| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| H Tohgi, K Utsugisawa, Y Nagane, M Yoshimura, M Ukitsu, Y Gend. The methylation status of cytosines in a tau gene promoter region alters with age to downregulate transcriptional activity in human cerebral cortex. Neuroscience letters. vol 275. issue 2. 1999-12-16. PMID:10568506. |
the methylation status of cytosines in a tau gene promoter region alters with age to downregulate transcriptional activity in human cerebral cortex. |
1999-12-16 |
2023-08-12 |
human |
| H Tohgi, K Utsugisawa, Y Nagane, M Yoshimura, M Ukitsu, Y Gend. The methylation status of cytosines in a tau gene promoter region alters with age to downregulate transcriptional activity in human cerebral cortex. Neuroscience letters. vol 275. issue 2. 1999-12-16. PMID:10568506. |
changes with age in the methylation status of cytosines in a promoter region of the tau gene were investigated in autopsy human cerebral cortex, using the bisulfite method, polymerase chain reaction (pcr) and direct sequencing of pcr products. |
1999-12-16 |
2023-08-12 |
human |
| H Tohgi, K Utsugisawa, Y Nagane, M Yoshimura, M Ukitsu, Y Gend. The methylation status of cytosines in a tau gene promoter region alters with age to downregulate transcriptional activity in human cerebral cortex. Neuroscience letters. vol 275. issue 2. 1999-12-16. PMID:10568506. |
these findings suggest that the methylation status of cytosines in the promoter region of the tau gene alters with age to decrease its transcriptional activity in the human cerebral cortex. |
1999-12-16 |
2023-08-12 |
human |
| L Chen, L Baum, H K Ng, L Y Chan, C P Pan. Apolipoprotein E genotype and its pathological correlation in Chinese Alzheimer's disease with late onset. Human pathology. vol 30. issue 10. 1999-11-02. PMID:10534164. |
hippocampus (including entorhinal cortex), amygdala, superior temporal lobe, middle frontal gyrus, and inferior parietal lobule of the brains of ad and poss were examined with beta amyloid (a beta) immunostaining, and the same regions plus medial occipital lobe were examined with tau immunostaining. |
1999-11-02 |
2023-08-12 |
human |
| M B Delisle, J R Murrell, R Richardson, J A Trofatter, O Rascol, X Soulages, M Mohr, P Calvas, B Ghett. A mutation at codon 279 (N279K) in exon 10 of the Tau gene causes a tauopathy with dementia and supranuclear palsy. Acta neuropathologica. vol 98. issue 1. 1999-09-24. PMID:10412802. |
neuropathologically, widespread neuronal and glial tau accumulation in the cortex, basal ganglia, brain stem nuclei as well as in the white matter were the hallmark of the disease. |
1999-09-24 |
2023-08-12 |
Not clear |
| b' P M Mattila, J O Rinne, H Helenius, M R\\xc3\\xb6ytt\\xc3\\xa. Neuritic degeneration in the hippocampus and amygdala in Parkinson\'s disease in relation to Alzheimer pathology. Acta neuropathologica. vol 98. issue 2. 1999-09-09. PMID:10442555.' |
samples from amygdala, hippocampus, entorhinal cortex (erc) and cortical gyri were examined for alzheimer-type (ad) changes and lewy bodies (lbs) using antibodies against ubiquitin and tau. |
1999-09-09 |
2023-08-12 |
Not clear |
| X Wei, Y Zhang, J Zho. Alzheimer's disease-related gene expression in the brain of senescence accelerated mouse. Neuroscience letters. vol 268. issue 3. 1999-09-01. PMID:10406024. |
the levels of alzheimer's disease (ad)-related genes, including beta-amyloid precursor protein(app), presenilin-1 (ps-1), ps-2, apoe, tau, c-fos, neural cell adhesion molecular 180 (ncam-180), tgf-beta 1, il-1 alpha/beta, il-6, tnf-alpha/beta, alpha-2-macroglobulin (alpha 2m), class ii major histocompatibility antigen la (mhcii la), bcl-2 alpha, glucocorticoid receptor-alpha (gr alpha) and mineralocorticoid receptor (mr) mrnas were determined by reverse transcription polymerase chain reaction (rt-pcr) in the hippocampus and cerebral cortex of senescence accelerated mouse (sam). |
