| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yuan-Shih Hu, Peng Xu, Gustavo Pigino, Scott T Brady, John Larson, Orly Lazaro. Complex environment experience rescues impaired neurogenesis, enhances synaptic plasticity, and attenuates neuropathology in familial Alzheimer's disease-linked APPswe/PS1DeltaE9 mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 24. issue 6. 2010-07-21. PMID:20086049. |
enhanced neurogenesis was accompanied by a significant reduction in levels of hyperphosphorylated tau and oligomeric abeta, the precursors of ad hallmarks, in the hippocampus and cortex of enriched mice. |
2010-07-21 |
2023-08-12 |
mouse |
| Jaehong Suh, Doo Soon Im, Gyeong Joon Moon, Keun Sil Ryu, Rohan de Silva, In Sun Choi, Andrew J Lees, Suzanne Y Guénette, Rudolph E Tanzi, Byoung Joo Gwa. Hypoxic ischemia and proteasome dysfunction alter tau isoform ratio by inhibiting exon 10 splicing. Journal of neurochemistry. vol 114. issue 1. 2010-07-19. PMID:20374429. |
decreased levels of tra2beta, an rna splicing factor responsible for tau exon 10 inclusion, were detected both in cortical cell cultures exposed to mg132 and in cerebral cortex after ischemic injury. |
2010-07-19 |
2023-08-12 |
Not clear |
| Kenichi Oshima, Hirotake Uchikado, Dennis W Dickso. Perivascular neuritic dystrophy associated with cerebral amyloid angiopathy in Alzheimer's disease. International journal of clinical and experimental pathology. vol 1. issue 5. 2010-05-20. PMID:18787622. |
the severity of perivascular neuritic dystrophy and abeta deposition was scored in an association cortex (brodmann area 18) and a primary cortex (brodmann area 17) with double labeling immunohistochemistry for tau and abeta in 31 cases of ad with severe caa. |
2010-05-20 |
2023-08-12 |
Not clear |
| Kenichi Oshima, Hirotake Uchikado, Dennis W Dickso. Perivascular neuritic dystrophy associated with cerebral amyloid angiopathy in Alzheimer's disease. International journal of clinical and experimental pathology. vol 1. issue 5. 2010-05-20. PMID:18787622. |
the perivascular tau neuritic dystrophy score was significantly worse in visual association cortex than in primary visual cortex. |
2010-05-20 |
2023-08-12 |
Not clear |
| Masatake Fujimura, Fusako Usuki, Masumi Sawada, Akihiko Takashim. Methylmercury induces neuropathological changes with tau hyperphosphorylation mainly through the activation of the c-jun-N-terminal kinase pathway in the cerebral cortex, but not in the hippocampus of the mouse brain. Neurotoxicology. vol 30. issue 6. 2010-03-09. PMID:19666049. |
methylmercury induces neuropathological changes with tau hyperphosphorylation mainly through the activation of the c-jun-n-terminal kinase pathway in the cerebral cortex, but not in the hippocampus of the mouse brain. |
2010-03-09 |
2023-08-12 |
mouse |
| Masatake Fujimura, Fusako Usuki, Masumi Sawada, Akihiko Takashim. Methylmercury induces neuropathological changes with tau hyperphosphorylation mainly through the activation of the c-jun-N-terminal kinase pathway in the cerebral cortex, but not in the hippocampus of the mouse brain. Neurotoxicology. vol 30. issue 6. 2010-03-09. PMID:19666049. |
western blotting revealed that mehg exposure increased tau phosphorylation at thr-205, ser-396 and ser-422 in the cerebral cortex, consistent with the phosphorylation patterns noted in alzheimer's disease and frontotemporal dementia. |
2010-03-09 |
2023-08-12 |
mouse |
| Masatake Fujimura, Fusako Usuki, Masumi Sawada, Akihiko Takashim. Methylmercury induces neuropathological changes with tau hyperphosphorylation mainly through the activation of the c-jun-N-terminal kinase pathway in the cerebral cortex, but not in the hippocampus of the mouse brain. Neurotoxicology. vol 30. issue 6. 2010-03-09. PMID:19666049. |
