| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kyoko Itoh, Maki Mitani, Kunihiko Kawamoto, Naonobu Futamura, Itaru Funakawa, Kenji Jinnai, Shinji Fushik. Neuropathology does not Correlate with Regional Differences in the Extent of Expansion of CTG Repeats in the Brain with Myotonic Dystrophy Type 1. Acta histochemica et cytochemica. vol 43. issue 6. 2011-07-14. PMID:21245981. |
the neuropathological changes included état criblé in the cerebral deep white matter and neurofibrillary tangles immunoreactive for phosphorylated tau in the hippocampus and entorhinal cortex, both of which were compatible with the subcortical dementia in dm1 patients. |
2011-07-14 |
2023-08-12 |
human |
| Ming Jin, Nina Shepardson, Ting Yang, Gang Chen, Dominic Walsh, Dennis J Selko. Soluble amyloid beta-protein dimers isolated from Alzheimer cortex directly induce Tau hyperphosphorylation and neuritic degeneration. Proceedings of the National Academy of Sciences of the United States of America. vol 108. issue 14. 2011-07-01. PMID:21421841. |
soluble amyloid beta-protein dimers isolated from alzheimer cortex directly induce tau hyperphosphorylation and neuritic degeneration. |
2011-07-01 |
2023-08-12 |
human |
| Ming Cheng Liu, Firas Kobeissy, Wenrong Zheng, Zhiqun Zhang, Ronald L Hayes, Kevin K W Wan. Dual vulnerability of tau to calpains and caspase-3 proteolysis under neurotoxic and neurodegenerative conditions. ASN neuro. vol 3. issue 1. 2011-06-10. PMID:21359008. |
tau was also fragmented in injured rat cortex following tbi in vivo to bdps of 45-42 kda (minor), 35 kda and 15 kda, followed by taubdp-25k. |
2011-06-10 |
2023-08-12 |
rat |
| Adam E Ludvigson, Jennifer I Luebke, Jada Lewis, Alan Peter. Structural abnormalities in the cortex of the rTg4510 mouse model of tauopathy: a light and electron microscopy study. Brain structure & function. vol 216. issue 1. 2011-06-09. PMID:21152933. |
in tg mice, spherical, empty vacuoles, up to 60 μm in diameter, become increasingly abundant with age and by 9 months, pyramidal and non-pyramidal neurons with large intracellular tangles of tau protein are common throughout the cortex. |
2011-06-09 |
2023-08-12 |
mouse |
| Frauke Glöckner, Volker Meske, Dieter Lütjohann, Thomas G Oh. Dietary cholesterol and its effect on tau protein: a study in apolipoprotein E-deficient and P301L human tau mice. Journal of neuropathology and experimental neurology. vol 70. issue 4. 2011-05-27. PMID:21412171. |
the numbers of neurons with hyperphosphorylated and conformationally changed tau in the cerebral cortex were assessed by immunohistochemistry, and sterol levels were determined. |
2011-05-27 |
2023-08-12 |
mouse |
| Alexis M Stranahan, Rebecca P Haberman, Michela Gallaghe. Cognitive decline is associated with reduced reelin expression in the entorhinal cortex of aged rats. Cerebral cortex (New York, N.Y. : 1991). vol 21. issue 2. 2011-04-27. PMID:20538740. |
the lateral entorhinal cortex of aged rats with cognitive impairment also exhibited changes in other molecular markers, including increased accumulation of phosphorylated tau and decreased synaptophysin immunoreactivity. |
2011-04-27 |
2023-08-12 |
rat |
| Natalia Shiryaev, Yan Jouroukhin, Illana Goze. 3R tau expression modifies behavior in transgenic mice. Journal of neuroscience research. vol 88. issue 12. 2011-03-11. PMID:20544828. |
in contrast, increased tau expression and phosphorylation were measured in the cerebral cortex of the tau-tg mice. |