1999-09-01 |
2023-08-12 |
mouse |
| C M Hulette, M A Pericak-Vance, A D Roses, D E Schmechel, L H Yamaoka, P C Gaskell, K A Welsh-Bohmer, R A Crowther, M G Spillantin. Neuropathological features of frontotemporal dementia and parkinsonism linked to chromosome 17q21-22 (FTDP-17): Duke Family 1684. Journal of neuropathology and experimental neurology. vol 58. issue 8. 1999-08-30. PMID:10446810. |
sarkosyl-insoluble tau extracted from the hippocampus and cortex migrated as 2 major bands at 64 and 68 kilodaltons and a minor band at 72 kilodaltons, which after alkaline phosphatase treatment appeared to contain mainly tau isoforms with 4 repeats. |
1999-08-30 |
2023-08-12 |
Not clear |
| X Bi, J Zhou, G Lync. Lysosomal protease inhibitors induce meganeurites and tangle-like structures in entorhinohippocampal regions vulnerable to Alzheimer's disease. Experimental neurology. vol 158. issue 2. 1999-08-24. PMID:10415139. |
antibodies against the phosphorylated tau protein in neurofibrillary tangles labeled thick filaments running through neurons in the superficial layers of entorhinal cortex in 6-day zpad-treated slices. |
1999-08-24 |
2023-08-12 |
human |
| M Verny, C Duyckaerts, J J Hau. [Cortical lesions in progressive supranuclear palsy (Steele-Richardson-Olszewski disease)]. Revue neurologique. vol 155. issue 1. 1999-04-22. PMID:10093844. |
tau positive fibrillary accumulation in the nevroglia has also been seen in the cortex. |
1999-04-22 |
2023-08-12 |
Not clear |
| C Geula, C K Wu, D Saroff, A Lorenzo, M Yuan, B A Yankne. Aging renders the brain vulnerable to amyloid beta-protein neurotoxicity. Nature medicine. vol 4. issue 7. 1999-04-07. PMID:9662375. |
here we show that microinjection of plaque-equivalent concentrations of fibrillar, but not soluble, abeta in the aged rhesus monkey cerebral cortex results in profound neuronal loss, tau phosphorylation and microglial proliferation. |
1999-04-07 |
2023-08-12 |
mouse |
| K A Jellinger, C Banche. Neuropathology of Alzheimer's disease: a critical update. Journal of neural transmission. Supplementum. vol 54. 1999-03-11. PMID:9850917. |
the morphology of ad includes cerebral atrophy, deposition of beta a4 amyloid (a beta) (senile plaques and amyloid angiopathy), neuritic changes (neuritic plaques, neurofibrillary tangles (nft) and neuropil threads) with formation of paired helical filaments (phf) containing polymerized hyperphosphorylated tau protein triplet, causing disruption of the neuronal cytoskeleton with loss of synapses and neurons, with altered cortico-cortical connectivity, leading to disconnection of the cerebral cortex. |
1999-03-11 |
2023-08-12 |
human |
| T Uchihara, H Mizusawa, K Tsuchiya, H Kondo, T Oda, K Iked. Discrepancy between tau immunoreactivity and argyrophilia by the Bodian method in neocortical neurons of corticobasal degeneration. Acta neuropathologica. vol 96. issue 6. 1999-02-22. PMID:9845283. |
to clarify different features of cytoskeletal pathology in neocortical neurons between corticobasal degeneration (cbd) and alzheimer's disease (ad), the relationship between neurofibrillary tangles (nfts), which are defined as a fibrillary structure stained by the bodian method, and tau-immunopositive neurons in layers ii-iii of the premotor cortex was assessed by sequential staining for tau immunohistochemistry followed by the bodian method on the same section. |
1999-02-22 |
2023-08-12 |
Not clear |
