| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S Williams, K Chalmers, G K Wilcock, S Lov. Relationship of neurofibrillary pathology to cerebral amyloid angiopathy in Alzheimer's disease. Neuropathology and applied neurobiology. vol 31. issue 4. 2005-09-06. PMID:16008825. |
however, tau labelling around a beta-laden arteries and arterioles significantly exceeded that around non-a beta-laden blood vessels (p<0.001) and this, in turn was greater than the labelling of cortex away from blood vessels (p<0.001). |
2005-09-06 |
2023-08-12 |
Not clear |
| S Williams, K Chalmers, G K Wilcock, S Lov. Relationship of neurofibrillary pathology to cerebral amyloid angiopathy in Alzheimer's disease. Neuropathology and applied neurobiology. vol 31. issue 4. 2005-09-06. PMID:16008825. |
there was no association between apoe epsilon 4 and the immunolabelling density for tau, whether around amyloid- or non-amyloid-laden arteries and arterioles, or in the cerebral cortex away from these. |
2005-09-06 |
2023-08-12 |
Not clear |
| Sigrun Roeber, Bjarne Krebs, Manuela Neumann, Otto Windl, Inga Zerr, Eva-Maria Grasbon-Frodl, Hans A Kretzschma. Creutzfeldt-Jakob disease in a patient with an R208H mutation of the prion protein gene (PRNP) and a 17-kDa prion protein fragment. Acta neuropathologica. vol 109. issue 4. 2005-09-01. PMID:15739100. |
neuropathological examination of the post mortem brain revealed tau pathology in the hippocampus and entorhinal cortex, as well as ballooned neurons in the cortex, hippocampus and subcortical gray matter. |
2005-09-01 |
2023-08-12 |
Not clear |
| Wang Xiao-Chuan, Hu Zheng-Hui, Fang Zheng-Yu, Feng Yue, Yang Yun-Huang, Wang Qun, Tang Xiao-Wei, Wu Yi-Gen, Wang Jian-Zh. Correlation of Alzheimer-like tau hyperphosphorylation and fMRI bold intensity. Current Alzheimer research. vol 1. issue 2. 2005-07-21. PMID:15975079. |
immunohistochemical staining of hippocampus and cortex was carried out using phosphorylation-dependent tau antibodies. |
2005-07-21 |
2023-08-12 |
rat |
| Wang Xiao-Chuan, Hu Zheng-Hui, Fang Zheng-Yu, Feng Yue, Yang Yun-Huang, Wang Qun, Tang Xiao-Wei, Wu Yi-Gen, Wang Jian-Zh. Correlation of Alzheimer-like tau hyperphosphorylation and fMRI bold intensity. Current Alzheimer research. vol 1. issue 2. 2005-07-21. PMID:15975079. |
the results showed (1) that bold intensity in hippocampus and cortex of ip-injected rats was obviously lower than that of sham-operated group, indicating a decrease in cmro2 and cbf of the particular brain regions in ip-treated rats; (2) that tau was hyperphosphorylated at ser-262/ser-356 (12e8), ser-396/ser-404 (phf-1) sites in ca1 ca2 ca3 ca4 and dentate gyrus regions of hippocampal formation and cortex area in ip group, but not in sham rats; (3) that a negative correlation between tau hyperphosphorylation and bold intensity in hippocampus and cortex area of ip rats was observed. |
2005-07-21 |
2023-08-12 |
rat |
| Su Jeon Shin, Sung-Eun Lee, Jung Hyun Boo, Mihyang Kim, Young-Dae Yoon, Su-il Kim, Inhee Mook-Jun. Profiling proteins related to amyloid deposited brain of Tg2576 mice. Proteomics. vol 4. issue 11. 2005-04-13. PMID:15378736. |
alzheimer's disease (ad) is an age-related neurodegenerative disorder that is characterized by the extracellular deposition of beta-amyloid and intracellular hyperphosphorylation of tau in the cortex and hippocampus of the brain. |
2005-04-13 |
2023-08-12 |
mouse |
| Masaki Ikeda, Mikio Shoji, Toshitaka Kawarai, Takeshi Kawarabayashi, Etsuro Matsubara, Tetsuro Murakami, Atsushi Sasaki, Yasushi Tomidokoro, Yasushi Ikarashi, Hisashi Kuribara, Koichi Ishiguro, Masato Hasegawa, Shu-Hui Yen, M Azhar Chishti, Yasuo Harigaya, Koji Abe, Koichi Okamoto, Peter St George-Hyslop, David Westawa. Accumulation of filamentous tau in the cerebral cortex of human tau R406W transgenic mice. The American journal of pathology. vol 166. issue 2. 2005-03-29. PMID:15681835. |
accumulation of filamentous tau in the cerebral cortex of human tau r406w transgenic mice. |
2005-03-29 |
2023-08-12 |
mouse |
