| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hillel Grossma. Does diabetes protect or provoke Alzheimer's disease? Insights into the pathobiology and future treatment of Alzheimer's disease. CNS spectrums. vol 8. issue 11. 2004-02-23. PMID:14702004. |
insulin dysregulation may contribute to ad pathology through several mechanisms including decreased cortical glucose utilization particularly in the hippocampus and entorhinal cortex; increased oxidative stress through the formation of advanced glycation end-products; increased tau phosphorylation and neurofibrillary tangle formation; increased b-amyloid aggregation through inhibition of insulin-degrading enzyme. |
2004-02-23 |
2023-08-12 |
Not clear |
| I Ferrer, I Hernández, M Boada, A Llorente, M J Rey, A Cardozo, M Ezquerra, B Pui. Primary progressive aphasia as the initial manifestation of corticobasal degeneration and unusual tauopathies. Acta neuropathologica. vol 106. issue 5. 2004-01-09. PMID:12955398. |
this was characterized by severe cerebral atrophy, marked neuronal loss in the cerebral cortex and abnormal tau deposition in neurons of the cerebral cortex, diencephalon and brain stem. |
2004-01-09 |
2023-08-12 |
Not clear |
| Zheng-Yu Fang, Shi-Jie Liu, Xiao-Chuan Wang, Rong Liu, Qun Wang, Zheng-Yue Chen, Jian-Zhi Wan. [Effect of calpain on the degradation of tau protein in rat brain cortex extracts]. Sheng wu hua xue yu sheng wu wu li xue bao Acta biochimica et biophysica Sinica. vol 35. issue 7. 2003-12-10. PMID:12883633. |
[effect of calpain on the degradation of tau protein in rat brain cortex extracts]. |
2003-12-10 |
2023-08-12 |
rat |
| Zheng-Yu Fang, Shi-Jie Liu, Xiao-Chuan Wang, Rong Liu, Qun Wang, Zheng-Yue Chen, Jian-Zhi Wan. [Effect of calpain on the degradation of tau protein in rat brain cortex extracts]. Sheng wu hua xue yu sheng wu wu li xue bao Acta biochimica et biophysica Sinica. vol 35. issue 7. 2003-12-10. PMID:12883633. |
to determine the nature of different subtypes of calpain on degradation of microtubule-associated protein tau, the rat cortex extracts were incubated with 0.2 mmol/l, 1 mmol/l, 3 mmol/l and 5 mmol/l of cacl(2 )for 15 min at 37 degrees c, respectively, and it was found that ca(2+) treatment at concentrations 1-5 mmol/l led to significant proteolysis of the tau protein and this degradation was blocked by calpain inhibitor, calpeptin. |
2003-12-10 |
2023-08-12 |
rat |
| Zheng-Yu Fang, Shi-Jie Liu, Xiao-Chuan Wang, Rong Liu, Qun Wang, Zheng-Yue Chen, Jian-Zhi Wan. [Effect of calpain on the degradation of tau protein in rat brain cortex extracts]. Sheng wu hua xue yu sheng wu wu li xue bao Acta biochimica et biophysica Sinica. vol 35. issue 7. 2003-12-10. PMID:12883633. |
these data suggest that both mu-calpain and m-calpain in brain cortex extracts are activated by ca(2+) and both of them degraded tau protein, although, m-calpain plays a more important role in proteolysis of the tau protein. |
2003-12-10 |
2023-08-12 |
rat |
| Esther van Herpen, Sonia M Rosso, Lies-Anne Serverijnen, Hirotaka Yoshida, Guido Breedveld, Raoul van de Graaf, Wouter Kamphorst, Rivka Ravid, Rob Willemsen, Dennis Dooijes, Daniëlle Majoor-Krakauer, Johan M Kros, R Anthony Crowther, Michel Goedert, Peter Heutink, John C van Swiete. Variable phenotypic expression and extensive tau pathology in two families with the novel tau mutation L315R. Annals of neurology. vol 54. issue 5. 2003-12-10. PMID:14595646. |
the brains of two affected subjects were studied and showed extensive tau pathology in neurons (pick-like inclusions) and astroglial cells, particularly in the frontotemporal cortex and the hippocampal formation. |
2003-12-10 |
2023-08-12 |
human |
| Esther van Herpen, Sonia M Rosso, Lies-Anne Serverijnen, Hirotaka Yoshida, Guido Breedveld, Raoul van de Graaf, Wouter Kamphorst, Rivka Ravid, Rob Willemsen, Dennis Dooijes, Daniëlle Majoor-Krakauer, Johan M Kros, R Anthony Crowther, Michel Goedert, Peter Heutink, John C van Swiete. Variable phenotypic expression and extensive tau pathology in two families with the novel tau mutation L315R. Annals of neurology. vol 54. issue 5. 2003-12-10. PMID:14595646. |