| S L Minger, J W Geddes, M L Holtz, S D Craddock, S W Whiteheart, R G Siman, L C Pettigre. Glutamate receptor antagonists inhibit calpain-mediated cytoskeletal proteolysis in focal cerebral ischemia. Brain research. vol 810. issue 1-2. 1999-01-29. PMID:9813316. |
western analysis performed on ischemic cortex taken from controls or rats pretreated with either nbqx or cgs 19755 suggested that loss of tau protein immunoreactivity was caused by dephosphorylation, rather than proteolysis. |
1999-01-29 |
2023-08-12 |
rat |
| R J Lucas, F R Cagampang, A S Loudon, J A Stirland, C W Coe. Expression of vasoactive intestinal peptide mRNA in the suprachiasmatic nuclei of the circadian tau mutant hamster. Neuroscience letters. vol 249. issue 2-3. 1998-09-30. PMID:9682838. |
in order to investigate the molecular mechanisms associated with this mutation, we have compared the level of expression of the mrna for vasoactive intestinal peptide (vip) in the suprachiasmatic nuclei (scn) and cerebral cortex of homozygous tau mutant and wild-type animals using in situ hybridization histochemistry. |
1998-09-30 |
2023-08-12 |
Not clear |
| J G Sheng, R E Mrak, W S Griffi. Progressive neuronal DNA damage associated with neurofibrillary tangle formation in Alzheimer disease. Journal of neuropathology and experimental neurology. vol 57. issue 4. 1998-06-04. PMID:9600224. |
to assess possible relationships between neurofibrillary tangle formation and dna damage, we used tau immunohistochemistry and tunel in tangle-rich fields of tissue sections of subiculum and parahippocampal cortex tissue from 12 alzheimer and 6 control patients. |
1998-06-04 |
2023-08-12 |
Not clear |
| J Collet, L Fehrat, H Pollard, L Ribas de Pouplana, G Charton, A Bernard, J Moreau, Y Ben-Ari, M Khrestchatisk. Developmentally regulated alternative splicing of mRNAs encoding N-terminal tau variants in the rat hippocampus: structural and functional implications. The European journal of neuroscience. vol 9. issue 12. 1998-04-24. PMID:9517477. |
we studied the expression of the mrnas encoding n-terminal variants of tau, and we showed distinct alternative splicing of exons 2 and 3 in nervous tissues of the adult rat, including the inner ear, hippocampus, cortex, striatum, brainstem, cerebellum, olfactory bulb and retina. |
1998-04-24 |
2023-08-12 |
rat |
| K Tashiro, M Hasegawa, Y Ihara, T Iwatsub. Somatodendritic localization of phosphorylated tau in neonatal and adult rat cerebral cortex. Neuroreport. vol 8. issue 12. 1997-10-23. PMID:9295120. |
somatodendritic localization of phosphorylated tau in neonatal and adult rat cerebral cortex. |
1997-10-23 |
2023-08-12 |
rat |
| P Giannakopoulos, S Silhol, V Jallageas, J Mallet, N Bons, C Bouras, P Delaèr. Quantitative analysis of tau protein-immunoreactive accumulations and beta amyloid protein deposits in the cerebral cortex of the mouse lemur, Microcebus murinus. Acta neuropathologica. vol 94. issue 2. 1997-09-17. PMID:9255387. |
quantitative analysis of tau protein-immunoreactive accumulations and beta amyloid protein deposits in the cerebral cortex of the mouse lemur, microcebus murinus. |
1997-09-17 |
2023-08-12 |
mouse |
| P Giannakopoulos, S Silhol, V Jallageas, J Mallet, N Bons, C Bouras, P Delaèr. Quantitative analysis of tau protein-immunoreactive accumulations and beta amyloid protein deposits in the cerebral cortex of the mouse lemur, Microcebus murinus. Acta neuropathologica. vol 94. issue 2. 1997-09-17. PMID:9255387. |
recent studies have revealed the presence of tau protein-immunoreactive accumulations and beta amyloid protein (a beta) deposits in the cerebral cortex of the aged mouse lemur, microcebus murinus. |
1997-09-17 |
2023-08-12 |
mouse |