2011-03-11 |
2023-08-12 |
mouse |
| Dong Liu, Michael Pitta, Jong-Hwan Lee, Balmiki Ray, Debomoy K Lahiri, Katsutoshi Furukawa, Mohamed Mughal, Haiyang Jiang, Julissa Villarreal, Roy G Cutler, Nigel H Greig, Mark P Mattso. The KATP channel activator diazoxide ameliorates amyloid-β and tau pathologies and improves memory in the 3xTgAD mouse model of Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 22. issue 2. 2011-03-09. PMID:20847430. |
3xtgad mice treated with diazoxide for 8 months exhibited improved performance in a learning and memory test, reduced levels of anxiety, decreased accumulation of aβ oligomers and hyperphosphorylated tau in the cortex and hippocampus, and increased cerebral blood flow. |
2011-03-09 |
2023-08-12 |
mouse |
| Julio J Ramirez, Winona E Poulton, Erik Knelson, Cole Barton, Michael A King, Ronald L Klei. Focal expression of mutated tau in entorhinal cortex neurons of rats impairs spatial working memory. Behavioural brain research. vol 216. issue 1. 2011-02-18. PMID:20727915. |
focal expression of mutated tau in entorhinal cortex neurons of rats impairs spatial working memory. |
2011-02-18 |
2023-08-12 |
human |
| Julio J Ramirez, Winona E Poulton, Erik Knelson, Cole Barton, Michael A King, Ronald L Klei. Focal expression of mutated tau in entorhinal cortex neurons of rats impairs spatial working memory. Behavioural brain research. vol 216. issue 1. 2011-02-18. PMID:20727915. |
gene transfer techniques were used to create a model neurofibrillary tauopathy by injecting a recombinant adeno-associated viral vector with a mutated human tau gene (p301l) into the entorhinal cortex of adult rats. |
2011-02-18 |
2023-08-12 |
human |
| Julio J Ramirez, Winona E Poulton, Erik Knelson, Cole Barton, Michael A King, Ronald L Klei. Focal expression of mutated tau in entorhinal cortex neurons of rats impairs spatial working memory. Behavioural brain research. vol 216. issue 1. 2011-02-18. PMID:20727915. |
histological analysis confirmed the presence of hyperphosphorylated tau and nfts in the entorhinal cortex and neighboring retrohippocampal areas as well as limited synaptic degeneration of the perforant path. |
2011-02-18 |
2023-08-12 |
human |
| Celine Ullrich, Michael Pirchl, Christian Humpe. Hypercholesterolemia in rats impairs the cholinergic system and leads to memory deficits. Molecular and cellular neurosciences. vol 45. issue 4. 2011-02-07. PMID:20696249. |
levels of amyloid precursor protein, beta-amyloid(1-42), as well as tau and phospho-tau 181 were significantly enhanced in the cortex of cholesterol-fed rats. |
2011-02-07 |
2023-08-12 |
rat |
| Julie Blanchard, Lukas Wanka, Yunn-Chyn Tung, María del Carmen Cárdenas-Aguayo, Frank M LaFerla, Khalid Iqbal, Inge Grundke-Iqba. Pharmacologic reversal of neurogenic and neuroplastic abnormalities and cognitive impairments without affecting Aβ and tau pathologies in 3xTg-AD mice. Acta neuropathologica. vol 120. issue 5. 2011-01-25. PMID:20697724. |
although this treatment had no detectable effect on aβ and tau pathologies in 9-month animals, it enhanced neurogenesis in dentate gyrus, reduced ectopic birth in the granular cell layer, and increased neuronal plasticity in the hippocampus and cerebral cortex. |
2011-01-25 |
2023-08-12 |
mouse |
| Stacey Fuller, Megan Steele, Gerald Münc. Activated astroglia during chronic inflammation in Alzheimer's disease--do they neglect their neurosupportive roles? Mutation research. vol 690. issue 1-2. 2010-12-02. PMID:19748514. |
