martin C Herzig, Rebecca Radde, Matthias Staufenbiel, Jada Lewis, Mike Hutton, Markus Tolnay, Mathias Jucke. Induction of tau pathology by intracerebral infusion of amyloid-beta -containing brain extract and by amyloid-beta deposition in APP x Tau transgenic mice. The American journal of pathology. vol 171. issue 6. 2008-02-08. PMID:18055549. |
six months after the infusion, tau pathology was induced in the injected hippocampus but also in brain regions well beyond the injection sites such as the entorhinal cortex and amygdala, areas with neuronal projection to the injection site. |
2008-02-08 |
2023-08-12 |
mouse |
| Adam R Cole, Wendy Noble, Lidy van Aalten, Florian Plattner, Rena Meimaridou, Dale Hogan, Margaret Taylor, John LaFrancois, Frank Gunn-Moore, Alex Verkhratsky, Salvatore Oddo, Frank LaFerla, K Peter Giese, Kelly T Dineley, Karen Duff, Jill C Richardson, Shi Du Yan, Diane P Hanger, Stuart M Allan, Calum Sutherlan. Collapsin response mediator protein-2 hyperphosphorylation is an early event in Alzheimer's disease progression. Journal of neurochemistry. vol 103. issue 3. 2007-12-21. PMID:17683481. |
similarly, crmp2 phosphorylation is normal in hippocampus and cortex of tau(p301l) mice that develop tangles but not plaques. |
2007-12-21 |
2023-08-12 |
mouse |
| G Niewiadomska, M Baksalerska-Pazera, I Lenarcik, G Riede. Compartmental protein expression of Tau, GSK-3beta and TrkA in cholinergic neurons of aged rats. Journal of neural transmission (Vienna, Austria : 1996). vol 113. issue 11. 2007-09-05. PMID:16736240. |
in young animals, expression of tau isoforms and glycogen synthase kinase-3beta (gsk-3beta) was restricted to neuritic structures in cortex, hippocampus, and basal forebrain. |
2007-09-05 |
2023-08-12 |
rat |
| W Gordon-Krajcer, E Kozniewska, J W Lazarewicz, H Ksiezak-Redin. Differential changes in phosphorylation of tau at PHF-1 and 12E8 epitopes during brain ischemia and reperfusion in gerbils. Neurochemical research. vol 32. issue 4-5. 2007-05-29. PMID:17191139. |
we examined the phosphorylation status of tau protein in the gerbil brain cortex during 5 min ischemia induced by bilateral common carotid artery occlusion followed by reperfusion for 20 min to 7 days. |
2007-05-29 |
2023-08-12 |
Not clear |
| Yi Wen, Shao-Hua Yang, Ran Liu, Evelyn J Perez, Anne Marie Brun-Zinkernagel, Peter Koulen, James W Simpkin. Cdk5 is involved in NFT-like tauopathy induced by transient cerebral ischemia in female rats. Biochimica et biophysica acta. vol 1772. issue 4. 2007-04-26. PMID:17113760. |
here we show that after transient cerebral ischemia, hyperphosphorylated tau accumulates in neurons of the cerebral cortex in the ischemic area, forms filaments similar to those present in human neurodegenerative tauopathies and colocalizes with markers of apoptosis. |
2007-04-26 |
2023-08-12 |
mouse |
| Kenji Sakai, Yue-Shan Piao, Koki Kikugawa, Shinji Ohara, Masato Hasegawa, Hiroki Takano, Masayuki Fukase, Masatoyo Nishizawa, Akiyoshi Kakita, Hitoshi Takahash. Corticobasal degeneration with focal, massive tau accumulation in the subcortical white matter astrocytes. Acta neuropathologica. vol 112. issue 3. 2007-02-08. PMID:16804710. |
the essential brain pathologies were similar to each other; although ballooned neurons and astrocytic tau lesions (astrocytic plaques) were present in the affected cerebral cortex, the most striking finding was focal, much heavier accumulation of tau in the subcortical white matter. |
2007-02-08 |
2023-08-12 |
Not clear |