| Pawel Grieb, Wanda Gordon-Krajcer, Małgorzata Frontczak-Baniewicz, Michał Walski, Miroslaw S Ryba, Tomasz Kryczka, Michal Fiedorowicz, Piotr Kulinowski, Zenon Sułek, Katarzyna Majcher, Andrzej Jasińsk. 2-deoxyglucose induces beta-APP overexpression, tau hyperphosphorylation and expansion of the trans-part of the Golgi complex in rat cerebral cortex. Acta neurobiologiae experimentalis. vol 64. issue 4. 2005-03-24. PMID:15586666. |
2-deoxyglucose induces beta-app overexpression, tau hyperphosphorylation and expansion of the trans-part of the golgi complex in rat cerebral cortex. |
2005-03-24 |
2023-08-12 |
rat |
| Pawel Grieb, Wanda Gordon-Krajcer, Małgorzata Frontczak-Baniewicz, Michał Walski, Miroslaw S Ryba, Tomasz Kryczka, Michal Fiedorowicz, Piotr Kulinowski, Zenon Sułek, Katarzyna Majcher, Andrzej Jasińsk. 2-deoxyglucose induces beta-APP overexpression, tau hyperphosphorylation and expansion of the trans-part of the Golgi complex in rat cerebral cortex. Acta neurobiologiae experimentalis. vol 64. issue 4. 2005-03-24. PMID:15586666. |
the effects of a single intraperitoneal injection of a non-metabolizable glucose analog 2-deoxyglucose (2-dg, 500 mg/kg) on the levels of beta-app expression, and phosphorylated and unphosphorylated tau protein in the rat cerebral cortex were investigated. |
2005-03-24 |
2023-08-12 |
rat |
| Pawel Grieb, Wanda Gordon-Krajcer, Małgorzata Frontczak-Baniewicz, Michał Walski, Miroslaw S Ryba, Tomasz Kryczka, Michal Fiedorowicz, Piotr Kulinowski, Zenon Sułek, Katarzyna Majcher, Andrzej Jasińsk. 2-deoxyglucose induces beta-APP overexpression, tau hyperphosphorylation and expansion of the trans-part of the Golgi complex in rat cerebral cortex. Acta neurobiologiae experimentalis. vol 64. issue 4. 2005-03-24. PMID:15586666. |
seven and a half hours after injection of 2-deoxyglucose a significant increase in brain cortex beta-app expression, increased tau phosphorylation, and a marked relative expansion of the trans- part of the golgi intracellular secretory pathway in cortical neurons has been found. |
2005-03-24 |
2023-08-12 |
rat |
| Baolin Li, John Ryder, Yuan Su, Steven A Moore, Feng Liu, Patricia Solenberg, Kellie Brune, Niles Fox, Binhui Ni, Rugao Liu, Yan Zho. Overexpression of GSK3betaS9A resulted in tau hyperphosphorylation and morphology reminiscent of pretangle-like neurons in the brain of PDGSK3beta transgenic mice. Transgenic research. vol 13. issue 4. 2005-02-22. PMID:15517997. |
by analyzing the offspring from several transgenic mouse lines, including lines other than 3083 and 3107, it was found that overexpressed constitutively active human gsk3betas9a resulted in hyperphosphorylation of tau and morphology reminiscent of pretangle-like neurons in cortex and hippocampus. |
2005-02-22 |
2023-08-12 |
mouse |
| D C Paviour, A J Lees, K A Josephs, T Ozawa, M Ganguly, C Strand, A Godbolt, R S Howard, T Revesz, J L Holto. Frontotemporal lobar degeneration with ubiquitin-only-immunoreactive neuronal changes: broadening the clinical picture to include progressive supranuclear palsy. Brain : a journal of neurology. vol 127. issue Pt 11. 2005-01-18. PMID:15459024. |
the ftld with ubiquitin-only-immunoreactive neuronal changes (ftld-u) subtype is pathologically characterized by ubiquitin-positive, tau and alpha-synuclein-negative neuronal cytoplasmic inclusions in the frontotemporal cortex and hippocampal dentate fascia. |
2005-01-18 |
2023-08-12 |
Not clear |
| A Boutajangout, A Boom, K Leroy, J P Brio. Expression of tau mRNA and soluble tau isoforms in affected and non-affected brain areas in Alzheimer's disease. FEBS letters. vol 576. issue 1-2. 2004-11-19. PMID:15474035. |
in this study, we have analyzed in control subjects and in sporadic ad patients the pattern of expression of tau mrna and tau proteins in areas unaffected (cerebellar cortex, white matter), moderately affected (occipital striate cortex, thalamus, caudate nucleus, and putamen) or strongly affected by neurofibrillary tangles (temporal and frontal associative cortex). |
2004-11-19 |
2023-08-12 |
human |