neither neuropathological changes nor tau hyperphosphorylation was detected in the hippocampus in this study although the mercury concentration here was twice that in the cerebral cortex. |
2010-03-09 |
2023-08-12 |
mouse |
| Masatake Fujimura, Fusako Usuki, Masumi Sawada, Akihiko Takashim. Methylmercury induces neuropathological changes with tau hyperphosphorylation mainly through the activation of the c-jun-N-terminal kinase pathway in the cerebral cortex, but not in the hippocampus of the mouse brain. Neurotoxicology. vol 30. issue 6. 2010-03-09. PMID:19666049. |
these findings suggest that mehg exposure induces tau hyperphosphorylation at specific sites of tau mainly through the activation of jnk pathways, leading to neuropathological changes in the cerebral cortex selectively, but not in the hippocampus of mouse brain. |
2010-03-09 |
2023-08-12 |
mouse |
| Juan Perucho, Maria J Casarejos, Isabel Rubio, José A Rodriguez-Navarro, Ana Gómez, Israel Ampuero, Izaskun Rodal, Rosa M Solano, Eva Carro, Justo García de Yébenes, Maria A Men. The effects of parkin suppression on the behaviour, amyloid processing, and cell survival in APP mutant transgenic mice. Experimental neurology. vol 221. issue 1. 2010-02-16. PMID:19815012. |
app mutant mice had an increased number of tau immunoreactive neuritic plaques in the cerebral cortex as well as increased levels of total and phosphorylated tau protein, and these changes were partially normalized in app/pk(+/-) heterozygotic and homozygotic app/pk(-/-) mice. |
2010-02-16 |
2023-08-12 |
mouse |
| Hiroki Asari, Anthony M Zado. Long-lasting context dependence constrains neural encoding models in rodent auditory cortex. Journal of neurophysiology. vol 102. issue 5. 2010-01-25. PMID:19675288. |
using natural sounds and other stimuli, we found that synaptic inputs to auditory cortical neurons showed a rather long context dependence, up to > or =4 s (tau approximately 1 s), even though sound-evoked excitatory and inhibitory conductances per se rarely lasted greater, similar 100 ms. thalamic neurons showed only a much faster form of adaptation with a decay constant tau <100 ms, indicating that the long-lasting form originated from presynaptic mechanisms in the cortex, such as synaptic depression. |
2010-01-25 |
2023-08-12 |
rat |
| Bhumsoo Kim, Carey Backus, Sangsu Oh, John M Hayes, Eva L Feldma. Increased tau phosphorylation and cleavage in mouse models of type 1 and type 2 diabetes. Endocrinology. vol 150. issue 12. 2010-01-19. PMID:19819959. |
tau phosphorylation is increased in the cortex and hippocampus of db/db mice compared with db+ control mouse brain. |
2010-01-19 |
2023-08-12 |
mouse |
| L Serenó, M Coma, M Rodríguez, P Sánchez-Ferrer, M B Sánchez, I Gich, J M Agulló, M Pérez, J Avila, C Guardia-Laguarta, J Clarimón, A Lleó, T Gómez-Isl. A novel GSK-3beta inhibitor reduces Alzheimer's pathology and rescues neuronal loss in vivo. Neurobiology of disease. vol 35. issue 3. 2009-12-03. PMID:19523516. |
treatment with this thiadiazolidinone compound resulted in lower levels of tau phosphorylation, decreased amyloid deposition and plaque-associated astrocytic proliferation, protection of neurons in the entorhinal cortex and ca1 hippocampal subfield against cell death, and prevention of memory deficits in this transgenic mouse model. |
2009-12-03 |
2023-08-12 |
mouse |