sarkosyl-insoluble tau extracted from the cerebral cortex showed the presence of straight and twisted tau filaments and a pattern of pathological tau bands similar to that of pick's disease. |
2003-12-10 |
2023-08-12 |
human |
| Kun Zou, Daesung Kim, Atsuko Kakio, Kyunghee Byun, Jian-Sheng Gong, Jaewoo Kim, Myeungju Kim, Naoya Sawamura, Sei-ichi Nishimoto, Katsumi Matsuzaki, Bonghee Lee, Katsuhiko Yanagisawa, Makoto Michikaw. Amyloid beta-protein (Abeta)1-40 protects neurons from damage induced by Abeta1-42 in culture and in rat brain. Journal of neurochemistry. vol 87. issue 3. 2003-11-24. PMID:14535944. |
abeta1-42 injection into the rat entorhinal cortex (ec) caused the hyperphosphorylation of tau on both sides of ec and hippocampus and increased the number of glial fibrillary acidic protein (gfap)-positive astrocytes in the ipsilateral ec, which were prevented by the concurrent injection of abeta1-40. |
2003-11-24 |
2023-08-12 |
rat |
| Faith M Harris, Walter J Brecht, Qin Xu, Ina Tesseur, Lisa Kekonius, Tony Wyss-Coray, Jo Dee Fish, Eliezer Masliah, Paul C Hopkins, Kimberly Scearce-Levie, Karl H Weisgraber, Lennart Mucke, Robert W Mahley, Yadong Huan. Carboxyl-terminal-truncated apolipoprotein E4 causes Alzheimer's disease-like neurodegeneration and behavioral deficits in transgenic mice. Proceedings of the National Academy of Sciences of the United States of America. vol 100. issue 19. 2003-10-29. PMID:12939405. |
the cortex and hippocampus of these mice displayed ad-like neurodegenerative alterations, including abnormally phosphorylated tau (p-tau) and gallyas silver-positive neurons that contained cytosolic straight filaments with diameters of 15-20 nm, resembling preneurofibrillary tangles. |
2003-10-29 |
2023-08-12 |
mouse |
| M A Kurt, D C Davies, M Kidd, K Duff, D R Howlet. Hyperphosphorylated tau and paired helical filament-like structures in the brains of mice carrying mutant amyloid precursor protein and mutant presenilin-1 transgenes. Neurobiology of disease. vol 14. issue 1. 2003-10-29. PMID:13678670. |
lm immunocytochemistry revealed cerebral abeta deposits to be present from 8 weeks of age, whereas hyperphosphorylated tau was not detected until 24 weeks of age, when it appeared as punctate deposits in close association with the abeta deposits in the cortex and hippocampus. |
2003-10-29 |
2023-08-12 |
mouse |
| Wen-Lin An, Richard F Cowburn, Lin Li, Heiko Braak, Irina Alafuzoff, Khalid Iqbal, Inge-Grundke Iqbal, Bengt Winblad, Jin-Jing Pe. Up-regulation of phosphorylated/activated p70 S6 kinase and its relationship to neurofibrillary pathology in Alzheimer's disease. The American journal of pathology. vol 163. issue 2. 2003-09-10. PMID:12875979. |
in primary cultured neurons of rat cortical cortex, zinc sulfate treatment could repeat p70 s6 kinase phosphorylation and activation at thr421/ser424, followed by increased expression and phosphorylation of tau. |
2003-09-10 |
2023-08-12 |
rat |
| Thomas Arendt, Jens Stieler, Arjen M Strijkstra, Roelof A Hut, Jan Rüdiger, Eddy A Van der Zee, Tibor Harkany, Max Holzer, Wolfgang Härti. Reversible paired helical filament-like phosphorylation of tau is an adaptive process associated with neuronal plasticity in hibernating animals. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 18. 2003-09-09. PMID:12904458. |
distribution of phf-like tau followed a consistent pattern, being most intense in the entorhinal cortex, hippocampus, and isocortical areas. |
2003-09-09 |
2023-08-12 |
Not clear |
| A González-Quevedo, F Obregón, M Urbina, T Roussó, L Lim. Effects of taurine deficiency and chronic methanol administration on rat retina, optic nerve and brain amino acids and monoamines. Nutritional neuroscience. vol 6. issue 4. 2003-09-03. PMID:12887142. |
beta-ala administration reduced taurine (tau) levels in plasma, hippocampus and posterior cortex, but not in retina and optic nerve. |
2003-09-03 |
2023-08-12 |
rat |