alzheimer's disease (ad) is a neurodegenerative disorder, characterized histopathologically by the extracellular deposition of beta-amyloid peptide in senile plaques, as well as intracellular neurofibrillary tangles (nft) of hyperphosphorylated tau protein, extensive neuronal loss and synaptic changes in the hippocampus and cerebral cortex. |
2010-12-02 |
2023-08-12 |
Not clear |
| Jose A Rodríguez-Navarro, Laura Rodríguez, María J Casarejos, Rosa M Solano, Ana Gómez, Juan Perucho, Ana María Cuervo, Justo García de Yébenes, María A Men. Trehalose ameliorates dopaminergic and tau pathology in parkin deleted/tau overexpressing mice through autophagy activation. Neurobiology of disease. vol 39. issue 3. 2010-11-16. PMID:20546895. |
tauopathies are neurodegenerative diseases, sporadic or familial, mainly characterized by dementia and parkinsonism associated to atrophy of the frontotemporal cortex and the basal ganglia, with deposition of abnormal tau in brain. |
2010-11-16 |
2023-08-12 |
mouse |
| Jie Yan, Xiao-Bo Sun, Hong-Quan Wang, Hong Zhao, Xiao-Yan Zhao, Yu-Xia Xu, Jing-Chun Guo, Cui-Qing Zh. Chronic restraint stress alters the expression and distribution of phosphorylated tau and MAP2 in cortex and hippocampus of rat brain. Brain research. vol 1347. 2010-11-02. PMID:20513368. |
chronic restraint stress alters the expression and distribution of phosphorylated tau and map2 in cortex and hippocampus of rat brain. |
2010-11-02 |
2023-08-12 |
rat |
| Jie Yan, Xiao-Bo Sun, Hong-Quan Wang, Hong Zhao, Xiao-Yan Zhao, Yu-Xia Xu, Jing-Chun Guo, Cui-Qing Zh. Chronic restraint stress alters the expression and distribution of phosphorylated tau and MAP2 in cortex and hippocampus of rat brain. Brain research. vol 1347. 2010-11-02. PMID:20513368. |
robust hyperphosphorylated tau immunolabeling was observed both in cortex and hippocampus of stressed animals and mainly located to perikaryal/dendritic elements. |
2010-11-02 |
2023-08-12 |
rat |
| C Köhler, P Bista, J Götz, H Schröde. Analysis of the cholinergic pathology in the P301L tau transgenic pR5 model of tauopathy. Brain research. vol 1347. 2010-11-02. PMID:20513372. |
to test the suitability of the pr5 model as a model of alzheimer's disease concerning the cholinergic innervation of the telencephalon, we determined the expression of the human tau transgene and the presence of neurofibrillary changes in the basal nucleus of meynert, the septal nuclei and the diagonal band of broca, sources of cholinergic innervation of the cerebral cortex and hippocampus. |
2010-11-02 |
2023-08-12 |
mouse |
| Akihiko Takashim. [Significance of tau in the development of Alzheimer's disease]. Brain and nerve = Shinkei kenkyu no shinpo. vol 62. issue 7. 2010-10-07. PMID:20675874. |
neurofibrillary tangles (nfts), which contain hyperphosphorylated tau are the other pathological hallmark of ad; clinical progression of nfts is from the entorhinal cortex to the limbic cortex, and neocortex. |
2010-10-07 |
2023-08-12 |
mouse |
| Zsolt Radak, Nikoletta Hart, Linda Sarga, Erika Koltai, Mustafa Atalay, Hideki Ohno, Istvan Boldog. Exercise plays a preventive role against Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 20. issue 3. 2010-09-08. PMID:20182027. |
it features increased oxidative state and deposition of amyloid plaques and neurofibrillary tangles of protein tau in the central cortex and limbic system of the brain. |
2010-09-08 |
2023-08-12 |
Not clear |