| Estelle Leclerc, Emmanuel Sturchler, Stefan W Vetter, Claus W Heizman. Crosstalk between calcium, amyloid beta and the receptor for advanced glycation endproducts in Alzheimer's disease. Reviews in the neurosciences. vol 20. issue 2. 2009-10-20. PMID:19774788. |
hallmarks of alzheimer's disease (ad) include the accumulation of amyloid beta peptide (abeta), hyperphosphorylation of tau protein, and increased inflammatory activity in the hippocampus and cerebral cortex. |
2009-10-20 |
2023-08-12 |
Not clear |
| Henrik Viber. Exposure to polybrominated diphenyl ethers 203 and 206 during the neonatal brain growth spurt affects proteins important for normal neurodevelopment in mice. Toxicological sciences : an official journal of the Society of Toxicology. vol 109. issue 2. 2009-09-03. PMID:19380496. |
furthermore, there were no significant changes in the levels of gap-43 and tau in the cerebral cortex or hippocampus after neonatal exposure to pbde 203 or 206. |
2009-09-03 |
2023-08-12 |
mouse |
| Henrik Viber. Neonatal ontogeny and neurotoxic effect of decabrominated diphenyl ether (PBDE 209) on levels of synaptophysin and tau. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 27. issue 5. 2009-08-12. PMID:19465108. |
the animals were euthanized 7 days after exposure to pbde 209 and levels of synaptophysin and tau were analyzed in the hippocampus and cerebral cortex. |
2009-08-12 |
2023-08-12 |
mouse |
| Henrik Viber. Neonatal ontogeny and neurotoxic effect of decabrominated diphenyl ether (PBDE 209) on levels of synaptophysin and tau. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 27. issue 5. 2009-08-12. PMID:19465108. |
the analysis of protein levels showed no changes in tau in the hippocampus or cerebral cortex 7 days after exposure to pbde 209 on postnatal day 3. |
2009-08-12 |
2023-08-12 |
mouse |
| Claire Shepherd, Heather McCann, Glenda Margaret Hallida. Variations in the neuropathology of familial Alzheimer's disease. Acta neuropathologica. vol 118. issue 1. 2009-07-29. PMID:19306098. |
additional frontotemporal neuronal loss in association with increased tau pathology appears unique to psen mutations, with mutations in exons 8 and 9 having enlarged cotton wool plaques throughout their cortex. |
2009-07-29 |
2023-08-12 |
Not clear |
| Charles Duyckaerts, Benoît Delatour, Marie-Claude Potie. Classification and basic pathology of Alzheimer disease. Acta neuropathologica. vol 118. issue 1. 2009-07-29. PMID:19381658. |
the progression of tau pathology is stepwise and stereotyped from the entorhinal cortex, through the hippocampus, to the isocortex. |
2009-07-29 |
2023-08-12 |
Not clear |
| Florence Clavaguera, Tristan Bolmont, R Anthony Crowther, Dorothee Abramowski, Stephan Frank, Alphonse Probst, Graham Fraser, Anna K Stalder, Martin Beibel, Matthias Staufenbiel, Mathias Jucker, Michel Goedert, Markus Tolna. Transmission and spreading of tauopathy in transgenic mouse brain. Nature cell biology. vol 11. issue 7. 2009-07-20. PMID:19503072. |
in the disease process, neuronal tau inclusions first appear in the transentorhinal cortex from where they seem to spread to the hippocampal formation and neocortex. |
2009-07-20 |
2023-08-12 |
mouse |
| Niclas Johansson, Per Eriksson, Henrik Viber. Neonatal exposure to PFOS and PFOA in mice results in changes in proteins which are important for neuronal growth and synaptogenesis in the developing brain. Toxicological sciences : an official journal of the Society of Toxicology. vol 108. issue 2. 2009-06-15. PMID:19211617. |
both compounds significantly increased the levels of synaptophysin and tau in cerebral cortex, and pfoa also increased the levels of tau in hippocampus. |
2009-06-15 |
2023-08-12 |
mouse |