| Raymonde Porchet, Alphonse Probst, Eda Dráberová, Pavel Dráber, Irène M Riederer, Beat M Riedere. Differential subcellular localization of phosphorylated neurofilament and tau proteins in degenerating neurons of the human entorhinal cortex. Neuroreport. vol 14. issue 7. 2003-09-02. PMID:12802177. |
differential subcellular localization of phosphorylated neurofilament and tau proteins in degenerating neurons of the human entorhinal cortex. |
2003-09-02 |
2023-08-12 |
human |
| Wendy Noble, Vicki Olm, Kazuyuki Takata, Evelyn Casey, O Mary, Jordana Meyerson, Kate Gaynor, John LaFrancois, Lili Wang, Takayuki Kondo, Peter Davies, Mark Burns, Veeranna, Ralph Nixon, Dennis Dickson, Yasuji Matsuoka, Michael Ahlijanian, Lit-Fui Lau, Karen Duf. Cdk5 is a key factor in tau aggregation and tangle formation in vivo. Neuron. vol 38. issue 4. 2003-06-25. PMID:12765608. |
tau was hyperphosphorylated at several sites in the double transgenics, and there was a highly significant accumulation of aggregated tau in brainstem and cortex. |
2003-06-25 |
2023-08-12 |
mouse |
| Gaël Chetelat, Jean-Claude Baro. Early diagnosis of Alzheimer's disease: contribution of structural neuroimaging. NeuroImage. vol 18. issue 2. 2003-04-11. PMID:12595205. |
these data, although still preliminary, are consistent with postmortem studies describing the hierarchical progression of tau lesions in normal aging and early stages of ad, such that damage to the medial temporal lobe and association cortex would account for the memory and nonmemory cognitive impairments, respectively, the combination of which is required to operationally define probable ad. |
2003-04-11 |
2023-08-12 |
human |
| W-H Zheng, S Bastianetto, F Mennicken, W Ma, S Ka. Amyloid beta peptide induces tau phosphorylation and loss of cholinergic neurons in rat primary septal cultures. Neuroscience. vol 115. issue 1. 2003-02-05. PMID:12401334. |
the neuropathological features associated with alzheimer's disease (ad) brain include the presence of extracellular neuritic plaques composed of amyloid beta protein (abeta), intracellular neurofibrillary tangles containing phosphorylated tau protein and the loss of basal forebrain cholinergic neurons which innervate regions such as the hippocampus and the cortex. |
2003-02-05 |
2023-08-12 |
rat |
| Anete C Ferraz, Janete A Anselmo-Franci, Sandra R Perosa, Eduardo F de Castro-Neto, Maria Ines Bellissimo, Brás H de Oliveira, Esper A Cavalheiro, Maria da Graça Naffah-Mazzacoratti, Cláudio Da Cunh. Amino acid and monoamine alterations in the cerebral cortex and hippocampus of mice submitted to ricinine-induced seizures. Pharmacology, biochemistry, and behavior. vol 72. issue 4. 2003-01-08. PMID:12062566. |
animals killed during the preseizure period presented an increased utilization rate (hva/da) of dopamine (da), an increased concentration of noradrenaline (na), and a decreased concentration of glutamate (glu), glutamine (gln), taurine (tau), and serotonin (5-ht) in the cerebral cortex. |
2003-01-08 |
2023-08-12 |
mouse |
| Anete C Ferraz, Janete A Anselmo-Franci, Sandra R Perosa, Eduardo F de Castro-Neto, Maria Ines Bellissimo, Brás H de Oliveira, Esper A Cavalheiro, Maria da Graça Naffah-Mazzacoratti, Cláudio Da Cunh. Amino acid and monoamine alterations in the cerebral cortex and hippocampus of mice submitted to ricinine-induced seizures. Pharmacology, biochemistry, and behavior. vol 72. issue 4. 2003-01-08. PMID:12062566. |
the present results suggest that an increased release of glu in the cerebral cortex can be implicated in the genesis of the ricinine-induced seizure and that it triggers many anticonvulsive mechanisms, like the release of tau, da, 5-ht, and na. |
2003-01-08 |
2023-08-12 |
mouse |
| Andrea Reyna-Neyra, Ignacio Camacho-Arroyo, Patricia Ferrera, Clorinda Aria. Estradiol and progesterone modify microtubule associated protein 2 content in the rat hippocampus. Brain research bulletin. vol 58. issue 6. 2002-12-23. PMID:12372566. |
while tau expression was unaffected by e(2) and p(4), an increase in map2 protein content in the hippocampus but not in the cortex was observed after e(2) and p(4) treatments. |
2002-12-23 |
2023-08-12 |
rat |