| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Karunya K Kandimalla, Olenych G Scott, Smita Fulzele, Michael W Davidson, Joseph F Podusl. Mechanism of neuronal versus endothelial cell uptake of Alzheimer's disease amyloid beta protein. PloS one. vol 4. issue 2. 2009-04-27. PMID:19247480. |
alzheimer's disease (ad) is characterized by significant neurodegeneration in the cortex and hippocampus; intraneuronal tangles of hyperphosphorylated tau protein; and accumulation of beta-amyloid (abeta) proteins 40 and 42 in the brain parenchyma as well as in the cerebral vasculature. |
2009-04-27 |
2023-08-12 |
mouse |
| M E Kalaitzakis, L M Christian, L B Moran, M B Graeber, R K B Pearce, S M Gentlema. Dementia and visual hallucinations associated with limbic pathology in Parkinson's disease. Parkinsonism & related disorders. vol 15. issue 3. 2009-04-20. PMID:18602855. |
abeta in the anterior cingulate gyrus, entorhinal cortex, amygdaloid complex and nucleus basalis of meynert is also associated with dementia as is tau in the ca2 sector of the hippocampus. |
2009-04-20 |
2023-08-12 |
Not clear |
| P Navarro, R Guerrero, E Gallego, J Avila, R Luquin, P J Garcia Ruiz, M P Sanche. Motor alterations are reduced in mice lacking the PARK2 gene in the presence of a human FTDP-17 mutant form of four-repeat tau. Journal of the neurological sciences. vol 275. issue 1-2. 2009-04-09. PMID:18817929. |
however, the presence of both mutations in a parkin-deficient and htauvlw double mutant mouse causes a tau neuropathology, reactive astrocytosis, and neuronal loss in the cortex and hippocampus, as well as lesions in nigrostriatal and motor neurons. |
2009-04-09 |
2023-08-12 |
mouse |
| Carl Julien, Cyntia Tremblay, Vincent Emond, Meryem Lebbadi, Norman Salem, David A Bennett, Frédéric Calo. Sirtuin 1 reduction parallels the accumulation of tau in Alzheimer disease. Journal of neuropathology and experimental neurology. vol 68. issue 1. 2009-04-09. PMID:19104446. |
collectively, our results indicate that loss of sirt1 is closely associated with the accumulation of amyloid-beta and tau in the cerebral cortex of persons with ad. |
2009-04-09 |
2023-08-12 |
human |
| Ramasamy Thangavel, Gary W Van Hoesen, Asgar Zahee. The abnormally phosphorylated tau lesion of early Alzheimer's disease. Neurochemical research. vol 34. issue 1. 2009-02-23. PMID:18437565. |
we have observed in the mildly affected ad tau immunoreactive lesion that extends from the temporopolar/insular region anteriorly to the posterior parahippocampal cortex. |
2009-02-23 |
2023-08-12 |
human |
| Ramasamy Thangavel, Gary W Van Hoesen, Asgar Zahee. The abnormally phosphorylated tau lesion of early Alzheimer's disease. Neurochemical research. vol 34. issue 1. 2009-02-23. PMID:18437565. |
although the tau lesion encroaches slightly into the temporopolar cortex (area tg) anteriorly and medially and the ectorhinal cortex (area 36) laterally, area 35 is unambiguously defined. |
2009-02-23 |
2023-08-12 |
human |
| Rosa Guerrero, Paloma Navarro, Eva Gallego, Ana M Garcia-Cabrero, Jesus Avila, Marina P Sanche. Hyperphosphorylated tau aggregates in the cortex and hippocampus of transgenic mice with mutant human FTDP-17 Tau and lacking the PARK2 gene. Acta neuropathologica. vol 117. issue 2. 2009-02-23. PMID:19057915. |
hyperphosphorylated tau aggregates in the cortex and hippocampus of transgenic mice with mutant human ftdp-17 tau and lacking the park2 gene. |
2009-02-23 |
2023-08-12 |
mouse |
| Guanghong Liao, Miou Zhou, Simon Cheung, James Galeano, Nam Nguyen, Michel Baudry, Xiaoning B. Reduced early hypoxic/ischemic brain damage is associated with increased GLT-1 levels in mice expressing mutant (P301L) human tau. Brain research. vol 1247. 2009-02-19. PMID:18992725. |
h/i resulted in a significant increase in tau fragments generated by caspase activation and a marked decrease in tau phosphorylation at residue t231 in cortex of wild-type but not transgenic mice. |
2009-02-19 |
2023-08-12 |
mouse |
| Yu A Merkulov, I A Zavalishin, D M Merkulov. The role of axonopathy in the mechanisms of development of demyelination processes in the central and peripheral nervous system. Neuroscience and behavioral physiology. vol 39. issue 1. 2009-02-19. PMID:19089637. |
patients with ms were found to have foci of reduced mri intensity in the t1 regime ("black holes," present in 28%) and regional atrophy of the cerebral cortex (in 46%), which showed a significant association with the degree of invalidity on the edss (kendall tau = 0.38 and 0.43; p = 0.038 and 0.021, respectively). |
2009-02-19 |
2023-08-12 |
Not clear |
| Geneviève Leuba, Claude Walzer, André Vernay, Béatrice Carnal, Rudolf Kraftsik, Françoise Piotton, Pascale Marin, Constantin Bouras, Armand Savio. Postsynaptic density protein PSD-95 expression in Alzheimer's disease and okadaic acid induced neuritic retraction. Neurobiology of disease. vol 30. issue 3. 2008-11-07. PMID:18424056. |
