| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Hayes, U Thaker, T Iwatsubo, S M Pickering-Brown, D M A Man. Pathological relationships between microglial cell activity and tau and amyloid beta protein in patients with Alzheimer's disease. Neuroscience letters. vol 331. issue 3. 2002-11-29. PMID:12383924. |
it is possible that because the presence of microglial cells predates that of pathological tau proteins within the cerebral cortex in ad, neurofibrillary damage to nerve cells may stem from the release of proinflammatory and other potentially neurotoxic molecules from microglial cells. |
2002-11-29 |
2023-08-12 |
Not clear |
| A Takashim. [Analysis of mouse model exhibiting neurofibrillary changes]. Rinsho shinkeigaku = Clinical neurology. vol 41. issue 12. 2002-11-08. PMID:12235811. |
in the present study, neurons of hippocampus and cerebral cortex in our tg mice showed phosphorylated and ubiquitinated tau aggregations with a beta-sheet structure. |
2002-11-08 |
2023-08-12 |
mouse |
| Victoria Zhukareva, David Mann, Stuart Pickering-Brown, Kunihiro Uryu, Theresa Shuck, Keyur Shah, Murray Grossman, Bruce L Miller, Christine M Hulette, Stuart C Feinstein, John Q Trojanowski, Virginia M-Y Le. Sporadic Pick's disease: a tauopathy characterized by a spectrum of pathological tau isoforms in gray and white matter. Annals of neurology. vol 51. issue 6. 2002-08-09. PMID:12112079. |
therefore, pick's disease is characterized by an accumulations of pick bodies in the hippocampal region and cortex as well as the presence of three and four microtubule-binding repeat tau pathology in both cortical gray and white matter that distinguish this tauopathy from other neurodegenerative disorders. |
2002-08-09 |
2023-08-12 |
Not clear |
| R Sinigaglia-Coimbra, E A Cavalheiro, C G Coimbr. Postischemic hyperthermia induces Alzheimer-like pathology in the rat brain. Acta neuropathologica. vol 103. issue 5. 2002-06-21. PMID:11935259. |
associated immunohistochemical findings after 2 or 6 months of recovery included: (1) complement activation (membrane attack complex formation); (2) generalized overexpression of ubiquitin in surviving forebrain neurons; (3) persistent activation of macrophages; (4) presence of gemistocytic astrocytes in the hippocampus; (5) maturation of amyloid plaques (identified by immunohistochemistry using anti-human beta-a4 primary antibody) in cerebral cortex; and (6) intracellular deposits identified by anti-human hyperphosphorylated tau protein antibodies. |
2002-06-21 |
2023-08-12 |
human |
| Béatrice Desgranges, Jean-Claude Baron, Catherine Lalevée, Bénédicte Giffard, Fausto Viader, Vincent de La Sayette, Francis Eustach. The neural substrates of episodic memory impairment in Alzheimer's disease as revealed by FDG-PET: relationship to degree of deterioration. Brain : a journal of neurology. vol 125. issue Pt 5. 2002-06-17. PMID:11960900. |
however, the subgroup analysis disclosed that, in the less severe subgroup, all significant correlations (p < 0.005, uncorrected) were restricted to the parahippocampal gyrus and retrosplenial cortex, in accordance with both the distribution of changes in tau in early alzheimer's disease and the known involvement of this network in normal and impaired memory function, while in the more severe subgroup they mainly involved the left temporal neocortex, which is known to be implicated in semantic memory. |
2002-06-17 |
2023-08-12 |
Not clear |
| Patrizia LoPrest. Regulation and differential expression of tau mRNA isoforms as oligodendrocytes mature in vivo: implications for myelination. Glia. vol 37. issue 3. 2002-04-18. PMID:11857683. |
we examined the developmental regulation of tau mrna isoforms at the amino domain by comparing tau expression in oligodendrocytes (olgs) isolated from 1- and 20-day-old rat brain and in age-matched cortex, which abounds in neurons. |
2002-04-18 |
2023-08-12 |
rat |
| Patrizia LoPrest. Regulation and differential expression of tau mRNA isoforms as oligodendrocytes mature in vivo: implications for myelination. Glia. vol 37. issue 3. 2002-04-18. PMID:11857683. |
by using semiquantitative rt-pcr, we found that olgs and cortex from 1-day-old rat brain largely had amino-derived tau isoforms with no insert, whereas olgs from 20-day-old rat brain had similar levels of amino-derived tau isoforms with no insert or with one insert. |
2002-04-18 |
2023-08-12 |
rat |
| Patrizia LoPrest. Regulation and differential expression of tau mRNA isoforms as oligodendrocytes mature in vivo: implications for myelination. Glia. vol 37. issue 3. 2002-04-18. PMID:11857683. |
in contrast to olgs from 20-day-old rat brain, age-matched cortex had comparable levels of a0, a1, and a2 tau amino-derived isoforms. |
2002-04-18 |
2023-08-12 |
rat |
| Patrizia LoPrest. Regulation and differential expression of tau mRNA isoforms as oligodendrocytes mature in vivo: implications for myelination. Glia. vol 37. issue 3. 2002-04-18. PMID:11857683. |
in contrast, younger and older cortex expressed either 3r or 4r tau. |
2002-04-18 |
2023-08-12 |
rat |
| Steven M Singer, Gina M Zainelli, Maryam A Norlund, John M Lee, Nancy A Mum. Transglutaminase bonds in neurofibrillary tangles and paired helical filament tau early in Alzheimer's disease. Neurochemistry international. vol 40. issue 1. 2002-03-06. PMID:11738469. |