| Christopher L Hunter, Heather A Bimonte-Nelson, Mathew Nelson, Christopher B Eckman, Ann-Charlotte Granhol. Behavioral and neurobiological markers of Alzheimer's disease in Ts65Dn mice: effects of estrogen. Neurobiology of aging. vol 25. issue 7. 2004-09-21. PMID:15212841. |
estrogen treatment prior to behavioral testing did not improve cognitive deficits in 6-month-old male ts65dn mice, but decreased total and phosphorylated (ps199) tau in the entorhinal cortex compared to normosomic animals. |
2004-09-21 |
2023-08-12 |
mouse |
| Bin Zhang, Makoto Higuchi, Yasumasa Yoshiyama, Takeshi Ishihara, Mark S Forman, Dan Martinez, Sonali Joyce, John Q Trojanowski, Virginia M-Y Le. Retarded axonal transport of R406W mutant tau in transgenic mice with a neurodegenerative tauopathy. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 24. issue 19. 2004-08-13. PMID:15140937. |
rw but not hwt tau tg mice developed an age-dependent accumulation of insoluble filamentous tau aggregates in neuronal perikarya of the cerebral cortex, hippocampus, cerebellum, and spinal cord. |
2004-08-13 |
2023-08-12 |
mouse |
| Nobue Kitanaka, Junichi Kitanaka, Minori Nishiguchi, Hiroshi Kinoshita, Harumi Ouchi, Takako Minami, Shigeru Hishida, Motohiko Takemur. Decreased histamine-stimulated phosphoinositide hydrolysis in the cerebral cortex of a rat line selectively bred for high alcohol preference. Neurochemical research. vol 29. issue 7. 2004-08-10. PMID:15202776. |
the contents of monoamines (dopamine, norepinephrine, and serotonin) and histamine in the cerebral cortex did not significantly differ between lap and hap rats, nor did the contents of their metabolites, except 3-methoxy-4-hydroxyphenylglycol (one of the metabolites of norepinephrine) and n(tau)-methylhistamine, which was not detected in our system. |
2004-08-10 |
2023-08-12 |
rat |
| Yi Wen, Shaohua Yang, Ran Liu, Anne Marie Brun-Zinkernagel, Peter Koulen, James W Simpkin. Transient cerebral ischemia induces aberrant neuronal cell cycle re-entry and Alzheimer's disease-like tauopathy in female rats. The Journal of biological chemistry. vol 279. issue 21. 2004-06-30. PMID:14982935. |
in this study, we report for the first time that transient cerebral ischemia induces aberrant mitotic proteins and hyperphosphorylation of tau protein with neurofibrillary tangle-like conformational epitopes in adult female rat cortex. |
2004-06-30 |
2023-08-12 |
rat |
| F F Cruz-Sánchez, N Durany, J Thome, P Riederer, D Zambó. Correlation between Apolipoprotein-E polymorphism and Alzheimer's disease pathology. Journal of Alzheimer's disease : JAD. vol 2. issue 3-4. 2004-05-05. PMID:12214086. |
representative cerebral regions (cortex, gyrus cinguli, putamen, hippocampus, white matter) from 28 ad cases, 7 svdd and 38 non-neurological controls were studied using classical histological techniques and immunohistochemistry for tau protein and amyloid-beta. |
2004-05-05 |
2023-08-12 |
Not clear |
| Salvatore Oddo, Antonella Caccamo, Masashi Kitazawa, Bertrand P Tseng, Frank M LaFerl. Amyloid deposition precedes tangle formation in a triple transgenic model of Alzheimer's disease. Neurobiology of aging. vol 24. issue 8. 2004-03-11. PMID:14643377. |
we find that abeta deposits initiate in the cortex and progress to the hippocampus with aging, whereas tau pathology is first apparent in the hippocampus and then progresses to the cortex. |
2004-03-11 |
2023-08-12 |
mouse |
| S Taniguchi, A M McDonagh, S M Pickering-Brown, Y Umeda, T Iwatsubo, M Hasegawa, D M A Man. The neuropathology of frontotemporal lobar degeneration with respect to the cytological and biochemical characteristics of tau protein. Neuropathology and applied neurobiology. vol 30. issue 1. 2004-03-10. PMID:14720172. |
these 33 nontau ftld cases, along with five alzheimer's disease (ad) and six huntington's disease (hd) cases with severe pathology, showed a variable loss of soluble tau proteins, broadly comparable with the extent of neuronal loss from the cortex and loss of the intracortical perikaryal marker, neun, but unrelated to proteins within afferent projection fibres such as neurofilament and alpha-synuclein. |
2004-03-10 |
2023-08-12 |
Not clear |