therefore, increased psd-95 immunoreactivity in the entorhinal cortex might result from compensatory mechanisms, as in the sh-sy5y clone, whereas increased alzheimer-like tau phosphorylation is not related to psd-95 expression, as suggested by the oa-treated cell models. |
2008-11-07 |
2023-08-12 |
Not clear |
| E B Shubenina, V S Kudrin, P M Klodt, A A Pokrovskiĭ, T A Gudasheva, T A Voronina, R U Ostrovskai. [Interstrain differences in the content of excitatory and inhibitory amino acids in the brain of DBA/2J, Balb/c and C57BL/6 mice: characteristics of the effect of a dipeptide antipsychotic drug dilept]. Eksperimental'naia i klinicheskaia farmakologiia. vol 71. issue 4. 2008-10-27. PMID:18819433. |
we have performed a comparative study of the content of glutamate (glu), aspartate (asp), taurine (tau), glycine (gly) and gamma-amino-butyric acid (gaba) in the cortex, hippocampus, and striatum of the dba/2j, balb/c and c57bl/6 mice brain. |
2008-10-27 |
2023-08-12 |
mouse |
| E B Shubenina, V S Kudrin, P M Klodt, A A Pokrovskiĭ, T A Gudasheva, T A Voronina, R U Ostrovskai. [Interstrain differences in the content of excitatory and inhibitory amino acids in the brain of DBA/2J, Balb/c and C57BL/6 mice: characteristics of the effect of a dipeptide antipsychotic drug dilept]. Eksperimental'naia i klinicheskaia farmakologiia. vol 71. issue 4. 2008-10-27. PMID:18819433. |
dilept induced a statistically significant increase in the levels of glu, tau and gaba in striatum of dba/2j, as well as insignificant increase in the levels of these amino acids in the cortex. |
2008-10-27 |
2023-08-12 |
mouse |
| Alicia Rubio, Mar Pérez, Luis de Lecea, Jesús Avil. Effect of cortistatin on tau phosphorylation at Ser262 site. Journal of neuroscience research. vol 86. issue 11. 2008-09-30. PMID:18438934. |
the development of intraneuronal lesions as a result of the progressive deposition of hyperphosphorylated tau at specific brain regions (such as hippocampus and cortex) plays a key role in the pathological process of alzheimer's disease. |
2008-09-30 |
2023-08-12 |
mouse |
| Alicia Rubio, Mar Pérez, Luis de Lecea, Jesús Avil. Effect of cortistatin on tau phosphorylation at Ser262 site. Journal of neuroscience research. vol 86. issue 11. 2008-09-30. PMID:18438934. |
however, the mechanisms by which tau phosphorylation is regulated, mainly in the pathology found in the cortex, are still poorly understood. |
2008-09-30 |
2023-08-12 |
mouse |
| Alicia Rubio, Mar Pérez, Luis de Lecea, Jesús Avil. Effect of cortistatin on tau phosphorylation at Ser262 site. Journal of neuroscience research. vol 86. issue 11. 2008-09-30. PMID:18438934. |
both somatostatin and cortistatin induce tau phosphorylation at ser262, a site modified in alzheimer's disease, although with different kinetics in cortex. |
2008-09-30 |
2023-08-12 |
mouse |
| Alicia Rubio, Mar Pérez, Luis de Lecea, Jesús Avil. Effect of cortistatin on tau phosphorylation at Ser262 site. Journal of neuroscience research. vol 86. issue 11. 2008-09-30. PMID:18438934. |
cortistatin-deficient mice show decreased tau phosphorylation at ser262 in the cortex but not in other brain regions tested. |
2008-09-30 |
2023-08-12 |
mouse |
| Alicia Rubio, Mar Pérez, Luis de Lecea, Jesús Avil. Effect of cortistatin on tau phosphorylation at Ser262 site. Journal of neuroscience research. vol 86. issue 11. 2008-09-30. PMID:18438934. |
our results suggest an important role for cortistatin in the regulation of tau phosphorylation that may be associated with the pathophysiology of alzheimer's disease in regions such as the cerebral cortex. |
2008-09-30 |
2023-08-12 |
mouse |
| Kimiko Hamano, Masaharu Hayashi, Kei Shioda, Ryo Fukatsu, Shuki Mizutan. Mechanisms of neurodegeneration in mucopolysaccharidoses II and IIIB: analysis of human brain tissue. Acta neuropathologica. vol 115. issue 5. 2008-09-24. PMID:18060551. |
the swollen neurons showed immunoreactivity for phosphorylated alpha-synuclein but not for phosphorylated tau protein or beta-amyloid protein; those in the cerebral cortex demonstrated nuclear immunoreactivity for tunel, single-stranded dna and 8-ohdg. |
2008-09-24 |
2023-08-12 |
human |
| Bronwen Martin, Randall Brenneman, Kevin G Becker, Marjan Gucek, Robert N Cole, Stuart Maudsle. iTRAQ analysis of complex proteome alterations in 3xTgAD Alzheimer's mice: understanding the interface between physiology and disease. PloS one. vol 3. issue 7. 2008-09-24. PMID:18648646. |
the 3xtgad mice express mutant presenilin-1, amyloid precursor protein and tau, and exhibit ad-like amyloid and tau pathology in the hippocampus and cortex, and associated cognitive impairment. |
2008-09-24 |
2023-08-12 |
mouse |
| Marisol Espinoza, Rohan de Silva, Dennis W Dickson, Peter Davie. Differential incorporation of tau isoforms in Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 14. issue 1. 2008-08-18. PMID:18525123. |
while biochemical studies showed that both isoforms were present in insoluble tau aggregates in ad hippocampus and cortex, not all tangles appear to be labeled with the 3r and 4r tau specific monoclonal antibodies. |
2008-08-18 |
2023-08-12 |
human |