in control cases with nft present in the entorhinal cortex and hippocampus, indicative of braak and braak stage ii, epsilon(gamma-glutamyl)lysine bonds were present in phf tau in parietal and frontal cortex, despite the lack of microscopically detectable nft or senile plaques in these cortical regions. |
2002-03-06 |
2023-08-12 |
Not clear |
| I K Takeuchi, Y K Takeuch. Transient accumulation of Gallyas-Braak-positive and phosphorylated tau-immunopositive substances in neuronal lipofuscin granules in the amygdala, hippocampus and entorhinal cortex of rats during long-term chloroquine intoxication. Acta neuropathologica. vol 102. issue 2. 2002-02-25. PMID:11563636. |
long-term chloroquine (cq) intoxication of normal and groggy mutant rats resulted in transient accumulation of gallyas-braak (g-b) -positive and phosphorylated tau (at8) -immunopositive substances in neuronal lipofuscin granules in the amygdala, hippocampus and entorhinal cortex. |
2002-02-25 |
2023-08-12 |
rat |
| J Eidenmüller, T Fath, T Maas, M Pool, E Sontag, R Brand. Phosphorylation-mimicking glutamate clusters in the proline-rich region are sufficient to simulate the functional deficiencies of hyperphosphorylated tau protein. The Biochemical journal. vol 357. issue Pt 3. 2001-08-30. PMID:11463346. |
a glutamate cluster in both the p- and c-regions induces the formation of sds-resistant conformational domains in tau and suppresses tau's interaction with the neural membrane cortex. |
2001-08-30 |
2023-08-12 |
Not clear |
| R Le, L Cruz, B Urbanc, R B Knowles, K Hsiao-Ashe, K Duff, M C Irizarry, H E Stanley, B T Hyma. Plaque-induced abnormalities in neurite geometry in transgenic models of Alzheimer disease: implications for neural system disruption. Journal of neuropathology and experimental neurology. vol 60. issue 8. 2001-08-16. PMID:11487049. |
these results are consistent with previous observations in ad, and suggest that thioflavine s-positive amyloid-beta deposits have a marked effect on dendritic microarchitecture in the cortex, even in the relative absence of phosphorylated tau alterations. |
2001-08-16 |
2023-08-12 |
mouse |
| F Eustache, B Desgranges, B Giffard, V de la Sayette, J C Baro. Entorhinal cortex disruption causes memory deficit in early Alzheimer's disease as shown by PET. Neuroreport. vol 12. issue 4. 2001-08-02. PMID:11277563. |
we have now applied this approach using a novel cognitive paradigm designed to selectively assess verbal episodic memory, and show that in early ad disruption of the left entorhinal cortex underlies this memory deficit, consistent with post mortem data showing that this brain area is affected earliest and most severely by tau pathology in ad. |
2001-08-02 |
2023-08-12 |
Not clear |
| C Shukla, L R Bridge. Tau, beta-amyloid and beta-amyloid precursor protein distribution in the entorhinal-hippocampal alvear and perforant pathways in the Alzheimer's brain. Neuroscience letters. vol 303. issue 3. 2001-08-02. PMID:11323118. |
paraffin-sections of hippocampal-entorhinal cortex from 25 ad cases were immunolabelled for tau, beta-amyloid (abeta) and beta-amyloid precursor protein (betaapp). |
2001-08-02 |
2023-08-12 |
Not clear |
| C M Watanabe, S Wolffram, P Ader, G Rimbach, L Packer, J J Maguire, P G Schultz, K Gohi. The in vivo neuromodulatory effects of the herbal medicine ginkgo biloba. Proceedings of the National Academy of Sciences of the United States of America. vol 98. issue 12. 2001-06-28. PMID:11381109. |
in the cortex, mrnas for neuronal tyrosine/threonine phosphatase 1, and microtubule-associated tau were significantly enhanced. |
2001-06-28 |
2023-08-12 |
mouse |
| V M Lee, J Q Trojanowsk. Transgenic mouse models of tauopathies: prospects for animal models of Pick's disease. Neurology. vol 56. issue 11 Suppl 4. 2001-06-28. PMID:11402147. |
these tg mice accumulated argyrophilic and filamentous tau immunoreactive neuronal inclusions with age in cortex and brainstem as well as in spinal cord, where these inclusions were most abundant and associated with gliosis. |
2001-06-28 |
2023-08-12 |
mouse |
| L Narici, N Forss, V Jousmäki, M Peresson, R Har. Evidence for a 7- to 9-Hz "sigma" rhythm in the human SII cortex. NeuroImage. vol 13. issue 4. 2001-06-21. PMID:11305895. |
we describe a new 7- to 9-hz "sigma" rhythm in the human second somatosensory cortex, distinct from both the mu rhythm of the primary sensorimotor cortex and the tau rhythm of the supratemporal auditory cortex. |
2001-06-21 |
2023-08-12 |
human |
| B Eppler, R Dawso. Dietary taurine manipulations in aged male Fischer 344 rat tissue: taurine concentration, taurine biosynthesis, and oxidative markers. Biochemical pharmacology. vol 62. issue 1. 2001-06-14. PMID:11377394. |
protein carbonyl content was elevated in the cerebral cortex and kidney of aged rats and was attenuated by tau supplementation. |
2001-06-14 |
2023-08-12 |
rat |
| A K Mudher, B Yee, A D Smith, V H Perr. Deafferentation of the hippocampus results in the induction of AT8 positive 'granules' in the rat. Neuroscience letters. vol 301. issue 1. 2001-06-07. PMID:11239703. |
to investigate what effect deafferentation of the hippocampus has on the phosphorylation state of tau, we lesioned the entorhinal cortex in rats and looked for hyperphosphorylated tau in the hippocampus at various days post lesioning. |
2001-06-07 |
2023-08-12 |
rat |